Allotransplantation for patients age ≥40 years with non-Hodgkin lymphoma: encouraging progression-free survival.
Identifieur interne : 003631 ( PubMed/Corpus ); précédent : 003630; suivant : 003632Allotransplantation for patients age ≥40 years with non-Hodgkin lymphoma: encouraging progression-free survival.
Auteurs : Brian L. Mcclune ; Kwang Woo Ahn ; Hai-Lin Wang ; Joseph H. Antin ; Andrew S. Artz ; Jean-Yves Cahn ; Abhinav Deol ; César O. Freytes ; Mehdi Hamadani ; Leona A. Holmberg ; Madan H. Jagasia ; Ann A. Jakubowski ; Mohamed A. Kharfan-Dabaja ; Hillard M. Lazarus ; Alan M. Miller ; Richard Olsson ; Tanya L. Pedersen ; Joseph Pidala ; Michael A. Pulsipher ; Jacob M. Rowe ; Wael Saber ; Koen W. Van Besien ; Edmund K. Waller ; Mahmoud D. Aljurf ; Görgun Akpek ; Ulrike Bacher ; Nelson J. Chao ; Yi-Bin Chen ; Brenda W. Cooper ; Jason Dehn ; Marcos J. De Lima ; Jack W. Hsu ; Ian D. Lewis ; David I. Marks ; Joseph Mcguirk ; Mitchell S. Cairo ; Harry C. Schouten ; Jeffrey Szer ; Muthalagu Ramanathan ; Bipin N. Savani ; Matthew Seftel ; Gérard Socie ; Ravi Vij ; Erica D. Warlick ; Daniel J. WeisdorfSource :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1523-6536 ] ; 2014.
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Abstract
Non-Hodgkin lymphoma (NHL) disproportionately affects older patients, who do not often undergo allogeneic hematopoietic cell transplantation (HCT). We analyzed Center for International Blood and Marrow Transplant Research data on 1248 patients age ≥40 years receiving reduced-intensity conditioning (RIC) or nonmyeloablative (NMA) conditioning HCT for aggressive (n = 668) or indolent (n = 580) NHL. Aggressive lymphoma was more frequent in the oldest cohort 49% for age 40 to 54 versus 57% for age 55 to 64 versus 67% for age ≥65; P = .0008). Fewer patients aged ≥65 had previous autografting (26% versus 24% versus 9%; P = .002). Rates of relapse, acute and chronic GVHD, and nonrelapse mortality (NRM) at 1 year post-HCT were similar in the 3 age cohorts (22% [95% confidence interval (CI), 19% to 26%] for age 40 to 54, 27% [95% CI, 23% to 31%] for age 55 to 64, and 34% [95% CI, 24% to 44%] for age ≥65. Progression-free survival (PFS) and overall survival (OS) at 3 years was slightly lower in the older cohorts (OS: 54% [95% CI, 50% to 58%] for age 40 to 54; 40% [95% CI, 36% to 44%] for age 55 to 64, and 39% [95% CI, 28% to 50%] for age ≥65; P < .0001). Multivariate analysis revealed no significant effect of age on the incidence of acute or chronic GVHD or relapse. Age ≥55 years, Karnofsky Performance Status <80, and HLA mismatch adversely affected NRM, PFS, and OS. Disease status at HCT, but not histological subtype, was associated with worse NRM, relapse, PFS, and OS. Even for patients age ≥55 years, OS still approached 40% at 3 years, suggesting that HCT affects long-term remission and remains underused in qualified older patients with NHL.
DOI: 10.1016/j.bbmt.2014.03.013
PubMed: 24641829
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Allotransplantation for patients age ≥40 years with non-Hodgkin lymphoma: encouraging progression-free survival.</title><author><name sortKey="Mcclune, Brian L" sort="Mcclune, Brian L" uniqKey="Mcclune B" first="Brian L" last="Mcclune">Brian L. Mcclune</name><affiliation><nlm:affiliation>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:affiliation>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, Wisconsin; Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Hai Lin" sort="Wang, Hai Lin" uniqKey="Wang H" first="Hai-Lin" last="Wang">Hai-Lin Wang</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H" last="Antin">Joseph H. Antin</name><affiliation><nlm:affiliation>Division of Hematologic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Artz, Andrew S" sort="Artz, Andrew S" uniqKey="Artz A" first="Andrew S" last="Artz">Andrew S. Artz</name><affiliation><nlm:affiliation>Section of Hematology/Oncology, University of Chicago School of Medicine, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:affiliation>Department of Hematology, University Hospital, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Deol, Abhinav" sort="Deol, Abhinav" uniqKey="Deol A" first="Abhinav" last="Deol">Abhinav Deol</name><affiliation><nlm:affiliation>Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.</nlm:affiliation></affiliation></author><author><name sortKey="Freytes, Cesar O" sort="Freytes, Cesar O" uniqKey="Freytes C" first="César O" last="Freytes">César O. Freytes</name><affiliation><nlm:affiliation>Department of Hematology, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, Texas.</nlm:affiliation></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Holmberg, Leona A" sort="Holmberg, Leona A" uniqKey="Holmberg L" first="Leona A" last="Holmberg">Leona A. Holmberg</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Jagasia, Madan H" sort="Jagasia, Madan H" uniqKey="Jagasia M" first="Madan H" last="Jagasia">Madan H. Jagasia</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN.</nlm:affiliation></affiliation></author><author><name sortKey="Jakubowski, Ann A" sort="Jakubowski, Ann A" uniqKey="Jakubowski A" first="Ann A" last="Jakubowski">Ann A. Jakubowski</name><affiliation><nlm:affiliation>Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Kharfan Dabaja, Mohamed A" sort="Kharfan Dabaja, Mohamed A" uniqKey="Kharfan Dabaja M" first="Mohamed A" last="Kharfan-Dabaja">Mohamed A. Kharfan-Dabaja</name><affiliation><nlm:affiliation>Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL.</nlm:affiliation></affiliation></author><author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M" last="Lazarus">Hillard M. Lazarus</name><affiliation><nlm:affiliation>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH.</nlm:affiliation></affiliation></author><author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M" last="Miller">Alan M. Miller</name><affiliation><nlm:affiliation>Department of Oncology, Baylor University Medical Center, Dallas, TX.</nlm:affiliation></affiliation></author><author><name sortKey="Olsson, Richard" sort="Olsson, Richard" uniqKey="Olsson R" first="Richard" last="Olsson">Richard Olsson</name><affiliation><nlm:affiliation>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Pedersen, Tanya L" sort="Pedersen, Tanya L" uniqKey="Pedersen T" first="Tanya L" last="Pedersen">Tanya L. Pedersen</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Pidala, Joseph" sort="Pidala, Joseph" uniqKey="Pidala J" first="Joseph" last="Pidala">Joseph Pidala</name><affiliation><nlm:affiliation>Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL.</nlm:affiliation></affiliation></author><author><name sortKey="Pulsipher, Michael A" sort="Pulsipher, Michael A" uniqKey="Pulsipher M" first="Michael A" last="Pulsipher">Michael A. Pulsipher</name><affiliation><nlm:affiliation>Primary Children's Hospital, Division of Hematology/Hematological Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.</nlm:affiliation></affiliation></author><author><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M" last="Rowe">Jacob M. Rowe</name><affiliation><nlm:affiliation>Department of Hematology, Rambam Medical Center, Haifa, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Van Besien, Koen W" sort="Van Besien, Koen W" uniqKey="Van Besien K" first="Koen W" last="Van Besien">Koen W. Van Besien</name><affiliation><nlm:affiliation>Weill Cornell Medical College, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K" last="Waller">Edmund K. Waller</name><affiliation><nlm:affiliation>Bone Marrow and Stem Cell Transplant Center, Winship Cancer Institute, Emory University Hospital, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D" last="Aljurf">Mahmoud D. Aljurf</name><affiliation><nlm:affiliation>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Görgun" last="Akpek">Görgun Akpek</name><affiliation><nlm:affiliation>Banner M.D. Anderson Cancer Center, Gilbert, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Bacher, Ulrike" sort="Bacher, Ulrike" uniqKey="Bacher U" first="Ulrike" last="Bacher">Ulrike Bacher</name><affiliation><nlm:affiliation>Department of Stem Cell Transplantation, University of Hamburg, Hamburg, Germany; MLL Munich Leukemia Laboratory, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chao, Nelson J" sort="Chao, Nelson J" uniqKey="Chao N" first="Nelson J" last="Chao">Nelson J. Chao</name><affiliation><nlm:affiliation>Division of Cell Therapy, Duke University Medical Center, Durham, NC.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Yi Bin" sort="Chen, Yi Bin" uniqKey="Chen Y" first="Yi-Bin" last="Chen">Yi-Bin Chen</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Brenda W" sort="Cooper, Brenda W" uniqKey="Cooper B" first="Brenda W" last="Cooper">Brenda W. Cooper</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH.</nlm:affiliation></affiliation></author><author><name sortKey="Dehn, Jason" sort="Dehn, Jason" uniqKey="Dehn J" first="Jason" last="Dehn">Jason Dehn</name><affiliation><nlm:affiliation>National Marrow Donor Program, Minneapolis, MN.</nlm:affiliation></affiliation></author><author><name sortKey="De Lima, Marcos J" sort="De Lima, Marcos J" uniqKey="De Lima M" first="Marcos J" last="De Lima">Marcos J. De Lima</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH.</nlm:affiliation></affiliation></author><author><name sortKey="Hsu, Jack W" sort="Hsu, Jack W" uniqKey="Hsu J" first="Jack W" last="Hsu">Jack W. Hsu</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Shands HealthCare, University of Florida, Gainesville, FL.</nlm:affiliation></affiliation></author><author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D" last="Lewis">Ian D. Lewis</name><affiliation><nlm:affiliation>Haematology Clinical Trial Office, Royal Adelaide Hospital/SA Pathology, Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name><affiliation><nlm:affiliation>Avon Haematology Unit and BCH BMT Unit, Bristol Children's Hospital, Bristol, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Mcguirk, Joseph" sort="Mcguirk, Joseph" uniqKey="Mcguirk J" first="Joseph" last="Mcguirk">Joseph Mcguirk</name><affiliation><nlm:affiliation>Division of Hematology & Oncology, University of Kansas, Westwood, KS.</nlm:affiliation></affiliation></author><author><name sortKey="Cairo, Mitchell S" sort="Cairo, Mitchell S" uniqKey="Cairo M" first="Mitchell S" last="Cairo">Mitchell S. Cairo</name><affiliation><nlm:affiliation>Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, New York Medical College, Valhalla, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C" last="Schouten">Harry C. Schouten</name><affiliation><nlm:affiliation>Division of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name><affiliation><nlm:affiliation>Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital City Campus, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ramanathan, Muthalagu" sort="Ramanathan, Muthalagu" uniqKey="Ramanathan M" first="Muthalagu" last="Ramanathan">Muthalagu Ramanathan</name><affiliation><nlm:affiliation>Department of Hematologic Malignancies Bone Marrow Transplant, UMass Memorial Medical Center, Worcester, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N" last="Savani">Bipin N. Savani</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN.</nlm:affiliation></affiliation></author><author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name><affiliation><nlm:affiliation>Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socie">Gérard Socie</name><affiliation><nlm:affiliation>Department of Hematology, Hopital Saint Louis, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name><affiliation><nlm:affiliation>Division of Medical Oncology, Barnes Jewish Hospital, St. Louis Children's Hospital, Washington University, St. Louis, MO.</nlm:affiliation></affiliation></author><author><name sortKey="Warlick, Erica D" sort="Warlick, Erica D" uniqKey="Warlick E" first="Erica D" last="Warlick">Erica D. Warlick</name><affiliation><nlm:affiliation>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J" last="Weisdorf">Daniel J. Weisdorf</name><affiliation><nlm:affiliation>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota. Electronic address: weisd001@umn.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24641829</idno><idno type="pmid">24641829</idno><idno type="doi">10.1016/j.bbmt.2014.03.013</idno><idno type="wicri:Area/PubMed/Corpus">003631</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003631</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Allotransplantation for patients age ≥40 years with non-Hodgkin lymphoma: encouraging progression-free survival.</title><author><name sortKey="Mcclune, Brian L" sort="Mcclune, Brian L" uniqKey="Mcclune B" first="Brian L" last="Mcclune">Brian L. Mcclune</name><affiliation><nlm:affiliation>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:affiliation>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, Wisconsin; Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Hai Lin" sort="Wang, Hai Lin" uniqKey="Wang H" first="Hai-Lin" last="Wang">Hai-Lin Wang</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H" last="Antin">Joseph H. Antin</name><affiliation><nlm:affiliation>Division of Hematologic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Artz, Andrew S" sort="Artz, Andrew S" uniqKey="Artz A" first="Andrew S" last="Artz">Andrew S. Artz</name><affiliation><nlm:affiliation>Section of Hematology/Oncology, University of Chicago School of Medicine, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:affiliation>Department of Hematology, University Hospital, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Deol, Abhinav" sort="Deol, Abhinav" uniqKey="Deol A" first="Abhinav" last="Deol">Abhinav Deol</name><affiliation><nlm:affiliation>Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.</nlm:affiliation></affiliation></author><author><name sortKey="Freytes, Cesar O" sort="Freytes, Cesar O" uniqKey="Freytes C" first="César O" last="Freytes">César O. Freytes</name><affiliation><nlm:affiliation>Department of Hematology, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, Texas.</nlm:affiliation></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Holmberg, Leona A" sort="Holmberg, Leona A" uniqKey="Holmberg L" first="Leona A" last="Holmberg">Leona A. Holmberg</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Jagasia, Madan H" sort="Jagasia, Madan H" uniqKey="Jagasia M" first="Madan H" last="Jagasia">Madan H. Jagasia</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN.</nlm:affiliation></affiliation></author><author><name sortKey="Jakubowski, Ann A" sort="Jakubowski, Ann A" uniqKey="Jakubowski A" first="Ann A" last="Jakubowski">Ann A. Jakubowski</name><affiliation><nlm:affiliation>Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Kharfan Dabaja, Mohamed A" sort="Kharfan Dabaja, Mohamed A" uniqKey="Kharfan Dabaja M" first="Mohamed A" last="Kharfan-Dabaja">Mohamed A. Kharfan-Dabaja</name><affiliation><nlm:affiliation>Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL.</nlm:affiliation></affiliation></author><author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M" last="Lazarus">Hillard M. Lazarus</name><affiliation><nlm:affiliation>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH.</nlm:affiliation></affiliation></author><author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M" last="Miller">Alan M. Miller</name><affiliation><nlm:affiliation>Department of Oncology, Baylor University Medical Center, Dallas, TX.</nlm:affiliation></affiliation></author><author><name sortKey="Olsson, Richard" sort="Olsson, Richard" uniqKey="Olsson R" first="Richard" last="Olsson">Richard Olsson</name><affiliation><nlm:affiliation>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Pedersen, Tanya L" sort="Pedersen, Tanya L" uniqKey="Pedersen T" first="Tanya L" last="Pedersen">Tanya L. Pedersen</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Pidala, Joseph" sort="Pidala, Joseph" uniqKey="Pidala J" first="Joseph" last="Pidala">Joseph Pidala</name><affiliation><nlm:affiliation>Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL.</nlm:affiliation></affiliation></author><author><name sortKey="Pulsipher, Michael A" sort="Pulsipher, Michael A" uniqKey="Pulsipher M" first="Michael A" last="Pulsipher">Michael A. Pulsipher</name><affiliation><nlm:affiliation>Primary Children's Hospital, Division of Hematology/Hematological Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.</nlm:affiliation></affiliation></author><author><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M" last="Rowe">Jacob M. Rowe</name><affiliation><nlm:affiliation>Department of Hematology, Rambam Medical Center, Haifa, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Van Besien, Koen W" sort="Van Besien, Koen W" uniqKey="Van Besien K" first="Koen W" last="Van Besien">Koen W. Van Besien</name><affiliation><nlm:affiliation>Weill Cornell Medical College, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K" last="Waller">Edmund K. Waller</name><affiliation><nlm:affiliation>Bone Marrow and Stem Cell Transplant Center, Winship Cancer Institute, Emory University Hospital, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D" last="Aljurf">Mahmoud D. Aljurf</name><affiliation><nlm:affiliation>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Görgun" last="Akpek">Görgun Akpek</name><affiliation><nlm:affiliation>Banner M.D. Anderson Cancer Center, Gilbert, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Bacher, Ulrike" sort="Bacher, Ulrike" uniqKey="Bacher U" first="Ulrike" last="Bacher">Ulrike Bacher</name><affiliation><nlm:affiliation>Department of Stem Cell Transplantation, University of Hamburg, Hamburg, Germany; MLL Munich Leukemia Laboratory, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chao, Nelson J" sort="Chao, Nelson J" uniqKey="Chao N" first="Nelson J" last="Chao">Nelson J. Chao</name><affiliation><nlm:affiliation>Division of Cell Therapy, Duke University Medical Center, Durham, NC.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Yi Bin" sort="Chen, Yi Bin" uniqKey="Chen Y" first="Yi-Bin" last="Chen">Yi-Bin Chen</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Brenda W" sort="Cooper, Brenda W" uniqKey="Cooper B" first="Brenda W" last="Cooper">Brenda W. Cooper</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH.</nlm:affiliation></affiliation></author><author><name sortKey="Dehn, Jason" sort="Dehn, Jason" uniqKey="Dehn J" first="Jason" last="Dehn">Jason Dehn</name><affiliation><nlm:affiliation>National Marrow Donor Program, Minneapolis, MN.</nlm:affiliation></affiliation></author><author><name sortKey="De Lima, Marcos J" sort="De Lima, Marcos J" uniqKey="De Lima M" first="Marcos J" last="De Lima">Marcos J. De Lima</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH.</nlm:affiliation></affiliation></author><author><name sortKey="Hsu, Jack W" sort="Hsu, Jack W" uniqKey="Hsu J" first="Jack W" last="Hsu">Jack W. Hsu</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Shands HealthCare, University of Florida, Gainesville, FL.</nlm:affiliation></affiliation></author><author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D" last="Lewis">Ian D. Lewis</name><affiliation><nlm:affiliation>Haematology Clinical Trial Office, Royal Adelaide Hospital/SA Pathology, Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name><affiliation><nlm:affiliation>Avon Haematology Unit and BCH BMT Unit, Bristol Children's Hospital, Bristol, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Mcguirk, Joseph" sort="Mcguirk, Joseph" uniqKey="Mcguirk J" first="Joseph" last="Mcguirk">Joseph Mcguirk</name><affiliation><nlm:affiliation>Division of Hematology & Oncology, University of Kansas, Westwood, KS.</nlm:affiliation></affiliation></author><author><name sortKey="Cairo, Mitchell S" sort="Cairo, Mitchell S" uniqKey="Cairo M" first="Mitchell S" last="Cairo">Mitchell S. Cairo</name><affiliation><nlm:affiliation>Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, New York Medical College, Valhalla, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C" last="Schouten">Harry C. Schouten</name><affiliation><nlm:affiliation>Division of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name><affiliation><nlm:affiliation>Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital City Campus, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ramanathan, Muthalagu" sort="Ramanathan, Muthalagu" uniqKey="Ramanathan M" first="Muthalagu" last="Ramanathan">Muthalagu Ramanathan</name><affiliation><nlm:affiliation>Department of Hematologic Malignancies Bone Marrow Transplant, UMass Memorial Medical Center, Worcester, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N" last="Savani">Bipin N. Savani</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN.</nlm:affiliation></affiliation></author><author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name><affiliation><nlm:affiliation>Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socie">Gérard Socie</name><affiliation><nlm:affiliation>Department of Hematology, Hopital Saint Louis, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name><affiliation><nlm:affiliation>Division of Medical Oncology, Barnes Jewish Hospital, St. Louis Children's Hospital, Washington University, St. Louis, MO.</nlm:affiliation></affiliation></author><author><name sortKey="Warlick, Erica D" sort="Warlick, Erica D" uniqKey="Warlick E" first="Erica D" last="Warlick">Erica D. Warlick</name><affiliation><nlm:affiliation>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J" last="Weisdorf">Daniel J. Weisdorf</name><affiliation><nlm:affiliation>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota. Electronic address: weisd001@umn.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="eISSN">1523-6536</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Disease-Free Survival</term><term>Female</term><term>Hematopoietic Stem Cell Transplantation (methods)</term><term>Humans</term><term>Lymphoma, Non-Hodgkin (therapy)</term><term>Male</term><term>Middle Aged</term><term>Survival Analysis</term><term>Transplantation Conditioning (methods)</term><term>Transplantation, Homologous</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Hematopoietic Stem Cell Transplantation</term><term>Transplantation Conditioning</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphoma, Non-Hodgkin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Survival Analysis</term><term>Transplantation, Homologous</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Non-Hodgkin lymphoma (NHL) disproportionately affects older patients, who do not often undergo allogeneic hematopoietic cell transplantation (HCT). We analyzed Center for International Blood and Marrow Transplant Research data on 1248 patients age ≥40 years receiving reduced-intensity conditioning (RIC) or nonmyeloablative (NMA) conditioning HCT for aggressive (n = 668) or indolent (n = 580) NHL. Aggressive lymphoma was more frequent in the oldest cohort 49% for age 40 to 54 versus 57% for age 55 to 64 versus 67% for age ≥65; P = .0008). Fewer patients aged ≥65 had previous autografting (26% versus 24% versus 9%; P = .002). Rates of relapse, acute and chronic GVHD, and nonrelapse mortality (NRM) at 1 year post-HCT were similar in the 3 age cohorts (22% [95% confidence interval (CI), 19% to 26%] for age 40 to 54, 27% [95% CI, 23% to 31%] for age 55 to 64, and 34% [95% CI, 24% to 44%] for age ≥65. Progression-free survival (PFS) and overall survival (OS) at 3 years was slightly lower in the older cohorts (OS: 54% [95% CI, 50% to 58%] for age 40 to 54; 40% [95% CI, 36% to 44%] for age 55 to 64, and 39% [95% CI, 28% to 50%] for age ≥65; P < .0001). Multivariate analysis revealed no significant effect of age on the incidence of acute or chronic GVHD or relapse. Age ≥55 years, Karnofsky Performance Status <80, and HLA mismatch adversely affected NRM, PFS, and OS. Disease status at HCT, but not histological subtype, was associated with worse NRM, relapse, PFS, and OS. Even for patients age ≥55 years, OS still approached 40% at 3 years, suggesting that HCT affects long-term remission and remains underused in qualified older patients with NHL.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24641829</PMID><DateCreated><Year>2014</Year><Month>06</Month><Day>13</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>15</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1523-6536</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>7</Issue><PubDate><Year>2014</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</Title><ISOAbbreviation>Biol. Blood Marrow Transplant.</ISOAbbreviation></Journal><ArticleTitle>Allotransplantation for patients age ≥40 years with non-Hodgkin lymphoma: encouraging progression-free survival.</ArticleTitle><Pagination><MedlinePgn>960-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbmt.2014.03.013</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1083-8791(14)00162-1</ELocationID><Abstract><AbstractText>Non-Hodgkin lymphoma (NHL) disproportionately affects older patients, who do not often undergo allogeneic hematopoietic cell transplantation (HCT). We analyzed Center for International Blood and Marrow Transplant Research data on 1248 patients age ≥40 years receiving reduced-intensity conditioning (RIC) or nonmyeloablative (NMA) conditioning HCT for aggressive (n = 668) or indolent (n = 580) NHL. Aggressive lymphoma was more frequent in the oldest cohort 49% for age 40 to 54 versus 57% for age 55 to 64 versus 67% for age ≥65; P = .0008). Fewer patients aged ≥65 had previous autografting (26% versus 24% versus 9%; P = .002). Rates of relapse, acute and chronic GVHD, and nonrelapse mortality (NRM) at 1 year post-HCT were similar in the 3 age cohorts (22% [95% confidence interval (CI), 19% to 26%] for age 40 to 54, 27% [95% CI, 23% to 31%] for age 55 to 64, and 34% [95% CI, 24% to 44%] for age ≥65. Progression-free survival (PFS) and overall survival (OS) at 3 years was slightly lower in the older cohorts (OS: 54% [95% CI, 50% to 58%] for age 40 to 54; 40% [95% CI, 36% to 44%] for age 55 to 64, and 39% [95% CI, 28% to 50%] for age ≥65; P < .0001). Multivariate analysis revealed no significant effect of age on the incidence of acute or chronic GVHD or relapse. Age ≥55 years, Karnofsky Performance Status <80, and HLA mismatch adversely affected NRM, PFS, and OS. Disease status at HCT, but not histological subtype, was associated with worse NRM, relapse, PFS, and OS. Even for patients age ≥55 years, OS still approached 40% at 3 years, suggesting that HCT affects long-term remission and remains underused in qualified older patients with NHL.</AbstractText><CopyrightInformation>Copyright © 2014 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McClune</LastName><ForeName>Brian L</ForeName><Initials>BL</Initials><AffiliationInfo><Affiliation>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahn</LastName><ForeName>Kwang Woo</ForeName><Initials>KW</Initials><AffiliationInfo><Affiliation>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, Wisconsin; Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hai-Lin</ForeName><Initials>HL</Initials><AffiliationInfo><Affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Antin</LastName><ForeName>Joseph H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Division of Hematologic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Artz</LastName><ForeName>Andrew S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Section of Hematology/Oncology, University of Chicago School of Medicine, Chicago, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cahn</LastName><ForeName>Jean-Yves</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Department of Hematology, University Hospital, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deol</LastName><ForeName>Abhinav</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Freytes</LastName><ForeName>César O</ForeName><Initials>CO</Initials><AffiliationInfo><Affiliation>Department of Hematology, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, Texas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamadani</LastName><ForeName>Mehdi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holmberg</LastName><ForeName>Leona A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jagasia</LastName><ForeName>Madan H</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jakubowski</LastName><ForeName>Ann A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kharfan-Dabaja</LastName><ForeName>Mohamed A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lazarus</LastName><ForeName>Hillard M</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miller</LastName><ForeName>Alan M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Oncology, Baylor University Medical Center, Dallas, TX.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olsson</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pedersen</LastName><ForeName>Tanya L</ForeName><Initials>TL</Initials><AffiliationInfo><Affiliation>Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pidala</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pulsipher</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Primary Children's Hospital, Division of Hematology/Hematological Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rowe</LastName><ForeName>Jacob M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Hematology, Rambam Medical Center, Haifa, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saber</LastName><ForeName>Wael</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Besien</LastName><ForeName>Koen W</ForeName><Initials>KW</Initials><AffiliationInfo><Affiliation>Weill Cornell Medical College, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waller</LastName><ForeName>Edmund K</ForeName><Initials>EK</Initials><AffiliationInfo><Affiliation>Bone Marrow and Stem Cell Transplant Center, Winship Cancer Institute, Emory University Hospital, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aljurf</LastName><ForeName>Mahmoud D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akpek</LastName><ForeName>Görgun</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Banner M.D. Anderson Cancer Center, Gilbert, Arizona.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bacher</LastName><ForeName>Ulrike</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Stem Cell Transplantation, University of Hamburg, Hamburg, Germany; MLL Munich Leukemia Laboratory, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chao</LastName><ForeName>Nelson J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Division of Cell Therapy, Duke University Medical Center, Durham, NC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yi-Bin</ForeName><Initials>YB</Initials><AffiliationInfo><Affiliation>Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>Brenda W</ForeName><Initials>BW</Initials><AffiliationInfo><Affiliation>Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dehn</LastName><ForeName>Jason</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>National Marrow Donor Program, Minneapolis, MN.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Lima</LastName><ForeName>Marcos J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hsu</LastName><ForeName>Jack W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Division of Hematology/Oncology, Shands HealthCare, University of Florida, Gainesville, FL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lewis</LastName><ForeName>Ian D</ForeName><Initials>ID</Initials><AffiliationInfo><Affiliation>Haematology Clinical Trial Office, Royal Adelaide Hospital/SA Pathology, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marks</LastName><ForeName>David I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Avon Haematology Unit and BCH BMT Unit, Bristol Children's Hospital, Bristol, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McGuirk</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Hematology & Oncology, University of Kansas, Westwood, KS.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cairo</LastName><ForeName>Mitchell S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, New York Medical College, Valhalla, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schouten</LastName><ForeName>Harry C</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>Division of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Szer</LastName><ForeName>Jeffrey</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital City Campus, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramanathan</LastName><ForeName>Muthalagu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Hematologic Malignancies Bone Marrow Transplant, UMass Memorial Medical Center, Worcester, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Savani</LastName><ForeName>Bipin N</ForeName><Initials>BN</Initials><AffiliationInfo><Affiliation>Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seftel</LastName><ForeName>Matthew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Socie</LastName><ForeName>Gérard</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Hematology, Hopital Saint Louis, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vij</LastName><ForeName>Ravi</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Medical Oncology, Barnes Jewish Hospital, St. Louis Children's Hospital, Washington University, St. Louis, MO.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Warlick</LastName><ForeName>Erica D</ForeName><Initials>ED</Initials><AffiliationInfo><Affiliation>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weisdorf</LastName><ForeName>Daniel J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota. Electronic address: weisd001@umn.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>UL1 TR000430</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>5U01HL069294</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSH234200637020C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 CA076518</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSH234200637015C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24-CA76518</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HL069294</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>03</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biol Blood Marrow Transplant</MedlineTA><NlmUniqueID>9600628</NlmUniqueID><ISSNLinking>1083-8791</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Br J Haematol. 2000 Oct;111(1):18-29</RefSource><PMID 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Conditioning</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014184" MajorTopicYN="N">Transplantation, Homologous</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS577269</OtherID><OtherID Source="NLM">PMC4057955</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Allogeneic</Keyword><Keyword MajorTopicYN="N">Elderly</Keyword><Keyword MajorTopicYN="N">Hematopoietic cell transplantation</Keyword><Keyword MajorTopicYN="N">Lymphoma</Keyword><Keyword MajorTopicYN="N">Nonmyeloablative</Keyword><Keyword MajorTopicYN="N">Reduced intensity</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>01</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>03</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>3</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>3</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24641829</ArticleId><ArticleId IdType="pii">S1083-8791(14)00162-1</ArticleId><ArticleId IdType="doi">10.1016/j.bbmt.2014.03.013</ArticleId><ArticleId IdType="pmc">PMC4057955</ArticleId><ArticleId IdType="mid">NIHMS577269</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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