Allotransplantation for patients age 40 years and greater with non-Hodgkin Lymphoma (NHL): encouraging progression-free survival
Identifieur interne : 001873 ( Ncbi/Curation ); précédent : 001872; suivant : 001874Allotransplantation for patients age 40 years and greater with non-Hodgkin Lymphoma (NHL): encouraging progression-free survival
Auteurs : Brian L. Mcclune [États-Unis] ; Kwang Woo Ahn [États-Unis] ; Hai-Lin Wang [États-Unis] ; Joseph H. Antin [États-Unis] ; Andrew S. Artz ; Jean-Yves Cahn [France] ; Abhinav Deol [États-Unis] ; César O. Freytes [États-Unis] ; Mehdi Hamadani [États-Unis] ; Leona A. Holmberg [États-Unis] ; Madan H. Jagasia [États-Unis] ; Ann A. Jakubowski [États-Unis] ; Mohamed A. Kharfan-Dabaja [États-Unis] ; Hillard M. Lazarus [États-Unis] ; Alan M. Miller [États-Unis] ; Richard Olsson [Suède] ; Tanya L. Pedersen [États-Unis] ; Joseph Pidala [États-Unis] ; Michael A. Pulsipher [États-Unis] ; Jacob M. Rowe [Israël] ; Wael Saber [États-Unis] ; Koen W. Van Besien [États-Unis] ; Edmund K. Waller [États-Unis] ; Mahmoud D. Aljurf [Arabie saoudite] ; Görgun Akpek [États-Unis] ; Ulrike Bacher [Allemagne] ; Nelson J. Chao [États-Unis] ; Yi-Bin Chen [États-Unis] ; Brenda W. Cooper [États-Unis] ; Jason Dehn [États-Unis] ; Marcos J. De Lima [États-Unis] ; Jack W. Hsu [États-Unis] ; Ian D. Lewis [Australie] ; David I. Marks [Royaume-Uni] ; Joseph Mcguirk [États-Unis] ; Mitchell S. Cairo [États-Unis] ; Harry C. Schouten [Pays-Bas] ; Jeffrey Szer [Australie] ; Muthalagu Ramanathan [États-Unis] ; Bipin N. Savani [États-Unis] ; Matthew Seftel [Canada] ; Gérard Socie [France] ; Ravi Vij [États-Unis] ; Erica D. Warlick [États-Unis] ; Daniel J. Weisdorf [États-Unis]Source :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1083-8791 ] ; 2014.
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Abstract
Non-Hodgkin lymphomas (NHL) disproportionately affect older patients who uncommonly receive allogeneic hematopoietic cell transplantation (HCT). We analyzed CIBMTR data on 1248 patients ≥40 years receiving reduced-intensity conditioning (RIC) or non-myeloablative (NMA) HCT for aggressive (n=668) and indolent (n=580) NHL. Aggressive lymphoma was more frequent in the oldest cohort [(age 40–54) 49% vs. (55–64) 57% vs. (≥65) 67% p=0.0008]; fewer patients ≥65 had prior autografting [26% vs. 24% vs. 9%; p=0.002)]. Rates of relapse, acute and chronic GVHD and non-relapse mortality (NRM) at one year were similar [22%, 95% confidence interval (CI) 19–26%; 27%, 95% CI 23–31%; 34%, 95% CI 24–44%]. Progression-free (PFS) and overall (OS) survival at 3 years was slightly lower in older cohorts [OS:54%, 95% CI 50–58%; 40%, 95% CI 36–44%; 39%, 95% CI 28–50%; p<0.0001]. Multivariate analysis revealed no significant effect of age on acute or chronic GVHD or relapse. Age ≥55 years, Karnofsky performance status <80, and HLA-mismatch adversely impacted NRM, PFS, and OS. Disease status at HCT, but not histologic subtype, worsened NRM, relapse, PFS and OS. Even for patients ≥55 years, OS still approached 40% at 3 years suggesting HCT effects long-term remissions and remains underutilized in qualified older patients with NHL.
Url:
DOI: 10.1016/j.bbmt.2014.03.013
PubMed: 24641829
PubMed Central: 4057955
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Andrew S. Artz<affiliation><nlm:aff id="A5">University of Chicago School of Medicine, Chicago IL</nlm:aff>
<wicri:noCountry code="subfield">Chicago IL</wicri:noCountry>
</affiliation>
Le document en format XML
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<author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
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<author><name sortKey="Wang, Hai Lin" sort="Wang, Hai Lin" uniqKey="Wang H" first="Hai-Lin" last="Wang">Hai-Lin Wang</name>
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<author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H." last="Antin">Joseph H. Antin</name>
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<author><name sortKey="Artz, Andrew S" sort="Artz, Andrew S" uniqKey="Artz A" first="Andrew S." last="Artz">Andrew S. Artz</name>
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<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
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<author><name sortKey="Freytes, Cesar O" sort="Freytes, Cesar O" uniqKey="Freytes C" first="César O." last="Freytes">César O. Freytes</name>
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<wicri:cityArea>South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio</wicri:cityArea>
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<author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name>
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<author><name sortKey="Holmberg, Leona A" sort="Holmberg, Leona A" uniqKey="Holmberg L" first="Leona A." last="Holmberg">Leona A. Holmberg</name>
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<author><name sortKey="Jagasia, Madan H" sort="Jagasia, Madan H" uniqKey="Jagasia M" first="Madan H." last="Jagasia">Madan H. Jagasia</name>
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<placeName><region type="state">Tennessee</region>
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<author><name sortKey="Jakubowski, Ann A" sort="Jakubowski, Ann A" uniqKey="Jakubowski A" first="Ann A." last="Jakubowski">Ann A. Jakubowski</name>
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<author><name sortKey="Kharfan Dabaja, Mohamed A" sort="Kharfan Dabaja, Mohamed A" uniqKey="Kharfan Dabaja M" first="Mohamed A." last="Kharfan-Dabaja">Mohamed A. Kharfan-Dabaja</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL</nlm:aff>
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<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa</wicri:cityArea>
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<author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name>
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<wicri:cityArea>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea>
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<author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name>
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<author><name sortKey="Olsson, Richard" sort="Olsson, Richard" uniqKey="Olsson R" first="Richard" last="Olsson">Richard Olsson</name>
<affiliation wicri:level="3"><nlm:aff id="A16">Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden</nlm:aff>
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<wicri:regionArea>Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm</wicri:regionArea>
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<author><name sortKey="Pedersen, Tanya L" sort="Pedersen, Tanya L" uniqKey="Pedersen T" first="Tanya L." last="Pedersen">Tanya L. Pedersen</name>
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<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
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<author><name sortKey="Pidala, Joseph" sort="Pidala, Joseph" uniqKey="Pidala J" first="Joseph" last="Pidala">Joseph Pidala</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa</wicri:cityArea>
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<author><name sortKey="Pulsipher, Michael A" sort="Pulsipher, Michael A" uniqKey="Pulsipher M" first="Michael A." last="Pulsipher">Michael A. Pulsipher</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Primary Children’s Hospital, Division of Hematology/Hematological Malignancies, Huntsman Cancer Institute/University of Utah, Salt Lake City, UT</nlm:aff>
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<placeName><region type="state">Utah</region>
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<wicri:cityArea>Primary Children’s Hospital, Division of Hematology/Hematological Malignancies, Huntsman Cancer Institute/University of Utah, Salt Lake City</wicri:cityArea>
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<author><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M." last="Rowe">Jacob M. Rowe</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Department of Hematology, Rambam Medical Center, Haifa, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Hematology, Rambam Medical Center, Haifa</wicri:regionArea>
<wicri:noRegion>Haifa</wicri:noRegion>
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</author>
<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
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<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
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</author>
<author><name sortKey="Van Besien, Koen W" sort="Van Besien, Koen W" uniqKey="Van Besien K" first="Koen W." last="Van Besien">Koen W. Van Besien</name>
<affiliation wicri:level="2"><nlm:aff id="A20">Weill Cornell Medical College, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Görgun" last="Akpek">Görgun Akpek</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Banner MD Anderson Cancer Center, Gilbert, AZ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Banner MD Anderson Cancer Center, Gilbert</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bacher, Ulrike" sort="Bacher, Ulrike" uniqKey="Bacher U" first="Ulrike" last="Bacher">Ulrike Bacher</name>
<affiliation wicri:level="3"><nlm:aff id="A24">Universitatsklinikum Hamburg, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitatsklinikum Hamburg, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chao, Nelson J" sort="Chao, Nelson J" uniqKey="Chao N" first="Nelson J." last="Chao">Nelson J. Chao</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Division of Cell Therapy, Duke University Medical Center, Durham, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Division of Cell Therapy, Duke University Medical Center, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chen, Yi Bin" sort="Chen, Yi Bin" uniqKey="Chen Y" first="Yi-Bin" last="Chen">Yi-Bin Chen</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cooper, Brenda W" sort="Cooper, Brenda W" uniqKey="Cooper B" first="Brenda W." last="Cooper">Brenda W. Cooper</name>
<affiliation wicri:level="2"><nlm:aff id="A27">Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dehn, Jason" sort="Dehn, Jason" uniqKey="Dehn J" first="Jason" last="Dehn">Jason Dehn</name>
<affiliation wicri:level="2"><nlm:aff id="A28">National Marrow Donor Program, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>National Marrow Donor Program, Minneapolis</wicri:cityArea>
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<author><name sortKey="De Lima, Marcos J" sort="De Lima, Marcos J" uniqKey="De Lima M" first="Marcos J." last="De Lima">Marcos J. De Lima</name>
<affiliation wicri:level="2"><nlm:aff id="A27">Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hsu, Jack W" sort="Hsu, Jack W" uniqKey="Hsu J" first="Jack W." last="Hsu">Jack W. Hsu</name>
<affiliation wicri:level="2"><nlm:aff id="A29">Division of Hematology/Oncology, Shands HealthCare, University of Florida, Gainesville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Shands HealthCare, University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Haematology Clinical Trial Office, Royal Adelaide Hospital/SA Pathology, Adelaide, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Haematology Clinical Trial Office, Royal Adelaide Hospital/SA Pathology, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
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</author>
<author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Avon Haematology Unit and BCH BMT Unit, Bristol Children’s Hospital, Bristol, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Avon Haematology Unit and BCH BMT Unit, Bristol Children’s Hospital, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcguirk, Joseph" sort="Mcguirk, Joseph" uniqKey="Mcguirk J" first="Joseph" last="Mcguirk">Joseph Mcguirk</name>
<affiliation wicri:level="2"><nlm:aff id="A32">Division of Hematology & Oncology, University of Kansas, Westwood, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea>Division of Hematology & Oncology, University of Kansas, Westwood</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cairo, Mitchell S" sort="Cairo, Mitchell S" uniqKey="Cairo M" first="Mitchell S." last="Cairo">Mitchell S. Cairo</name>
<affiliation wicri:level="2"><nlm:aff id="A33">Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, New York Medical College, Valhalla, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, New York Medical College, Valhalla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Division of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Division of Hematology, Academische Ziekenhuis Maastricht, Maastricht</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name>
<affiliation wicri:level="1"><nlm:aff id="A35">Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital City Campus, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital City Campus, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ramanathan, Muthalagu" sort="Ramanathan, Muthalagu" uniqKey="Ramanathan M" first="Muthalagu" last="Ramanathan">Muthalagu Ramanathan</name>
<affiliation wicri:level="2"><nlm:aff id="A36">Department of Hematologic Malignancies Bone Marrow Transplant, UMass Memorial Medical Center, Worcester, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Hematologic Malignancies Bone Marrow Transplant, UMass Memorial Medical Center, Worcester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name>
<affiliation wicri:level="1"><nlm:aff id="A37">Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socie">Gérard Socie</name>
<affiliation wicri:level="3"><nlm:aff id="A38">Department of Hematology, Hopital Saint Louis, Paris</nlm:aff>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
<wicri:orgArea>Department of Hematology, Hopital Saint Louis</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name>
<affiliation wicri:level="2"><nlm:aff id="A39">Division of Medical Oncology, Barnes Jewish Hospital, St. Louis Children’s Hospital, Washington University, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Medical Oncology, Barnes Jewish Hospital, St. Louis Children’s Hospital, Washington University, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Warlick, Erica D" sort="Warlick, Erica D" uniqKey="Warlick E" first="Erica D." last="Warlick">Erica D. Warlick</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Allotransplantation for patients age 40 years and greater with non-Hodgkin Lymphoma (NHL): encouraging progression-free survival</title>
<author><name sortKey="Mcclune, Brian L" sort="Mcclune, Brian L" uniqKey="Mcclune B" first="Brian L." last="Mcclune">Brian L. Mcclune</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Hai Lin" sort="Wang, Hai Lin" uniqKey="Wang H" first="Hai-Lin" last="Wang">Hai-Lin Wang</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H." last="Antin">Joseph H. Antin</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Division of Hematologic Oncology, Dana Farber Cancer Institute, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Division of Hematologic Oncology, Dana Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Artz, Andrew S" sort="Artz, Andrew S" uniqKey="Artz A" first="Andrew S." last="Artz">Andrew S. Artz</name>
<affiliation><nlm:aff id="A5">University of Chicago School of Medicine, Chicago IL</nlm:aff>
<wicri:noCountry code="subfield">Chicago IL</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Hematology, University Hospital, Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deol, Abhinav" sort="Deol, Abhinav" uniqKey="Deol A" first="Abhinav" last="Deol">Abhinav Deol</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Karmanos Cancer Institute, Wayne State University, Detroit, MI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Karmanos Cancer Institute, Wayne State University, Detroit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Freytes, Cesar O" sort="Freytes, Cesar O" uniqKey="Freytes C" first="César O." last="Freytes">César O. Freytes</name>
<affiliation wicri:level="2"><nlm:aff id="A8">South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name>
<affiliation wicri:level="2"><nlm:aff id="A9">West Virginia University Hospitals, Inc., Morgantown, WV</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie-Occidentale</region>
</placeName>
<wicri:cityArea>West Virginia University Hospitals, Inc., Morgantown</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Holmberg, Leona A" sort="Holmberg, Leona A" uniqKey="Holmberg L" first="Leona A." last="Holmberg">Leona A. Holmberg</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jagasia, Madan H" sort="Jagasia, Madan H" uniqKey="Jagasia M" first="Madan H." last="Jagasia">Madan H. Jagasia</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jakubowski, Ann A" sort="Jakubowski, Ann A" uniqKey="Jakubowski A" first="Ann A." last="Jakubowski">Ann A. Jakubowski</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Memorial Sloan-Kettering Cancer Center, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Memorial Sloan-Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kharfan Dabaja, Mohamed A" sort="Kharfan Dabaja, Mohamed A" uniqKey="Kharfan Dabaja M" first="Mohamed A." last="Kharfan-Dabaja">Mohamed A. Kharfan-Dabaja</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Baylor University Medical Center, Dallas, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Baylor University Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Olsson, Richard" sort="Olsson, Richard" uniqKey="Olsson R" first="Richard" last="Olsson">Richard Olsson</name>
<affiliation wicri:level="3"><nlm:aff id="A16">Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pedersen, Tanya L" sort="Pedersen, Tanya L" uniqKey="Pedersen T" first="Tanya L." last="Pedersen">Tanya L. Pedersen</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Center for International Blood and Marrow Transplant Research, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pidala, Joseph" sort="Pidala, Joseph" uniqKey="Pidala J" first="Joseph" last="Pidala">Joseph Pidala</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pulsipher, Michael A" sort="Pulsipher, Michael A" uniqKey="Pulsipher M" first="Michael A." last="Pulsipher">Michael A. Pulsipher</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Primary Children’s Hospital, Division of Hematology/Hematological Malignancies, Huntsman Cancer Institute/University of Utah, Salt Lake City, UT</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Utah</region>
</placeName>
<wicri:cityArea>Primary Children’s Hospital, Division of Hematology/Hematological Malignancies, Huntsman Cancer Institute/University of Utah, Salt Lake City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M." last="Rowe">Jacob M. Rowe</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Department of Hematology, Rambam Medical Center, Haifa, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Hematology, Rambam Medical Center, Haifa</wicri:regionArea>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van Besien, Koen W" sort="Van Besien, Koen W" uniqKey="Van Besien K" first="Koen W." last="Van Besien">Koen W. Van Besien</name>
<affiliation wicri:level="2"><nlm:aff id="A20">Weill Cornell Medical College, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Görgun" last="Akpek">Görgun Akpek</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Banner MD Anderson Cancer Center, Gilbert, AZ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Banner MD Anderson Cancer Center, Gilbert</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bacher, Ulrike" sort="Bacher, Ulrike" uniqKey="Bacher U" first="Ulrike" last="Bacher">Ulrike Bacher</name>
<affiliation wicri:level="3"><nlm:aff id="A24">Universitatsklinikum Hamburg, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitatsklinikum Hamburg, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chao, Nelson J" sort="Chao, Nelson J" uniqKey="Chao N" first="Nelson J." last="Chao">Nelson J. Chao</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Division of Cell Therapy, Duke University Medical Center, Durham, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Division of Cell Therapy, Duke University Medical Center, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chen, Yi Bin" sort="Chen, Yi Bin" uniqKey="Chen Y" first="Yi-Bin" last="Chen">Yi-Bin Chen</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cooper, Brenda W" sort="Cooper, Brenda W" uniqKey="Cooper B" first="Brenda W." last="Cooper">Brenda W. Cooper</name>
<affiliation wicri:level="2"><nlm:aff id="A27">Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dehn, Jason" sort="Dehn, Jason" uniqKey="Dehn J" first="Jason" last="Dehn">Jason Dehn</name>
<affiliation wicri:level="2"><nlm:aff id="A28">National Marrow Donor Program, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>National Marrow Donor Program, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="De Lima, Marcos J" sort="De Lima, Marcos J" uniqKey="De Lima M" first="Marcos J." last="De Lima">Marcos J. De Lima</name>
<affiliation wicri:level="2"><nlm:aff id="A27">Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hsu, Jack W" sort="Hsu, Jack W" uniqKey="Hsu J" first="Jack W." last="Hsu">Jack W. Hsu</name>
<affiliation wicri:level="2"><nlm:aff id="A29">Division of Hematology/Oncology, Shands HealthCare, University of Florida, Gainesville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Shands HealthCare, University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Haematology Clinical Trial Office, Royal Adelaide Hospital/SA Pathology, Adelaide, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Haematology Clinical Trial Office, Royal Adelaide Hospital/SA Pathology, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Avon Haematology Unit and BCH BMT Unit, Bristol Children’s Hospital, Bristol, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Avon Haematology Unit and BCH BMT Unit, Bristol Children’s Hospital, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcguirk, Joseph" sort="Mcguirk, Joseph" uniqKey="Mcguirk J" first="Joseph" last="Mcguirk">Joseph Mcguirk</name>
<affiliation wicri:level="2"><nlm:aff id="A32">Division of Hematology & Oncology, University of Kansas, Westwood, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea>Division of Hematology & Oncology, University of Kansas, Westwood</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cairo, Mitchell S" sort="Cairo, Mitchell S" uniqKey="Cairo M" first="Mitchell S." last="Cairo">Mitchell S. Cairo</name>
<affiliation wicri:level="2"><nlm:aff id="A33">Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, New York Medical College, Valhalla, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, New York Medical College, Valhalla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Division of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Division of Hematology, Academische Ziekenhuis Maastricht, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name>
<affiliation wicri:level="1"><nlm:aff id="A35">Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital City Campus, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital City Campus, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ramanathan, Muthalagu" sort="Ramanathan, Muthalagu" uniqKey="Ramanathan M" first="Muthalagu" last="Ramanathan">Muthalagu Ramanathan</name>
<affiliation wicri:level="2"><nlm:aff id="A36">Department of Hematologic Malignancies Bone Marrow Transplant, UMass Memorial Medical Center, Worcester, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Hematologic Malignancies Bone Marrow Transplant, UMass Memorial Medical Center, Worcester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name>
<affiliation wicri:level="1"><nlm:aff id="A37">Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socie">Gérard Socie</name>
<affiliation wicri:level="3"><nlm:aff id="A38">Department of Hematology, Hopital Saint Louis, Paris</nlm:aff>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
<wicri:orgArea>Department of Hematology, Hopital Saint Louis</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name>
<affiliation wicri:level="2"><nlm:aff id="A39">Division of Medical Oncology, Barnes Jewish Hospital, St. Louis Children’s Hospital, Washington University, St. Louis, MO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Division of Medical Oncology, Barnes Jewish Hospital, St. Louis Children’s Hospital, Washington University, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Warlick, Erica D" sort="Warlick, Erica D" uniqKey="Warlick E" first="Erica D." last="Warlick">Erica D. Warlick</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title>
<idno type="ISSN">1083-8791</idno>
<idno type="eISSN">1523-6536</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Disease-Free Survival</term>
<term>Female</term>
<term>Hematopoietic Stem Cell Transplantation (methods)</term>
<term>Humans</term>
<term>Lymphoma, Non-Hodgkin (therapy)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Survival Analysis</term>
<term>Transplantation Conditioning (methods)</term>
<term>Transplantation, Homologous</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Conditionnement pour greffe ()</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphome malin non hodgkinien ()</term>
<term>Mâle</term>
<term>Survie sans rechute</term>
<term>Transplantation de cellules souches hématopoïétiques ()</term>
<term>Transplantation homologue</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Hematopoietic Stem Cell Transplantation</term>
<term>Transplantation Conditioning</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphoma, Non-Hodgkin</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Disease-Free Survival</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Survival Analysis</term>
<term>Transplantation, Homologous</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Conditionnement pour greffe</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphome malin non hodgkinien</term>
<term>Mâle</term>
<term>Survie sans rechute</term>
<term>Transplantation de cellules souches hématopoïétiques</term>
<term>Transplantation homologue</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Non-Hodgkin lymphomas (NHL) disproportionately affect older patients who uncommonly receive allogeneic hematopoietic cell transplantation (HCT). We analyzed CIBMTR data on 1248 patients ≥40 years receiving reduced-intensity conditioning (RIC) or non-myeloablative (NMA) HCT for aggressive (n=668) and indolent (n=580) NHL. Aggressive lymphoma was more frequent in the oldest cohort [(age 40–54) 49% vs. (55–64) 57% vs. (≥65) 67% p=0.0008]; fewer patients ≥65 had prior autografting [26% vs. 24% vs. 9%; p=0.002)]. Rates of relapse, acute and chronic GVHD and non-relapse mortality (NRM) at one year were similar [22%, 95% confidence interval (CI) 19–26%; 27%, 95% CI 23–31%; 34%, 95% CI 24–44%]. Progression-free (PFS) and overall (OS) survival at 3 years was slightly lower in older cohorts [OS:54%, 95% CI 50–58%; 40%, 95% CI 36–44%; 39%, 95% CI 28–50%; p<0.0001]. Multivariate analysis revealed no significant effect of age on acute or chronic GVHD or relapse. Age ≥55 years, Karnofsky performance status <80, and HLA-mismatch adversely impacted NRM, PFS, and OS. Disease status at HCT, but not histologic subtype, worsened NRM, relapse, PFS and OS. Even for patients ≥55 years, OS still approached 40% at 3 years suggesting HCT effects long-term remissions and remains underutilized in qualified older patients with NHL.</p>
</div>
</front>
</TEI>
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