Genome-wide association study of colorectal cancer identifies six new susceptibility loci
Identifieur interne : 002814 ( Ncbi/Checkpoint ); précédent : 002813; suivant : 002815Genome-wide association study of colorectal cancer identifies six new susceptibility loci
Auteurs : Fredrick R. Schumacher [États-Unis] ; Stephanie L. Schmit [États-Unis] ; Shuo Jiao [États-Unis] ; Christopher K. Edlund [États-Unis] ; Hansong Wang [États-Unis] ; Ben Zhang [République populaire de Chine] ; Li Hsu [États-Unis] ; Shu-Chen Huang [États-Unis] ; Christopher P. Fischer [États-Unis] ; John F. Harju [États-Unis] ; Gregory E. Idos [États-Unis] ; Flavio Lejbkowicz [Israël] ; Frank J. Manion [États-Unis] ; Kevin Mcdonnell [États-Unis] ; Caroline E. Mcneil [États-Unis] ; Marilena Melas [États-Unis] ; Hedy S. Rennert [Israël] ; Wei Shi [États-Unis] ; Duncan C. Thomas [États-Unis] ; David J. Van Den Berg [États-Unis] ; Carolyn M. Hutter [États-Unis] ; Aaron K. Aragaki [États-Unis] ; Katja Butterbach [Allemagne] ; Bette J. Caan [États-Unis] ; Christopher S. Carlson [États-Unis] ; Stephen J. Chanock [États-Unis] ; Keith R. Curtis [États-Unis] ; Charles S. Fuchs [États-Unis] ; Manish Gala [États-Unis] ; Edward L. Giovannucci [États-Unis] ; Stephanie M. Gogarten [États-Unis] ; Richard B. Hayes [États-Unis] ; Brian Henderson [États-Unis] ; David J. Hunter [États-Unis] ; Rebecca D. Jackson [États-Unis] ; Laurence N. Kolonel [États-Unis] ; Charles Kooperberg [États-Unis] ; Sébastien Küry [France] ; Andrea Lacroix [États-Unis] ; Cathy C. Laurie [États-Unis] ; Cecelia A. Laurie [États-Unis] ; Mathieu Lemire [Canada] ; David Levine [États-Unis] ; Jing Ma [États-Unis] ; Karen W. Makar [États-Unis] ; Conghui Qu [États-Unis] ; Darin Taverna [États-Unis] ; Cornelia M. Ulrich [États-Unis, Allemagne] ; Kana Wu [États-Unis] ; Suminori Kono [Japon] ; Dee W. West [États-Unis] ; Sonja I. Berndt [États-Unis] ; Stéphane Bezieau [France] ; Hermann Brenner [Allemagne] ; Peter T. Campbell [États-Unis] ; Andrew T. Chan [États-Unis] ; Jenny Chang-Claude [Allemagne] ; Gerhard A. Coetzee [États-Unis] ; David V. Conti [États-Unis] ; David Duggan [États-Unis] ; Jane C. Figueiredo [États-Unis] ; Barbara K. Fortini [États-Unis] ; Steven J. Gallinger [Canada] ; W. James Gauderman [États-Unis] ; Graham Giles [Australie] ; Roger Green [Canada] ; Robert Haile [États-Unis] ; Tabitha A. Harrison [États-Unis] ; Michael Hoffmeister [Allemagne] ; John L. Hopper [Australie] ; Thomas J. Hudson [Canada] ; Eric Jacobs [États-Unis] ; Motoki Iwasaki [Japon] ; Sun Ha Jee [Corée du Sud] ; Mark Jenkins [Australie] ; Wei-Hua Jia [République populaire de Chine] ; Amit Joshi [États-Unis] ; Li Li [États-Unis] ; Noralene M. Lindor [États-Unis] ; Keitaro Matsuo [Japon] ; Victor Moreno [Espagne] ; Bhramar Mukherjee [États-Unis] ; Polly A. Newcomb [États-Unis] ; John D. Potter [États-Unis] ; Leon Raskin [États-Unis] ; Gad Rennert [États-Unis, Israël] ; Stephanie Rosse [États-Unis] ; Gianluca Severi [Australie, Italie] ; Robert E. Schoen [États-Unis] ; Daniela Seminara [États-Unis] ; Xiao-Ou Shu [États-Unis] ; Martha L. Slattery [États-Unis] ; Shoichiro Tsugane [Japon] ; Emily White [États-Unis] ; Yong-Bing Xiang [République populaire de Chine] ; Brent W. Zanke [Canada] ; Wei Zheng [États-Unis] ; Loic Le Marchand [États-Unis] ; Graham Casey [États-Unis] ; Stephen B. Gruber [États-Unis] ; Ulrike Peters [États-Unis]Source :
- Nature communications [ 2041-1723 ] ; 2015.
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Abstract
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of
Url:
DOI: 10.1038/ncomms8138
PubMed: 26151821
PubMed Central: 4967357
Affiliations:
- Allemagne, Australie, Canada, Corée du Sud, Espagne, France, Israël, Italie, Japon, République populaire de Chine, États-Unis
- Bade-Wurtemberg, Californie, Catalogne, District de Karlsruhe, Guangdong, Kyūshū, Piémont, Préfecture de Fukuoka, Région capitale de Séoul, Région de Kantō, Victoria (État), Washington (État)
- Barcelone, Fukuoka, Heidelberg, Jiangmen, Los Angeles, Melbourne, Seattle, Séoul, Tokyo, Turin
- Université de Californie du Sud, Université de Kyūshū, Université de Melbourne, Université de Washington
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Hutter</name><affiliation wicri:level="1"><nlm:aff id="A10">Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Aragaki, Aaron K" sort="Aragaki, Aaron K" uniqKey="Aragaki A" first="Aaron K." last="Aragaki">Aaron K. 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Caan</name><affiliation wicri:level="1"><nlm:aff id="A12">Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, California 94612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, California 94612</wicri:regionArea><wicri:noRegion>California 94612</wicri:noRegion></affiliation></author><author><name sortKey="Carlson, Christopher S" sort="Carlson, Christopher S" uniqKey="Carlson C" first="Christopher S." last="Carlson">Christopher S. Carlson</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A13">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776</wicri:regionArea><wicri:noRegion>Maryland 20892-9776</wicri:noRegion></affiliation></author><author><name sortKey="Curtis, Keith R" sort="Curtis, Keith R" uniqKey="Curtis K" first="Keith R." last="Curtis">Keith R. 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Giovannucci</name><affiliation wicri:level="1"><nlm:aff id="A17">Harvard Medical School, Boston, Massachusetts 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Gogarten, Stephanie M" sort="Gogarten, Stephanie M" uniqKey="Gogarten S" first="Stephanie M." last="Gogarten">Stephanie M. Gogarten</name><affiliation wicri:level="4"><nlm:aff id="A19">Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, Washington 98195</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><affiliation wicri:level="1"><nlm:aff id="A20">Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York 10016, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York 10016</wicri:regionArea><wicri:noRegion>New York 10016</wicri:noRegion></affiliation></author><author><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="1"><nlm:aff id="A21">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Jackson, Rebecca D" sort="Jackson, Rebecca D" uniqKey="Jackson R" first="Rebecca D." last="Jackson">Rebecca D. Jackson</name><affiliation wicri:level="1"><nlm:aff id="A22">Department of Medicine, Ohio State University, Columbus, Ohio 43210, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Ohio State University, Columbus, Ohio 43210</wicri:regionArea><wicri:noRegion>Ohio 43210</wicri:noRegion></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="1"><nlm:aff id="A23">Office of Public Health Studies, University of Hawaii Manoa, Honolulu, Hawaii 96822, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Office of Public Health Studies, University of Hawaii Manoa, Honolulu, Hawaii 96822</wicri:regionArea><wicri:noRegion>Hawaii 96822</wicri:noRegion></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><affiliation wicri:level="3"><nlm:aff id="A24">Service de Génétique Médicale, CHU Nantes, Nantes 44093, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Génétique Médicale, CHU Nantes, Nantes 44093</wicri:regionArea><placeName><region type="region" nuts="2">Pays de la Loire</region></placeName></affiliation></author><author><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Laurie, Cathy C" sort="Laurie, Cathy C" uniqKey="Laurie C" first="Cathy C." last="Laurie">Cathy C. Laurie</name><affiliation wicri:level="4"><nlm:aff id="A19">Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, Washington 98195</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Laurie, Cecelia A" sort="Laurie, Cecelia A" uniqKey="Laurie C" first="Cecelia A." last="Laurie">Cecelia A. Laurie</name><affiliation wicri:level="4"><nlm:aff id="A19">Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, Washington 98195</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation wicri:level="1"><nlm:aff id="A25">Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3</wicri:regionArea><wicri:noRegion>Ontario M5G 0A3</wicri:noRegion></affiliation></author><author><name sortKey="Levine, David" sort="Levine, David" uniqKey="Levine D" first="David" last="Levine">David Levine</name><affiliation wicri:level="4"><nlm:aff id="A19">Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, Washington 98195</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation wicri:level="1"><nlm:aff id="A26">Harvard School of Public Health, Boston, Massachusetts 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard School of Public Health, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Makar, Karen W" sort="Makar, Karen W" uniqKey="Makar K" first="Karen W." last="Makar">Karen W. Makar</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Taverna, Darin" sort="Taverna, Darin" uniqKey="Taverna D" first="Darin" last="Taverna">Darin Taverna</name><affiliation wicri:level="1"><nlm:aff id="A27">Phoenix College, Phoenix, Arizona 85013, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Phoenix College, Phoenix, Arizona 85013</wicri:regionArea><wicri:noRegion>Arizona 85013</wicri:noRegion></affiliation></author><author><name sortKey="Ulrich, Cornelia M" sort="Ulrich, Cornelia M" uniqKey="Ulrich C" first="Cornelia M." last="Ulrich">Cornelia M. Ulrich</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Division of Preventive Oncology, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center, Heidelberg 69120</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington 98195</wicri:regionArea><wicri:noRegion>Washington 98195</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Kono, Suminori" sort="Kono, Suminori" uniqKey="Kono S" first="Suminori" last="Kono">Suminori Kono</name><affiliation wicri:level="4"><nlm:aff id="A31">Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author><author><name sortKey="West, Dee W" sort="West, Dee W" uniqKey="West D" first="Dee W." last="West">Dee W. West</name><affiliation wicri:level="1"><nlm:aff id="A32">Cancer Registry of Greater California, Public Health Institute, Sacramento, California 95825, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Registry of Greater California, Public Health Institute, Sacramento, California 95825</wicri:regionArea><wicri:noRegion>California 95825</wicri:noRegion></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:aff id="A13">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776</wicri:regionArea><wicri:noRegion>Maryland 20892-9776</wicri:noRegion></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bezieau">Stéphane Bezieau</name><affiliation wicri:level="3"><nlm:aff id="A33">Centre Hospitalier Universitaire Hotel-Dieu, Nantes 44093, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire Hotel-Dieu, Nantes 44093</wicri:regionArea><placeName><region type="region" nuts="2">Pays de la Loire</region></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="A11">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Campbell, Peter T" sort="Campbell, Peter T" uniqKey="Campbell P" first="Peter T." last="Campbell">Peter T. Campbell</name><affiliation wicri:level="1"><nlm:aff id="A34">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251</wicri:regionArea><wicri:noRegion>Georgia 30329-4251</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation wicri:level="1"><nlm:aff id="A16">Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Harvard Medical School, Boston, Massachusetts 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><nlm:aff id="A35">Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69121</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Coetzee, Gerhard A" sort="Coetzee, Gerhard A" uniqKey="Coetzee G" first="Gerhard A." last="Coetzee">Gerhard A. Coetzee</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A36">Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name><affiliation wicri:level="1"><nlm:aff id="A37">Genetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, Arizona 85004</wicri:regionArea><wicri:noRegion>Arizona 85004</wicri:noRegion></affiliation></author><author><name sortKey="Figueiredo, Jane C" sort="Figueiredo, Jane C" uniqKey="Figueiredo J" first="Jane C." last="Figueiredo">Jane C. Figueiredo</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fortini, Barbara K" sort="Fortini, Barbara K" uniqKey="Fortini B" first="Barbara K." last="Fortini">Barbara K. Fortini</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gallinger, Steven J" sort="Gallinger, Steven J" uniqKey="Gallinger S" first="Steven J." last="Gallinger">Steven J. Gallinger</name><affiliation wicri:level="1"><nlm:aff id="A38">Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario M5T 3L9</wicri:regionArea><wicri:noRegion>Ontario M5T 3L9</wicri:noRegion></affiliation></author><author><name sortKey="Gauderman, W James" sort="Gauderman, W James" uniqKey="Gauderman W" first="W. James" last="Gauderman">W. James Gauderman</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name><affiliation wicri:level="1"><nlm:aff id="A39">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004</wicri:regionArea><wicri:noRegion>Victoria 3004</wicri:noRegion></affiliation></author><author><name sortKey="Green, Roger" sort="Green, Roger" uniqKey="Green R" first="Roger" last="Green">Roger Green</name><affiliation wicri:level="1"><nlm:aff id="A40">Discipline of Genetics, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Discipline of Genetics, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6</wicri:regionArea><wicri:noRegion>Newfoundland A1B 3V6</wicri:noRegion></affiliation></author><author><name sortKey="Haile, Robert" sort="Haile, Robert" uniqKey="Haile R" first="Robert" last="Haile">Robert Haile</name><affiliation wicri:level="1"><nlm:aff id="A41">Department of Medicine, Division of Oncology, Stanford University, Stanford, California 94305, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Oncology, Stanford University, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A." last="Harrison">Tabitha A. Harrison</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation wicri:level="3"><nlm:aff id="A11">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="A42">Centre for MEGA Epidemiology, The University of Melbourne, Carlton, Victoria 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for MEGA Epidemiology, The University of Melbourne, Carlton, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Genomics, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Genomics, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3</wicri:regionArea><wicri:noRegion>Ontario M5G 0A3</wicri:noRegion></affiliation></author><author><name sortKey="Jacobs, Eric" sort="Jacobs, Eric" uniqKey="Jacobs E" first="Eric" last="Jacobs">Eric Jacobs</name><affiliation wicri:level="1"><nlm:aff id="A34">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251</wicri:regionArea><wicri:noRegion>Georgia 30329-4251</wicri:noRegion></affiliation></author><author><name sortKey="Iwasaki, Motoki" sort="Iwasaki, Motoki" uniqKey="Iwasaki M" first="Motoki" last="Iwasaki">Motoki Iwasaki</name><affiliation wicri:level="1"><nlm:aff id="A44">Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Jee, Sun Ha" sort="Jee, Sun Ha" uniqKey="Jee S" first="Sun Ha" last="Jee">Sun Ha Jee</name><affiliation wicri:level="1"><nlm:aff id="A45">Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 120-749, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 120-749</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jenkins, Mark" sort="Jenkins, Mark" uniqKey="Jenkins M" first="Mark" last="Jenkins">Mark Jenkins</name><affiliation wicri:level="4"><nlm:aff id="A46">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Jia, Wei Hua" sort="Jia, Wei Hua" uniqKey="Jia W" first="Wei-Hua" last="Jia">Wei-Hua Jia</name><affiliation wicri:level="1"><nlm:aff id="A47">State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Joshi, Amit" sort="Joshi, Amit" uniqKey="Joshi A" first="Amit" last="Joshi">Amit Joshi</name><affiliation wicri:level="1"><nlm:aff id="A48">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation wicri:level="1"><nlm:aff id="A49">Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation></author><author><name sortKey="Lindor, Noralene M" sort="Lindor, Noralene M" uniqKey="Lindor N" first="Noralene M." last="Lindor">Noralene M. Lindor</name><affiliation wicri:level="1"><nlm:aff id="A50">Department of Health Science Research, Mayo Clinic, Scottsdale, Arizona 85259, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Science Research, Mayo Clinic, Scottsdale, Arizona 85259</wicri:regionArea><wicri:noRegion>Arizona 85259</wicri:noRegion></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation wicri:level="4"><nlm:aff id="A31">Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author><author><name sortKey="Moreno, Victor" sort="Moreno, Victor" uniqKey="Moreno V" first="Victor" last="Moreno">Victor Moreno</name><affiliation wicri:level="1"><nlm:aff id="A51">Cancer Epidemiology Service, DDCF, Catalan Institute of Oncology, IDIBELL, Barcelona 08908, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epidemiology Service, DDCF, Catalan Institute of Oncology, IDIBELL, Barcelona 08908</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Mukherjee, Bhramar" sort="Mukherjee, Bhramar" uniqKey="Mukherjee B" first="Bhramar" last="Mukherjee">Bhramar Mukherjee</name><affiliation wicri:level="1"><nlm:aff id="A52">Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109</wicri:regionArea><wicri:noRegion>Michigan 48109</wicri:noRegion></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="1"><nlm:aff id="A53">Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109</wicri:regionArea><wicri:noRegion>Washington 98109</wicri:noRegion></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><affiliation wicri:level="1"><nlm:aff id="A53">Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109</wicri:regionArea><wicri:noRegion>Washington 98109</wicri:noRegion></affiliation></author><author><name sortKey="Raskin, Leon" sort="Raskin, Leon" uniqKey="Raskin L" first="Leon" last="Raskin">Leon Raskin</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738</wicri:regionArea><wicri:noRegion>Tennessee 37203-1738</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A55">Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738</wicri:regionArea><wicri:noRegion>Tennessee 37203-1738</wicri:noRegion></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361</wicri:regionArea><wicri:noRegion>Haifa 34361</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Clalit Health Services National Cancer Control Center, Haifa 34361, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Clalit Health Services National Cancer Control Center, Haifa 34361</wicri:regionArea><wicri:noRegion>Haifa 34361</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A56">Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3200003, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3200003</wicri:regionArea><wicri:noRegion>Haifa 3200003</wicri:noRegion></affiliation></author><author><name sortKey="Rosse, Stephanie" sort="Rosse, Stephanie" uniqKey="Rosse S" first="Stephanie" last="Rosse">Stephanie Rosse</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="1"><nlm:aff id="A39">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004</wicri:regionArea><wicri:noRegion>Victoria 3004</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Human Genetics Foundation (HuGeF), Torino 10126, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Human Genetics Foundation (HuGeF), Torino 10126</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation wicri:level="1"><nlm:aff id="A58">Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 151213, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 151213</wicri:regionArea><wicri:noRegion>Pennsylvania 151213</wicri:noRegion></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="1"><nlm:aff id="A59">Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="1"><nlm:aff id="A55">Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738</wicri:regionArea><wicri:noRegion>Tennessee 37203-1738</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A60">Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738</wicri:regionArea><wicri:noRegion>Tennessee 37203-1738</wicri:noRegion></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation wicri:level="1"><nlm:aff id="A61">Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132</wicri:regionArea><wicri:noRegion>Utah 84132</wicri:noRegion></affiliation></author><author><name sortKey="Tsugane, Shoichiro" sort="Tsugane, Shoichiro" uniqKey="Tsugane S" first="Shoichiro" last="Tsugane">Shoichiro Tsugane</name><affiliation wicri:level="1"><nlm:aff id="A44">Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Xiang, Yong Bing" sort="Xiang, Yong Bing" uniqKey="Xiang Y" first="Yong-Bing" last="Xiang">Yong-Bing Xiang</name><affiliation wicri:level="1"><nlm:aff id="A62">Department of Epidemiology, Shanghai Cancer Institute, Shanghai 2200-25, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Shanghai 2200-25</wicri:regionArea><wicri:noRegion>Shanghai 2200-25</wicri:noRegion></affiliation></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W." last="Zanke">Brent W. Zanke</name><affiliation wicri:level="1"><nlm:aff id="A63">The University of Ottawa, Ottawa, Ontario K1N 6N5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The University of Ottawa, Ottawa, Ontario K1N 6N5</wicri:regionArea><wicri:noRegion>Ontario K1N 6N5</wicri:noRegion></affiliation><affiliation><nlm:aff id="A64">Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, K1Y 4E9 Canada</nlm:aff><wicri:noCountry code="subfield">K1Y 4E9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="A54">Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738</wicri:regionArea><wicri:noRegion>Tennessee 37203-1738</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A55">Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738</wicri:regionArea><wicri:noRegion>Tennessee 37203-1738</wicri:noRegion></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="A4">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822</wicri:regionArea><wicri:noRegion>Hawaii 96822</wicri:noRegion></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26151821</idno><idno type="pmc">4967357</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967357</idno><idno type="RBID">PMC:4967357</idno><idno type="doi">10.1038/ncomms8138</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001E72</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E72</idno><idno type="wicri:Area/Pmc/Curation">001D28</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001D28</idno><idno type="wicri:Area/Pmc/Checkpoint">000F68</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F68</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002B94</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B94</idno><idno type="wicri:Area/PubMed/Curation">002B21</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002B21</idno><idno type="wicri:Area/PubMed/Checkpoint">002B21</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002B21</idno><idno type="wicri:Area/Ncbi/Merge">002814</idno><idno type="wicri:Area/Ncbi/Curation">002814</idno><idno type="wicri:Area/Ncbi/Checkpoint">002814</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association study of colorectal cancer identifies six new susceptibility loci</title><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Schmit, Stephanie L" sort="Schmit, Stephanie L" uniqKey="Schmit S" first="Stephanie L." last="Schmit">Stephanie L. Schmit</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jiao, Shuo" sort="Jiao, Shuo" uniqKey="Jiao S" first="Shuo" last="Jiao">Shuo Jiao</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Edlund, Christopher K" sort="Edlund, Christopher K" uniqKey="Edlund C" first="Christopher K." last="Edlund">Christopher K. Edlund</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wang, Hansong" sort="Wang, Hansong" uniqKey="Wang H" first="Hansong" last="Wang">Hansong Wang</name><affiliation wicri:level="1"><nlm:aff id="A4">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822</wicri:regionArea><wicri:noRegion>Hawaii 96822</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Ben" sort="Zhang, Ben" uniqKey="Zhang B" first="Ben" last="Zhang">Ben Zhang</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of General Surgery, Third Military Medical University Southwest Hospital, Chongqing 400038, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of General Surgery, Third Military Medical University Southwest Hospital, Chongqing 400038</wicri:regionArea><wicri:noRegion>Chongqing 400038</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Shu Chen" sort="Huang, Shu Chen" uniqKey="Huang S" first="Shu-Chen" last="Huang">Shu-Chen Huang</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fischer, Christopher P" sort="Fischer, Christopher P" uniqKey="Fischer C" first="Christopher P." last="Fischer">Christopher P. Fischer</name><affiliation wicri:level="1"><nlm:aff id="A6">University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105</wicri:regionArea><wicri:noRegion>Michigan 48105</wicri:noRegion></affiliation></author><author><name sortKey="Harju, John F" sort="Harju, John F" uniqKey="Harju J" first="John F." last="Harju">John F. Harju</name><affiliation wicri:level="1"><nlm:aff id="A6">University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105</wicri:regionArea><wicri:noRegion>Michigan 48105</wicri:noRegion></affiliation></author><author><name sortKey="Idos, Gregory E" sort="Idos, Gregory E" uniqKey="Idos G" first="Gregory E." last="Idos">Gregory E. Idos</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lejbkowicz, Flavio" sort="Lejbkowicz, Flavio" uniqKey="Lejbkowicz F" first="Flavio" last="Lejbkowicz">Flavio Lejbkowicz</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361</wicri:regionArea><wicri:noRegion>Haifa 34361</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Clalit Health Services National Cancer Control Center, Haifa 34361, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Clalit Health Services National Cancer Control Center, Haifa 34361</wicri:regionArea><wicri:noRegion>Haifa 34361</wicri:noRegion></affiliation></author><author><name sortKey="Manion, Frank J" sort="Manion, Frank J" uniqKey="Manion F" first="Frank J." last="Manion">Frank J. Manion</name><affiliation wicri:level="1"><nlm:aff id="A6">University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105</wicri:regionArea><wicri:noRegion>Michigan 48105</wicri:noRegion></affiliation></author><author><name sortKey="Mcdonnell, Kevin" sort="Mcdonnell, Kevin" uniqKey="Mcdonnell K" first="Kevin" last="Mcdonnell">Kevin Mcdonnell</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mcneil, Caroline E" sort="Mcneil, Caroline E" uniqKey="Mcneil C" first="Caroline E." last="Mcneil">Caroline E. Mcneil</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Melas, Marilena" sort="Melas, Marilena" uniqKey="Melas M" first="Marilena" last="Melas">Marilena Melas</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rennert, Hedy S" sort="Rennert, Hedy S" uniqKey="Rennert H" first="Hedy S." last="Rennert">Hedy S. Rennert</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361</wicri:regionArea><wicri:noRegion>Haifa 34361</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Clalit Health Services National Cancer Control Center, Haifa 34361, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Clalit Health Services National Cancer Control Center, Haifa 34361</wicri:regionArea><wicri:noRegion>Haifa 34361</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Surgery, Children’s Hospital Los Angeles, Los Angeles, California 90027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, Children’s Hospital Los Angeles, Los Angeles, California 90027</wicri:regionArea><wicri:noRegion>California 90027</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Duncan C" sort="Thomas, Duncan C" uniqKey="Thomas D" first="Duncan C." last="Thomas">Duncan C. Thomas</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Van Den Berg, David J" sort="Van Den Berg, David J" uniqKey="Van Den Berg D" first="David J." last="Van Den Berg">David J. Van Den Berg</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M." last="Hutter">Carolyn M. Hutter</name><affiliation wicri:level="1"><nlm:aff id="A10">Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Aragaki, Aaron K" sort="Aragaki, Aaron K" uniqKey="Aragaki A" first="Aaron K." last="Aragaki">Aaron K. Aragaki</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Butterbach, Katja" sort="Butterbach, Katja" uniqKey="Butterbach K" first="Katja" last="Butterbach">Katja Butterbach</name><affiliation wicri:level="3"><nlm:aff id="A11">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J." last="Caan">Bette J. Caan</name><affiliation wicri:level="1"><nlm:aff id="A12">Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, California 94612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, California 94612</wicri:regionArea><wicri:noRegion>California 94612</wicri:noRegion></affiliation></author><author><name sortKey="Carlson, Christopher S" sort="Carlson, Christopher S" uniqKey="Carlson C" first="Christopher S." last="Carlson">Christopher S. Carlson</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A13">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776</wicri:regionArea><wicri:noRegion>Maryland 20892-9776</wicri:noRegion></affiliation></author><author><name sortKey="Curtis, Keith R" sort="Curtis, Keith R" uniqKey="Curtis K" first="Keith R." last="Curtis">Keith R. Curtis</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S." last="Fuchs">Charles S. Fuchs</name><affiliation wicri:level="1"><nlm:aff id="A14">Department of Medicine, Brigham and Women’s Hospital, Brookline, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Brigham and Women’s Hospital, Brookline, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Department of Medical Oncology, Dana-Farber Cancer Institute, Brookline, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Brookline, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Gala, Manish" sort="Gala, Manish" uniqKey="Gala M" first="Manish" last="Gala">Manish Gala</name><affiliation wicri:level="1"><nlm:aff id="A16">Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name><affiliation wicri:level="1"><nlm:aff id="A17">Harvard Medical School, Boston, Massachusetts 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Gogarten, Stephanie M" sort="Gogarten, Stephanie M" uniqKey="Gogarten S" first="Stephanie M." last="Gogarten">Stephanie M. Gogarten</name><affiliation wicri:level="4"><nlm:aff id="A19">Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, Washington 98195</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><affiliation wicri:level="1"><nlm:aff id="A20">Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York 10016, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York 10016</wicri:regionArea><wicri:noRegion>New York 10016</wicri:noRegion></affiliation></author><author><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="1"><nlm:aff id="A21">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Jackson, Rebecca D" sort="Jackson, Rebecca D" uniqKey="Jackson R" first="Rebecca D." last="Jackson">Rebecca D. Jackson</name><affiliation wicri:level="1"><nlm:aff id="A22">Department of Medicine, Ohio State University, Columbus, Ohio 43210, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Ohio State University, Columbus, Ohio 43210</wicri:regionArea><wicri:noRegion>Ohio 43210</wicri:noRegion></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="1"><nlm:aff id="A23">Office of Public Health Studies, University of Hawaii Manoa, Honolulu, Hawaii 96822, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Office of Public Health Studies, University of Hawaii Manoa, Honolulu, Hawaii 96822</wicri:regionArea><wicri:noRegion>Hawaii 96822</wicri:noRegion></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><affiliation wicri:level="1"><nlm:aff id="A24">Service de Génétique Médicale, CHU Nantes, Nantes 44093, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Génétique Médicale, CHU Nantes, Nantes 44093</wicri:regionArea><wicri:noRegion>44093</wicri:noRegion><wicri:noRegion>44093</wicri:noRegion></affiliation></author><author><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Laurie, Cathy C" sort="Laurie, Cathy C" uniqKey="Laurie C" first="Cathy C." last="Laurie">Cathy C. Laurie</name><affiliation wicri:level="4"><nlm:aff id="A19">Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, Washington 98195</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Laurie, Cecelia A" sort="Laurie, Cecelia A" uniqKey="Laurie C" first="Cecelia A." last="Laurie">Cecelia A. Laurie</name><affiliation wicri:level="4"><nlm:aff id="A19">Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, Washington 98195</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation wicri:level="1"><nlm:aff id="A25">Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3</wicri:regionArea><wicri:noRegion>Ontario M5G 0A3</wicri:noRegion></affiliation></author><author><name sortKey="Levine, David" sort="Levine, David" uniqKey="Levine D" first="David" last="Levine">David Levine</name><affiliation wicri:level="4"><nlm:aff id="A19">Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, Washington 98195</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation wicri:level="1"><nlm:aff id="A26">Harvard School of Public Health, Boston, Massachusetts 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard School of Public Health, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Makar, Karen W" sort="Makar, Karen W" uniqKey="Makar K" first="Karen W." last="Makar">Karen W. Makar</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Taverna, Darin" sort="Taverna, Darin" uniqKey="Taverna D" first="Darin" last="Taverna">Darin Taverna</name><affiliation wicri:level="1"><nlm:aff id="A27">Phoenix College, Phoenix, Arizona 85013, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Phoenix College, Phoenix, Arizona 85013</wicri:regionArea><wicri:noRegion>Arizona 85013</wicri:noRegion></affiliation></author><author><name sortKey="Ulrich, Cornelia M" sort="Ulrich, Cornelia M" uniqKey="Ulrich C" first="Cornelia M." last="Ulrich">Cornelia M. Ulrich</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Division of Preventive Oncology, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center, Heidelberg 69120</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington 98195</wicri:regionArea><wicri:noRegion>Washington 98195</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Kono, Suminori" sort="Kono, Suminori" uniqKey="Kono S" first="Suminori" last="Kono">Suminori Kono</name><affiliation wicri:level="4"><nlm:aff id="A31">Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author><author><name sortKey="West, Dee W" sort="West, Dee W" uniqKey="West D" first="Dee W." last="West">Dee W. West</name><affiliation wicri:level="1"><nlm:aff id="A32">Cancer Registry of Greater California, Public Health Institute, Sacramento, California 95825, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Registry of Greater California, Public Health Institute, Sacramento, California 95825</wicri:regionArea><wicri:noRegion>California 95825</wicri:noRegion></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:aff id="A13">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776</wicri:regionArea><wicri:noRegion>Maryland 20892-9776</wicri:noRegion></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bezieau">Stéphane Bezieau</name><affiliation wicri:level="1"><nlm:aff id="A33">Centre Hospitalier Universitaire Hotel-Dieu, Nantes 44093, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire Hotel-Dieu, Nantes 44093</wicri:regionArea><wicri:noRegion>44093</wicri:noRegion><wicri:noRegion>44093</wicri:noRegion></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="A11">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Campbell, Peter T" sort="Campbell, Peter T" uniqKey="Campbell P" first="Peter T." last="Campbell">Peter T. Campbell</name><affiliation wicri:level="1"><nlm:aff id="A34">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251</wicri:regionArea><wicri:noRegion>Georgia 30329-4251</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation wicri:level="1"><nlm:aff id="A16">Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Harvard Medical School, Boston, Massachusetts 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><nlm:aff id="A35">Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69121</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Coetzee, Gerhard A" sort="Coetzee, Gerhard A" uniqKey="Coetzee G" first="Gerhard A." last="Coetzee">Gerhard A. Coetzee</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A36">Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name><affiliation wicri:level="1"><nlm:aff id="A37">Genetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, Arizona 85004</wicri:regionArea><wicri:noRegion>Arizona 85004</wicri:noRegion></affiliation></author><author><name sortKey="Figueiredo, Jane C" sort="Figueiredo, Jane C" uniqKey="Figueiredo J" first="Jane C." last="Figueiredo">Jane C. Figueiredo</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fortini, Barbara K" sort="Fortini, Barbara K" uniqKey="Fortini B" first="Barbara K." last="Fortini">Barbara K. Fortini</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gallinger, Steven J" sort="Gallinger, Steven J" uniqKey="Gallinger S" first="Steven J." last="Gallinger">Steven J. Gallinger</name><affiliation wicri:level="1"><nlm:aff id="A38">Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario M5T 3L9</wicri:regionArea><wicri:noRegion>Ontario M5T 3L9</wicri:noRegion></affiliation></author><author><name sortKey="Gauderman, W James" sort="Gauderman, W James" uniqKey="Gauderman W" first="W. James" last="Gauderman">W. James Gauderman</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name><affiliation wicri:level="1"><nlm:aff id="A39">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004</wicri:regionArea><wicri:noRegion>Victoria 3004</wicri:noRegion></affiliation></author><author><name sortKey="Green, Roger" sort="Green, Roger" uniqKey="Green R" first="Roger" last="Green">Roger Green</name><affiliation wicri:level="1"><nlm:aff id="A40">Discipline of Genetics, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Discipline of Genetics, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6</wicri:regionArea><wicri:noRegion>Newfoundland A1B 3V6</wicri:noRegion></affiliation></author><author><name sortKey="Haile, Robert" sort="Haile, Robert" uniqKey="Haile R" first="Robert" last="Haile">Robert Haile</name><affiliation wicri:level="1"><nlm:aff id="A41">Department of Medicine, Division of Oncology, Stanford University, Stanford, California 94305, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Oncology, Stanford University, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A." last="Harrison">Tabitha A. Harrison</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation wicri:level="3"><nlm:aff id="A11">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="A42">Centre for MEGA Epidemiology, The University of Melbourne, Carlton, Victoria 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for MEGA Epidemiology, The University of Melbourne, Carlton, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Genomics, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Genomics, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3</wicri:regionArea><wicri:noRegion>Ontario M5G 0A3</wicri:noRegion></affiliation></author><author><name sortKey="Jacobs, Eric" sort="Jacobs, Eric" uniqKey="Jacobs E" first="Eric" last="Jacobs">Eric Jacobs</name><affiliation wicri:level="1"><nlm:aff id="A34">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251</wicri:regionArea><wicri:noRegion>Georgia 30329-4251</wicri:noRegion></affiliation></author><author><name sortKey="Iwasaki, Motoki" sort="Iwasaki, Motoki" uniqKey="Iwasaki M" first="Motoki" last="Iwasaki">Motoki Iwasaki</name><affiliation wicri:level="1"><nlm:aff id="A44">Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Jee, Sun Ha" sort="Jee, Sun Ha" uniqKey="Jee S" first="Sun Ha" last="Jee">Sun Ha Jee</name><affiliation wicri:level="1"><nlm:aff id="A45">Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 120-749, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 120-749</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jenkins, Mark" sort="Jenkins, Mark" uniqKey="Jenkins M" first="Mark" last="Jenkins">Mark Jenkins</name><affiliation wicri:level="4"><nlm:aff id="A46">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Jia, Wei Hua" sort="Jia, Wei Hua" uniqKey="Jia W" first="Wei-Hua" last="Jia">Wei-Hua Jia</name><affiliation wicri:level="1"><nlm:aff id="A47">State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Joshi, Amit" sort="Joshi, Amit" uniqKey="Joshi A" first="Amit" last="Joshi">Amit Joshi</name><affiliation wicri:level="1"><nlm:aff id="A48">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation wicri:level="1"><nlm:aff id="A49">Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation></author><author><name sortKey="Lindor, Noralene M" sort="Lindor, Noralene M" uniqKey="Lindor N" first="Noralene M." last="Lindor">Noralene M. Lindor</name><affiliation wicri:level="1"><nlm:aff id="A50">Department of Health Science Research, Mayo Clinic, Scottsdale, Arizona 85259, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Science Research, Mayo Clinic, Scottsdale, Arizona 85259</wicri:regionArea><wicri:noRegion>Arizona 85259</wicri:noRegion></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation wicri:level="4"><nlm:aff id="A31">Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author><author><name sortKey="Moreno, Victor" sort="Moreno, Victor" uniqKey="Moreno V" first="Victor" last="Moreno">Victor Moreno</name><affiliation wicri:level="1"><nlm:aff id="A51">Cancer Epidemiology Service, DDCF, Catalan Institute of Oncology, IDIBELL, Barcelona 08908, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epidemiology Service, DDCF, Catalan Institute of Oncology, IDIBELL, Barcelona 08908</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Mukherjee, Bhramar" sort="Mukherjee, Bhramar" uniqKey="Mukherjee B" first="Bhramar" last="Mukherjee">Bhramar Mukherjee</name><affiliation wicri:level="1"><nlm:aff id="A52">Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109</wicri:regionArea><wicri:noRegion>Michigan 48109</wicri:noRegion></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="1"><nlm:aff id="A53">Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109</wicri:regionArea><wicri:noRegion>Washington 98109</wicri:noRegion></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><affiliation wicri:level="1"><nlm:aff id="A53">Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109</wicri:regionArea><wicri:noRegion>Washington 98109</wicri:noRegion></affiliation></author><author><name sortKey="Raskin, Leon" sort="Raskin, Leon" uniqKey="Raskin L" first="Leon" last="Raskin">Leon Raskin</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738</wicri:regionArea><wicri:noRegion>Tennessee 37203-1738</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A55">Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738</wicri:regionArea><wicri:noRegion>Tennessee 37203-1738</wicri:noRegion></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361</wicri:regionArea><wicri:noRegion>Haifa 34361</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Clalit Health Services National Cancer Control Center, Haifa 34361, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Clalit Health Services National Cancer Control Center, Haifa 34361</wicri:regionArea><wicri:noRegion>Haifa 34361</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A56">Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3200003, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3200003</wicri:regionArea><wicri:noRegion>Haifa 3200003</wicri:noRegion></affiliation></author><author><name sortKey="Rosse, Stephanie" sort="Rosse, Stephanie" uniqKey="Rosse S" first="Stephanie" last="Rosse">Stephanie Rosse</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="1"><nlm:aff id="A39">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004</wicri:regionArea><wicri:noRegion>Victoria 3004</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Human Genetics Foundation (HuGeF), Torino 10126, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Human Genetics Foundation (HuGeF), Torino 10126</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation wicri:level="1"><nlm:aff id="A58">Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 151213, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 151213</wicri:regionArea><wicri:noRegion>Pennsylvania 151213</wicri:noRegion></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="1"><nlm:aff id="A59">Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="1"><nlm:aff id="A55">Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738</wicri:regionArea><wicri:noRegion>Tennessee 37203-1738</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A60">Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738</wicri:regionArea><wicri:noRegion>Tennessee 37203-1738</wicri:noRegion></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation wicri:level="1"><nlm:aff id="A61">Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132</wicri:regionArea><wicri:noRegion>Utah 84132</wicri:noRegion></affiliation></author><author><name sortKey="Tsugane, Shoichiro" sort="Tsugane, Shoichiro" uniqKey="Tsugane S" first="Shoichiro" last="Tsugane">Shoichiro Tsugane</name><affiliation wicri:level="1"><nlm:aff id="A44">Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author><author><name sortKey="Xiang, Yong Bing" sort="Xiang, Yong Bing" uniqKey="Xiang Y" first="Yong-Bing" last="Xiang">Yong-Bing Xiang</name><affiliation wicri:level="1"><nlm:aff id="A62">Department of Epidemiology, Shanghai Cancer Institute, Shanghai 2200-25, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Shanghai 2200-25</wicri:regionArea><wicri:noRegion>Shanghai 2200-25</wicri:noRegion></affiliation></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W." last="Zanke">Brent W. Zanke</name><affiliation wicri:level="1"><nlm:aff id="A63">The University of Ottawa, Ottawa, Ontario K1N 6N5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The University of Ottawa, Ottawa, Ontario K1N 6N5</wicri:regionArea><wicri:noRegion>Ontario K1N 6N5</wicri:noRegion></affiliation><affiliation><nlm:aff id="A64">Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, K1Y 4E9 Canada</nlm:aff><wicri:noCountry code="subfield">K1Y 4E9 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="A54">Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738</wicri:regionArea><wicri:noRegion>Tennessee 37203-1738</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A55">Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738</wicri:regionArea><wicri:noRegion>Tennessee 37203-1738</wicri:noRegion></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="A4">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822</wicri:regionArea><wicri:noRegion>Hawaii 96822</wicri:noRegion></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="1"><nlm:aff id="A3">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124</wicri:regionArea><wicri:noRegion>Washington 98124</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case-Control Studies</term><term>Colorectal Neoplasms (genetics)</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Odds Ratio</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Odds ratio</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Tumeurs colorectales (génétique)</term><term>Étude d'association pangénomique</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tumeurs colorectales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Odds Ratio</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Odds ratio</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Étude d'association pangénomique</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of <italic>P</italic><5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Corée du Sud</li><li>Espagne</li><li>France</li><li>Israël</li><li>Italie</li><li>Japon</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Californie</li><li>Catalogne</li><li>District de Karlsruhe</li><li>Guangdong</li><li>Kyūshū</li><li>Piémont</li><li>Préfecture de Fukuoka</li><li>Région capitale de Séoul</li><li>Région de Kantō</li><li>Victoria (État)</li><li>Washington (État)</li></region><settlement><li>Barcelone</li><li>Fukuoka</li><li>Heidelberg</li><li>Jiangmen</li><li>Los Angeles</li><li>Melbourne</li><li>Seattle</li><li>Séoul</li><li>Tokyo</li><li>Turin</li></settlement><orgName><li>Université de Californie du Sud</li><li>Université de Kyūshū</li><li>Université de Melbourne</li><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. 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