coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated BRAFV600 mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)
Identifieur interne : 005337 ( Ncbi/Merge ); précédent : 005336coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated BRAFV600 mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)
Auteurs : Paolo A. Ascierto [Italie] ; Grant A. Mcarthur [Australie] ; Brigitte Dréno [France] ; James Larkin [Royaume-Uni] ; Gabriella Liszkay [Hongrie] ; Michele Maio [Italie] ; Mario Mandala [Italie] ; Lev Demidov [Russie] ; Daniil Stroyakovskiy [Russie] ; Luc Thomas [France] ; Luis De La Cruz-Merino [Espagne] ; Victoria Atkinson [Australie] ; Caroline Dutriaux [France] ; Claus Garbe [Allemagne] ; Ilsung Chang [États-Unis] ; Stephen P Hack [États-Unis] ; Antoni Ribas [États-Unis]Source :
- Journal of Translational Medicine [ 1479-5876 ] ; 2015.
Url:
DOI: 10.1186/1479-5876-13-S1-O4
PubMed: NONE
PubMed Central: 4315268
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PMC:4315268Le document en format XML
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<sup>V600</sup>
mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated <italic>BRAF</italic>
<sup>V600</sup>
mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)</title>
<author><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name>
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<title-group><article-title>coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated <italic>BRAF</italic>
<sup>V600</sup>
mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)</article-title>
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<contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Ascierto</surname>
<given-names>Paolo A</given-names>
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<xref ref-type="aff" rid="I1">1</xref>
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<contrib contrib-type="author" id="A2"><name><surname>McArthur</surname>
<given-names>Grant A</given-names>
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<xref ref-type="aff" rid="I2">2</xref>
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<contrib contrib-type="author" id="A3"><name><surname>Dréno</surname>
<given-names>Brigitte</given-names>
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<xref ref-type="aff" rid="I3">3</xref>
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<contrib contrib-type="author" id="A4"><name><surname>Larkin</surname>
<given-names>James</given-names>
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<xref ref-type="aff" rid="I4">4</xref>
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<contrib contrib-type="author" id="A5"><name><surname>Liszkay</surname>
<given-names>Gabriella</given-names>
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<xref ref-type="aff" rid="I5">5</xref>
</contrib>
<contrib contrib-type="author" id="A6"><name><surname>Maio</surname>
<given-names>Michele</given-names>
</name>
<xref ref-type="aff" rid="I6">6</xref>
</contrib>
<contrib contrib-type="author" id="A7"><name><surname>Mandala</surname>
<given-names>Mario</given-names>
</name>
<xref ref-type="aff" rid="I7">7</xref>
</contrib>
<contrib contrib-type="author" id="A8"><name><surname>Demidov</surname>
<given-names>Lev</given-names>
</name>
<xref ref-type="aff" rid="I8">8</xref>
</contrib>
<contrib contrib-type="author" id="A9"><name><surname>Stroyakovskiy</surname>
<given-names>Daniil</given-names>
</name>
<xref ref-type="aff" rid="I9">9</xref>
</contrib>
<contrib contrib-type="author" id="A10"><name><surname>Thomas</surname>
<given-names>Luc</given-names>
</name>
<xref ref-type="aff" rid="I10">10</xref>
</contrib>
<contrib contrib-type="author" id="A11"><name><surname>de la Cruz-Merino</surname>
<given-names>Luis</given-names>
</name>
<xref ref-type="aff" rid="I11">11</xref>
</contrib>
<contrib contrib-type="author" id="A12"><name><surname>Atkinson</surname>
<given-names>Victoria</given-names>
</name>
<xref ref-type="aff" rid="I12">12</xref>
</contrib>
<contrib contrib-type="author" id="A13"><name><surname>Dutriaux</surname>
<given-names>Caroline</given-names>
</name>
<xref ref-type="aff" rid="I13">13</xref>
</contrib>
<contrib contrib-type="author" id="A14"><name><surname>Garbe</surname>
<given-names>Claus</given-names>
</name>
<xref ref-type="aff" rid="I14">14</xref>
</contrib>
<contrib contrib-type="author" id="A15"><name><surname>Chang</surname>
<given-names>Ilsung</given-names>
</name>
<xref ref-type="aff" rid="I15">15</xref>
</contrib>
<contrib contrib-type="author" id="A16"><name><surname>Hack</surname>
<given-names>Stephen P </given-names>
</name>
<xref ref-type="aff" rid="I15">15</xref>
</contrib>
<contrib contrib-type="author" id="A17"><name><surname>Ribas</surname>
<given-names>Antoni</given-names>
</name>
<xref ref-type="aff" rid="I16">16</xref>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy</aff>
<aff id="I2"><label>2</label>
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</aff>
<aff id="I3"><label>3</label>
Hôtel Dieu Place Alexis Ricordeau, Nantes, France</aff>
<aff id="I4"><label>4</label>
The Royal Marsden Hospital, London, UK</aff>
<aff id="I5"><label>5</label>
National Institute of Oncology, Budapest, Hungary</aff>
<aff id="I6"><label>6</label>
Azienda Ospedaliera Universitaria Senese, Siena, Italy</aff>
<aff id="I7"><label>7</label>
Papa Giovanni XXIII Hospital, Bergamo, Italy</aff>
<aff id="I8"><label>8</label>
N.N. Blokhin Russian Cancer Research Center, Moscow, Russia</aff>
<aff id="I9"><label>9</label>
Moscow City Oncology Hospital 62, Krasnogorsk, Russia</aff>
<aff id="I10"><label>10</label>
Centre Hospitalier Lyon Sud, Pierre-Bénite, France</aff>
<aff id="I11"><label>11</label>
Hospital Universitario Virgen Macarena, Seville, Spain</aff>
<aff id="I12"><label>12</label>
Princess Alexandra Hospital, Woolloongabba, QLD, Australia</aff>
<aff id="I13"><label>13</label>
Hopital Saint André, Bordeaux, France</aff>
<aff id="I14"><label>14</label>
University of Tübingen, Tübingen, Germany</aff>
<aff id="I15"><label>15</label>
Genentech, Inc, South San Francisco, CA, USA</aff>
<aff id="I16"><label>16</label>
Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, Los Angeles, CA, USA</aff>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>1</month>
<year>2015</year>
</pub-date>
<volume>13</volume>
<issue>Suppl 1</issue>
<supplement><named-content content-type="supplement-title">Melanoma Bridge 2014: meeting abstracts</named-content>
<named-content content-type="supplement-editor">Paolo A Ascierto, Gennaro Ciliberto, John M Kirkwood, Francesco M Marincola, Giuseppe Masucci, Ignacio Melero, Nicola Mozzillo, Giuseppe Palmieri and Magdalena Thurin.</named-content>
<named-content content-type="supplement-sponsor">The publication charges for this supplement were funded by 3P solutions. Abstracts were evaluated by the Supplement Editors. Supplement Editor declarations: John Kirkwood reports grants from Prometheus and personal fees from BMS, Merck, GSK, Celgene, Vica and Ziopharm Oncology. Malero has received Consulting honoraria from Bristol Myers Squibb, Roche Genentech and Astra Zeneca. All other Supplement Editors declare that they have no competing interests.</named-content>
</supplement>
<fpage>O4</fpage>
<lpage>O4</lpage>
<permissions><copyright-statement>Copyright © 2015 Ascierto et al; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>Ascierto et al; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.translational-medicine.com/content/13/S1/O4"></self-uri>
<conference><conf-date>3-6 December 2014</conf-date>
<conf-name>Melanoma Bridge Meeting 2014</conf-name>
<conf-loc>Naples, Italy</conf-loc>
</conference>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Espagne</li>
<li>France</li>
<li>Hongrie</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>Russie</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Aquitaine</li>
<li>Bade-Wurtemberg</li>
<li>Californie</li>
<li>District de Tübingen</li>
<li>District fédéral central</li>
<li>Grand Londres</li>
<li>Hongrie centrale</li>
<li>Nouvelle-Aquitaine</li>
<li>Pays de la Loire</li>
</region>
<settlement><li>Bordeaux</li>
<li>Budapest</li>
<li>Londres</li>
<li>Moscou</li>
<li>Nantes</li>
<li>Tübingen</li>
</settlement>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name>
</noRegion>
<name sortKey="Maio, Michele" sort="Maio, Michele" uniqKey="Maio M" first="Michele" last="Maio">Michele Maio</name>
<name sortKey="Mandala, Mario" sort="Mandala, Mario" uniqKey="Mandala M" first="Mario" last="Mandala">Mario Mandala</name>
</country>
<country name="Australie"><noRegion><name sortKey="Mcarthur, Grant A" sort="Mcarthur, Grant A" uniqKey="Mcarthur G" first="Grant A" last="Mcarthur">Grant A. Mcarthur</name>
</noRegion>
<name sortKey="Atkinson, Victoria" sort="Atkinson, Victoria" uniqKey="Atkinson V" first="Victoria" last="Atkinson">Victoria Atkinson</name>
</country>
<country name="France"><region name="Pays de la Loire"><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dréno">Brigitte Dréno</name>
</region>
<name sortKey="Dutriaux, Caroline" sort="Dutriaux, Caroline" uniqKey="Dutriaux C" first="Caroline" last="Dutriaux">Caroline Dutriaux</name>
<name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Larkin, James" sort="Larkin, James" uniqKey="Larkin J" first="James" last="Larkin">James Larkin</name>
</region>
</country>
<country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Liszkay, Gabriella" sort="Liszkay, Gabriella" uniqKey="Liszkay G" first="Gabriella" last="Liszkay">Gabriella Liszkay</name>
</region>
</country>
<country name="Russie"><region name="District fédéral central"><name sortKey="Demidov, Lev" sort="Demidov, Lev" uniqKey="Demidov L" first="Lev" last="Demidov">Lev Demidov</name>
</region>
<name sortKey="Stroyakovskiy, Daniil" sort="Stroyakovskiy, Daniil" uniqKey="Stroyakovskiy D" first="Daniil" last="Stroyakovskiy">Daniil Stroyakovskiy</name>
</country>
<country name="Espagne"><noRegion><name sortKey="De La Cruz Merino, Luis" sort="De La Cruz Merino, Luis" uniqKey="De La Cruz Merino L" first="Luis" last="De La Cruz-Merino">Luis De La Cruz-Merino</name>
</noRegion>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name>
</region>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Chang, Ilsung" sort="Chang, Ilsung" uniqKey="Chang I" first="Ilsung" last="Chang">Ilsung Chang</name>
</region>
<name sortKey="Hack, Stephen P" sort="Hack, Stephen P" uniqKey="Hack S" first="Stephen P" last="Hack">Stephen P Hack</name>
<name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name>
</country>
</tree>
</affiliations>
</record>
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