AustralieFrV1, Ncbi, Checkpoint, bibRecord, 003395

The 12-month analysis from Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT): A phase II, randomized, double-blind study of sonidegib in patients with advanced basal cell carcinoma.

Identifieur interne : 003395 ( Ncbi/Checkpoint ); précédent : 003394; suivant : 003396

The 12-month analysis from Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT): A phase II, randomized, double-blind study of sonidegib in patients with advanced basal cell carcinoma.

Auteurs : Reinhard Dummer [Suisse] ; Alexander Guminski [Australie] ; Ralf Gutzmer [Allemagne] ; Luc Dirix [Belgique] ; Karl D. Lewis [États-Unis] ; Patrick Combemale [France] ; Robert M. Herd [Royaume-Uni] ; Martin Kaatz [Allemagne] ; Carmen Loquai [Allemagne] ; Alexander J. Stratigos [Grèce] ; Hans-Joachim Schulze [Allemagne] ; Ruth Plummer [Royaume-Uni] ; Sven Gogov [Suisse] ; Celine Pallaud [Suisse] ; Tingting Yi [États-Unis] ; Manisha Mone [États-Unis] ; Anne Lynn S. Chang [États-Unis] ; Frank Cornélis [Belgique] ; Ragini Kudchadkar [Géorgie (pays)] ; Uwe Trefzer [Allemagne] ; John T. Lear [Royaume-Uni] ; Dalila Sellami [États-Unis] ; Michael R. Migden [États-Unis]

Source :

Journal of the American Academy of Dermatology [ 1097-6787 ] ; 2016.

RBID : pubmed:27067394

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Antinéoplasiques (administration et posologie), Antinéoplasiques (effets indésirables), Antinéoplasiques (usage thérapeutique), Carcinome basocellulaire (secondaire), Carcinome basocellulaire (traitement médicamenteux), Dérivés du biphényle (administration et posologie), Dérivés du biphényle (effets indésirables), Dérivés du biphényle (usage thérapeutique), Femelle, Humains, Jeune adulte, Mâle, Méthode en double aveugle, Pyridines (administration et posologie), Pyridines (effets indésirables), Pyridines (usage thérapeutique), Récepteur Smoothened (antagonistes et inhibiteurs), Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Tumeurs cutanées (anatomopathologie), Tumeurs cutanées (traitement médicamenteux), Évolution de la maladie.
MESH :
- administration et posologie : Antinéoplasiques, Dérivés du biphényle, Pyridines.
- anatomopathologie : Tumeurs cutanées.
- antagonistes et inhibiteurs : Récepteur Smoothened.
- effets indésirables : Antinéoplasiques, Dérivés du biphényle, Pyridines.
- secondaire : Carcinome basocellulaire.
- traitement médicamenteux : Carcinome basocellulaire, Tumeurs cutanées.
- usage thérapeutique : Antinéoplasiques, Dérivés du biphényle, Pyridines.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Méthode en double aveugle, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Évolution de la maladie.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents (administration & dosage), Antineoplastic Agents (adverse effects), Antineoplastic Agents (therapeutic use), Biphenyl Compounds (administration & dosage), Biphenyl Compounds (adverse effects), Biphenyl Compounds (therapeutic use), Carcinoma, Basal Cell (drug therapy), Carcinoma, Basal Cell (secondary), Disease Progression, Double-Blind Method, Female, Humans, Male, Middle Aged, Pyridines (administration & dosage), Pyridines (adverse effects), Pyridines (therapeutic use), Skin Neoplasms (drug therapy), Skin Neoplasms (pathology), Smoothened Receptor (antagonists & inhibitors), Survival Rate, Young Adult.
MESH :
- chemical , administration & dosage : Antineoplastic Agents, Biphenyl Compounds, Pyridines.
- chemical , adverse effects : Antineoplastic Agents, Biphenyl Compounds, Pyridines.
- chemical , antagonists & inhibitors : Smoothened Receptor.
- chemical , therapeutic use : Antineoplastic Agents, Biphenyl Compounds, Pyridines.
- drug therapy : Carcinoma, Basal Cell, Skin Neoplasms.
- pathology : Skin Neoplasms.
- secondary : Carcinoma, Basal Cell.
- Adult, Aged, Aged, 80 and over, Disease Progression, Double-Blind Method, Female, Humans, Male, Middle Aged, Survival Rate, Young Adult.

Abstract

The hedgehog pathway inhibitor sonidegib demonstrated meaningful tumor shrinkage in more than 90% of patients with locally advanced basal cell carcinoma (BCC) or metastatic BCC in the BCC Outcomes with LDE225 Treatment study.

DOI: 10.1016/j.jaad.2016.02.1226
PubMed: 27067394

Affiliations:

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pubmed:27067394

Le document en format XML

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<author><name sortKey="Chang, Anne Lynn S" sort="Chang, Anne Lynn S" uniqKey="Chang A" first="Anne Lynn S" last="Chang">Anne Lynn S. Chang</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The 12-month analysis from Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT): A phase II, randomized, double-blind study of sonidegib in patients with advanced basal cell carcinoma.</title>
<author><name sortKey="Dummer, Reinhard" sort="Dummer, Reinhard" uniqKey="Dummer R" first="Reinhard" last="Dummer">Reinhard Dummer</name>
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<author><name sortKey="Gutzmer, Ralf" sort="Gutzmer, Ralf" uniqKey="Gutzmer R" first="Ralf" last="Gutzmer">Ralf Gutzmer</name>
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<author><name sortKey="Dirix, Luc" sort="Dirix, Luc" uniqKey="Dirix L" first="Luc" last="Dirix">Luc Dirix</name>
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<author><name sortKey="Lewis, Karl D" sort="Lewis, Karl D" uniqKey="Lewis K" first="Karl D" last="Lewis">Karl D. Lewis</name>
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<author><name sortKey="Combemale, Patrick" sort="Combemale, Patrick" uniqKey="Combemale P" first="Patrick" last="Combemale">Patrick Combemale</name>
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<author><name sortKey="Herd, Robert M" sort="Herd, Robert M" uniqKey="Herd R" first="Robert M" last="Herd">Robert M. Herd</name>
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<author><name sortKey="Kaatz, Martin" sort="Kaatz, Martin" uniqKey="Kaatz M" first="Martin" last="Kaatz">Martin Kaatz</name>
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<wicri:regionArea>University Hospital Jena, Jena, Germany; SRH Wald-Klinikum Gera GmbH, Gera</wicri:regionArea>
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<author><name sortKey="Loquai, Carmen" sort="Loquai, Carmen" uniqKey="Loquai C" first="Carmen" last="Loquai">Carmen Loquai</name>
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<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
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<author><name sortKey="Stratigos, Alexander J" sort="Stratigos, Alexander J" uniqKey="Stratigos A" first="Alexander J" last="Stratigos">Alexander J. Stratigos</name>
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<country xml:lang="fr">Grèce</country>
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<series><title level="j">Journal of the American Academy of Dermatology</title>
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<front><div type="abstract" xml:lang="en">The hedgehog pathway inhibitor sonidegib demonstrated meaningful tumor shrinkage in more than 90% of patients with locally advanced basal cell carcinoma (BCC) or metastatic BCC in the BCC Outcomes with LDE225 Treatment study.</div>
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The 12-month analysis from Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT): A phase II, randomized, double-blind study of sonidegib in patients with advanced basal cell carcinoma.

The 12-month analysis from Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT): A phase II, randomized, double-blind study of sonidegib in patients with advanced basal cell carcinoma.

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