AustralieFrV1, Ncbi, Curation, bibRecord, 001B57

A simple way to track single gold-loaded alginate microcapsules using x-ray CT in small animal longitudinal studies.

Identifieur interne : 001B57 ( Ncbi/Curation ); précédent : 001B56; suivant : 001B58

A simple way to track single gold-loaded alginate microcapsules using x-ray CT in small animal longitudinal studies.

Auteurs : Alberto Astolfo [Australie] ; Fengxiang Qie [Australie] ; Astrid Kibleur [France] ; Xiaojuan Hao [Australie] ; Ralf Hendrik Menk [Italie] ; Fulvia Arfelli [Italie] ; Luigi Rigon [Italie] ; Tracey M. Hinton [Australie] ; Malsha Wickramaratna [Australie] ; Tianwei Tan [République populaire de Chine] ; Timothy C. Hughes [Australie]

Source :

Nanomedicine : nanotechnology, biology, and medicine [ 1549-9642 ] ; 2014.

RBID : pubmed:24954384

Descripteurs français

KwdFr :
- Acide glucuronique (), Acides hexuroniques (), Alginates (), Animaux, Capsules (), Nanoparticules métalliques (), Or (), Tomodensitométrie.
MESH :
- Acide glucuronique, Acides hexuroniques, Alginates, Animaux, Capsules, Nanoparticules métalliques, Or, Tomodensitométrie.

English descriptors

KwdEn :
- Alginates (chemistry), Animals, Capsules (chemistry), Glucuronic Acid (chemistry), Gold (chemistry), Hexuronic Acids (chemistry), Metal Nanoparticles (chemistry), Tomography, X-Ray Computed.
MESH :
- chemical , chemistry : Alginates, Capsules, Glucuronic Acid, Gold, Hexuronic Acids.
- chemistry : Metal Nanoparticles.
- Animals, Tomography, X-Ray Computed.

Abstract

The use of alginate based microcapsules to deliver drugs and cells with a minimal host interaction is increasingly being proposed. A proficient method to track the position of the microcapsules during such therapies, particularly if they are amenable to commonly used instrumentation, would greatly help the development of such treatments. Here we propose to label the microcapsules with gold nanoparticles to provide a bright contrast on small animal x-ray micro-CT systems enabling single microcapsule detection. The microcapsules preparation is based on a simple protocol using inexpensive compounds. This, combined with the widespread availability of micro-CT apparatus, renders our method more accessible compared with other methods. Our labeled microcapsules showed good mechanical stability and low cytotoxicity in-vitro. Our post-mortem rodent model data strongly suggest that the high signal intensity generated by the labeled microcapsules permits the use of a reduced radiation dose yielding a method fully compatible with longitudinal in-vivo studies.

DOI: 10.1016/j.nano.2014.06.008
PubMed: 24954384

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pubmed:24954384

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<series><title level="j">Nanomedicine : nanotechnology, biology, and medicine</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alginates (chemistry)</term>
<term>Animals</term>
<term>Capsules (chemistry)</term>
<term>Glucuronic Acid (chemistry)</term>
<term>Gold (chemistry)</term>
<term>Hexuronic Acids (chemistry)</term>
<term>Metal Nanoparticles (chemistry)</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide glucuronique ()</term>
<term>Acides hexuroniques ()</term>
<term>Alginates ()</term>
<term>Animaux</term>
<term>Capsules ()</term>
<term>Nanoparticules métalliques ()</term>
<term>Or ()</term>
<term>Tomodensitométrie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Alginates</term>
<term>Capsules</term>
<term>Glucuronic Acid</term>
<term>Gold</term>
<term>Hexuronic Acids</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Metal Nanoparticles</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Acide glucuronique</term>
<term>Acides hexuroniques</term>
<term>Alginates</term>
<term>Animaux</term>
<term>Capsules</term>
<term>Nanoparticules métalliques</term>
<term>Or</term>
<term>Tomodensitométrie</term>
</keywords>
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<front><div type="abstract" xml:lang="en">The use of alginate based microcapsules to deliver drugs and cells with a minimal host interaction is increasingly being proposed. A proficient method to track the position of the microcapsules during such therapies, particularly if they are amenable to commonly used instrumentation, would greatly help the development of such treatments. Here we propose to label the microcapsules with gold nanoparticles to provide a bright contrast on small animal x-ray micro-CT systems enabling single microcapsule detection. The microcapsules preparation is based on a simple protocol using inexpensive compounds. This, combined with the widespread availability of micro-CT apparatus, renders our method more accessible compared with other methods. Our labeled microcapsules showed good mechanical stability and low cytotoxicity in-vitro. Our post-mortem rodent model data strongly suggest that the high signal intensity generated by the labeled microcapsules permits the use of a reduced radiation dose yielding a method fully compatible with longitudinal in-vivo studies.</div>
</front>
</TEI>
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A simple way to track single gold-loaded alginate microcapsules using x-ray CT in small animal longitudinal studies.

A simple way to track single gold-loaded alginate microcapsules using x-ray CT in small animal longitudinal studies.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki