coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated BRAFV600 mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)
Identifieur interne : 005337 ( Ncbi/Merge ); précédent : 005336coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated BRAFV600 mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)
Auteurs : Paolo A. Ascierto [Italie] ; Grant A. Mcarthur [Australie] ; Brigitte Dréno [France] ; James Larkin [Royaume-Uni] ; Gabriella Liszkay [Hongrie] ; Michele Maio [Italie] ; Mario Mandala [Italie] ; Lev Demidov [Russie] ; Daniil Stroyakovskiy [Russie] ; Luc Thomas [France] ; Luis De La Cruz-Merino [Espagne] ; Victoria Atkinson [Australie] ; Caroline Dutriaux [France] ; Claus Garbe [Allemagne] ; Ilsung Chang [États-Unis] ; Stephen P Hack [États-Unis] ; Antoni Ribas [États-Unis]Source :
- Journal of Translational Medicine [ 1479-5876 ] ; 2015.
Url:
DOI: 10.1186/1479-5876-13-S1-O4
PubMed: NONE
PubMed Central: 4315268
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated <italic>BRAF</italic><sup>V600</sup> mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)</title><author><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name><affiliation wicri:level="1"><nlm:aff id="I1">Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Tumori Fondazione G. Pascale, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Mcarthur, Grant A" sort="Mcarthur, Grant A" uniqKey="Mcarthur G" first="Grant A" last="Mcarthur">Grant A. Mcarthur</name><affiliation wicri:level="1"><nlm:aff id="I2">Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dréno">Brigitte Dréno</name><affiliation wicri:level="3"><nlm:aff id="I3">Hôtel Dieu Place Alexis Ricordeau, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hôtel Dieu Place Alexis Ricordeau, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Larkin, James" sort="Larkin, James" uniqKey="Larkin J" first="James" last="Larkin">James Larkin</name><affiliation wicri:level="3"><nlm:aff id="I4">The Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Liszkay, Gabriella" sort="Liszkay, Gabriella" uniqKey="Liszkay G" first="Gabriella" last="Liszkay">Gabriella Liszkay</name><affiliation wicri:level="3"><nlm:aff id="I5">National Institute of Oncology, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Maio, Michele" sort="Maio, Michele" uniqKey="Maio M" first="Michele" last="Maio">Michele Maio</name><affiliation wicri:level="1"><nlm:aff id="I6">Azienda Ospedaliera Universitaria Senese, Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliera Universitaria Senese, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author><author><name sortKey="Mandala, Mario" sort="Mandala, Mario" uniqKey="Mandala M" first="Mario" last="Mandala">Mario Mandala</name><affiliation wicri:level="1"><nlm:aff id="I7">Papa Giovanni XXIII Hospital, Bergamo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Papa Giovanni XXIII Hospital, Bergamo</wicri:regionArea><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Demidov, Lev" sort="Demidov, Lev" uniqKey="Demidov L" first="Lev" last="Demidov">Lev Demidov</name><affiliation wicri:level="3"><nlm:aff id="I8">N.N. Blokhin Russian Cancer Research Center, Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>N.N. Blokhin Russian Cancer Research Center, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Stroyakovskiy, Daniil" sort="Stroyakovskiy, Daniil" uniqKey="Stroyakovskiy D" first="Daniil" last="Stroyakovskiy">Daniil Stroyakovskiy</name><affiliation wicri:level="1"><nlm:aff id="I9">Moscow City Oncology Hospital 62, Krasnogorsk, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Moscow City Oncology Hospital 62, Krasnogorsk</wicri:regionArea><wicri:noRegion>Krasnogorsk</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name><affiliation wicri:level="1"><nlm:aff id="I10">Centre Hospitalier Lyon Sud, Pierre-Bénite, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Lyon Sud, Pierre-Bénite</wicri:regionArea><wicri:noRegion>Pierre-Bénite</wicri:noRegion><wicri:noRegion>Pierre-Bénite</wicri:noRegion></affiliation></author><author><name sortKey="De La Cruz Merino, Luis" sort="De La Cruz Merino, Luis" uniqKey="De La Cruz Merino L" first="Luis" last="De La Cruz-Merino">Luis De La Cruz-Merino</name><affiliation wicri:level="1"><nlm:aff id="I11">Hospital Universitario Virgen Macarena, Seville, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Virgen Macarena, Seville</wicri:regionArea><wicri:noRegion>Seville</wicri:noRegion></affiliation></author><author><name sortKey="Atkinson, Victoria" sort="Atkinson, Victoria" uniqKey="Atkinson V" first="Victoria" last="Atkinson">Victoria Atkinson</name><affiliation wicri:level="1"><nlm:aff id="I12">Princess Alexandra Hospital, Woolloongabba, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Princess Alexandra Hospital, Woolloongabba, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Dutriaux, Caroline" sort="Dutriaux, Caroline" uniqKey="Dutriaux C" first="Caroline" last="Dutriaux">Caroline Dutriaux</name><affiliation wicri:level="3"><nlm:aff id="I13">Hopital Saint André, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hopital Saint André, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name><affiliation wicri:level="3"><nlm:aff id="I14">University of Tübingen, Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Chang, Ilsung" sort="Chang, Ilsung" uniqKey="Chang I" first="Ilsung" last="Chang">Ilsung Chang</name><affiliation wicri:level="2"><nlm:aff id="I15">Genentech, Inc, South San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, Inc, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hack, Stephen P" sort="Hack, Stephen P" uniqKey="Hack S" first="Stephen P" last="Hack">Stephen P Hack</name><affiliation wicri:level="2"><nlm:aff id="I15">Genentech, Inc, South San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, Inc, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name><affiliation wicri:level="2"><nlm:aff id="I16">Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">4315268</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315268</idno><idno type="RBID">PMC:4315268</idno><idno type="doi">10.1186/1479-5876-13-S1-O4</idno><idno type="pmid">NONE</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001162</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001162</idno><idno type="wicri:Area/Pmc/Curation">001023</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001023</idno><idno type="wicri:Area/Pmc/Checkpoint">000C27</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C27</idno><idno type="wicri:Area/Ncbi/Merge">005337</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated <italic>BRAF</italic><sup>V600</sup> mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)</title><author><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name><affiliation wicri:level="1"><nlm:aff id="I1">Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Tumori Fondazione G. Pascale, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Mcarthur, Grant A" sort="Mcarthur, Grant A" uniqKey="Mcarthur G" first="Grant A" last="Mcarthur">Grant A. Mcarthur</name><affiliation wicri:level="1"><nlm:aff id="I2">Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dréno">Brigitte Dréno</name><affiliation wicri:level="3"><nlm:aff id="I3">Hôtel Dieu Place Alexis Ricordeau, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hôtel Dieu Place Alexis Ricordeau, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Larkin, James" sort="Larkin, James" uniqKey="Larkin J" first="James" last="Larkin">James Larkin</name><affiliation wicri:level="3"><nlm:aff id="I4">The Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Liszkay, Gabriella" sort="Liszkay, Gabriella" uniqKey="Liszkay G" first="Gabriella" last="Liszkay">Gabriella Liszkay</name><affiliation wicri:level="3"><nlm:aff id="I5">National Institute of Oncology, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Maio, Michele" sort="Maio, Michele" uniqKey="Maio M" first="Michele" last="Maio">Michele Maio</name><affiliation wicri:level="1"><nlm:aff id="I6">Azienda Ospedaliera Universitaria Senese, Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliera Universitaria Senese, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author><author><name sortKey="Mandala, Mario" sort="Mandala, Mario" uniqKey="Mandala M" first="Mario" last="Mandala">Mario Mandala</name><affiliation wicri:level="1"><nlm:aff id="I7">Papa Giovanni XXIII Hospital, Bergamo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Papa Giovanni XXIII Hospital, Bergamo</wicri:regionArea><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Demidov, Lev" sort="Demidov, Lev" uniqKey="Demidov L" first="Lev" last="Demidov">Lev Demidov</name><affiliation wicri:level="3"><nlm:aff id="I8">N.N. Blokhin Russian Cancer Research Center, Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>N.N. Blokhin Russian Cancer Research Center, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Stroyakovskiy, Daniil" sort="Stroyakovskiy, Daniil" uniqKey="Stroyakovskiy D" first="Daniil" last="Stroyakovskiy">Daniil Stroyakovskiy</name><affiliation wicri:level="1"><nlm:aff id="I9">Moscow City Oncology Hospital 62, Krasnogorsk, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Moscow City Oncology Hospital 62, Krasnogorsk</wicri:regionArea><wicri:noRegion>Krasnogorsk</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name><affiliation wicri:level="1"><nlm:aff id="I10">Centre Hospitalier Lyon Sud, Pierre-Bénite, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Lyon Sud, Pierre-Bénite</wicri:regionArea><wicri:noRegion>Pierre-Bénite</wicri:noRegion><wicri:noRegion>Pierre-Bénite</wicri:noRegion></affiliation></author><author><name sortKey="De La Cruz Merino, Luis" sort="De La Cruz Merino, Luis" uniqKey="De La Cruz Merino L" first="Luis" last="De La Cruz-Merino">Luis De La Cruz-Merino</name><affiliation wicri:level="1"><nlm:aff id="I11">Hospital Universitario Virgen Macarena, Seville, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Virgen Macarena, Seville</wicri:regionArea><wicri:noRegion>Seville</wicri:noRegion></affiliation></author><author><name sortKey="Atkinson, Victoria" sort="Atkinson, Victoria" uniqKey="Atkinson V" first="Victoria" last="Atkinson">Victoria Atkinson</name><affiliation wicri:level="1"><nlm:aff id="I12">Princess Alexandra Hospital, Woolloongabba, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Princess Alexandra Hospital, Woolloongabba, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Dutriaux, Caroline" sort="Dutriaux, Caroline" uniqKey="Dutriaux C" first="Caroline" last="Dutriaux">Caroline Dutriaux</name><affiliation wicri:level="3"><nlm:aff id="I13">Hopital Saint André, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hopital Saint André, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name><affiliation wicri:level="3"><nlm:aff id="I14">University of Tübingen, Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Chang, Ilsung" sort="Chang, Ilsung" uniqKey="Chang I" first="Ilsung" last="Chang">Ilsung Chang</name><affiliation wicri:level="2"><nlm:aff id="I15">Genentech, Inc, South San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, Inc, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hack, Stephen P" sort="Hack, Stephen P" uniqKey="Hack S" first="Stephen P" last="Hack">Stephen P Hack</name><affiliation wicri:level="2"><nlm:aff id="I15">Genentech, Inc, South San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, Inc, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name><affiliation wicri:level="2"><nlm:aff id="I16">Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Translational Medicine</title><idno type="eISSN">1479-5876</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Transl Med</journal-id><journal-id journal-id-type="iso-abbrev">J Transl Med</journal-id><journal-title-group><journal-title>Journal of Translational Medicine</journal-title></journal-title-group><issn pub-type="epub">1479-5876</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">4315268</article-id><article-id pub-id-type="publisher-id">1479-5876-13-S1-O4</article-id><article-id pub-id-type="doi">10.1186/1479-5876-13-S1-O4</article-id><article-categories><subj-group subj-group-type="heading"><subject>Oral Presentation</subject></subj-group></article-categories><title-group><article-title>coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated <italic>BRAF</italic><sup>V600</sup> mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Ascierto</surname><given-names>Paolo A</given-names></name><xref ref-type="aff" rid="I1">1</xref></contrib><contrib contrib-type="author" id="A2"><name><surname>McArthur</surname><given-names>Grant A</given-names></name><xref ref-type="aff" rid="I2">2</xref></contrib><contrib contrib-type="author" id="A3"><name><surname>Dréno</surname><given-names>Brigitte</given-names></name><xref ref-type="aff" rid="I3">3</xref></contrib><contrib contrib-type="author" id="A4"><name><surname>Larkin</surname><given-names>James</given-names></name><xref ref-type="aff" rid="I4">4</xref></contrib><contrib contrib-type="author" id="A5"><name><surname>Liszkay</surname><given-names>Gabriella</given-names></name><xref ref-type="aff" rid="I5">5</xref></contrib><contrib contrib-type="author" id="A6"><name><surname>Maio</surname><given-names>Michele</given-names></name><xref ref-type="aff" rid="I6">6</xref></contrib><contrib contrib-type="author" id="A7"><name><surname>Mandala</surname><given-names>Mario</given-names></name><xref ref-type="aff" rid="I7">7</xref></contrib><contrib contrib-type="author" id="A8"><name><surname>Demidov</surname><given-names>Lev</given-names></name><xref ref-type="aff" rid="I8">8</xref></contrib><contrib contrib-type="author" id="A9"><name><surname>Stroyakovskiy</surname><given-names>Daniil</given-names></name><xref ref-type="aff" rid="I9">9</xref></contrib><contrib contrib-type="author" id="A10"><name><surname>Thomas</surname><given-names>Luc</given-names></name><xref ref-type="aff" rid="I10">10</xref></contrib><contrib contrib-type="author" id="A11"><name><surname>de la Cruz-Merino</surname><given-names>Luis</given-names></name><xref ref-type="aff" rid="I11">11</xref></contrib><contrib contrib-type="author" id="A12"><name><surname>Atkinson</surname><given-names>Victoria</given-names></name><xref ref-type="aff" rid="I12">12</xref></contrib><contrib contrib-type="author" id="A13"><name><surname>Dutriaux</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="I13">13</xref></contrib><contrib contrib-type="author" id="A14"><name><surname>Garbe</surname><given-names>Claus</given-names></name><xref ref-type="aff" rid="I14">14</xref></contrib><contrib contrib-type="author" id="A15"><name><surname>Chang</surname><given-names>Ilsung</given-names></name><xref ref-type="aff" rid="I15">15</xref></contrib><contrib contrib-type="author" id="A16"><name><surname>Hack</surname><given-names>Stephen P </given-names></name><xref ref-type="aff" rid="I15">15</xref></contrib><contrib contrib-type="author" id="A17"><name><surname>Ribas</surname><given-names>Antoni</given-names></name><xref ref-type="aff" rid="I16">16</xref></contrib></contrib-group><aff id="I1"><label>1</label>Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy</aff><aff id="I2"><label>2</label>Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</aff><aff id="I3"><label>3</label>Hôtel Dieu Place Alexis Ricordeau, Nantes, France</aff><aff id="I4"><label>4</label>The Royal Marsden Hospital, London, UK</aff><aff id="I5"><label>5</label>National Institute of Oncology, Budapest, Hungary</aff><aff id="I6"><label>6</label>Azienda Ospedaliera Universitaria Senese, Siena, Italy</aff><aff id="I7"><label>7</label>Papa Giovanni XXIII Hospital, Bergamo, Italy</aff><aff id="I8"><label>8</label>N.N. Blokhin Russian Cancer Research Center, Moscow, Russia</aff><aff id="I9"><label>9</label>Moscow City Oncology Hospital 62, Krasnogorsk, Russia</aff><aff id="I10"><label>10</label>Centre Hospitalier Lyon Sud, Pierre-Bénite, France</aff><aff id="I11"><label>11</label>Hospital Universitario Virgen Macarena, Seville, Spain</aff><aff id="I12"><label>12</label>Princess Alexandra Hospital, Woolloongabba, QLD, Australia</aff><aff id="I13"><label>13</label>Hopital Saint André, Bordeaux, France</aff><aff id="I14"><label>14</label>University of Tübingen, Tübingen, Germany</aff><aff id="I15"><label>15</label>Genentech, Inc, South San Francisco, CA, USA</aff><aff id="I16"><label>16</label>Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, Los Angeles, CA, USA</aff><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>15</day><month>1</month><year>2015</year></pub-date><volume>13</volume><issue>Suppl 1</issue><supplement><named-content content-type="supplement-title">Melanoma Bridge 2014: meeting abstracts</named-content><named-content content-type="supplement-editor">Paolo A Ascierto, Gennaro Ciliberto, John M Kirkwood, Francesco M Marincola, Giuseppe Masucci, Ignacio Melero, Nicola Mozzillo, Giuseppe Palmieri and Magdalena Thurin.</named-content><named-content content-type="supplement-sponsor">The publication charges for this supplement were funded by 3P solutions. Abstracts were evaluated by the Supplement Editors. Supplement Editor declarations: John Kirkwood reports grants from Prometheus and personal fees from BMS, Merck, GSK, Celgene, Vica and Ziopharm Oncology. Malero has received Consulting honoraria from Bristol Myers Squibb, Roche Genentech and Astra Zeneca. All other Supplement Editors declare that they have no competing interests.</named-content></supplement><fpage>O4</fpage><lpage>O4</lpage><permissions><copyright-statement>Copyright © 2015 Ascierto et al; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Ascierto et al; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><self-uri xlink:href="http://www.translational-medicine.com/content/13/S1/O4"></self-uri><conference><conf-date>3-6 December 2014</conf-date><conf-name>Melanoma Bridge Meeting 2014</conf-name><conf-loc>Naples, Italy</conf-loc></conference></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>France</li><li>Hongrie</li><li>Italie</li><li>Royaume-Uni</li><li>Russie</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Bade-Wurtemberg</li><li>Californie</li><li>District de Tübingen</li><li>District fédéral central</li><li>Grand Londres</li><li>Hongrie centrale</li><li>Nouvelle-Aquitaine</li><li>Pays de la Loire</li></region><settlement><li>Bordeaux</li><li>Budapest</li><li>Londres</li><li>Moscou</li><li>Nantes</li><li>Tübingen</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name></noRegion><name sortKey="Maio, Michele" sort="Maio, Michele" uniqKey="Maio M" first="Michele" last="Maio">Michele Maio</name><name sortKey="Mandala, Mario" sort="Mandala, Mario" uniqKey="Mandala M" first="Mario" last="Mandala">Mario Mandala</name></country><country name="Australie"><noRegion><name sortKey="Mcarthur, Grant A" sort="Mcarthur, Grant A" uniqKey="Mcarthur G" first="Grant A" last="Mcarthur">Grant A. Mcarthur</name></noRegion><name sortKey="Atkinson, Victoria" sort="Atkinson, Victoria" uniqKey="Atkinson V" first="Victoria" last="Atkinson">Victoria Atkinson</name></country><country name="France"><region name="Pays de la Loire"><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dréno">Brigitte Dréno</name></region><name sortKey="Dutriaux, Caroline" sort="Dutriaux, Caroline" uniqKey="Dutriaux C" first="Caroline" last="Dutriaux">Caroline Dutriaux</name><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Larkin, James" sort="Larkin, James" uniqKey="Larkin J" first="James" last="Larkin">James Larkin</name></region></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Liszkay, Gabriella" sort="Liszkay, Gabriella" uniqKey="Liszkay G" first="Gabriella" last="Liszkay">Gabriella Liszkay</name></region></country><country name="Russie"><region name="District fédéral central"><name sortKey="Demidov, Lev" sort="Demidov, Lev" uniqKey="Demidov L" first="Lev" last="Demidov">Lev Demidov</name></region><name sortKey="Stroyakovskiy, Daniil" sort="Stroyakovskiy, Daniil" uniqKey="Stroyakovskiy D" first="Daniil" last="Stroyakovskiy">Daniil Stroyakovskiy</name></country><country name="Espagne"><noRegion><name sortKey="De La Cruz Merino, Luis" sort="De La Cruz Merino, Luis" uniqKey="De La Cruz Merino L" first="Luis" last="De La Cruz-Merino">Luis De La Cruz-Merino</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name></region></country><country name="États-Unis"><region name="Californie"><name sortKey="Chang, Ilsung" sort="Chang, Ilsung" uniqKey="Chang I" first="Ilsung" last="Chang">Ilsung Chang</name></region><name sortKey="Hack, Stephen P" sort="Hack, Stephen P" uniqKey="Hack S" first="Stephen P" last="Hack">Stephen P Hack</name><name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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