Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development.
Identifieur interne : 004F39 ( Ncbi/Checkpoint ); précédent : 004F38; suivant : 004F40Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development.
Auteurs : Camila Tenorio França [Australie] ; Michael T. White [Australie] ; Wen-Qiang He [Australie] ; Jessica B. Hostetler [Royaume-Uni] ; Jessica Brewster [Australie] ; Gabriel Frato [États-Unis] ; Indu Malhotra [États-Unis] ; Jakub Gruszczyk [Australie] ; Christele Huon [France] ; Enmoore Lin [Papouasie-Nouvelle-Guinée] ; Benson Kiniboro [Papouasie-Nouvelle-Guinée] ; Anjali Yadava [États-Unis] ; Peter Siba [Papouasie-Nouvelle-Guinée] ; Mary R. Galinski [États-Unis] ; Julie Healer [Australie] ; Chetan Chitnis [France] ; Alan F. Cowman [Australie] ; Eizo Takashima [États-Unis] ; Takafumi Tsuboi [Japon] ; Wai-Hong Tham [Australie] ; Rick M. Fairhurst [États-Unis] ; Julian C. Rayner [Royaume-Uni] ; Christopher L. King [États-Unis] ; Ivo Mueller [Australie]Source :
- eLife [ 2050-084X ] ; 2017.
Abstract
The study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We measured total IgG antibodies to 38 P. vivax antigens, investigating their relationship with prospective risk of malaria in a cohort of 1-3 years old Papua New Guinean children. Using simulated annealing algorithms, the potential protective efficacy of antibodies to multiple antigen-combinations, and the antibody thresholds associated with protection were investigated for the first time. High antibody levels to multiple known and newly identified proteins were strongly associated with protection (IRR 0.44-0.74, p<0.001-0.041). Among five-antigen combinations with the strongest protective effect (>90%), EBP, DBPII, RBP1a, CyRPA, and PVX_081550 were most frequently identified; several of them requiring very low antibody levels to show a protective association. These data identify individual antigens that should be prioritized for further functional testing and establish a clear path to testing a multicomponent P. vivax vaccine.
DOI: 10.7554/eLife.28673
PubMed: 28949293
Affiliations:
- Australie, France, Japon, Papouasie-Nouvelle-Guinée, Royaume-Uni, États-Unis
- Victoria (État), Île-de-France
- Melbourne, Paris
- Université de Melbourne
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pubmed:28949293Le document en format XML
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<author><name sortKey="Lin, Enmoore" sort="Lin, Enmoore" uniqKey="Lin E" first="Enmoore" last="Lin">Enmoore Lin</name>
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<author><name sortKey="Kiniboro, Benson" sort="Kiniboro, Benson" uniqKey="Kiniboro B" first="Benson" last="Kiniboro">Benson Kiniboro</name>
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<author><name sortKey="Yadava, Anjali" sort="Yadava, Anjali" uniqKey="Yadava A" first="Anjali" last="Yadava">Anjali Yadava</name>
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<author><name sortKey="Siba, Peter" sort="Siba, Peter" uniqKey="Siba P" first="Peter" last="Siba">Peter Siba</name>
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</author>
<author><name sortKey="Galinski, Mary R" sort="Galinski, Mary R" uniqKey="Galinski M" first="Mary R" last="Galinski">Mary R. Galinski</name>
<affiliation wicri:level="1"><nlm:affiliation>International Center for Malaria Research, Education, and Development, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, United States.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>International Center for Malaria Research, Education, and Development, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Healer, Julie" sort="Healer, Julie" uniqKey="Healer J" first="Julie" last="Healer">Julie Healer</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chitnis, Chetan" sort="Chitnis, Chetan" uniqKey="Chitnis C" first="Chetan" last="Chitnis">Chetan Chitnis</name>
<affiliation wicri:level="3"><nlm:affiliation>Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cowman, Alan F" sort="Cowman, Alan F" uniqKey="Cowman A" first="Alan F" last="Cowman">Alan F. Cowman</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Takashima, Eizo" sort="Takashima, Eizo" uniqKey="Takashima E" first="Eizo" last="Takashima">Eizo Takashima</name>
<affiliation wicri:level="1"><nlm:affiliation>Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring, United States.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring</wicri:regionArea>
<wicri:noRegion>Silver Spring</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsuboi, Takafumi" sort="Tsuboi, Takafumi" uniqKey="Tsuboi T" first="Takafumi" last="Tsuboi">Takafumi Tsuboi</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama</wicri:regionArea>
<wicri:noRegion>Matsuyama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tham, Wai Hong" sort="Tham, Wai Hong" uniqKey="Tham W" first="Wai-Hong" last="Tham">Wai-Hong Tham</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fairhurst, Rick M" sort="Fairhurst, Rick M" uniqKey="Fairhurst R" first="Rick M" last="Fairhurst">Rick M. Fairhurst</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, United States.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville</wicri:regionArea>
<wicri:noRegion>Rockville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rayner, Julian C" sort="Rayner, Julian C" uniqKey="Rayner J" first="Julian C" last="Rayner">Julian C. Rayner</name>
<affiliation wicri:level="1"><nlm:affiliation>Malaria Programme, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Malaria Programme, Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea>
<wicri:noRegion>Hinxton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="King, Christopher L" sort="King, Christopher L" uniqKey="King C" first="Christopher L" last="King">Christopher L. King</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Global Health and Diseases, Case Western Reserve University, Cleveland, United States.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Global Health and Diseases, Case Western Reserve University, Cleveland</wicri:regionArea>
<wicri:noRegion>Cleveland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mueller, Ivo" sort="Mueller, Ivo" uniqKey="Mueller I" first="Ivo" last="Mueller">Ivo Mueller</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville</wicri:regionArea>
<wicri:noRegion>Parkville</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">eLife</title>
<idno type="eISSN">2050-084X</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We measured total IgG antibodies to 38 P. vivax antigens, investigating their relationship with prospective risk of malaria in a cohort of 1-3 years old Papua New Guinean children. Using simulated annealing algorithms, the potential protective efficacy of antibodies to multiple antigen-combinations, and the antibody thresholds associated with protection were investigated for the first time. High antibody levels to multiple known and newly identified proteins were strongly associated with protection (IRR 0.44-0.74, p<0.001-0.041). Among five-antigen combinations with the strongest protective effect (>90%), EBP, DBPII, RBP1a, CyRPA, and PVX_081550 were most frequently identified; several of them requiring very low antibody levels to show a protective association. These data identify individual antigens that should be prioritized for further functional testing and establish a clear path to testing a multicomponent P. vivax vaccine.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Japon</li>
<li>Papouasie-Nouvelle-Guinée</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Melbourne</li>
<li>Paris</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Franca, Camila Tenorio" sort="Franca, Camila Tenorio" uniqKey="Franca C" first="Camila Tenorio" last="França">Camila Tenorio França</name>
</noRegion>
<name sortKey="Brewster, Jessica" sort="Brewster, Jessica" uniqKey="Brewster J" first="Jessica" last="Brewster">Jessica Brewster</name>
<name sortKey="Cowman, Alan F" sort="Cowman, Alan F" uniqKey="Cowman A" first="Alan F" last="Cowman">Alan F. Cowman</name>
<name sortKey="Gruszczyk, Jakub" sort="Gruszczyk, Jakub" uniqKey="Gruszczyk J" first="Jakub" last="Gruszczyk">Jakub Gruszczyk</name>
<name sortKey="He, Wen Qiang" sort="He, Wen Qiang" uniqKey="He W" first="Wen-Qiang" last="He">Wen-Qiang He</name>
<name sortKey="Healer, Julie" sort="Healer, Julie" uniqKey="Healer J" first="Julie" last="Healer">Julie Healer</name>
<name sortKey="Mueller, Ivo" sort="Mueller, Ivo" uniqKey="Mueller I" first="Ivo" last="Mueller">Ivo Mueller</name>
<name sortKey="Tham, Wai Hong" sort="Tham, Wai Hong" uniqKey="Tham W" first="Wai-Hong" last="Tham">Wai-Hong Tham</name>
<name sortKey="White, Michael T" sort="White, Michael T" uniqKey="White M" first="Michael T" last="White">Michael T. White</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Hostetler, Jessica B" sort="Hostetler, Jessica B" uniqKey="Hostetler J" first="Jessica B" last="Hostetler">Jessica B. Hostetler</name>
</noRegion>
<name sortKey="Rayner, Julian C" sort="Rayner, Julian C" uniqKey="Rayner J" first="Julian C" last="Rayner">Julian C. Rayner</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Frato, Gabriel" sort="Frato, Gabriel" uniqKey="Frato G" first="Gabriel" last="Frato">Gabriel Frato</name>
</noRegion>
<name sortKey="Fairhurst, Rick M" sort="Fairhurst, Rick M" uniqKey="Fairhurst R" first="Rick M" last="Fairhurst">Rick M. Fairhurst</name>
<name sortKey="Galinski, Mary R" sort="Galinski, Mary R" uniqKey="Galinski M" first="Mary R" last="Galinski">Mary R. Galinski</name>
<name sortKey="King, Christopher L" sort="King, Christopher L" uniqKey="King C" first="Christopher L" last="King">Christopher L. King</name>
<name sortKey="Malhotra, Indu" sort="Malhotra, Indu" uniqKey="Malhotra I" first="Indu" last="Malhotra">Indu Malhotra</name>
<name sortKey="Takashima, Eizo" sort="Takashima, Eizo" uniqKey="Takashima E" first="Eizo" last="Takashima">Eizo Takashima</name>
<name sortKey="Yadava, Anjali" sort="Yadava, Anjali" uniqKey="Yadava A" first="Anjali" last="Yadava">Anjali Yadava</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Huon, Christele" sort="Huon, Christele" uniqKey="Huon C" first="Christele" last="Huon">Christele Huon</name>
</region>
<name sortKey="Chitnis, Chetan" sort="Chitnis, Chetan" uniqKey="Chitnis C" first="Chetan" last="Chitnis">Chetan Chitnis</name>
</country>
<country name="Papouasie-Nouvelle-Guinée"><noRegion><name sortKey="Lin, Enmoore" sort="Lin, Enmoore" uniqKey="Lin E" first="Enmoore" last="Lin">Enmoore Lin</name>
</noRegion>
<name sortKey="Kiniboro, Benson" sort="Kiniboro, Benson" uniqKey="Kiniboro B" first="Benson" last="Kiniboro">Benson Kiniboro</name>
<name sortKey="Siba, Peter" sort="Siba, Peter" uniqKey="Siba P" first="Peter" last="Siba">Peter Siba</name>
</country>
<country name="Japon"><noRegion><name sortKey="Tsuboi, Takafumi" sort="Tsuboi, Takafumi" uniqKey="Tsuboi T" first="Takafumi" last="Tsuboi">Takafumi Tsuboi</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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