Serveur d'exploration sur les relations entre la France et l'Australie

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The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length

Identifieur interne : 001E14 ( Ncbi/Curation ); précédent : 001E13; suivant : 001E15

The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length

Auteurs : Mark M. Iles ; D. Timothy Bishop ; John C. Taylor ; Nicholas K. Hayward ; Myriam Brossard ; Anne E. Cust ; Alison M. Dunning ; Jeffrey E. Lee ; Eric K. Moses ; Lars A. Akslen ; Per A. Andresen ; Marie-Françoise Avril ; Esther Azizi ; Giovanna Bianchi Scarrà ; Kevin M. Brown ; Tadeusz D Bniak ; David E. Elder ; Eitan Friedman ; Paola Ghiorzo ; Elizabeth M. Gillanders ; Alisa M. Goldstein ; Nelleke A. Gruis ; Johan Hansson ; Mark Harland ; Per Helsing ; Marko Ho Evar ; Veronica Höiom ; Christian Ingvar ; Peter A. Kanetsky ; Maria Teresa Landi ; Julie Lang ; G. Mark Lathrop ; Jan Lubi Ski ; Rona M. Mackie ; Nicholas G. Martin ; Anders Molven ; Grant W. Montgomery ; Srdjan Novakovi ; H Kan Olsson ; Susana Puig ; Joan Anton Puig-Butille ; Graham L. Radford-Smith ; Juliette Randerson-Moor ; Nienke Van Der Stoep ; Remco Van Doorn ; David C. Whiteman ; Stuart Macgregor ; Karen A. Pooley ; Sarah V. Ward ; Graham J. Mann ; Christopher I. Amos ; Paul D. P. Pharoah ; Florence Demenais ; Matthew H. Law ; Julia A. Newton Bishop ; Jennifer H. Barrett

Source :

RBID : PMC:4196080

Descripteurs français

English descriptors

Abstract

Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10-9, two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.


Url:
DOI: 10.1093/jnci/dju267
PubMed: 25231748
PubMed Central: 4196080

Links toward previous steps (curation, corpus...)


Links to Exploration step

PMC:4196080

Le document en format XML

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<title xml:lang="en" level="a" type="main">The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length</title>
<author>
<name sortKey="Iles, Mark M" sort="Iles, Mark M" uniqKey="Iles M" first="Mark M." last="Iles">Mark M. Iles</name>
</author>
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<name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name>
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<name sortKey="Taylor, John C" sort="Taylor, John C" uniqKey="Taylor J" first="John C." last="Taylor">John C. Taylor</name>
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<name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name>
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<name sortKey="Brossard, Myriam" sort="Brossard, Myriam" uniqKey="Brossard M" first="Myriam" last="Brossard">Myriam Brossard</name>
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<name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name>
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<name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name>
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<name sortKey="Lee, Jeffrey E" sort="Lee, Jeffrey E" uniqKey="Lee J" first="Jeffrey E." last="Lee">Jeffrey E. Lee</name>
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<name sortKey="Avril, Marie Francoise" sort="Avril, Marie Francoise" uniqKey="Avril M" first="Marie-Françoise" last="Avril">Marie-Françoise Avril</name>
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<name sortKey="Azizi, Esther" sort="Azizi, Esther" uniqKey="Azizi E" first="Esther" last="Azizi">Esther Azizi</name>
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<name sortKey="Scarra, Giovanna Bianchi" sort="Scarra, Giovanna Bianchi" uniqKey="Scarra G" first="Giovanna Bianchi" last="Scarrà">Giovanna Bianchi Scarrà</name>
</author>
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<name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name>
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<name sortKey="D Bniak, Tadeusz" sort="D Bniak, Tadeusz" uniqKey="D Bniak T" first="Tadeusz" last="D Bniak">Tadeusz D Bniak</name>
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<name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
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<name sortKey="Molven, Anders" sort="Molven, Anders" uniqKey="Molven A" first="Anders" last="Molven">Anders Molven</name>
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<name sortKey="Novakovi, Srdjan" sort="Novakovi, Srdjan" uniqKey="Novakovi S" first="Srdjan" last="Novakovi">Srdjan Novakovi</name>
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<name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name>
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<name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name>
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<name sortKey="Puig Butille, Joan Anton" sort="Puig Butille, Joan Anton" uniqKey="Puig Butille J" first="Joan Anton" last="Puig-Butille">Joan Anton Puig-Butille</name>
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<name sortKey="Radford Smith, Graham L" sort="Radford Smith, Graham L" uniqKey="Radford Smith G" first="Graham L." last="Radford-Smith">Graham L. Radford-Smith</name>
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<name sortKey="Randerson Moor, Juliette" sort="Randerson Moor, Juliette" uniqKey="Randerson Moor J" first="Juliette" last="Randerson-Moor">Juliette Randerson-Moor</name>
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<name sortKey="Van Der Stoep, Nienke" sort="Van Der Stoep, Nienke" uniqKey="Van Der Stoep N" first="Nienke" last="Van Der Stoep">Nienke Van Der Stoep</name>
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<name sortKey="Van Doorn, Remco" sort="Van Doorn, Remco" uniqKey="Van Doorn R" first="Remco" last="Van Doorn">Remco Van Doorn</name>
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<name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name>
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<name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name>
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<name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name>
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<name sortKey="Ward, Sarah V" sort="Ward, Sarah V" uniqKey="Ward S" first="Sarah V." last="Ward">Sarah V. Ward</name>
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<name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name>
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<name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name>
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<name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name>
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<name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
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<name sortKey="Law, Matthew H" sort="Law, Matthew H" uniqKey="Law M" first="Matthew H." last="Law">Matthew H. Law</name>
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<name sortKey="Newton Bishop, Julia A" sort="Newton Bishop, Julia A" uniqKey="Newton Bishop J" first="Julia A." last="Newton Bishop">Julia A. Newton Bishop</name>
</author>
<author>
<name sortKey="Barrett, Jennifer H" sort="Barrett, Jennifer H" uniqKey="Barrett J" first="Jennifer H." last="Barrett">Jennifer H. Barrett</name>
</author>
</analytic>
<series>
<title level="j">JNCI Journal of the National Cancer Institute</title>
<idno type="ISSN">0027-8874</idno>
<idno type="eISSN">1460-2105</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Australia</term>
<term>Confounding Factors (Epidemiology)</term>
<term>DNA Helicases (genetics)</term>
<term>Europe</term>
<term>Germ-Line Mutation</term>
<term>Humans</term>
<term>Israel</term>
<term>Melanoma (genetics)</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Predictive Value of Tests</term>
<term>RNA (genetics)</term>
<term>Research Design</term>
<term>Ribonucleoproteins (genetics)</term>
<term>Skin Neoplasms (genetics)</term>
<term>Telomerase (genetics)</term>
<term>Telomere (genetics)</term>
<term>Telomere-Binding Proteins (genetics)</term>
<term>United States</term>
<term>Zinc Fingers (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>ARN (génétique)</term>
<term>Australie</term>
<term>Doigts de zinc (génétique)</term>
<term>Europe</term>
<term>Facteurs de confusion (épidémiologie)</term>
<term>Helicase (génétique)</term>
<term>Humains</term>
<term>Israël</term>
<term>Mutation germinale</term>
<term>Mélanome (génétique)</term>
<term>Plan de recherche</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Protéines télomériques (génétique)</term>
<term>Ribonucléoprotéines (génétique)</term>
<term>Telomerase (génétique)</term>
<term>Tumeurs cutanées (génétique)</term>
<term>Télomère (génétique)</term>
<term>Valeur prédictive des tests</term>
<term>États-Unis d'Amérique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>DNA Helicases</term>
<term>RNA</term>
<term>Ribonucleoproteins</term>
<term>Telomerase</term>
<term>Telomere-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en">
<term>Australia</term>
<term>Europe</term>
<term>Israel</term>
<term>United States</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Melanoma</term>
<term>Skin Neoplasms</term>
<term>Telomere</term>
<term>Zinc Fingers</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>ARN</term>
<term>Doigts de zinc</term>
<term>Helicase</term>
<term>Mélanome</term>
<term>Protéines télomériques</term>
<term>Ribonucléoprotéines</term>
<term>Telomerase</term>
<term>Tumeurs cutanées</term>
<term>Télomère</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Confounding Factors (Epidemiology)</term>
<term>Germ-Line Mutation</term>
<term>Humans</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Predictive Value of Tests</term>
<term>Research Design</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Australie</term>
<term>Europe</term>
<term>Facteurs de confusion (épidémiologie)</term>
<term>Humains</term>
<term>Israël</term>
<term>Mutation germinale</term>
<term>Plan de recherche</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Valeur prédictive des tests</term>
<term>États-Unis d'Amérique</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr">
<term>Australie</term>
<term>Israël</term>
<term>États-Unis</term>
</keywords>
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<front>
<div type="abstract" xml:lang="en">
<p>Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a
<italic>P</italic>
value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (
<italic>P =</italic>
8.92x10
<sup>-9</sup>
, two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.</p>
</div>
</front>
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