Efficacy and Safety of Alirocumab 150 mg Every 4 Weeks in Patients With Hypercholesterolemia Not on Statin Therapy: The ODYSSEY CHOICE II Study.
Identifieur interne : 003B40 ( Ncbi/Checkpoint ); précédent : 003B39; suivant : 003B41Efficacy and Safety of Alirocumab 150 mg Every 4 Weeks in Patients With Hypercholesterolemia Not on Statin Therapy: The ODYSSEY CHOICE II Study.
Auteurs : Erik Stroes [Pays-Bas] ; John R. Guyton [États-Unis] ; Norman Lepor [États-Unis] ; Fernando Civeira [Espagne] ; Daniel Gaudet [Canada] ; Gerald F. Watts [Australie] ; Marie T. Baccara-Dinet [France] ; Guillaume Lecorps [France] ; Garen Manvelian [États-Unis] ; Michel Farnier [France]Source :
- Journal of the American Heart Association [ 2047-9980 ] ; 2016.
Abstract
The PCSK9 antibody alirocumab (75 mg every 2 weeks; Q2W) as monotherapy reduced low-density lipoprotein-cholesterol (LDL-C) levels by 47%. Because the option of a monthly dosing regimen is convenient, ODYSSEY CHOICE II evaluated alirocumab 150 mg Q4W in patients with inadequately controlled hypercholesterolemia and not on statin (majority with statin-associated muscle symptoms), receiving treatment with fenofibrate, ezetimibe, or diet alone.
DOI: 10.1161/JAHA.116.003421
PubMed: 27625344
Affiliations:
- Australie, Canada, Espagne, France, Pays-Bas, États-Unis
- Bourgogne, Bourgogne-Franche-Comté, Californie, Caroline du Nord, Hollande-Septentrionale, Languedoc-Roussillon, Occitanie (région administrative), État de New York
- Amsterdam, Dijon, Montpellier
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pubmed:27625344Le document en format XML
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<front><div type="abstract" xml:lang="en">The PCSK9 antibody alirocumab (75 mg every 2 weeks; Q2W) as monotherapy reduced low-density lipoprotein-cholesterol (LDL-C) levels by 47%. Because the option of a monthly dosing regimen is convenient, ODYSSEY CHOICE II evaluated alirocumab 150 mg Q4W in patients with inadequately controlled hypercholesterolemia and not on statin (majority with statin-associated muscle symptoms), receiving treatment with fenofibrate, ezetimibe, or diet alone.</div>
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