Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice.
Identifieur interne : 003723 ( PubMed/Curation ); précédent : 003722; suivant : 003724Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice.
Auteurs : Andrew J. Murphy ; Vincent Sarrazy ; Nan Wang ; Nora Bijl ; Sandra Abramowicz ; Marit Westerterp ; Carrie B. Welch ; John D. Schuetz ; Laurent Yvan-CharvetSource :
- Arteriosclerosis, thrombosis, and vascular biology [ 1524-4636 ] ; 2014.
Descripteurs français
- KwdFr :
- Activation plaquettaire, Animaux, Athérosclérose (), Athérosclérose (anatomopathologie), Athérosclérose (génétique), Athérosclérose (métabolisme), Athérosclérose (sang), Cellules cultivées, Chimiokine CCL5 (métabolisme), Espèces réactives de l'oxygène (métabolisme), Facteurs temps, Femelle, Modèles animaux de maladie humaine, Plaquettes (métabolisme), Progéniteurs mégacaryocytaires (métabolisme), Prolifération cellulaire, Récepteurs aux lipoprotéines LDL (génétique), Récepteurs aux lipoprotéines LDL (métabolisme), Régulation de l'expression des gènes, Souris, Souris de lignée C57BL, Souris knockout, Thrombopoïèse, Transplantation de moelle osseuse, Transporteurs ABC (déficit), Transporteurs ABC (génétique), Évolution de la maladie.
- MESH :
- anatomopathologie : Athérosclérose.
- déficit : Transporteurs ABC.
- génétique : Athérosclérose, Récepteurs aux lipoprotéines LDL, Transporteurs ABC.
- métabolisme : Athérosclérose, Chimiokine CCL5, Espèces réactives de l'oxygène, Plaquettes, Progéniteurs mégacaryocytaires, Récepteurs aux lipoprotéines LDL.
- sang : Athérosclérose.
- Activation plaquettaire, Animaux, Athérosclérose, Cellules cultivées, Facteurs temps, Femelle, Modèles animaux de maladie humaine, Prolifération cellulaire, Régulation de l'expression des gènes, Souris, Souris de lignée C57BL, Souris knockout, Thrombopoïèse, Transplantation de moelle osseuse, Évolution de la maladie.
English descriptors
- KwdEn :
- ATP-Binding Cassette Transporters (deficiency), ATP-Binding Cassette Transporters (genetics), Animals, Atherosclerosis (blood), Atherosclerosis (genetics), Atherosclerosis (metabolism), Atherosclerosis (pathology), Atherosclerosis (prevention & control), Blood Platelets (metabolism), Bone Marrow Transplantation, Cell Proliferation, Cells, Cultured, Chemokine CCL5 (metabolism), Disease Models, Animal, Disease Progression, Female, Gene Expression Regulation, Megakaryocyte Progenitor Cells (metabolism), Mice, Mice, Inbred C57BL, Mice, Knockout, Platelet Activation, Reactive Oxygen Species (metabolism), Receptors, LDL (genetics), Receptors, LDL (metabolism), Thrombopoiesis, Time Factors.
- MESH :
- chemical , genetics : Receptors, LDL.
- chemical , metabolism : Chemokine CCL5, Reactive Oxygen Species, Receptors, LDL.
- blood : Atherosclerosis.
- deficiency : ATP-Binding Cassette Transporters.
- genetics : ATP-Binding Cassette Transporters, Atherosclerosis.
- metabolism : Atherosclerosis, Blood Platelets, Megakaryocyte Progenitor Cells.
- pathology : Atherosclerosis.
- prevention & control : Atherosclerosis.
- Animals, Bone Marrow Transplantation, Cell Proliferation, Cells, Cultured, Disease Models, Animal, Disease Progression, Female, Gene Expression Regulation, Mice, Mice, Inbred C57BL, Mice, Knockout, Platelet Activation, Thrombopoiesis, Time Factors.
Abstract
The ATP-binding cassette (ABC) transporter B6 (ABCB6) is highly expressed in megakaryocyte progenitors, but its role in platelet production and disease has not been elucidated.
DOI: 10.1161/ATVBAHA.113.302613
PubMed: 24504733
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- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003837
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Andrew J. Murphy<affiliation><nlm:affiliation>From Haematopoiesis and Leukocyte Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia (A.J.M.); Department of Immunology, Monash University, Melbourne, Australia (A.J.M.); Institut National de la Sante et de la Recherche Medicale U1065, Centre Mediterraneen de Medecine Molecuaire (C3M), Atip-Avenir, Nice, France (V.S., L.Y.-C.); Department of Medicine, Division of Molecular Medicine, Columbia University, New York, NY (N.W., N.B., S.A., M.W., C.B.W.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN (J.D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">TN (J.D.S.).</wicri:noCountry>
</affiliation>
Le document en format XML
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<series><title level="j">Arteriosclerosis, thrombosis, and vascular biology</title>
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<term>ATP-Binding Cassette Transporters (genetics)</term>
<term>Animals</term>
<term>Atherosclerosis (blood)</term>
<term>Atherosclerosis (genetics)</term>
<term>Atherosclerosis (metabolism)</term>
<term>Atherosclerosis (pathology)</term>
<term>Atherosclerosis (prevention & control)</term>
<term>Blood Platelets (metabolism)</term>
<term>Bone Marrow Transplantation</term>
<term>Cell Proliferation</term>
<term>Cells, Cultured</term>
<term>Chemokine CCL5 (metabolism)</term>
<term>Disease Models, Animal</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Megakaryocyte Progenitor Cells (metabolism)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Platelet Activation</term>
<term>Reactive Oxygen Species (metabolism)</term>
<term>Receptors, LDL (genetics)</term>
<term>Receptors, LDL (metabolism)</term>
<term>Thrombopoiesis</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation plaquettaire</term>
<term>Animaux</term>
<term>Athérosclérose ()</term>
<term>Athérosclérose (anatomopathologie)</term>
<term>Athérosclérose (génétique)</term>
<term>Athérosclérose (métabolisme)</term>
<term>Athérosclérose (sang)</term>
<term>Cellules cultivées</term>
<term>Chimiokine CCL5 (métabolisme)</term>
<term>Espèces réactives de l'oxygène (métabolisme)</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Modèles animaux de maladie humaine</term>
<term>Plaquettes (métabolisme)</term>
<term>Progéniteurs mégacaryocytaires (métabolisme)</term>
<term>Prolifération cellulaire</term>
<term>Récepteurs aux lipoprotéines LDL (génétique)</term>
<term>Récepteurs aux lipoprotéines LDL (métabolisme)</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Thrombopoïèse</term>
<term>Transplantation de moelle osseuse</term>
<term>Transporteurs ABC (déficit)</term>
<term>Transporteurs ABC (génétique)</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, LDL</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Chemokine CCL5</term>
<term>Reactive Oxygen Species</term>
<term>Receptors, LDL</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Athérosclérose</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Atherosclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="deficiency" xml:lang="en"><term>ATP-Binding Cassette Transporters</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Transporteurs ABC</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>ATP-Binding Cassette Transporters</term>
<term>Atherosclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Athérosclérose</term>
<term>Récepteurs aux lipoprotéines LDL</term>
<term>Transporteurs ABC</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Atherosclerosis</term>
<term>Blood Platelets</term>
<term>Megakaryocyte Progenitor Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Athérosclérose</term>
<term>Chimiokine CCL5</term>
<term>Espèces réactives de l'oxygène</term>
<term>Plaquettes</term>
<term>Progéniteurs mégacaryocytaires</term>
<term>Récepteurs aux lipoprotéines LDL</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atherosclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Atherosclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Athérosclérose</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Bone Marrow Transplantation</term>
<term>Cell Proliferation</term>
<term>Cells, Cultured</term>
<term>Disease Models, Animal</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Platelet Activation</term>
<term>Thrombopoiesis</term>
<term>Time Factors</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Activation plaquettaire</term>
<term>Animaux</term>
<term>Athérosclérose</term>
<term>Cellules cultivées</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Modèles animaux de maladie humaine</term>
<term>Prolifération cellulaire</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Thrombopoïèse</term>
<term>Transplantation de moelle osseuse</term>
<term>Évolution de la maladie</term>
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<front><div type="abstract" xml:lang="en">The ATP-binding cassette (ABC) transporter B6 (ABCB6) is highly expressed in megakaryocyte progenitors, but its role in platelet production and disease has not been elucidated.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24504733</PMID>
<DateCreated><Year>2014</Year>
<Month>03</Month>
<Day>25</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>05</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>12</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4636</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>34</Volume>
<Issue>4</Issue>
<PubDate><Year>2014</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>Arteriosclerosis, thrombosis, and vascular biology</Title>
<ISOAbbreviation>Arterioscler. Thromb. Vasc. Biol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice.</ArticleTitle>
<Pagination><MedlinePgn>751-8</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1161/ATVBAHA.113.302613</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The ATP-binding cassette (ABC) transporter B6 (ABCB6) is highly expressed in megakaryocyte progenitors, but its role in platelet production and disease has not been elucidated.</AbstractText>
<AbstractText Label="APPROACH AND RESULTS" NlmCategory="RESULTS">Among various ABC transporters, ABCB6 was highly expressed in megakaryocyte progenitors, exhibiting the same pattern of expression of genes involved in heme synthesis pathway. Transplantation of Abcb6 deficient (Abcb6(-/-)) bone marrow into low density lipoprotein receptor deficient recipient mice resulted in expansion and proliferation of megakaryocyte progenitors, attributable to increased reactive oxygen species production in response to porphyrin loading. The enhanced megakaryopoiesis in Abcb6(-/-) bone marrow-transplanted mice was further illustrated by increased platelet counts, mean platelet volume, and platelet activity. Platelets from Abcb6(-/-) bone marrow-transplanted mice had higher levels of chemokine (C-C motif) ligand 5, which was associated with increased plasma chemokine (C-C motif) ligand 5 levels. There were also increased platelet-leukocyte aggregates, which resulted in leukocyte activation. Abcb6(-/-) bone marrow-transplanted mice had accelerated atherosclerosis which was associated with deposition of the chemotactic agent, chemokine (C-C motif) ligand 5 in atherosclerotic plaques, resulting in increased macrophage accumulation.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our findings identify a new role of ABCB6 in preventing atherosclerosis development by dampening platelet production, reactivity, and chemokine (C-C motif) ligand 5 deposition in atherosclerotic lesions.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Murphy</LastName>
<ForeName>Andrew J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>From Haematopoiesis and Leukocyte Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia (A.J.M.); Department of Immunology, Monash University, Melbourne, Australia (A.J.M.); Institut National de la Sante et de la Recherche Medicale U1065, Centre Mediterraneen de Medecine Molecuaire (C3M), Atip-Avenir, Nice, France (V.S., L.Y.-C.); Department of Medicine, Division of Molecular Medicine, Columbia University, New York, NY (N.W., N.B., S.A., M.W., C.B.W.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN (J.D.S.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sarrazy</LastName>
<ForeName>Vincent</ForeName>
<Initials>V</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Nan</ForeName>
<Initials>N</Initials>
</Author>
<Author ValidYN="Y"><LastName>Bijl</LastName>
<ForeName>Nora</ForeName>
<Initials>N</Initials>
</Author>
<Author ValidYN="Y"><LastName>Abramowicz</LastName>
<ForeName>Sandra</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Westerterp</LastName>
<ForeName>Marit</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Welch</LastName>
<ForeName>Carrie B</ForeName>
<Initials>CB</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schuetz</LastName>
<ForeName>John D</ForeName>
<Initials>JD</Initials>
</Author>
<Author ValidYN="Y"><LastName>Yvan-Charvet</LastName>
<ForeName>Laurent</ForeName>
<Initials>L</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>02</Month>
<Day>06</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Arterioscler Thromb Vasc Biol</MedlineTA>
<NlmUniqueID>9505803</NlmUniqueID>
<ISSNLinking>1079-5642</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C514489">Abcb6 protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C503460">Ccl5 protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018946">Chemokine CCL5</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011973">Receptors, LDL</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):700-1</RefSource>
<PMID Version="1">24665122</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D018528" MajorTopicYN="N">ATP-Binding Cassette Transporters</DescriptorName>
<QualifierName UI="Q000172" MajorTopicYN="Y">deficiency</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050197" MajorTopicYN="N">Atherosclerosis</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001792" MajorTopicYN="N">Blood Platelets</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016026" MajorTopicYN="N">Bone Marrow Transplantation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018946" MajorTopicYN="N">Chemokine CCL5</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055016" MajorTopicYN="N">Megakaryocyte Progenitor Cells</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015539" MajorTopicYN="N">Platelet Activation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011973" MajorTopicYN="N">Receptors, LDL</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D034061" MajorTopicYN="N">Thrombopoiesis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ATP binding cassette transporter</Keyword>
<Keyword MajorTopicYN="N">atherosclerosis</Keyword>
<Keyword MajorTopicYN="N">platelet</Keyword>
</KeywordList>
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<Day>8</Day>
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<Month>2</Month>
<Day>8</Day>
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<PubMedPubDate PubStatus="medline"><Year>2014</Year>
<Month>5</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">24504733</ArticleId>
<ArticleId IdType="pii">ATVBAHA.113.302613</ArticleId>
<ArticleId IdType="doi">10.1161/ATVBAHA.113.302613</ArticleId>
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