Plasma Lipidomic Profiling of Treated HIV-Positive Individuals and the Implications for Cardiovascular Risk Prediction
Identifieur interne : 001962 ( Ncbi/Curation ); précédent : 001961; suivant : 001963Plasma Lipidomic Profiling of Treated HIV-Positive Individuals and the Implications for Cardiovascular Risk Prediction
Auteurs : Gerard Wong [Australie] ; Janine M. Trevillyan [Australie] ; Benoit Fatou [Australie] ; Michelle Cinel [Australie] ; Jacquelyn M. Weir [Australie] ; Jennifer F. Hoy [Australie] ; Peter J. Meikle [Australie]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Lipides (sang), Maladies cardiovasculaires (étiologie), Modèles biologiques, Mâle, Métabolisme des lipides, Reproductibilité des résultats, Séropositivité VIH (), Séropositivité VIH (sang), Séropositivité VIH (traitement médicamenteux).
- MESH :
- sang : Lipides, Séropositivité VIH.
- traitement médicamenteux : Séropositivité VIH.
- étiologie : Maladies cardiovasculaires.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Modèles biologiques, Mâle, Métabolisme des lipides, Reproductibilité des résultats, Séropositivité VIH.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Lipids.
- blood : HIV Seropositivity.
- complications : HIV Seropositivity.
- drug therapy : HIV Seropositivity.
- etiology : Cardiovascular Diseases.
- Adult, Female, Humans, Lipid Metabolism, Male, Middle Aged, Models, Biological, Reproducibility of Results, Risk Factors.
Abstract
The increased risk of coronary artery disease in human immunodeficiency virus (HIV) positive patients is collectively contributed to by the human immunodeficiency virus and antiretroviral-associated dyslipidaemia. In this study, we investigate the characterisation of the plasma lipid profiles of treated HIV patients and the relationship of 316 plasma lipid species across multiple lipid classes with the risk of future cardiovascular events in HIV- positive patients.
In a retrospective case-control study, we analysed plasma lipid profiles of 113 subjects. Cases (n = 23) were HIV-positive individuals with a stored blood sample available 12 months prior to their diagnosis of coronary artery disease (CAD). They were age and sex matched to HIV-positive individuals without a diagnosis of CAD (n = 45) and with healthy HIV-negative volunteers (n = 45).
Association of plasma lipid species and classes with HIV infection and cardiovascular risk in HIV were determined. In multiple logistic regression, we identified 83 lipids species and 7 lipid classes significantly associated with HIV infection and a further identified 74 lipid species and 8 lipid classes significantly associated with future cardiovascular events in HIV-positive subjects. Risk prediction models incorporating lipid species attained an area under the receiver operator characteristic curve (AUC) of 0.78 (0.775, 0.785)) and outperformed all other tested markers and risk scores in the identification of HIV-positive subjects with increased risk of cardiovascular events.
Our results demonstrate that HIV-positive patients have significant differences in their plasma lipid profiles compared with healthy HIV-negative controls and that numerous lipid species were significantly associated with elevated cardiovascular risk. This suggests a potential novel application for plasma lipids in cardiovascular risk screening of HIV-positive patients.
Url:
DOI: 10.1371/journal.pone.0094810
PubMed: 24733512
PubMed Central: 3986244
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Benoit Fatou<affiliation><nlm:aff id="aff4"><addr-line>University of Sciences and Technologies of Lille, Lille France</addr-line></nlm:aff><wicri:noCountry code="subfield">Lille France</wicri:noCountry></affiliation>Le document en format XML
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Trevillyan</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Infectious Diseases, Faculty of Medicine, Nursing and Health Science, Monash University, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Infectious Diseases, Faculty of Medicine, Nursing and Health Science, Monash University, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Fatou, Benoit" sort="Fatou, Benoit" uniqKey="Fatou B" first="Benoit" last="Fatou">Benoit Fatou</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Baker IDI Heart and Diabetes Institute, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation><nlm:aff id="aff4"><addr-line>University of Sciences and Technologies of Lille, Lille France</addr-line></nlm:aff><wicri:noCountry code="subfield">Lille France</wicri:noCountry></affiliation></author><author><name sortKey="Cinel, Michelle" sort="Cinel, Michelle" uniqKey="Cinel M" first="Michelle" last="Cinel">Michelle Cinel</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Baker IDI Heart and Diabetes Institute, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Weir, Jacquelyn M" sort="Weir, Jacquelyn M" uniqKey="Weir J" first="Jacquelyn M." last="Weir">Jacquelyn M. Weir</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Baker IDI Heart and Diabetes Institute, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Hoy, Jennifer F" sort="Hoy, Jennifer F" uniqKey="Hoy J" first="Jennifer F." last="Hoy">Jennifer F. Hoy</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Infectious Diseases, Faculty of Medicine, Nursing and Health Science, Monash University, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Infectious Diseases, Faculty of Medicine, Nursing and Health Science, Monash University, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Meikle, Peter J" sort="Meikle, Peter J" uniqKey="Meikle P" first="Peter J." last="Meikle">Peter J. Meikle</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Baker IDI Heart and Diabetes Institute, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cardiovascular Diseases (etiology)</term><term>Female</term><term>HIV Seropositivity (blood)</term><term>HIV Seropositivity (complications)</term><term>HIV Seropositivity (drug therapy)</term><term>Humans</term><term>Lipid Metabolism</term><term>Lipids (blood)</term><term>Male</term><term>Middle Aged</term><term>Models, Biological</term><term>Reproducibility of Results</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Lipides (sang)</term><term>Maladies cardiovasculaires (étiologie)</term><term>Modèles biologiques</term><term>Mâle</term><term>Métabolisme des lipides</term><term>Reproductibilité des résultats</term><term>Séropositivité VIH ()</term><term>Séropositivité VIH (sang)</term><term>Séropositivité VIH (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Lipids</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Lipides</term><term>Séropositivité VIH</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Séropositivité VIH</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Maladies cardiovasculaires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Lipid Metabolism</term><term>Male</term><term>Middle Aged</term><term>Models, Biological</term><term>Reproducibility of Results</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Modèles biologiques</term><term>Mâle</term><term>Métabolisme des lipides</term><term>Reproductibilité des résultats</term><term>Séropositivité VIH</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The increased risk of coronary artery disease in human immunodeficiency virus (HIV) positive patients is collectively contributed to by the human immunodeficiency virus and antiretroviral-associated dyslipidaemia. In this study, we investigate the characterisation of the plasma lipid profiles of treated HIV patients and the relationship of 316 plasma lipid species across multiple lipid classes with the risk of future cardiovascular events in HIV- positive patients.</p></sec><sec><title>Methods</title><p>In a retrospective case-control study, we analysed plasma lipid profiles of 113 subjects. Cases (n = 23) were HIV-positive individuals with a stored blood sample available 12 months prior to their diagnosis of coronary artery disease (CAD). They were age and sex matched to HIV-positive individuals without a diagnosis of CAD (n = 45) and with healthy HIV-negative volunteers (n = 45).</p></sec><sec><title>Results</title><p>Association of plasma lipid species and classes with HIV infection and cardiovascular risk in HIV were determined. In multiple logistic regression, we identified 83 lipids species and 7 lipid classes significantly associated with HIV infection and a further identified 74 lipid species and 8 lipid classes significantly associated with future cardiovascular events in HIV-positive subjects. Risk prediction models incorporating lipid species attained an area under the receiver operator characteristic curve (AUC) of 0.78 (0.775, 0.785)) and outperformed all other tested markers and risk scores in the identification of HIV-positive subjects with increased risk of cardiovascular events.</p></sec><sec><title>Conclusions</title><p>Our results demonstrate that HIV-positive patients have significant differences in their plasma lipid profiles compared with healthy HIV-negative controls and that numerous lipid species were significantly associated with elevated cardiovascular risk. This suggests a potential novel application for plasma lipids in cardiovascular risk screening of HIV-positive patients.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mocroft, A" uniqKey="Mocroft A">A Mocroft</name></author><author><name sortKey="Ledergerber, B" uniqKey="Ledergerber B">B Ledergerber</name></author><author><name sortKey="Katlama, C" uniqKey="Katlama C">C Katlama</name></author><author><name sortKey="Kirk, O" uniqKey="Kirk O">O Kirk</name></author><author><name sortKey="Reiss, P" uniqKey="Reiss P">P Reiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lohse, N" uniqKey="Lohse N">N Lohse</name></author><author><name sortKey="Hansen, Ab" uniqKey="Hansen A">AB Hansen</name></author><author><name sortKey="Pedersen, G" uniqKey="Pedersen G">G Pedersen</name></author><author><name sortKey="Kronborg, G" uniqKey="Kronborg G">G Kronborg</name></author><author><name sortKey="Gerstoft, J" uniqKey="Gerstoft J">J Gerstoft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Obel, N" uniqKey="Obel N">N Obel</name></author><author><name sortKey="Thomsen, Hf" uniqKey="Thomsen H">HF Thomsen</name></author><author><name sortKey="Kronborg, G" uniqKey="Kronborg G">G Kronborg</name></author><author><name sortKey="Larsen, Cs" uniqKey="Larsen C">CS Larsen</name></author><author><name sortKey="Hildebrandt, Pr" uniqKey="Hildebrandt P">PR Hildebrandt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Triant, Va" uniqKey="Triant V">VA Triant</name></author><author><name sortKey="Lee, H" uniqKey="Lee H">H Lee</name></author><author><name sortKey="Hadigan, C" uniqKey="Hadigan C">C Hadigan</name></author><author><name sortKey="Grinspoon, Sk" uniqKey="Grinspoon S">SK Grinspoon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Friis Moller, N" uniqKey="Friis Moller N">N 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Salit</name></author><author><name sortKey="Lewis, Gf" uniqKey="Lewis G">GF Lewis</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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