Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development.
Identifieur interne : 000573 ( PubMed/Curation ); précédent : 000572; suivant : 000574Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development.
Auteurs : Camila Tenorio França [Australie] ; Michael T. White [Australie] ; Wen-Qiang He [Australie] ; Jessica B. Hostetler [Royaume-Uni] ; Jessica Brewster [Australie] ; Gabriel Frato [États-Unis] ; Indu Malhotra [États-Unis] ; Jakub Gruszczyk [Australie] ; Christele Huon [France] ; Enmoore Lin [Papouasie-Nouvelle-Guinée] ; Benson Kiniboro [Papouasie-Nouvelle-Guinée] ; Anjali Yadava [États-Unis] ; Peter Siba [Papouasie-Nouvelle-Guinée] ; Mary R. Galinski [États-Unis] ; Julie Healer [Australie] ; Chetan Chitnis [France] ; Alan F. Cowman [Australie] ; Eizo Takashima [États-Unis] ; Takafumi Tsuboi [Japon] ; Wai-Hong Tham [Australie] ; Rick M. Fairhurst [États-Unis] ; Julian C. Rayner [Royaume-Uni] ; Christopher L. King [États-Unis] ; Ivo Mueller [Australie]Source :
- eLife [ 2050-084X ] ; 2017.
Abstract
The study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We measured total IgG antibodies to 38 P. vivax antigens, investigating their relationship with prospective risk of malaria in a cohort of 1-3 years old Papua New Guinean children. Using simulated annealing algorithms, the potential protective efficacy of antibodies to multiple antigen-combinations, and the antibody thresholds associated with protection were investigated for the first time. High antibody levels to multiple known and newly identified proteins were strongly associated with protection (IRR 0.44-0.74, p<0.001-0.041). Among five-antigen combinations with the strongest protective effect (>90%), EBP, DBPII, RBP1a, CyRPA, and PVX_081550 were most frequently identified; several of them requiring very low antibody levels to show a protective association. These data identify individual antigens that should be prioritized for further functional testing and establish a clear path to testing a multicomponent P. vivax vaccine.
DOI: 10.7554/eLife.28673
PubMed: 28949293
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Hostetler</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Programme, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Malaria Programme, Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea></affiliation></author><author><name sortKey="Brewster, Jessica" sort="Brewster, Jessica" uniqKey="Brewster J" first="Jessica" last="Brewster">Jessica Brewster</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="Frato, Gabriel" sort="Frato, Gabriel" uniqKey="Frato G" first="Gabriel" last="Frato">Gabriel Frato</name><affiliation wicri:level="1"><nlm:affiliation>Center for Global Health and Diseases, Case Western Reserve University, Cleveland, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Global Health and Diseases, Case Western Reserve University, Cleveland</wicri:regionArea></affiliation></author><author><name sortKey="Malhotra, Indu" sort="Malhotra, Indu" uniqKey="Malhotra I" first="Indu" last="Malhotra">Indu Malhotra</name><affiliation wicri:level="1"><nlm:affiliation>Center for Global Health and Diseases, Case Western Reserve University, Cleveland, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Global Health and Diseases, Case Western Reserve University, Cleveland</wicri:regionArea></affiliation></author><author><name sortKey="Gruszczyk, Jakub" sort="Gruszczyk, Jakub" uniqKey="Gruszczyk J" first="Jakub" last="Gruszczyk">Jakub Gruszczyk</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="Huon, Christele" sort="Huon, Christele" uniqKey="Huon C" first="Christele" last="Huon">Christele Huon</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Enmoore" sort="Lin, Enmoore" uniqKey="Lin E" first="Enmoore" last="Lin">Enmoore Lin</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum, Papua New Guinea.</nlm:affiliation><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum</wicri:regionArea></affiliation></author><author><name sortKey="Kiniboro, Benson" sort="Kiniboro, Benson" uniqKey="Kiniboro B" first="Benson" last="Kiniboro">Benson Kiniboro</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum, Papua New Guinea.</nlm:affiliation><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum</wicri:regionArea></affiliation></author><author><name sortKey="Yadava, Anjali" sort="Yadava, Anjali" uniqKey="Yadava A" first="Anjali" last="Yadava">Anjali Yadava</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring</wicri:regionArea></affiliation></author><author><name sortKey="Siba, Peter" sort="Siba, Peter" uniqKey="Siba P" first="Peter" last="Siba">Peter Siba</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum, Papua New Guinea.</nlm:affiliation><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum</wicri:regionArea></affiliation></author><author><name sortKey="Galinski, Mary R" sort="Galinski, Mary R" uniqKey="Galinski M" first="Mary R" last="Galinski">Mary R. Galinski</name><affiliation wicri:level="1"><nlm:affiliation>International Center for Malaria Research, Education, and Development, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>International Center for Malaria Research, Education, and Development, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta</wicri:regionArea></affiliation></author><author><name sortKey="Healer, Julie" sort="Healer, Julie" uniqKey="Healer J" first="Julie" last="Healer">Julie Healer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="Chitnis, Chetan" sort="Chitnis, Chetan" uniqKey="Chitnis C" first="Chetan" last="Chitnis">Chetan Chitnis</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Cowman, Alan F" sort="Cowman, Alan F" uniqKey="Cowman A" first="Alan F" last="Cowman">Alan F. Cowman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="Takashima, Eizo" sort="Takashima, Eizo" uniqKey="Takashima E" first="Eizo" last="Takashima">Eizo Takashima</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring</wicri:regionArea></affiliation></author><author><name sortKey="Tsuboi, Takafumi" sort="Tsuboi, Takafumi" uniqKey="Tsuboi T" first="Takafumi" last="Tsuboi">Takafumi Tsuboi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama</wicri:regionArea></affiliation></author><author><name sortKey="Tham, Wai Hong" sort="Tham, Wai Hong" uniqKey="Tham W" first="Wai-Hong" last="Tham">Wai-Hong Tham</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="Fairhurst, Rick M" sort="Fairhurst, Rick M" uniqKey="Fairhurst R" first="Rick M" last="Fairhurst">Rick M. Fairhurst</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville</wicri:regionArea></affiliation></author><author><name sortKey="Rayner, Julian C" sort="Rayner, Julian C" uniqKey="Rayner J" first="Julian C" last="Rayner">Julian C. Rayner</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Programme, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Malaria Programme, Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea></affiliation></author><author><name sortKey="King, Christopher L" sort="King, Christopher L" uniqKey="King C" first="Christopher L" last="King">Christopher L. King</name><affiliation wicri:level="1"><nlm:affiliation>Center for Global Health and Diseases, Case Western Reserve University, Cleveland, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Global Health and Diseases, Case Western Reserve University, Cleveland</wicri:regionArea></affiliation></author><author><name sortKey="Mueller, Ivo" sort="Mueller, Ivo" uniqKey="Mueller I" first="Ivo" last="Mueller">Ivo Mueller</name><affiliation wicri:level="1"><nlm:affiliation>Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28949293</idno><idno type="pmid">28949293</idno><idno type="doi">10.7554/eLife.28673</idno><idno type="wicri:Area/PubMed/Corpus">000575</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000575</idno><idno type="wicri:Area/PubMed/Curation">000573</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000573</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development.</title><author><name sortKey="Franca, Camila Tenorio" sort="Franca, Camila Tenorio" uniqKey="Franca C" first="Camila Tenorio" last="França">Camila Tenorio França</name><affiliation wicri:level="1"><nlm:affiliation>Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="White, Michael T" sort="White, Michael T" uniqKey="White M" first="Michael T" last="White">Michael T. White</name><affiliation wicri:level="1"><nlm:affiliation>Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="He, Wen Qiang" sort="He, Wen Qiang" uniqKey="He W" first="Wen-Qiang" last="He">Wen-Qiang He</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="Hostetler, Jessica B" sort="Hostetler, Jessica B" uniqKey="Hostetler J" first="Jessica B" last="Hostetler">Jessica B. Hostetler</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Programme, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Malaria Programme, Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea></affiliation></author><author><name sortKey="Brewster, Jessica" sort="Brewster, Jessica" uniqKey="Brewster J" first="Jessica" last="Brewster">Jessica Brewster</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="Frato, Gabriel" sort="Frato, Gabriel" uniqKey="Frato G" first="Gabriel" last="Frato">Gabriel Frato</name><affiliation wicri:level="1"><nlm:affiliation>Center for Global Health and Diseases, Case Western Reserve University, Cleveland, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Global Health and Diseases, Case Western Reserve University, Cleveland</wicri:regionArea></affiliation></author><author><name sortKey="Malhotra, Indu" sort="Malhotra, Indu" uniqKey="Malhotra I" first="Indu" last="Malhotra">Indu Malhotra</name><affiliation wicri:level="1"><nlm:affiliation>Center for Global Health and Diseases, Case Western Reserve University, Cleveland, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Global Health and Diseases, Case Western Reserve University, Cleveland</wicri:regionArea></affiliation></author><author><name sortKey="Gruszczyk, Jakub" sort="Gruszczyk, Jakub" uniqKey="Gruszczyk J" first="Jakub" last="Gruszczyk">Jakub Gruszczyk</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="Huon, Christele" sort="Huon, Christele" uniqKey="Huon C" first="Christele" last="Huon">Christele Huon</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Enmoore" sort="Lin, Enmoore" uniqKey="Lin E" first="Enmoore" last="Lin">Enmoore Lin</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum, Papua New Guinea.</nlm:affiliation><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum</wicri:regionArea></affiliation></author><author><name sortKey="Kiniboro, Benson" sort="Kiniboro, Benson" uniqKey="Kiniboro B" first="Benson" last="Kiniboro">Benson Kiniboro</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum, Papua New Guinea.</nlm:affiliation><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum</wicri:regionArea></affiliation></author><author><name sortKey="Yadava, Anjali" sort="Yadava, Anjali" uniqKey="Yadava A" first="Anjali" last="Yadava">Anjali Yadava</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring</wicri:regionArea></affiliation></author><author><name sortKey="Siba, Peter" sort="Siba, Peter" uniqKey="Siba P" first="Peter" last="Siba">Peter Siba</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum, Papua New Guinea.</nlm:affiliation><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum</wicri:regionArea></affiliation></author><author><name sortKey="Galinski, Mary R" sort="Galinski, Mary R" uniqKey="Galinski M" first="Mary R" last="Galinski">Mary R. Galinski</name><affiliation wicri:level="1"><nlm:affiliation>International Center for Malaria Research, Education, and Development, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>International Center for Malaria Research, Education, and Development, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta</wicri:regionArea></affiliation></author><author><name sortKey="Healer, Julie" sort="Healer, Julie" uniqKey="Healer J" first="Julie" last="Healer">Julie Healer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="Chitnis, Chetan" sort="Chitnis, Chetan" uniqKey="Chitnis C" first="Chetan" last="Chitnis">Chetan Chitnis</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Cowman, Alan F" sort="Cowman, Alan F" uniqKey="Cowman A" first="Alan F" last="Cowman">Alan F. Cowman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="Takashima, Eizo" sort="Takashima, Eizo" uniqKey="Takashima E" first="Eizo" last="Takashima">Eizo Takashima</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring</wicri:regionArea></affiliation></author><author><name sortKey="Tsuboi, Takafumi" sort="Tsuboi, Takafumi" uniqKey="Tsuboi T" first="Takafumi" last="Tsuboi">Takafumi Tsuboi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama</wicri:regionArea></affiliation></author><author><name sortKey="Tham, Wai Hong" sort="Tham, Wai Hong" uniqKey="Tham W" first="Wai-Hong" last="Tham">Wai-Hong Tham</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="Fairhurst, Rick M" sort="Fairhurst, Rick M" uniqKey="Fairhurst R" first="Rick M" last="Fairhurst">Rick M. Fairhurst</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville</wicri:regionArea></affiliation></author><author><name sortKey="Rayner, Julian C" sort="Rayner, Julian C" uniqKey="Rayner J" first="Julian C" last="Rayner">Julian C. Rayner</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Programme, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Malaria Programme, Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea></affiliation></author><author><name sortKey="King, Christopher L" sort="King, Christopher L" uniqKey="King C" first="Christopher L" last="King">Christopher L. King</name><affiliation wicri:level="1"><nlm:affiliation>Center for Global Health and Diseases, Case Western Reserve University, Cleveland, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Global Health and Diseases, Case Western Reserve University, Cleveland</wicri:regionArea></affiliation></author><author><name sortKey="Mueller, Ivo" sort="Mueller, Ivo" uniqKey="Mueller I" first="Ivo" last="Mueller">Ivo Mueller</name><affiliation wicri:level="1"><nlm:affiliation>Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville</wicri:regionArea></affiliation></author></analytic><series><title level="j">eLife</title><idno type="eISSN">2050-084X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We measured total IgG antibodies to 38 P. vivax antigens, investigating their relationship with prospective risk of malaria in a cohort of 1-3 years old Papua New Guinean children. Using simulated annealing algorithms, the potential protective efficacy of antibodies to multiple antigen-combinations, and the antibody thresholds associated with protection were investigated for the first time. High antibody levels to multiple known and newly identified proteins were strongly associated with protection (IRR 0.44-0.74, p<0.001-0.041). Among five-antigen combinations with the strongest protective effect (>90%), EBP, DBPII, RBP1a, CyRPA, and PVX_081550 were most frequently identified; several of them requiring very low antibody levels to show a protective association. These data identify individual antigens that should be prioritized for further functional testing and establish a clear path to testing a multicomponent P. vivax vaccine.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28949293</PMID><DateCreated><Year>2017</Year><Month>09</Month><Day>26</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>27</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2050-084X</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><PubDate><Year>2017</Year><Month>Sep</Month><Day>26</Day></PubDate></JournalIssue><Title>eLife</Title><ISOAbbreviation>Elife</ISOAbbreviation></Journal><ArticleTitle>Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.7554/eLife.28673</ELocationID><ELocationID EIdType="pii" ValidYN="Y">e28673</ELocationID><Abstract><AbstractText>The study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We measured total IgG antibodies to 38 P. vivax antigens, investigating their relationship with prospective risk of malaria in a cohort of 1-3 years old Papua New Guinean children. Using simulated annealing algorithms, the potential protective efficacy of antibodies to multiple antigen-combinations, and the antibody thresholds associated with protection were investigated for the first time. High antibody levels to multiple known and newly identified proteins were strongly associated with protection (IRR 0.44-0.74, p<0.001-0.041). Among five-antigen combinations with the strongest protective effect (>90%), EBP, DBPII, RBP1a, CyRPA, and PVX_081550 were most frequently identified; several of them requiring very low antibody levels to show a protective association. These data identify individual antigens that should be prioritized for further functional testing and establish a clear path to testing a multicomponent P. vivax vaccine.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>França</LastName><ForeName>Camila Tenorio</ForeName><Initials>CT</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-5885-4410</Identifier><AffiliationInfo><Affiliation>Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Michael T</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>MRC Center for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Wen-Qiang</ForeName><Initials>WQ</Initials><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hostetler</LastName><ForeName>Jessica B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Malaria Programme, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brewster</LastName><ForeName>Jessica</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frato</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Center for Global Health and Diseases, Case Western Reserve University, Cleveland, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malhotra</LastName><ForeName>Indu</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Center for Global Health and Diseases, Case Western Reserve University, Cleveland, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gruszczyk</LastName><ForeName>Jakub</ForeName><Initials>J</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-4536-2964</Identifier><AffiliationInfo><Affiliation>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huon</LastName><ForeName>Christele</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Enmoore</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum, Papua New Guinea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kiniboro</LastName><ForeName>Benson</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum, Papua New Guinea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yadava</LastName><ForeName>Anjali</ForeName><Initials>A</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-6751-954X</Identifier><AffiliationInfo><Affiliation>Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siba</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Yagaum, Papua New Guinea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galinski</LastName><ForeName>Mary R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>International Center for Malaria Research, Education, and Development, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Infectious Diseases Division, Department of Medicine, Emory University, Atlanta, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Healer</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chitnis</LastName><ForeName>Chetan</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>International Centre for Genetic Engineering and Biotechnology, New Delhi, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cowman</LastName><ForeName>Alan F</ForeName><Initials>AF</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-5145-9004</Identifier><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Takashima</LastName><ForeName>Eizo</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsuboi</LastName><ForeName>Takafumi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tham</LastName><ForeName>Wai-Hong</ForeName><Initials>WH</Initials><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fairhurst</LastName><ForeName>Rick M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rayner</LastName><ForeName>Julian C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Malaria Programme, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>King</LastName><ForeName>Christopher L</ForeName><Initials>CL</Initials><AffiliationInfo><Affiliation>Center for Global Health and Diseases, Case Western Reserve University, Cleveland, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mueller</LastName><ForeName>Ivo</ForeName><Initials>I</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-6554-6889</Identifier><AffiliationInfo><Affiliation>Division of Population Health and Immunity, Walter and Eliza Hall Institute, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Malaria Parasites and Hosts Unit, Department of Parasites and Insect Vectors, Institut Pasteur, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Barcelona Institute of Global Health, Barcelona, 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Version="1">25329408</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2007 Mar;75(3):1177-85</RefSource><PMID Version="1">17158893</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">IgG antibody</Keyword><Keyword MajorTopicYN="N">Plasmodium vivax</Keyword><Keyword MajorTopicYN="N">clinical malaria</Keyword><Keyword MajorTopicYN="N">epidemiology</Keyword><Keyword MajorTopicYN="N">global health</Keyword><Keyword MajorTopicYN="N">natural immunity</Keyword><Keyword MajorTopicYN="N">protection</Keyword><Keyword MajorTopicYN="N">vaccine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>05</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>09</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>9</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>9</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28949293</ArticleId><ArticleId IdType="doi">10.7554/eLife.28673</ArticleId><ArticleId IdType="pmc">PMC5655538</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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