coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated BRAFV600 mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)
Identifieur interne : 005337 ( Ncbi/Checkpoint ); précédent : 005336coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated BRAFV600 mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)
Auteurs : Paolo A. Ascierto [Italie] ; Grant A. Mcarthur [Australie] ; Brigitte Dréno [France] ; James Larkin [Royaume-Uni] ; Gabriella Liszkay [Hongrie] ; Michele Maio [Italie] ; Mario Mandala [Italie] ; Lev Demidov [Russie] ; Daniil Stroyakovskiy [Russie] ; Luc Thomas [France] ; Luis De La Cruz-Merino [Espagne] ; Victoria Atkinson [Australie] ; Caroline Dutriaux [France] ; Claus Garbe [Allemagne] ; Ilsung Chang [États-Unis] ; Stephen P Hack [États-Unis] ; Antoni Ribas [États-Unis]Source :
- Journal of Translational Medicine [ 1479-5876 ] ; 2015.
Url:
DOI: 10.1186/1479-5876-13-S1-O4
PubMed: NONE
PubMed Central: 4315268
Affiliations:
- Allemagne, Australie, Espagne, France, Hongrie, Italie, Royaume-Uni, Russie, États-Unis
- Angleterre, Aquitaine, Bade-Wurtemberg, Californie, District de Tübingen, District fédéral central, Grand Londres, Hongrie centrale, Nouvelle-Aquitaine, Pays de la Loire
- Bordeaux, Budapest, Londres, Moscou, Nantes, Tübingen
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001162
- to stream Pmc, to step Curation: 001023
- to stream Pmc, to step Checkpoint: 000C27
- to stream Ncbi, to step Merge: 005337
- to stream Ncbi, to step Curation: 005337
Links to Exploration step
PMC:4315268Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated <italic>BRAF</italic><sup>V600</sup> mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)</title><author><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name><affiliation wicri:level="1"><nlm:aff id="I1">Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Tumori Fondazione G. Pascale, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Mcarthur, Grant A" sort="Mcarthur, Grant A" uniqKey="Mcarthur G" first="Grant A" last="Mcarthur">Grant A. Mcarthur</name><affiliation wicri:level="1"><nlm:aff id="I2">Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dréno">Brigitte Dréno</name><affiliation wicri:level="3"><nlm:aff id="I3">Hôtel Dieu Place Alexis Ricordeau, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hôtel Dieu Place Alexis Ricordeau, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Larkin, James" sort="Larkin, James" uniqKey="Larkin J" first="James" last="Larkin">James Larkin</name><affiliation wicri:level="3"><nlm:aff id="I4">The Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Liszkay, Gabriella" sort="Liszkay, Gabriella" uniqKey="Liszkay G" first="Gabriella" last="Liszkay">Gabriella Liszkay</name><affiliation wicri:level="3"><nlm:aff id="I5">National Institute of Oncology, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Maio, Michele" sort="Maio, Michele" uniqKey="Maio M" first="Michele" last="Maio">Michele Maio</name><affiliation wicri:level="1"><nlm:aff id="I6">Azienda Ospedaliera Universitaria Senese, Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliera Universitaria Senese, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author><author><name sortKey="Mandala, Mario" sort="Mandala, Mario" uniqKey="Mandala M" first="Mario" last="Mandala">Mario Mandala</name><affiliation wicri:level="1"><nlm:aff id="I7">Papa Giovanni XXIII Hospital, Bergamo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Papa Giovanni XXIII Hospital, Bergamo</wicri:regionArea><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Demidov, Lev" sort="Demidov, Lev" uniqKey="Demidov L" first="Lev" last="Demidov">Lev Demidov</name><affiliation wicri:level="3"><nlm:aff id="I8">N.N. Blokhin Russian Cancer Research Center, Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>N.N. Blokhin Russian Cancer Research Center, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Stroyakovskiy, Daniil" sort="Stroyakovskiy, Daniil" uniqKey="Stroyakovskiy D" first="Daniil" last="Stroyakovskiy">Daniil Stroyakovskiy</name><affiliation wicri:level="1"><nlm:aff id="I9">Moscow City Oncology Hospital 62, Krasnogorsk, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Moscow City Oncology Hospital 62, Krasnogorsk</wicri:regionArea><wicri:noRegion>Krasnogorsk</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name><affiliation wicri:level="1"><nlm:aff id="I10">Centre Hospitalier Lyon Sud, Pierre-Bénite, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Lyon Sud, Pierre-Bénite</wicri:regionArea><wicri:noRegion>Pierre-Bénite</wicri:noRegion><wicri:noRegion>Pierre-Bénite</wicri:noRegion></affiliation></author><author><name sortKey="De La Cruz Merino, Luis" sort="De La Cruz Merino, Luis" uniqKey="De La Cruz Merino L" first="Luis" last="De La Cruz-Merino">Luis De La Cruz-Merino</name><affiliation wicri:level="1"><nlm:aff id="I11">Hospital Universitario Virgen Macarena, Seville, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Virgen Macarena, Seville</wicri:regionArea><wicri:noRegion>Seville</wicri:noRegion></affiliation></author><author><name sortKey="Atkinson, Victoria" sort="Atkinson, Victoria" uniqKey="Atkinson V" first="Victoria" last="Atkinson">Victoria Atkinson</name><affiliation wicri:level="1"><nlm:aff id="I12">Princess Alexandra Hospital, Woolloongabba, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Princess Alexandra Hospital, Woolloongabba, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Dutriaux, Caroline" sort="Dutriaux, Caroline" uniqKey="Dutriaux C" first="Caroline" last="Dutriaux">Caroline Dutriaux</name><affiliation wicri:level="3"><nlm:aff id="I13">Hopital Saint André, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hopital Saint André, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name><affiliation wicri:level="3"><nlm:aff id="I14">University of Tübingen, Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Chang, Ilsung" sort="Chang, Ilsung" uniqKey="Chang I" first="Ilsung" last="Chang">Ilsung Chang</name><affiliation wicri:level="2"><nlm:aff id="I15">Genentech, Inc, South San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, Inc, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hack, Stephen P" sort="Hack, Stephen P" uniqKey="Hack S" first="Stephen P" last="Hack">Stephen P Hack</name><affiliation wicri:level="2"><nlm:aff id="I15">Genentech, Inc, South San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, Inc, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name><affiliation wicri:level="2"><nlm:aff id="I16">Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">4315268</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315268</idno><idno type="RBID">PMC:4315268</idno><idno type="doi">10.1186/1479-5876-13-S1-O4</idno><idno type="pmid">NONE</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001162</idno><idno 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last="Ascierto">Paolo A. Ascierto</name><affiliation wicri:level="1"><nlm:aff id="I1">Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Tumori Fondazione G. Pascale, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Mcarthur, Grant A" sort="Mcarthur, Grant A" uniqKey="Mcarthur G" first="Grant A" last="Mcarthur">Grant A. Mcarthur</name><affiliation wicri:level="1"><nlm:aff id="I2">Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dréno">Brigitte Dréno</name><affiliation wicri:level="3"><nlm:aff id="I3">Hôtel Dieu Place Alexis Ricordeau, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hôtel Dieu Place Alexis Ricordeau, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Larkin, James" sort="Larkin, James" uniqKey="Larkin J" first="James" last="Larkin">James Larkin</name><affiliation wicri:level="3"><nlm:aff id="I4">The Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Liszkay, Gabriella" sort="Liszkay, Gabriella" uniqKey="Liszkay G" first="Gabriella" last="Liszkay">Gabriella Liszkay</name><affiliation wicri:level="3"><nlm:aff id="I5">National Institute of Oncology, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Maio, Michele" sort="Maio, Michele" uniqKey="Maio M" first="Michele" last="Maio">Michele Maio</name><affiliation wicri:level="1"><nlm:aff id="I6">Azienda Ospedaliera Universitaria Senese, Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliera Universitaria Senese, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author><author><name sortKey="Mandala, Mario" sort="Mandala, Mario" uniqKey="Mandala M" first="Mario" last="Mandala">Mario Mandala</name><affiliation wicri:level="1"><nlm:aff id="I7">Papa Giovanni XXIII Hospital, Bergamo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Papa Giovanni XXIII Hospital, Bergamo</wicri:regionArea><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Demidov, Lev" sort="Demidov, Lev" uniqKey="Demidov L" first="Lev" last="Demidov">Lev Demidov</name><affiliation wicri:level="3"><nlm:aff id="I8">N.N. Blokhin Russian Cancer Research Center, Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>N.N. Blokhin Russian Cancer Research Center, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Stroyakovskiy, Daniil" sort="Stroyakovskiy, Daniil" uniqKey="Stroyakovskiy D" first="Daniil" last="Stroyakovskiy">Daniil Stroyakovskiy</name><affiliation wicri:level="1"><nlm:aff id="I9">Moscow City Oncology Hospital 62, Krasnogorsk, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Moscow City Oncology Hospital 62, Krasnogorsk</wicri:regionArea><wicri:noRegion>Krasnogorsk</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name><affiliation wicri:level="1"><nlm:aff id="I10">Centre Hospitalier Lyon Sud, Pierre-Bénite, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Lyon Sud, Pierre-Bénite</wicri:regionArea><wicri:noRegion>Pierre-Bénite</wicri:noRegion><wicri:noRegion>Pierre-Bénite</wicri:noRegion></affiliation></author><author><name sortKey="De La Cruz Merino, Luis" sort="De La Cruz Merino, Luis" uniqKey="De La Cruz Merino L" first="Luis" last="De La Cruz-Merino">Luis De La Cruz-Merino</name><affiliation wicri:level="1"><nlm:aff id="I11">Hospital Universitario Virgen Macarena, Seville, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Virgen Macarena, Seville</wicri:regionArea><wicri:noRegion>Seville</wicri:noRegion></affiliation></author><author><name sortKey="Atkinson, Victoria" sort="Atkinson, Victoria" uniqKey="Atkinson V" first="Victoria" last="Atkinson">Victoria Atkinson</name><affiliation wicri:level="1"><nlm:aff id="I12">Princess Alexandra Hospital, Woolloongabba, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Princess Alexandra Hospital, Woolloongabba, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Dutriaux, Caroline" sort="Dutriaux, Caroline" uniqKey="Dutriaux C" first="Caroline" last="Dutriaux">Caroline Dutriaux</name><affiliation wicri:level="3"><nlm:aff id="I13">Hopital Saint André, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hopital Saint André, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name><affiliation wicri:level="3"><nlm:aff id="I14">University of Tübingen, Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Chang, Ilsung" sort="Chang, Ilsung" uniqKey="Chang I" first="Ilsung" last="Chang">Ilsung Chang</name><affiliation wicri:level="2"><nlm:aff id="I15">Genentech, Inc, South San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, Inc, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hack, Stephen P" sort="Hack, Stephen P" uniqKey="Hack S" first="Stephen P" last="Hack">Stephen P Hack</name><affiliation wicri:level="2"><nlm:aff id="I15">Genentech, Inc, South San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, Inc, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name><affiliation wicri:level="2"><nlm:aff id="I16">Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Translational Medicine</title><idno type="eISSN">1479-5876</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>France</li><li>Hongrie</li><li>Italie</li><li>Royaume-Uni</li><li>Russie</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Bade-Wurtemberg</li><li>Californie</li><li>District de Tübingen</li><li>District fédéral central</li><li>Grand Londres</li><li>Hongrie centrale</li><li>Nouvelle-Aquitaine</li><li>Pays de la Loire</li></region><settlement><li>Bordeaux</li><li>Budapest</li><li>Londres</li><li>Moscou</li><li>Nantes</li><li>Tübingen</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name></noRegion><name sortKey="Maio, Michele" sort="Maio, Michele" uniqKey="Maio M" first="Michele" last="Maio">Michele Maio</name><name sortKey="Mandala, Mario" sort="Mandala, Mario" uniqKey="Mandala M" first="Mario" last="Mandala">Mario Mandala</name></country><country name="Australie"><noRegion><name sortKey="Mcarthur, Grant A" sort="Mcarthur, Grant A" uniqKey="Mcarthur G" first="Grant A" last="Mcarthur">Grant A. Mcarthur</name></noRegion><name sortKey="Atkinson, Victoria" sort="Atkinson, Victoria" uniqKey="Atkinson V" first="Victoria" last="Atkinson">Victoria Atkinson</name></country><country name="France"><region name="Pays de la Loire"><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dréno">Brigitte Dréno</name></region><name sortKey="Dutriaux, Caroline" sort="Dutriaux, Caroline" uniqKey="Dutriaux C" first="Caroline" last="Dutriaux">Caroline Dutriaux</name><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Larkin, James" sort="Larkin, James" uniqKey="Larkin J" first="James" last="Larkin">James Larkin</name></region></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Liszkay, Gabriella" sort="Liszkay, Gabriella" uniqKey="Liszkay G" first="Gabriella" last="Liszkay">Gabriella Liszkay</name></region></country><country name="Russie"><region name="District fédéral central"><name sortKey="Demidov, Lev" sort="Demidov, Lev" uniqKey="Demidov L" first="Lev" last="Demidov">Lev Demidov</name></region><name sortKey="Stroyakovskiy, Daniil" sort="Stroyakovskiy, Daniil" uniqKey="Stroyakovskiy D" first="Daniil" last="Stroyakovskiy">Daniil Stroyakovskiy</name></country><country name="Espagne"><noRegion><name sortKey="De La Cruz Merino, Luis" sort="De La Cruz Merino, Luis" uniqKey="De La Cruz Merino L" first="Luis" last="De La Cruz-Merino">Luis De La Cruz-Merino</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name></region></country><country name="États-Unis"><region name="Californie"><name sortKey="Chang, Ilsung" sort="Chang, Ilsung" uniqKey="Chang I" first="Ilsung" last="Chang">Ilsung Chang</name></region><name sortKey="Hack, Stephen P" sort="Hack, Stephen P" uniqKey="Hack S" first="Stephen P" last="Hack">Stephen P Hack</name><name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated BRAFV600 mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)
}}
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| NlmPubMed2Wicri -a AustralieFrV1
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