Predictors of long-term outcomes in patients treated with riociguat for pulmonary arterial hypertension: data from the PATENT-2 open-label, randomised, long-term extension trial.
Identifieur interne : 003396 ( Ncbi/Checkpoint ); précédent : 003395; suivant : 003397Predictors of long-term outcomes in patients treated with riociguat for pulmonary arterial hypertension: data from the PATENT-2 open-label, randomised, long-term extension trial.
Auteurs : Hossein-Ardeschir Ghofrani [Royaume-Uni] ; Friedrich Grimminger [Allemagne] ; Ekkehard Grünig [Allemagne] ; Yigao Huang [République populaire de Chine] ; Pavel Jansa [République tchèque] ; Zhi-Cheng Jing [République populaire de Chine] ; David Kilpatrick [Australie] ; David Langleben [Canada] ; Stephan Rosenkranz [Allemagne] ; Flavia Menezes [Brésil] ; Arno Fritsch [Allemagne] ; Sylvia Nikkho [Allemagne] ; Marc Humbert [France]Source :
- The Lancet. Respiratory medicine [ 2213-2619 ] ; 2016.
Abstract
Pulmonary arterial hypertension is a chronic disease associated with poor long-term outcomes. Identifying predictors of long-term outcome in pulmonary arterial hypertension is important to assess disease severity and guide treatment. We investigate associations between efficacy parameters and long-term outcomes in patients with pulmonary arterial hypertension receiving riociguat in the PATENT-2 study. We also present safety and efficacy data from the final data cutoff of PATENT-2, where most patients had received at least 2 years of riociguat treatment.
DOI: 10.1016/S2213-2600(16)30019-4
PubMed: 27067479
Affiliations:
- Allemagne, Australie, Brésil, Canada, France, Royaume-Uni, République populaire de Chine, République tchèque
- Angleterre, Bade-Wurtemberg, Berlin, Bohême centrale, District de Karlsruhe, Grand Londres, Québec, État de São Paulo, Île-de-France
- Berlin, Heidelberg, Londres, Montréal, Orsay, Prague, Pékin, São Paulo
- Université McGill, Université Paris-Sud
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<front><div type="abstract" xml:lang="en">Pulmonary arterial hypertension is a chronic disease associated with poor long-term outcomes. Identifying predictors of long-term outcome in pulmonary arterial hypertension is important to assess disease severity and guide treatment. We investigate associations between efficacy parameters and long-term outcomes in patients with pulmonary arterial hypertension receiving riociguat in the PATENT-2 study. We also present safety and efficacy data from the final data cutoff of PATENT-2, where most patients had received at least 2 years of riociguat treatment.</div>
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<country name="République populaire de Chine"><noRegion><name sortKey="Huang, Yigao" sort="Huang, Yigao" uniqKey="Huang Y" first="Yigao" last="Huang">Yigao Huang</name>
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<name sortKey="Jing, Zhi Cheng" sort="Jing, Zhi Cheng" uniqKey="Jing Z" first="Zhi-Cheng" last="Jing">Zhi-Cheng Jing</name>
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<country name="République tchèque"><region name="Bohême centrale"><name sortKey="Jansa, Pavel" sort="Jansa, Pavel" uniqKey="Jansa P" first="Pavel" last="Jansa">Pavel Jansa</name>
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<country name="Australie"><noRegion><name sortKey="Kilpatrick, David" sort="Kilpatrick, David" uniqKey="Kilpatrick D" first="David" last="Kilpatrick">David Kilpatrick</name>
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<country name="Canada"><region name="Québec"><name sortKey="Langleben, David" sort="Langleben, David" uniqKey="Langleben D" first="David" last="Langleben">David Langleben</name>
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<country name="Brésil"><region name="État de São Paulo"><name sortKey="Menezes, Flavia" sort="Menezes, Flavia" uniqKey="Menezes F" first="Flavia" last="Menezes">Flavia Menezes</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name>
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</record>
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