Phases of reprogramming.
Identifieur interne : 001963 ( Ncbi/Curation ); précédent : 001962; suivant : 001964Phases of reprogramming.
Auteurs : Laurent David [France] ; Jose M. Polo [Australie]Source :
- Stem cell research [ 1876-7753 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- cytologie : Cellules souches.
- métabolisme : Cellules souches.
- Animaux, Différenciation cellulaire, Humains, Reprogrammation cellulaire.
English descriptors
- KwdEn :
- MESH :
- cytology : Stem Cells.
- metabolism : Stem Cells.
- Animals, Cell Differentiation, Cellular Reprogramming, Humans.
Abstract
Despite advances in the field of somatic cell reprogramming, an understanding and exploration of the underlying mechanisms governing this process are only recently emerging. It is now increasingly apparent that key sequential events correlate with the reprogramming process; a process previously thought to be random and unpredictable is now looking, to a greater extent, defined and controlled. Herein, we will review the key cellular and molecular events associated with the reprogramming process, giving an integrative and conciliatory view of the different studies addressing the mechanism of nuclear reprogramming.
DOI: 10.1016/j.scr.2014.03.007
PubMed: 24735951
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