Prevalence, incidence and aetiologies of pulmonary hypertension in Africa: a systematic review and meta-analysis protocol
Identifieur interne : 004A00 ( Ncbi/Checkpoint ); précédent : 004999; suivant : 004A01Prevalence, incidence and aetiologies of pulmonary hypertension in Africa: a systematic review and meta-analysis protocol
Auteurs : Jean Joel Bigna [Cameroun, France] ; Jean Jacques Noubiap [Afrique du Sud] ; Jobert Richie Nansseu [Cameroun] ; Leopold Ndemnge Aminde [Cameroun, Australie]Source :
- BMJ Open [ 2044-6055 ] ; 2017.
Abstract
There are no data summarising the epidemiology of pulmonary hypertension (PH) among adults residing in Africa. Establishment of accurate epidemiological data on PH in this region may guide decision-making toward interventions to curb the burden of PH in Africa. The aim of this systematic review is to determine the prevalence, incidence and aetiologies of PH among people residing in Africa.
This systematic review and meta-analysis will follow the MOOSE guidelines for reporting. Relevant abstracts published until 30 September 2016 will be searched in PubMed/Medline, EMBASE (Excerpta Medica Database), African Journals Online and Africa Index Medicus. Full texts of eligible studies will then be accessed through PubMed, Google Scholar, HINARI and the respective journals’ websites. Relevant unpublished papers and conference proceedings will also be checked. Data will be analysed using STATA version 13 software. The study-specific estimates will be pooled through a random-effects meta-analysis model to obtain an overall summary estimate of the prevalence/incidence and aetiologies of PH across studies. Heterogeneity of studies will be evaluated by the χ2 test on Cochrane’s Q statistic. Funnel plot analysis and Egger’s test will be done to detect publication bias. Results will be presented by geographical region (central, eastern, northern, southern and western Africa).
The current study is based on published data; ethical approval is, therefore, not required. This review will guide policy, practice and research by providing information on the magnitude of PH among people residing in Africa. Findings will be presented in evidence tables of individual studies as well as in summary tables. The final report of this systematic review, in the form of a scientific paper, will be published in a peer-reviewed journal. Furthermore, findings will be presented at conferences and submitted to relevant health authorities.
PROSPERO CRD42016049351.
Url:
DOI: 10.1136/bmjopen-2016-014768
PubMed: 28624758
PubMed Central: 5623436
Affiliations:
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Kremlin Bicêtre</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Noubiap, Jean Jacques" sort="Noubiap, Jean Jacques" uniqKey="Noubiap J" first="Jean Jacques" last="Noubiap">Jean Jacques Noubiap</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Department of Medicine</institution>,<institution>Groote Schuur Hospital and University of Cape Town</institution>,<addr-line content-type="city">Cape Town</addr-line>,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nansseu, Jobert Richie" sort="Nansseu, Jobert Richie" uniqKey="Nansseu J" first="Jobert Richie" last="Nansseu">Jobert Richie Nansseu</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="department">Department of Public Health</institution>,<institution>Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1</institution>,<addr-line content-type="city">Yaoundé</addr-line>,<country>Cameroon</country></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Sickle Cell Disease Unit, Mother and Child Centre of the Chantal Biya Foundation</institution>,<addr-line content-type="city">Yaoundé</addr-line>,<country>Cameroon</country></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aminde, Leopold Ndemnge" sort="Aminde, Leopold Ndemnge" uniqKey="Aminde L" first="Leopold Ndemnge" last="Aminde">Leopold Ndemnge Aminde</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Clinical Research Education, Networking and Consultancy (CRENC)</institution>,<addr-line content-type="city">Douala</addr-line>,<country>Cameroon</country></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><institution content-type="department">Faculty of Medicine & Biomedical Sciences</institution>,<institution>School of Public Health, University of Queensland</institution>,<addr-line content-type="city">Brisbane</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMJ Open</title><idno type="eISSN">2044-6055</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>There are no data summarising the epidemiology of pulmonary hypertension (PH) among adults residing in Africa. Establishment of accurate epidemiological data on PH in this region may guide decision-making toward interventions to curb the burden of PH in Africa. The aim of this systematic review is to determine the prevalence, incidence and aetiologies of PH among people residing in Africa.</p></sec><sec><title>Methods and analysis</title><p>This systematic review and meta-analysis will follow the MOOSE guidelines for reporting. Relevant abstracts published until 30 September 2016 will be searched in PubMed/Medline, EMBASE (Excerpta Medica Database), African Journals Online and Africa Index Medicus. Full texts of eligible studies will then be accessed through PubMed, Google Scholar, HINARI and the respective journals’ websites. Relevant unpublished papers and conference proceedings will also be checked. Data will be analysed using STATA version 13 software. The study-specific estimates will be pooled through a random-effects meta-analysis model to obtain an overall summary estimate of the prevalence/incidence and aetiologies of PH across studies. Heterogeneity of studies will be evaluated by the χ<sup>2</sup> test on Cochrane’s Q statistic. Funnel plot analysis and Egger’s test will be done to detect publication bias. Results will be presented by geographical region (central, eastern, northern, southern and western Africa).</p></sec><sec><title><bold>Ethics and disseminatio</bold>n</title><p>The current study is based on published data; ethical approval is, therefore, not required. This review will guide policy, practice and research by providing information on the magnitude of PH among people residing in Africa. Findings will be presented in evidence tables of individual studies as well as in summary tables. The final report of this systematic review, in the form of a scientific paper, will be published in a peer-reviewed journal. Furthermore, findings will be presented at conferences and submitted to relevant health authorities.</p></sec><sec><title>Review registration number</title><p>PROSPERO CRD42016049351.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hoeper, Mm" uniqKey="Hoeper M">MM Hoeper</name></author><author><name sortKey="Bogaard, Hj" uniqKey="Bogaard H">HJ Bogaard</name></author><author><name sortKey="Condliffe, R" uniqKey="Condliffe R">R Condliffe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simonneau, G" uniqKey="Simonneau G">G Simonneau</name></author><author><name sortKey="Gatzoulis, Ma" uniqKey="Gatzoulis M">MA Gatzoulis</name></author><author><name sortKey="Adatia, I" uniqKey="Adatia I">I Adatia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thienemann, F" uniqKey="Thienemann F">F Thienemann</name></author><author><name sortKey="Sliwa, K" uniqKey="Sliwa K">K Sliwa</name></author><author><name sortKey="Rockstroh, Jk" uniqKey="Rockstroh J">JK Rockstroh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mocumbi, Ao" uniqKey="Mocumbi A">AO Mocumbi</name></author><author><name sortKey="Lameira, E" uniqKey="Lameira E">E Lameira</name></author><author><name sortKey="Yaksh, A" uniqKey="Yaksh A">A Yaksh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bigna, Jj" uniqKey="Bigna J">JJ Bigna</name></author><author><name sortKey="Nansseu, Jr" uniqKey="Nansseu J">JR Nansseu</name></author><author><name sortKey="Um, Ln" uniqKey="Um L">LN Um</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bigna, Jj" uniqKey="Bigna J">JJ Bigna</name></author><author><name sortKey="Sime, Ps" uniqKey="Sime P">PS Sime</name></author><author><name sortKey="Koulla Shiro, S" uniqKey="Koulla Shiro S">S Koulla-Shiro</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Schweitzer, A" uniqKey="Schweitzer A">A Schweitzer</name></author><author><name sortKey="Horn, J" uniqKey="Horn J">J Horn</name></author><author><name sortKey="Mikolajczyk, Rt" uniqKey="Mikolajczyk R">RT Mikolajczyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohd Hanafiah, K" uniqKey="Mohd Hanafiah K">K Mohd Hanafiah</name></author><author><name sortKey="Groeger, J" uniqKey="Groeger J">J Groeger</name></author><author><name sortKey="Flaxman, Ad" uniqKey="Flaxman A">AD Flaxman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sliwa, K" uniqKey="Sliwa K">K Sliwa</name></author><author><name sortKey="Wilkinson, D" uniqKey="Wilkinson D">D Wilkinson</name></author><author><name sortKey="Hansen, C" uniqKey="Hansen C">C Hansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stewart, S" uniqKey="Stewart S">S Stewart</name></author><author><name sortKey="Wilkinson, D" uniqKey="Wilkinson D">D Wilkinson</name></author><author><name sortKey="Hansen, C" uniqKey="Hansen C">C Hansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thienemann, F" uniqKey="Thienemann F">F Thienemann</name></author><author><name sortKey="Dzudie, A" uniqKey="Dzudie A">A Dzudie</name></author><author><name sortKey="Mocumbi, Ao" uniqKey="Mocumbi A">AO Mocumbi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thienemann, F" uniqKey="Thienemann F">F Thienemann</name></author><author><name sortKey="Dzudie, A" uniqKey="Dzudie A">A Dzudie</name></author><author><name sortKey="Mocumbi, Ao" uniqKey="Mocumbi A">AO Mocumbi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wells, Ga" uniqKey="Wells G">GA Wells</name></author><author><name sortKey="Shea, B" uniqKey="Shea B">B Shea</name></author><author><name sortKey="O Connell, D" uniqKey="O Connell D">D O'Connell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barendregt, Jj" uniqKey="Barendregt J">JJ Barendregt</name></author><author><name sortKey="Doi, Sa" uniqKey="Doi S">SA Doi</name></author><author><name sortKey="Lee, Yy" uniqKey="Lee Y">YY Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cochran, Wg" uniqKey="Cochran W">WG Cochran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Higgins, Jp" uniqKey="Higgins J">JP Higgins</name></author><author><name sortKey="Thompson, Sg" uniqKey="Thompson S">SG Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Viera, Aj" uniqKey="Viera A">AJ Viera</name></author><author><name sortKey="Garrett, Jm" uniqKey="Garrett J">JM Garrett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Egger, M" uniqKey="Egger M">M Egger</name></author><author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G Davey Smith</name></author><author><name sortKey="Schneider, M" uniqKey="Schneider M">M Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stroup, Df" uniqKey="Stroup D">DF Stroup</name></author><author><name sortKey="Berlin, Ja" uniqKey="Berlin J">JA Berlin</name></author><author><name sortKey="Morton, Sc" uniqKey="Morton S">SC Morton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nansseu, Jr" uniqKey="Nansseu J">JR Nansseu</name></author><author><name sortKey="Noubiap, Jj" uniqKey="Noubiap J">JJ Noubiap</name></author><author><name sortKey="Mengnjo, Mk" uniqKey="Mengnjo M">MK Mengnjo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moher, D" uniqKey="Moher D">D Moher</name></author><author><name sortKey="Shamseer, L" uniqKey="Shamseer L">L Shamseer</name></author><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Australie</li><li>Cameroun</li><li>France</li></country></list><tree><country name="Cameroun"><noRegion><name sortKey="Bigna, Jean Joel" sort="Bigna, Jean Joel" uniqKey="Bigna J" first="Jean Joel" last="Bigna">Jean Joel Bigna</name></noRegion><name sortKey="Aminde, Leopold Ndemnge" sort="Aminde, Leopold Ndemnge" uniqKey="Aminde L" first="Leopold Ndemnge" last="Aminde">Leopold Ndemnge Aminde</name><name sortKey="Nansseu, Jobert Richie" sort="Nansseu, Jobert Richie" uniqKey="Nansseu J" first="Jobert Richie" last="Nansseu">Jobert Richie Nansseu</name><name sortKey="Nansseu, Jobert Richie" sort="Nansseu, Jobert Richie" uniqKey="Nansseu J" first="Jobert Richie" last="Nansseu">Jobert Richie Nansseu</name></country><country name="France"><noRegion><name sortKey="Bigna, Jean Joel" sort="Bigna, Jean Joel" uniqKey="Bigna J" first="Jean Joel" last="Bigna">Jean Joel Bigna</name></noRegion></country><country name="Afrique du Sud"><noRegion><name sortKey="Noubiap, Jean Jacques" sort="Noubiap, Jean Jacques" uniqKey="Noubiap J" first="Jean Jacques" last="Noubiap">Jean Jacques Noubiap</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Aminde, Leopold Ndemnge" sort="Aminde, Leopold Ndemnge" uniqKey="Aminde L" first="Leopold Ndemnge" last="Aminde">Leopold Ndemnge Aminde</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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