Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice.
Identifieur interne : 001778 ( Ncbi/Curation ); précédent : 001777; suivant : 001779Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice.
Auteurs : Andrew J. Murphy ; Vincent Sarrazy ; Nan Wang ; Nora Bijl ; Sandra Abramowicz ; Marit Westerterp ; Carrie B. Welch ; John D. Schuetz ; Laurent Yvan-CharvetSource :
- Arteriosclerosis, thrombosis, and vascular biology [ 1524-4636 ] ; 2014.
Descripteurs français
- KwdFr :
- Activation plaquettaire, Animaux, Athérosclérose (), Athérosclérose (anatomopathologie), Athérosclérose (génétique), Athérosclérose (métabolisme), Athérosclérose (sang), Cellules cultivées, Chimiokine CCL5 (métabolisme), Espèces réactives de l'oxygène (métabolisme), Facteurs temps, Femelle, Modèles animaux de maladie humaine, Plaquettes (métabolisme), Progéniteurs mégacaryocytaires (métabolisme), Prolifération cellulaire, Récepteurs aux lipoprotéines LDL (génétique), Récepteurs aux lipoprotéines LDL (métabolisme), Régulation de l'expression des gènes, Souris, Souris de lignée C57BL, Souris knockout, Thrombopoïèse, Transplantation de moelle osseuse, Transporteurs ABC (déficit), Transporteurs ABC (génétique), Évolution de la maladie.
- MESH :
- anatomopathologie : Athérosclérose.
- déficit : Transporteurs ABC.
- génétique : Athérosclérose, Récepteurs aux lipoprotéines LDL, Transporteurs ABC.
- métabolisme : Athérosclérose, Chimiokine CCL5, Espèces réactives de l'oxygène, Plaquettes, Progéniteurs mégacaryocytaires, Récepteurs aux lipoprotéines LDL.
- sang : Athérosclérose.
- Activation plaquettaire, Animaux, Athérosclérose, Cellules cultivées, Facteurs temps, Femelle, Modèles animaux de maladie humaine, Prolifération cellulaire, Régulation de l'expression des gènes, Souris, Souris de lignée C57BL, Souris knockout, Thrombopoïèse, Transplantation de moelle osseuse, Évolution de la maladie.
English descriptors
- KwdEn :
- ATP-Binding Cassette Transporters (deficiency), ATP-Binding Cassette Transporters (genetics), Animals, Atherosclerosis (blood), Atherosclerosis (genetics), Atherosclerosis (metabolism), Atherosclerosis (pathology), Atherosclerosis (prevention & control), Blood Platelets (metabolism), Bone Marrow Transplantation, Cell Proliferation, Cells, Cultured, Chemokine CCL5 (metabolism), Disease Models, Animal, Disease Progression, Female, Gene Expression Regulation, Megakaryocyte Progenitor Cells (metabolism), Mice, Mice, Inbred C57BL, Mice, Knockout, Platelet Activation, Reactive Oxygen Species (metabolism), Receptors, LDL (genetics), Receptors, LDL (metabolism), Thrombopoiesis, Time Factors.
- MESH :
- chemical , genetics : Receptors, LDL.
- chemical , metabolism : Chemokine CCL5, Reactive Oxygen Species, Receptors, LDL.
- blood : Atherosclerosis.
- deficiency : ATP-Binding Cassette Transporters.
- genetics : ATP-Binding Cassette Transporters, Atherosclerosis.
- metabolism : Atherosclerosis, Blood Platelets, Megakaryocyte Progenitor Cells.
- pathology : Atherosclerosis.
- prevention & control : Atherosclerosis.
- Animals, Bone Marrow Transplantation, Cell Proliferation, Cells, Cultured, Disease Models, Animal, Disease Progression, Female, Gene Expression Regulation, Mice, Mice, Inbred C57BL, Mice, Knockout, Platelet Activation, Thrombopoiesis, Time Factors.
Abstract
The ATP-binding cassette (ABC) transporter B6 (ABCB6) is highly expressed in megakaryocyte progenitors, but its role in platelet production and disease has not been elucidated.
DOI: 10.1161/ATVBAHA.113.302613
PubMed: 24504733
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Andrew J. Murphy<affiliation><nlm:affiliation>From Haematopoiesis and Leukocyte Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia (A.J.M.); Department of Immunology, Monash University, Melbourne, Australia (A.J.M.); Institut National de la Sante et de la Recherche Medicale U1065, Centre Mediterraneen de Medecine Molecuaire (C3M), Atip-Avenir, Nice, France (V.S., L.Y.-C.); Department of Medicine, Division of Molecular Medicine, Columbia University, New York, NY (N.W., N.B., S.A., M.W., C.B.W.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN (J.D.S.).</nlm:affiliation><wicri:noCountry code="subField">TN (J.D.S.).</wicri:noCountry></affiliation>Le document en format XML
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Murphy</name><affiliation><nlm:affiliation>From Haematopoiesis and Leukocyte Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia (A.J.M.); Department of Immunology, Monash University, Melbourne, Australia (A.J.M.); Institut National de la Sante et de la Recherche Medicale U1065, Centre Mediterraneen de Medecine Molecuaire (C3M), Atip-Avenir, Nice, France (V.S., L.Y.-C.); Department of Medicine, Division of Molecular Medicine, Columbia University, New York, NY (N.W., N.B., S.A., M.W., C.B.W.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN (J.D.S.).</nlm:affiliation><wicri:noCountry code="subField">TN (J.D.S.).</wicri:noCountry></affiliation></author><author><name sortKey="Sarrazy, Vincent" sort="Sarrazy, Vincent" uniqKey="Sarrazy V" first="Vincent" last="Sarrazy">Vincent Sarrazy</name></author><author><name sortKey="Wang, Nan" sort="Wang, Nan" uniqKey="Wang N" first="Nan" last="Wang">Nan Wang</name></author><author><name sortKey="Bijl, Nora" sort="Bijl, Nora" uniqKey="Bijl N" first="Nora" last="Bijl">Nora Bijl</name></author><author><name sortKey="Abramowicz, Sandra" sort="Abramowicz, Sandra" uniqKey="Abramowicz S" first="Sandra" last="Abramowicz">Sandra Abramowicz</name></author><author><name sortKey="Westerterp, Marit" sort="Westerterp, Marit" uniqKey="Westerterp M" first="Marit" last="Westerterp">Marit Westerterp</name></author><author><name sortKey="Welch, Carrie B" sort="Welch, Carrie B" uniqKey="Welch C" first="Carrie B" last="Welch">Carrie B. 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Murphy</name><affiliation><nlm:affiliation>From Haematopoiesis and Leukocyte Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia (A.J.M.); Department of Immunology, Monash University, Melbourne, Australia (A.J.M.); Institut National de la Sante et de la Recherche Medicale U1065, Centre Mediterraneen de Medecine Molecuaire (C3M), Atip-Avenir, Nice, France (V.S., L.Y.-C.); Department of Medicine, Division of Molecular Medicine, Columbia University, New York, NY (N.W., N.B., S.A., M.W., C.B.W.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN (J.D.S.).</nlm:affiliation><wicri:noCountry code="subField">TN (J.D.S.).</wicri:noCountry></affiliation></author><author><name sortKey="Sarrazy, Vincent" sort="Sarrazy, Vincent" uniqKey="Sarrazy V" first="Vincent" last="Sarrazy">Vincent Sarrazy</name></author><author><name sortKey="Wang, Nan" sort="Wang, Nan" uniqKey="Wang N" first="Nan" last="Wang">Nan Wang</name></author><author><name sortKey="Bijl, Nora" sort="Bijl, Nora" uniqKey="Bijl N" first="Nora" last="Bijl">Nora Bijl</name></author><author><name sortKey="Abramowicz, Sandra" sort="Abramowicz, Sandra" uniqKey="Abramowicz S" first="Sandra" last="Abramowicz">Sandra Abramowicz</name></author><author><name sortKey="Westerterp, Marit" sort="Westerterp, Marit" uniqKey="Westerterp M" first="Marit" last="Westerterp">Marit Westerterp</name></author><author><name sortKey="Welch, Carrie B" sort="Welch, Carrie B" uniqKey="Welch C" first="Carrie B" last="Welch">Carrie B. Welch</name></author><author><name sortKey="Schuetz, John D" sort="Schuetz, John D" uniqKey="Schuetz J" first="John D" last="Schuetz">John D. Schuetz</name></author><author><name sortKey="Yvan Charvet, Laurent" sort="Yvan Charvet, Laurent" uniqKey="Yvan Charvet L" first="Laurent" last="Yvan-Charvet">Laurent Yvan-Charvet</name></author></analytic><series><title level="j">Arteriosclerosis, thrombosis, and vascular biology</title><idno type="eISSN">1524-4636</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ATP-Binding Cassette Transporters (deficiency)</term><term>ATP-Binding Cassette Transporters (genetics)</term><term>Animals</term><term>Atherosclerosis (blood)</term><term>Atherosclerosis (genetics)</term><term>Atherosclerosis (metabolism)</term><term>Atherosclerosis (pathology)</term><term>Atherosclerosis (prevention & control)</term><term>Blood Platelets (metabolism)</term><term>Bone Marrow Transplantation</term><term>Cell Proliferation</term><term>Cells, Cultured</term><term>Chemokine CCL5 (metabolism)</term><term>Disease Models, Animal</term><term>Disease Progression</term><term>Female</term><term>Gene Expression Regulation</term><term>Megakaryocyte Progenitor Cells (metabolism)</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Platelet Activation</term><term>Reactive Oxygen Species (metabolism)</term><term>Receptors, LDL (genetics)</term><term>Receptors, LDL (metabolism)</term><term>Thrombopoiesis</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation plaquettaire</term><term>Animaux</term><term>Athérosclérose ()</term><term>Athérosclérose (anatomopathologie)</term><term>Athérosclérose (génétique)</term><term>Athérosclérose (métabolisme)</term><term>Athérosclérose (sang)</term><term>Cellules cultivées</term><term>Chimiokine CCL5 (métabolisme)</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Facteurs temps</term><term>Femelle</term><term>Modèles animaux de maladie humaine</term><term>Plaquettes (métabolisme)</term><term>Progéniteurs mégacaryocytaires (métabolisme)</term><term>Prolifération cellulaire</term><term>Récepteurs aux lipoprotéines LDL (génétique)</term><term>Récepteurs aux lipoprotéines LDL (métabolisme)</term><term>Régulation de l'expression des gènes</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term><term>Thrombopoïèse</term><term>Transplantation de moelle osseuse</term><term>Transporteurs ABC (déficit)</term><term>Transporteurs ABC (génétique)</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, LDL</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Chemokine CCL5</term><term>Reactive Oxygen Species</term><term>Receptors, LDL</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Athérosclérose</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="deficiency" xml:lang="en"><term>ATP-Binding Cassette Transporters</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Transporteurs ABC</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>ATP-Binding Cassette Transporters</term><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Athérosclérose</term><term>Récepteurs aux lipoprotéines LDL</term><term>Transporteurs ABC</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Atherosclerosis</term><term>Blood Platelets</term><term>Megakaryocyte Progenitor Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Athérosclérose</term><term>Chimiokine CCL5</term><term>Espèces réactives de l'oxygène</term><term>Plaquettes</term><term>Progéniteurs mégacaryocytaires</term><term>Récepteurs aux lipoprotéines LDL</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Athérosclérose</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Bone Marrow Transplantation</term><term>Cell Proliferation</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Disease Progression</term><term>Female</term><term>Gene Expression Regulation</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Platelet Activation</term><term>Thrombopoiesis</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation plaquettaire</term><term>Animaux</term><term>Athérosclérose</term><term>Cellules cultivées</term><term>Facteurs temps</term><term>Femelle</term><term>Modèles animaux de maladie humaine</term><term>Prolifération cellulaire</term><term>Régulation de l'expression des gènes</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term><term>Thrombopoïèse</term><term>Transplantation de moelle osseuse</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The ATP-binding cassette (ABC) transporter B6 (ABCB6) is highly expressed in megakaryocyte progenitors, but its role in platelet production and disease has not been elucidated.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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