Common variants at 12q15 and 12q24 are associated with infant head circumference
Identifieur interne : 000D77 ( Ncbi/Curation ); précédent : 000D76; suivant : 000D78Common variants at 12q15 and 12q24 are associated with infant head circumference
Auteurs : H Rob Taal [Pays-Bas] ; Beate St Pourcain [Royaume-Uni] ; Elisabeth Thiering [Allemagne] ; Shikta Das [Royaume-Uni] ; Dennis O. Mook-Kanamori [Pays-Bas, Qatar] ; Nicole M. Warrington [Australie, Canada] ; Marika Kaakinen [Finlande] ; Eskil Kreiner-M Ller [Danemark] ; Jonathan P. Bradfield [États-Unis] ; Rachel M. Freathy [Royaume-Uni] ; Frank Geller [Danemark] ; M Nica Guxens [Espagne] ; Diana L. Cousminer [Finlande] ; Marjan Kerkhof [Pays-Bas] ; Nicholas J. Timpson [Royaume-Uni] ; M Arfan Ikram [Pays-Bas] ; Lawrence J. Beilin [Australie] ; Klaus B Nnelykke [Danemark] ; Jessica L. Buxton ; Pimphen Charoen [Royaume-Uni, Thaïlande] ; Bo Lund Krogsgaard Chawes [Danemark] ; Johan Eriksson [Finlande] ; David M. Evans [Royaume-Uni] ; Albert Hofman [Pays-Bas] ; John P. Kemp [Royaume-Uni] ; Cecilia E. Kim [États-Unis] ; Norman Klopp [Allemagne] ; Jari Lahti [Finlande] ; Stephen J. Lye [Canada] ; George Mcmahon [Royaume-Uni] ; Frank D. Mentch [États-Unis] ; Martina Müller [Allemagne] ; Paul F. O Eilly [Royaume-Uni] ; Inga Prokopenko [Royaume-Uni] ; Fernando Rivadeneira [Pays-Bas] ; Eric A P. Steegers [Pays-Bas] ; Jordi Sunyer [Espagne] ; Carla Tiesler [Allemagne] ; Hanieh Yaghootkar [Royaume-Uni] ; Monique M B. Breteler [Pays-Bas] ; Stephanie Debette [États-Unis] ; Myriam Fornage [États-Unis] ; Vilmundur Gudnason [Islande] ; Lenore J. Launer [États-Unis] ; Aad Van Der Lugt [Pays-Bas] ; Thomas H. Mosley [États-Unis] ; Sudha Seshadri [États-Unis] ; Albert V. Smith [Islande] ; Meike W. Vernooij [Pays-Bas] ; Alexandra If Blakemore ; Rosetta M. Chiavacci [États-Unis] ; Bjarke Feenstra [Danemark] ; Julio Fernandez-Benet [Royaume-Uni] ; Struan F A. Grant [États-Unis] ; Anna-Liisa Hartikainen [Finlande] ; Albert J. Van Der Heijden [Pays-Bas] ; Carmen I Iguez [Espagne] ; Mark Lathrop [France] ; Wendy L. Mcardle [Royaume-Uni] ; Anne M Lgaard [Danemark] ; John P. Newnham [Australie] ; Lyle J. Palmer [Canada] ; Aarno Palotie [Finlande, États-Unis, Royaume-Uni] ; Annneli Pouta [Finlande] ; Susan M. Ring [Royaume-Uni] ; Ulla Sovio [Royaume-Uni] ; Marie Standl [Allemagne] ; Andre G. Uitterlinden [Pays-Bas] ; H-Erich Wichmann [Allemagne] ; Nadja Hawwa Vissing [Danemark] ; Charles Decarli [États-Unis] ; Cornelia M. Van Duijn [Pays-Bas] ; Mark I. Mccarthy [Royaume-Uni] ; Gerard H. Koppelman [Pays-Bas] ; Xavier Estivill [Espagne] ; Andrew T. Hattersley [Royaume-Uni] ; Mads Melbye [Danemark] ; Hans Bisgaard [Danemark] ; Craig E. Pennell [Australie] ; Elisabeth Widen [Finlande] ; Hakon Hakonarson [États-Unis] ; George Davey Smith [Royaume-Uni] ; Joachim Heinrich [Allemagne] ; Marjo-Riitta Jarvelin [Finlande] ; Vincent W V. Jaddoe [Pays-Bas]Source :
- Nature genetics [ 1061-4036 ] ; 2012.
Descripteurs français
- KwdFr :
- Chromosomes humains de la paire 12 (génétique), Complications de la grossesse (anatomopathologie), Complications de la grossesse (étiologie), Femelle, Grossesse, Humains, Locus génétiques, Marqueurs génétiques, Mâle, Méta-analyse comme sujet, Nourrisson, Polymorphisme de nucléotide simple (génétique), Population d'origine européenne (génétique), Tête (anatomopathologie), Tête (croissance et développement), Étude d'association pangénomique.
- MESH :
- anatomopathologie : Complications de la grossesse, Tête.
- croissance et développement : Tête.
- génétique : Chromosomes humains de la paire 12, Polymorphisme de nucléotide simple, Population d'origine européenne.
- étiologie : Complications de la grossesse.
- Femelle, Grossesse, Humains, Locus génétiques, Marqueurs génétiques, Mâle, Méta-analyse comme sujet, Nourrisson, Étude d'association pangénomique.
English descriptors
- KwdEn :
- Chromosomes, Human, Pair 12 (genetics), European Continental Ancestry Group (genetics), Female, Genetic Loci, Genetic Markers, Genome-Wide Association Study, Head (growth & development), Head (pathology), Humans, Infant, Male, Meta-Analysis as Topic, Polymorphism, Single Nucleotide (genetics), Pregnancy, Pregnancy Complications (etiology), Pregnancy Complications (pathology).
- MESH :
- chemical : Genetic Markers.
- etiology : Pregnancy Complications.
- genetics : Chromosomes, Human, Pair 12, European Continental Ancestry Group, Polymorphism, Single Nucleotide.
- growth & development : Head.
- pathology : Head, Pregnancy Complications.
- Female, Genetic Loci, Genome-Wide Association Study, Humans, Infant, Male, Meta-Analysis as Topic, Pregnancy.
Abstract
To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association (GWA) studies (N=10,768 from European ancestry enrolled in pregnancy/birth cohorts) and followed up three lead signals in six replication studies (combined N=19,089). Rs7980687 on chromosome 12q24 (
Url:
DOI: 10.1038/ng.2238
PubMed: 22504419
PubMed Central: 3773913
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Jessica L. Buxton<affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Imperial College London</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Imperial College London</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A67">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Imperial College London</wicri:noCountry>
</affiliation>
Le document en format XML
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<affiliation wicri:level="4"><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff>
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<author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name>
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<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Epidemiology Research, Statens Serum Institut, Copenhagen</wicri:regionArea>
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<author><name sortKey="Guxens, M Nica" sort="Guxens, M Nica" uniqKey="Guxens M" first="M Nica" last="Guxens">M Nica Guxens</name>
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<affiliation wicri:level="1"><nlm:aff id="A17">Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
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<author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L" last="Cousminer">Diana L. Cousminer</name>
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<author><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name>
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<author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
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<author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
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<affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<author><name sortKey="Beilin, Lawrence J" sort="Beilin, Lawrence J" uniqKey="Beilin L" first="Lawrence J" last="Beilin">Lawrence J. Beilin</name>
<affiliation wicri:level="1"><nlm:aff id="A22">School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine and Pharmacology, The University of Western Australia, Perth</wicri:regionArea>
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<author><name sortKey="B Nnelykke, Klaus" sort="B Nnelykke, Klaus" uniqKey="B Nnelykke K" first="Klaus" last="B Nnelykke">Klaus B Nnelykke</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
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<author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L" last="Buxton">Jessica L. Buxton</name>
<affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff>
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</affiliation>
</author>
<author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</wicri:regionArea>
<wicri:noRegion>Imperial College London</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A24">Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</nlm:aff>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chawes, Bo Lund Krogsgaard" sort="Chawes, Bo Lund Krogsgaard" uniqKey="Chawes B" first="Bo Lund Krogsgaard" last="Chawes">Bo Lund Krogsgaard Chawes</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
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<author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
<affiliation wicri:level="1"><nlm:aff id="A25">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
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<wicri:noRegion>Helsinki</wicri:noRegion>
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<affiliation wicri:level="4"><nlm:aff id="A26">Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki</wicri:regionArea>
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<region type="région" nuts="2">Uusimaa</region>
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</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A27">Folkhalsan Research Centre, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Folkhalsan Research Centre, Biomedicum Helsinki, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>The Generation R Study Group, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P" last="Kemp">John P. Kemp</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Cecilia E" sort="Kim, Cecilia E" uniqKey="Kim C" first="Cecilia E" last="Kim">Cecilia E. Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A29">Hannover Unified Biobank, Hannover Medical School, Hannover, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hannover Unified Biobank, Hannover Medical School, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name>
<affiliation wicri:level="4"><nlm:aff id="A30">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Behavioural Sciences, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lye, Stephen J" sort="Lye, Stephen J" uniqKey="Lye S" first="Stephen J" last="Lye">Stephen J. Lye</name>
<affiliation wicri:level="4"><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Samuel Lunenfeld Research Institute, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mentch, Frank D" sort="Mentch, Frank D" uniqKey="Mentch F" first="Frank D" last="Mentch">Frank D. Mentch</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Muller, Martina" sort="Muller, Martina" uniqKey="Muller M" first="Martina" last="Müller">Martina Müller</name>
<affiliation wicri:level="3"><nlm:aff id="A31">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A32">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A33">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F" last="O Eilly">Paul F. O Eilly</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Department of Epidemiology and Biostatistics, Imperial College London, W2 1PG London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, W2 1PG London</wicri:regionArea>
<wicri:noRegion>W2 1PG London</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
<affiliation wicri:level="4"><nlm:aff id="A35">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A36">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A37">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A P" last="Steegers">Eric A P. Steegers</name>
<affiliation wicri:level="3"><nlm:aff id="A38">Department of Obstetrics & Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Obstetrics & Gynecology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A39">Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Pompeu Fabra University (UPF), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A40">Dr Von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr Von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yaghootkar, Hanieh" sort="Yaghootkar, Hanieh" uniqKey="Yaghootkar H" first="Hanieh" last="Yaghootkar">Hanieh Yaghootkar</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter</wicri:regionArea>
<wicri:noRegion>Exeter</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M B" last="Breteler">Monique M B. Breteler</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation wicri:level="2"><nlm:aff id="A42">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2"><nlm:aff id="A43">Institute of Molecular Medicine, Human Genetics Center and Division of Epidemiology, School of Public Health, University of Texas, Houston Health Sciences Center, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute of Molecular Medicine, Human Genetics Center and Division of Epidemiology, School of Public Health, University of Texas, Houston Health Sciences Center, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Icelandic Heart Association, Kopavogus, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogus</wicri:regionArea>
<wicri:noRegion>Kopavogus</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="2"><nlm:aff id="A46">Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="2"><nlm:aff id="A47">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation wicri:level="2"><nlm:aff id="A42">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Icelandic Heart Association, Kopavogus, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogus</wicri:regionArea>
<wicri:noRegion>Kopavogus</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W" last="Vernooij">Meike W. Vernooij</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blakemore, Alexandra If" sort="Blakemore, Alexandra If" uniqKey="Blakemore A" first="Alexandra If" last="Blakemore">Alexandra If Blakemore</name>
<affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Imperial College London</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chiavacci, Rosetta M" sort="Chiavacci, Rosetta M" uniqKey="Chiavacci R" first="Rosetta M" last="Chiavacci">Rosetta M. Chiavacci</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Feenstra, Bjarke" sort="Feenstra, Bjarke" uniqKey="Feenstra B" first="Bjarke" last="Feenstra">Bjarke Feenstra</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Epidemiology Research, Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fernandez Benet, Julio" sort="Fernandez Benet, Julio" uniqKey="Fernandez Benet J" first="Julio" last="Fernandez-Benet">Julio Fernandez-Benet</name>
<affiliation wicri:level="1"><nlm:aff id="A48">European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea>
<wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F A" last="Grant">Struan F A. Grant</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A49">Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A50">Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104</wicri:regionArea>
<wicri:noRegion>Philadelphia PA 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name>
<affiliation wicri:level="1"><nlm:aff id="A51">Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Heijden, Albert J" sort="Van Der Heijden, Albert J" uniqKey="Van Der Heijden A" first="Albert J" last="Van Der Heijden">Albert J. Van Der Heijden</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Paediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="I Iguez, Carmen" sort="I Iguez, Carmen" uniqKey="I Iguez C" first="Carmen" last="I Iguez">Carmen I Iguez</name>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A52">Division of Environment and Health, Center for Public Health Research-CSISP, Valencia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Division of Environment and Health, Center for Public Health Research-CSISP, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation wicri:level="3"><nlm:aff id="A53">Centre National de Génotypage, Evry, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Génotypage, Evry</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A54">Foundation Jean Dausset, CEPH, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Foundation Jean Dausset, CEPH, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name>
<affiliation wicri:level="1"><nlm:aff id="A55">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="M Lgaard, Anne" sort="M Lgaard, Anne" uniqKey="M Lgaard A" first="Anne" last="M Lgaard">Anne M Lgaard</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Newnham, John P" sort="Newnham, John P" uniqKey="Newnham J" first="John P" last="Newnham">John P. Newnham</name>
<affiliation wicri:level="1"><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, The University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name>
<affiliation wicri:level="4"><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Samuel Lunenfeld Research Institute, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A56">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<affiliation wicri:level="4"><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A57">Department of Medical Genetics, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Genetics, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A58">Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Broad Institute of Harvard and MIT, Cambridge, MA 02142</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A59">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pouta, Annneli" sort="Pouta, Annneli" uniqKey="Pouta A" first="Annneli" last="Pouta">Annneli Pouta</name>
<affiliation wicri:level="1"><nlm:aff id="A60">National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu</wicri:regionArea>
<wicri:noRegion>University of Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M" last="Ring">Susan M. Ring</name>
<affiliation wicri:level="1"><nlm:aff id="A55">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</wicri:regionArea>
<wicri:noRegion>Imperial College London</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A61">London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Standl, Marie" sort="Standl, Marie" uniqKey="Standl M" first="Marie" last="Standl">Marie Standl</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A37">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A31">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A33">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vissing, Nadja Hawwa" sort="Vissing, Nadja Hawwa" uniqKey="Vissing N" first="Nadja Hawwa" last="Vissing">Nadja Hawwa Vissing</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name>
<affiliation wicri:level="2"><nlm:aff id="A62">Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name>
<affiliation wicri:level="4"><nlm:aff id="A35">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A36">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A63">Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name>
<affiliation wicri:level="3"><nlm:aff id="A64">Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Estivill, Xavier" sort="Estivill, Xavier" uniqKey="Estivill X" first="Xavier" last="Estivill">Xavier Estivill</name>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A39">Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Pompeu Fabra University (UPF), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A65">Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T" last="Hattersley">Andrew T. Hattersley</name>
<affiliation wicri:level="1"><nlm:aff id="A66">Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter</wicri:regionArea>
<wicri:noRegion>Exeter</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Epidemiology Research, Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E" last="Pennell">Craig E. Pennell</name>
<affiliation wicri:level="1"><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, The University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name>
<affiliation wicri:level="4"><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A49">Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="1"><nlm:aff id="A50">Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</affiliation>
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<author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name>
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<country xml:lang="fr">Allemagne</country>
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<wicri:noRegion>Neuherberg</wicri:noRegion>
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<author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name>
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<affiliation wicri:level="1"><nlm:aff id="A60">National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Finland</nlm:aff>
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<affiliation><nlm:aff id="A67">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London</nlm:aff>
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<author><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W V" last="Jaddoe">Vincent W V. Jaddoe</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<affiliation wicri:level="3"><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Paediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>The Generation R Study Group, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common variants at 12q15 and 12q24 are associated with infant head circumference</title>
<author><name sortKey="Taal, H Rob" sort="Taal, H Rob" uniqKey="Taal H" first="H Rob" last="Taal">H Rob Taal</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Paediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<affiliation wicri:level="3"><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
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<wicri:regionArea>The Generation R Study Group, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<author><name sortKey="Pourcain, Beate St" sort="Pourcain, Beate St" uniqKey="Pourcain B" first="Beate St" last="Pourcain">Beate St Pourcain</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
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</author>
<author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
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<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
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</author>
<author><name sortKey="Das, Shikta" sort="Das, Shikta" uniqKey="Das S" first="Shikta" last="Das">Shikta Das</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</wicri:regionArea>
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</author>
<author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Paediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>The Generation R Study Group, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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<affiliation wicri:level="1"><nlm:aff id="A7">Weill Cornell Medical College - Qatar, Doha, Qatar</nlm:aff>
<country xml:lang="fr">Qatar</country>
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<wicri:noRegion>Doha</wicri:noRegion>
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<author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M" last="Warrington">Nicole M. Warrington</name>
<affiliation wicri:level="1"><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, The University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
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<affiliation wicri:level="4"><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Samuel Lunenfeld Research Institute, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
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<region type="state">Ontario</region>
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</affiliation>
</author>
<author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Institute of Health Sciences, University of Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Health Sciences, University of Oulu</wicri:regionArea>
<wicri:noRegion>University of Oulu</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="A11">Biocenter Oulu, University of Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Biocenter Oulu, University of Oulu</wicri:regionArea>
<wicri:noRegion>University of Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kreiner M Ller, Eskil" sort="Kreiner M Ller, Eskil" uniqKey="Kreiner M Ller E" first="Eskil" last="Kreiner-M Ller">Eskil Kreiner-M Ller</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P" last="Bradfield">Jonathan P. Bradfield</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Freathy, Rachel M" sort="Freathy, Rachel M" uniqKey="Freathy R" first="Rachel M" last="Freathy">Rachel M. Freathy</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter</wicri:regionArea>
<wicri:noRegion>Exeter</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Epidemiology Research, Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guxens, M Nica" sort="Guxens, M Nica" uniqKey="Guxens M" first="M Nica" last="Guxens">M Nica Guxens</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L" last="Cousminer">Diana L. Cousminer</name>
<affiliation wicri:level="4"><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beilin, Lawrence J" sort="Beilin, Lawrence J" uniqKey="Beilin L" first="Lawrence J" last="Beilin">Lawrence J. Beilin</name>
<affiliation wicri:level="1"><nlm:aff id="A22">School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine and Pharmacology, The University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="B Nnelykke, Klaus" sort="B Nnelykke, Klaus" uniqKey="B Nnelykke K" first="Klaus" last="B Nnelykke">Klaus B Nnelykke</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L" last="Buxton">Jessica L. Buxton</name>
<affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Imperial College London</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</wicri:regionArea>
<wicri:noRegion>Imperial College London</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A24">Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</nlm:aff>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chawes, Bo Lund Krogsgaard" sort="Chawes, Bo Lund Krogsgaard" uniqKey="Chawes B" first="Bo Lund Krogsgaard" last="Chawes">Bo Lund Krogsgaard Chawes</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
<affiliation wicri:level="1"><nlm:aff id="A25">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A26">Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A27">Folkhalsan Research Centre, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Folkhalsan Research Centre, Biomedicum Helsinki, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>The Generation R Study Group, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P" last="Kemp">John P. Kemp</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Cecilia E" sort="Kim, Cecilia E" uniqKey="Kim C" first="Cecilia E" last="Kim">Cecilia E. Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Research Unit for Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A29">Hannover Unified Biobank, Hannover Medical School, Hannover, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hannover Unified Biobank, Hannover Medical School, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name>
<affiliation wicri:level="4"><nlm:aff id="A30">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Behavioural Sciences, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lye, Stephen J" sort="Lye, Stephen J" uniqKey="Lye S" first="Stephen J" last="Lye">Stephen J. Lye</name>
<affiliation wicri:level="4"><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Samuel Lunenfeld Research Institute, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mentch, Frank D" sort="Mentch, Frank D" uniqKey="Mentch F" first="Frank D" last="Mentch">Frank D. Mentch</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Muller, Martina" sort="Muller, Martina" uniqKey="Muller M" first="Martina" last="Müller">Martina Müller</name>
<affiliation wicri:level="3"><nlm:aff id="A31">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A32">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A33">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F" last="O Eilly">Paul F. O Eilly</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Department of Epidemiology and Biostatistics, Imperial College London, W2 1PG London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, W2 1PG London</wicri:regionArea>
<wicri:noRegion>W2 1PG London</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
<affiliation wicri:level="4"><nlm:aff id="A35">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A36">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A37">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A P" last="Steegers">Eric A P. Steegers</name>
<affiliation wicri:level="3"><nlm:aff id="A38">Department of Obstetrics & Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Obstetrics & Gynecology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A39">Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Pompeu Fabra University (UPF), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A40">Dr Von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr Von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yaghootkar, Hanieh" sort="Yaghootkar, Hanieh" uniqKey="Yaghootkar H" first="Hanieh" last="Yaghootkar">Hanieh Yaghootkar</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter</wicri:regionArea>
<wicri:noRegion>Exeter</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M B" last="Breteler">Monique M B. Breteler</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation wicri:level="2"><nlm:aff id="A42">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2"><nlm:aff id="A43">Institute of Molecular Medicine, Human Genetics Center and Division of Epidemiology, School of Public Health, University of Texas, Houston Health Sciences Center, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute of Molecular Medicine, Human Genetics Center and Division of Epidemiology, School of Public Health, University of Texas, Houston Health Sciences Center, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Icelandic Heart Association, Kopavogus, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogus</wicri:regionArea>
<wicri:noRegion>Kopavogus</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="2"><nlm:aff id="A46">Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="2"><nlm:aff id="A47">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation wicri:level="2"><nlm:aff id="A42">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Icelandic Heart Association, Kopavogus, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogus</wicri:regionArea>
<wicri:noRegion>Kopavogus</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A45">University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W" last="Vernooij">Meike W. Vernooij</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blakemore, Alexandra If" sort="Blakemore, Alexandra If" uniqKey="Blakemore A" first="Alexandra If" last="Blakemore">Alexandra If Blakemore</name>
<affiliation><nlm:aff id="A23">Department of Genomics of Common Disease, School of Public Health, Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Imperial College London</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chiavacci, Rosetta M" sort="Chiavacci, Rosetta M" uniqKey="Chiavacci R" first="Rosetta M" last="Chiavacci">Rosetta M. Chiavacci</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Feenstra, Bjarke" sort="Feenstra, Bjarke" uniqKey="Feenstra B" first="Bjarke" last="Feenstra">Bjarke Feenstra</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Epidemiology Research, Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fernandez Benet, Julio" sort="Fernandez Benet, Julio" uniqKey="Fernandez Benet J" first="Julio" last="Fernandez-Benet">Julio Fernandez-Benet</name>
<affiliation wicri:level="1"><nlm:aff id="A48">European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD</wicri:regionArea>
<wicri:noRegion>Cambridge CB10 1SD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F A" last="Grant">Struan F A. Grant</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A49">Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A50">Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104</wicri:regionArea>
<wicri:noRegion>Philadelphia PA 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name>
<affiliation wicri:level="1"><nlm:aff id="A51">Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Heijden, Albert J" sort="Van Der Heijden, Albert J" uniqKey="Van Der Heijden A" first="Albert J" last="Van Der Heijden">Albert J. Van Der Heijden</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Paediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="I Iguez, Carmen" sort="I Iguez, Carmen" uniqKey="I Iguez C" first="Carmen" last="I Iguez">Carmen I Iguez</name>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A52">Division of Environment and Health, Center for Public Health Research-CSISP, Valencia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Division of Environment and Health, Center for Public Health Research-CSISP, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation wicri:level="3"><nlm:aff id="A53">Centre National de Génotypage, Evry, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Génotypage, Evry</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A54">Foundation Jean Dausset, CEPH, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Foundation Jean Dausset, CEPH, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name>
<affiliation wicri:level="1"><nlm:aff id="A55">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="M Lgaard, Anne" sort="M Lgaard, Anne" uniqKey="M Lgaard A" first="Anne" last="M Lgaard">Anne M Lgaard</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Newnham, John P" sort="Newnham, John P" uniqKey="Newnham J" first="John P" last="Newnham">John P. Newnham</name>
<affiliation wicri:level="1"><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, The University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name>
<affiliation wicri:level="4"><nlm:aff id="A9">Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Samuel Lunenfeld Research Institute, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A56">Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<affiliation wicri:level="4"><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A57">Department of Medical Genetics, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Genetics, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A58">Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Broad Institute of Harvard and MIT, Cambridge, MA 02142</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A59">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pouta, Annneli" sort="Pouta, Annneli" uniqKey="Pouta A" first="Annneli" last="Pouta">Annneli Pouta</name>
<affiliation wicri:level="1"><nlm:aff id="A60">National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu</wicri:regionArea>
<wicri:noRegion>University of Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M" last="Ring">Susan M. Ring</name>
<affiliation wicri:level="1"><nlm:aff id="A55">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</wicri:regionArea>
<wicri:noRegion>Imperial College London</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A61">London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Standl, Marie" sort="Standl, Marie" uniqKey="Standl M" first="Marie" last="Standl">Marie Standl</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A37">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A31">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A33">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vissing, Nadja Hawwa" sort="Vissing, Nadja Hawwa" uniqKey="Vissing N" first="Nadja Hawwa" last="Vissing">Nadja Hawwa Vissing</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name>
<affiliation wicri:level="2"><nlm:aff id="A62">Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name>
<affiliation wicri:level="4"><nlm:aff id="A35">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A36">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A63">Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name>
<affiliation wicri:level="3"><nlm:aff id="A64">Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Estivill, Xavier" sort="Estivill, Xavier" uniqKey="Estivill X" first="Xavier" last="Estivill">Xavier Estivill</name>
<affiliation wicri:level="1"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A39">Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Pompeu Fabra University (UPF), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A65">Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Barcelona, Catalonia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hattersley, Andrew T" sort="Hattersley, Andrew T" uniqKey="Hattersley A" first="Andrew T" last="Hattersley">Andrew T. Hattersley</name>
<affiliation wicri:level="1"><nlm:aff id="A66">Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Peninsula NIHR Clinical Research Facility, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter</wicri:regionArea>
<wicri:noRegion>Exeter</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Epidemiology Research, Statens Serum Institut, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Prospective Studies on Asthma in Childhood, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E" last="Pennell">Craig E. Pennell</name>
<affiliation wicri:level="1"><nlm:aff id="A8">School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, The University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name>
<affiliation wicri:level="4"><nlm:aff id="A19">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A49">Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104</wicri:regionArea>
<wicri:noRegion>Pennsylvania 19104</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A50">Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of Pennsylvania, Philadelphia PA 19104</wicri:regionArea>
<wicri:noRegion>Philadelphia PA 19104</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name>
<affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Institute of Health Sciences, University of Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Health Sciences, University of Oulu</wicri:regionArea>
<wicri:noRegion>University of Oulu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A60">National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu</wicri:regionArea>
<wicri:noRegion>University of Oulu</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff id="A67">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Imperial College London</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W V" last="Jaddoe">Vincent W V. Jaddoe</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Paediatrics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>The Generation R Study Group, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature genetics</title>
<idno type="ISSN">1061-4036</idno>
<idno type="eISSN">1546-1718</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromosomes, Human, Pair 12 (genetics)</term>
<term>European Continental Ancestry Group (genetics)</term>
<term>Female</term>
<term>Genetic Loci</term>
<term>Genetic Markers</term>
<term>Genome-Wide Association Study</term>
<term>Head (growth & development)</term>
<term>Head (pathology)</term>
<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>Meta-Analysis as Topic</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Pregnancy</term>
<term>Pregnancy Complications (etiology)</term>
<term>Pregnancy Complications (pathology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Chromosomes humains de la paire 12 (génétique)</term>
<term>Complications de la grossesse (anatomopathologie)</term>
<term>Complications de la grossesse (étiologie)</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Locus génétiques</term>
<term>Marqueurs génétiques</term>
<term>Mâle</term>
<term>Méta-analyse comme sujet</term>
<term>Nourrisson</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Population d'origine européenne (génétique)</term>
<term>Tête (anatomopathologie)</term>
<term>Tête (croissance et développement)</term>
<term>Étude d'association pangénomique</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Genetic Markers</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Complications de la grossesse</term>
<term>Tête</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Tête</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pregnancy Complications</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 12</term>
<term>European Continental Ancestry Group</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Head</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chromosomes humains de la paire 12</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Population d'origine européenne</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Head</term>
<term>Pregnancy Complications</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Complications de la grossesse</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Genetic Loci</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>Meta-Analysis as Topic</term>
<term>Pregnancy</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Locus génétiques</term>
<term>Marqueurs génétiques</term>
<term>Mâle</term>
<term>Méta-analyse comme sujet</term>
<term>Nourrisson</term>
<term>Étude d'association pangénomique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P7">To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association (GWA) studies (N=10,768 from European ancestry enrolled in pregnancy/birth cohorts) and followed up three lead signals in six replication studies (combined N=19,089). Rs7980687 on chromosome 12q24 (<italic>P</italic>
=8.1×10<sup>−9</sup>
), and rs1042725 on chromosome 12q15 (<italic>P</italic>
=2.8×10<sup>−10</sup>
) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height<sup><xref ref-type="bibr" rid="R1">1</xref>
</sup>
, their effects on infant head circumference were largely independent of height (<italic>P</italic>
=3.8×10<sup>−7</sup>
for rs7980687, <italic>P</italic>
=1.3×10<sup>−7</sup>
for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (<italic>P</italic>
=3.9×10<sup>−6</sup>
). SNPs correlated to the 17q21 signal show genome-wide association with adult intra cranial volume<sup><xref ref-type="bibr" rid="R2">2</xref>
</sup>
, Parkinson’s disease and other neurodegenerative diseases<sup><xref ref-type="bibr" rid="R3">3</xref>
-<xref ref-type="bibr" rid="R5">5</xref>
</sup>
, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.</p>
</div>
</front>
</TEI>
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