The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.
Identifieur interne : 001D94 ( Ncbi/Checkpoint ); précédent : 001D93; suivant : 001D95The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.
Auteurs : R. Salgado [Belgique] ; C. Denkert [Allemagne] ; S. Demaria [États-Unis] ; N. Sirtaine [Belgique] ; F. Klauschen [Allemagne] ; G. Pruneri [Italie] ; S. Wienert [Allemagne] ; G. Van Den Eynden [Belgique] ; F L Baehner [États-Unis] ; F. Penault-Llorca [France] ; E A Perez ; E A Thompson ; W F Symmans [États-Unis] ; A L Richardson [États-Unis] ; J. Brock [États-Unis] ; C. Criscitiello [Italie] ; H. Bailey [États-Unis] ; M. Ignatiadis [Belgique] ; G. Floris [Belgique] ; J. Sparano [États-Unis] ; Z. Kos ; T. Nielsen [Canada] ; D L Rimm ; K H Allison ; J S Reis-Filho [États-Unis] ; S. Loibl [Allemagne] ; C. Sotiriou [Belgique] ; G. Viale [Italie] ; S. Badve [États-Unis] ; S. Adams [États-Unis] ; K. Willard-Gallo [Belgique] ; S. Loi [Australie]Source :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Tumeurs du sein.
- Femelle, Humains, Lymphocytes TIL.
English descriptors
- KwdEn :
- MESH :
- immunology : Breast Neoplasms.
- Female, Humans, Lymphocytes, Tumor-Infiltrating.
Abstract
The morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer (BC) is gaining momentum as evidence strengthens for the clinical relevance of this immunological biomarker. Accumulating evidence suggests that the extent of lymphocytic infiltration in tumor tissue can be assessed as a major parameter by evaluation of hematoxylin and eosin (H&E)-stained tumor sections. TILs have been shown to provide prognostic and potentially predictive value, particularly in triple-negative and human epidermal growth factor receptor 2-overexpressing BC.
DOI: 10.1093/annonc/mdu450
PubMed: 25214542
Affiliations:
- Allemagne, Australie, Belgique, Canada, France, Italie, États-Unis
- Auvergne (région administrative), Auvergne-Rhône-Alpes, Berlin, Californie, Lombardie, Massachusetts, Région de Bruxelles-Capitale, Victoria (État), État de New York
- Berlin, Boston, Bruxelles, Clermont-Ferrand, Melbourne, Milan, San Francisco
- Université de Melbourne, Université libre de Bruxelles
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Brock</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cancer Biology, Dana Farber Cancer Institute, Boston Department of Cancer Biology, Harvard Medical School, Boston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Biology, Dana Farber Cancer Institute, Boston Department of Cancer Biology, Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Criscitiello, C" sort="Criscitiello, C" uniqKey="Criscitiello C" first="C" last="Criscitiello">C. Criscitiello</name><affiliation wicri:level="3"><nlm:affiliation>Istituto Europeo di Oncologia, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Europeo di Oncologia, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bailey, H" sort="Bailey, H" uniqKey="Bailey H" first="H" last="Bailey">H. Bailey</name><affiliation wicri:level="1"><nlm:affiliation>Genomic Health, Inc., Redwood City, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomic Health, Inc., Redwood City</wicri:regionArea><wicri:noRegion>Redwood City</wicri:noRegion></affiliation></author><author><name sortKey="Ignatiadis, M" sort="Ignatiadis, M" uniqKey="Ignatiadis M" first="M" last="Ignatiadis">M. Ignatiadis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels.</nlm:affiliation><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><wicri:orgArea>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles</wicri:orgArea></affiliation></author><author><name sortKey="Floris, G" sort="Floris, G" uniqKey="Floris G" first="G" last="Floris">G. Floris</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospital Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, University Hospital Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Sparano, J" sort="Sparano, J" uniqKey="Sparano J" first="J" last="Sparano">J. Sparano</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Department of Obstetrics and Gynecology and Women's Health, Albert Einstein Medical Center, Bronx, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Department of Obstetrics and Gynecology and Women's Health, Albert Einstein Medical Center, Bronx</wicri:regionArea><wicri:noRegion>Bronx</wicri:noRegion></affiliation></author><author><name sortKey="Kos, Z" sort="Kos, Z" uniqKey="Kos Z" first="Z" last="Kos">Z. Kos</name><affiliation><nlm:affiliation>Laboratory Medicine Program, University Health Network, University of Toronto, Toronto.</nlm:affiliation><wicri:noCountry code="subField">Toronto</wicri:noCountry></affiliation></author><author><name sortKey="Nielsen, T" sort="Nielsen, T" uniqKey="Nielsen T" first="T" last="Nielsen">T. Nielsen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Rimm, D L" sort="Rimm, D L" uniqKey="Rimm D" first="D L" last="Rimm">D L Rimm</name><affiliation><nlm:affiliation>Department of Pathology, Yale University School of Medicine, New Haven.</nlm:affiliation><wicri:noCountry code="subField">New Haven</wicri:noCountry></affiliation></author><author><name sortKey="Allison, K H" sort="Allison, K H" uniqKey="Allison K" first="K H" last="Allison">K H Allison</name><affiliation><nlm:affiliation>Department of Pathology, Stanford University Medical Centre, Stanford.</nlm:affiliation><wicri:noCountry code="subField">Stanford</wicri:noCountry></affiliation></author><author><name sortKey="Reis Filho, J S" sort="Reis Filho, J S" uniqKey="Reis Filho J" first="J S" last="Reis-Filho">J S Reis-Filho</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Loibl, S" sort="Loibl, S" uniqKey="Loibl S" first="S" last="Loibl">S. Loibl</name><affiliation wicri:level="1"><nlm:affiliation>German Breast Group, Neu-Isenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Breast Group, Neu-Isenburg</wicri:regionArea><wicri:noRegion>Neu-Isenburg</wicri:noRegion><wicri:noRegion>Neu-Isenburg</wicri:noRegion><wicri:noRegion>Neu-Isenburg</wicri:noRegion></affiliation></author><author><name sortKey="Sotiriou, C" sort="Sotiriou, C" uniqKey="Sotiriou C" first="C" last="Sotiriou">C. Sotiriou</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels.</nlm:affiliation><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><wicri:orgArea>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles</wicri:orgArea></affiliation></author><author><name sortKey="Viale, G" sort="Viale, G" uniqKey="Viale G" first="G" last="Viale">G. Viale</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Badve, S" sort="Badve, S" uniqKey="Badve S" first="S" last="Badve">S. Badve</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis</wicri:regionArea><wicri:noRegion>Indianapolis</wicri:noRegion></affiliation></author><author><name sortKey="Adams, S" sort="Adams, S" uniqKey="Adams S" first="S" last="Adams">S. Adams</name><affiliation wicri:level="2"><nlm:affiliation>Perlmutter Cancer Center, New York University Medical School, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Perlmutter Cancer Center, New York University Medical School, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Willard Gallo, K" sort="Willard Gallo, K" uniqKey="Willard Gallo K" first="K" last="Willard-Gallo">K. Willard-Gallo</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Bruxelles</settlement></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Loi, S" sort="Loi, S" uniqKey="Loi S" first="S" last="Loi">S. Loi</name><affiliation wicri:level="4"><nlm:affiliation>Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Victoria, Australia sherene.loi@petermac.org.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25214542</idno><idno type="pmid">25214542</idno><idno type="doi">10.1093/annonc/mdu450</idno><idno type="wicri:Area/PubMed/Corpus">003033</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003033</idno><idno type="wicri:Area/PubMed/Curation">002F52</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002F52</idno><idno type="wicri:Area/PubMed/Checkpoint">002F52</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002F52</idno><idno type="wicri:Area/Ncbi/Merge">001D94</idno><idno type="wicri:Area/Ncbi/Curation">001D94</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.</title><author><name sortKey="Salgado, R" sort="Salgado, R" uniqKey="Salgado R" first="R" last="Salgado">R. Salgado</name><affiliation wicri:level="1"><nlm:affiliation>Breast Cancer Translational Research Laboratory/Breast International Group, Institut Jules Bordet, Brussels Department of Pathology and TCRU, GZA, Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Breast Cancer Translational Research Laboratory/Breast International Group, Institut Jules Bordet, Brussels Department of Pathology and TCRU, GZA, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Denkert, C" sort="Denkert, C" uniqKey="Denkert C" first="C" last="Denkert">C. Denkert</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pathology, Charité -University Hospital, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Charité -University Hospital, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Demaria, S" sort="Demaria, S" uniqKey="Demaria S" first="S" last="Demaria">S. Demaria</name><affiliation wicri:level="2"><nlm:affiliation>Perlmutter Cancer Center, New York University Medical School, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Perlmutter Cancer Center, New York University Medical School, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Sirtaine, N" sort="Sirtaine, N" uniqKey="Sirtaine N" first="N" last="Sirtaine">N. Sirtaine</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Bruxelles</settlement></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Klauschen, F" sort="Klauschen, F" uniqKey="Klauschen F" first="F" last="Klauschen">F. Klauschen</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pathology, Charité -University Hospital, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Charité -University Hospital, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Pruneri, G" sort="Pruneri, G" uniqKey="Pruneri G" first="G" last="Pruneri">G. Pruneri</name><affiliation wicri:level="3"><nlm:affiliation>European Institute of Oncology (IEO) and University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>European Institute of Oncology (IEO) and University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Wienert, S" sort="Wienert, S" uniqKey="Wienert S" first="S" last="Wienert">S. Wienert</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pathology, Charité -University Hospital, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Charité -University Hospital, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Van Den Eynden, G" sort="Van Den Eynden, G" uniqKey="Van Den Eynden G" first="G" last="Van Den Eynden">G. Van Den Eynden</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology GZA, TCRU Hospitals and CORE Antwerp University, Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology GZA, TCRU Hospitals and CORE Antwerp University, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Baehner, F L" sort="Baehner, F L" uniqKey="Baehner F" first="F L" last="Baehner">F L Baehner</name><affiliation wicri:level="3"><nlm:affiliation>Genomic Health, Inc., Redwood City, USA University of California San Francisco, San Francisco, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomic Health, Inc., Redwood City, USA University of California San Francisco, San Francisco</wicri:regionArea><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Penault Llorca, F" sort="Penault Llorca, F" uniqKey="Penault Llorca F" first="F" last="Penault-Llorca">F. Penault-Llorca</name><affiliation wicri:level="3"><nlm:affiliation>Clermont-Ferrand Biopathology, University of Auvergne, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Clermont-Ferrand Biopathology, University of Auvergne, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Perez, E A" sort="Perez, E A" uniqKey="Perez E" first="E A" last="Perez">E A Perez</name><affiliation><nlm:affiliation>Division of Haematology/Medical Oncology and.</nlm:affiliation><wicri:noCountry code="no comma">Division of Haematology/Medical Oncology and.</wicri:noCountry></affiliation></author><author><name sortKey="Thompson, E A" sort="Thompson, E A" uniqKey="Thompson E" first="E A" last="Thompson">E A Thompson</name><affiliation><nlm:affiliation>Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville.</nlm:affiliation><wicri:noCountry code="subField">Jacksonville</wicri:noCountry></affiliation></author><author><name sortKey="Symmans, W F" sort="Symmans, W F" uniqKey="Symmans W" first="W F" last="Symmans">W F Symmans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, The UT M.D. Anderson Cancer Center, Boston.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Department of Pathology, The UT M.D. Anderson Cancer Center</wicri:orgArea></affiliation></author><author><name sortKey="Richardson, A L" sort="Richardson, A L" uniqKey="Richardson A" first="A L" last="Richardson">A L Richardson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Brigham and Women's Hospital, Boston Department of Cancer Biology, Dana Farber Cancer Institute, Boston.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Department of Pathology, Brigham and Women's Hospital, Boston Department of Cancer Biology, Dana Farber Cancer Institute</wicri:orgArea></affiliation></author><author><name sortKey="Brock, J" sort="Brock, J" uniqKey="Brock J" first="J" last="Brock">J. Brock</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cancer Biology, Dana Farber Cancer Institute, Boston Department of Cancer Biology, Harvard Medical School, Boston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Biology, Dana Farber Cancer Institute, Boston Department of Cancer Biology, Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Criscitiello, C" sort="Criscitiello, C" uniqKey="Criscitiello C" first="C" last="Criscitiello">C. Criscitiello</name><affiliation wicri:level="3"><nlm:affiliation>Istituto Europeo di Oncologia, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Europeo di Oncologia, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bailey, H" sort="Bailey, H" uniqKey="Bailey H" first="H" last="Bailey">H. Bailey</name><affiliation wicri:level="1"><nlm:affiliation>Genomic Health, Inc., Redwood City, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomic Health, Inc., Redwood City</wicri:regionArea><wicri:noRegion>Redwood City</wicri:noRegion></affiliation></author><author><name sortKey="Ignatiadis, M" sort="Ignatiadis, M" uniqKey="Ignatiadis M" first="M" last="Ignatiadis">M. Ignatiadis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels.</nlm:affiliation><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><wicri:orgArea>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles</wicri:orgArea></affiliation></author><author><name sortKey="Floris, G" sort="Floris, G" uniqKey="Floris G" first="G" last="Floris">G. Floris</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospital Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, University Hospital Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Sparano, J" sort="Sparano, J" uniqKey="Sparano J" first="J" last="Sparano">J. Sparano</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Department of Obstetrics and Gynecology and Women's Health, Albert Einstein Medical Center, Bronx, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Department of Obstetrics and Gynecology and Women's Health, Albert Einstein Medical Center, Bronx</wicri:regionArea><wicri:noRegion>Bronx</wicri:noRegion></affiliation></author><author><name sortKey="Kos, Z" sort="Kos, Z" uniqKey="Kos Z" first="Z" last="Kos">Z. Kos</name><affiliation><nlm:affiliation>Laboratory Medicine Program, University Health Network, University of Toronto, Toronto.</nlm:affiliation><wicri:noCountry code="subField">Toronto</wicri:noCountry></affiliation></author><author><name sortKey="Nielsen, T" sort="Nielsen, T" uniqKey="Nielsen T" first="T" last="Nielsen">T. Nielsen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Rimm, D L" sort="Rimm, D L" uniqKey="Rimm D" first="D L" last="Rimm">D L Rimm</name><affiliation><nlm:affiliation>Department of Pathology, Yale University School of Medicine, New Haven.</nlm:affiliation><wicri:noCountry code="subField">New Haven</wicri:noCountry></affiliation></author><author><name sortKey="Allison, K H" sort="Allison, K H" uniqKey="Allison K" first="K H" last="Allison">K H Allison</name><affiliation><nlm:affiliation>Department of Pathology, Stanford University Medical Centre, Stanford.</nlm:affiliation><wicri:noCountry code="subField">Stanford</wicri:noCountry></affiliation></author><author><name sortKey="Reis Filho, J S" sort="Reis Filho, J S" uniqKey="Reis Filho J" first="J S" last="Reis-Filho">J S Reis-Filho</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Loibl, S" sort="Loibl, S" uniqKey="Loibl S" first="S" last="Loibl">S. Loibl</name><affiliation wicri:level="1"><nlm:affiliation>German Breast Group, Neu-Isenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Breast Group, Neu-Isenburg</wicri:regionArea><wicri:noRegion>Neu-Isenburg</wicri:noRegion><wicri:noRegion>Neu-Isenburg</wicri:noRegion><wicri:noRegion>Neu-Isenburg</wicri:noRegion></affiliation></author><author><name sortKey="Sotiriou, C" sort="Sotiriou, C" uniqKey="Sotiriou C" first="C" last="Sotiriou">C. Sotiriou</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels.</nlm:affiliation><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><wicri:orgArea>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles</wicri:orgArea></affiliation></author><author><name sortKey="Viale, G" sort="Viale, G" uniqKey="Viale G" first="G" last="Viale">G. Viale</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Badve, S" sort="Badve, S" uniqKey="Badve S" first="S" last="Badve">S. Badve</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis</wicri:regionArea><wicri:noRegion>Indianapolis</wicri:noRegion></affiliation></author><author><name sortKey="Adams, S" sort="Adams, S" uniqKey="Adams S" first="S" last="Adams">S. Adams</name><affiliation wicri:level="2"><nlm:affiliation>Perlmutter Cancer Center, New York University Medical School, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Perlmutter Cancer Center, New York University Medical School, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Willard Gallo, K" sort="Willard Gallo, K" uniqKey="Willard Gallo K" first="K" last="Willard-Gallo">K. Willard-Gallo</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Bruxelles</settlement></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Loi, S" sort="Loi, S" uniqKey="Loi S" first="S" last="Loi">S. Loi</name><affiliation wicri:level="4"><nlm:affiliation>Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Victoria, Australia sherene.loi@petermac.org.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title><idno type="eISSN">1569-8041</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (immunology)</term><term>Female</term><term>Humans</term><term>Lymphocytes, Tumor-Infiltrating</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Lymphocytes TIL</term><term>Tumeurs du sein (immunologie)</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Lymphocytes, Tumor-Infiltrating</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Lymphocytes TIL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer (BC) is gaining momentum as evidence strengthens for the clinical relevance of this immunological biomarker. Accumulating evidence suggests that the extent of lymphocytic infiltration in tumor tissue can be assessed as a major parameter by evaluation of hematoxylin and eosin (H&E)-stained tumor sections. TILs have been shown to provide prognostic and potentially predictive value, particularly in triple-negative and human epidermal growth factor receptor 2-overexpressing BC.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>France</li><li>Italie</li><li>États-Unis</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li><li>Berlin</li><li>Californie</li><li>Lombardie</li><li>Massachusetts</li><li>Région de Bruxelles-Capitale</li><li>Victoria (État)</li><li>État de New York</li></region><settlement><li>Berlin</li><li>Boston</li><li>Bruxelles</li><li>Clermont-Ferrand</li><li>Melbourne</li><li>Milan</li><li>San Francisco</li></settlement><orgName><li>Université de Melbourne</li><li>Université libre de Bruxelles</li></orgName></list><tree><noCountry><name sortKey="Allison, K H" sort="Allison, K H" uniqKey="Allison K" first="K H" last="Allison">K H Allison</name><name sortKey="Kos, Z" sort="Kos, Z" uniqKey="Kos Z" first="Z" last="Kos">Z. Kos</name><name sortKey="Perez, E A" sort="Perez, E A" uniqKey="Perez E" first="E A" last="Perez">E A Perez</name><name sortKey="Rimm, D L" sort="Rimm, D L" uniqKey="Rimm D" first="D L" last="Rimm">D L Rimm</name><name sortKey="Thompson, E A" sort="Thompson, E A" uniqKey="Thompson E" first="E A" last="Thompson">E A Thompson</name></noCountry><country name="Belgique"><noRegion><name sortKey="Salgado, R" sort="Salgado, R" uniqKey="Salgado R" first="R" last="Salgado">R. Salgado</name></noRegion><name sortKey="Floris, G" sort="Floris, G" uniqKey="Floris G" first="G" last="Floris">G. Floris</name><name sortKey="Ignatiadis, M" sort="Ignatiadis, M" uniqKey="Ignatiadis M" first="M" last="Ignatiadis">M. Ignatiadis</name><name sortKey="Sirtaine, N" sort="Sirtaine, N" uniqKey="Sirtaine N" first="N" last="Sirtaine">N. Sirtaine</name><name sortKey="Sotiriou, C" sort="Sotiriou, C" uniqKey="Sotiriou C" first="C" last="Sotiriou">C. Sotiriou</name><name sortKey="Van Den Eynden, G" sort="Van Den Eynden, G" uniqKey="Van Den Eynden G" first="G" last="Van Den Eynden">G. Van Den Eynden</name><name sortKey="Willard Gallo, K" sort="Willard Gallo, K" uniqKey="Willard Gallo K" first="K" last="Willard-Gallo">K. Willard-Gallo</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Denkert, C" sort="Denkert, C" uniqKey="Denkert C" first="C" last="Denkert">C. Denkert</name></region><name sortKey="Klauschen, F" sort="Klauschen, F" uniqKey="Klauschen F" first="F" last="Klauschen">F. Klauschen</name><name sortKey="Loibl, S" sort="Loibl, S" uniqKey="Loibl S" first="S" last="Loibl">S. Loibl</name><name sortKey="Wienert, S" sort="Wienert, S" uniqKey="Wienert S" first="S" last="Wienert">S. Wienert</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Demaria, S" sort="Demaria, S" uniqKey="Demaria S" first="S" last="Demaria">S. Demaria</name></region><name sortKey="Adams, S" sort="Adams, S" uniqKey="Adams S" first="S" last="Adams">S. Adams</name><name sortKey="Badve, S" sort="Badve, S" uniqKey="Badve S" first="S" last="Badve">S. Badve</name><name sortKey="Baehner, F L" sort="Baehner, F L" uniqKey="Baehner F" first="F L" last="Baehner">F L Baehner</name><name sortKey="Bailey, H" sort="Bailey, H" uniqKey="Bailey H" first="H" last="Bailey">H. Bailey</name><name sortKey="Brock, J" sort="Brock, J" uniqKey="Brock J" first="J" last="Brock">J. Brock</name><name sortKey="Reis Filho, J S" sort="Reis Filho, J S" uniqKey="Reis Filho J" first="J S" last="Reis-Filho">J S Reis-Filho</name><name sortKey="Richardson, A L" sort="Richardson, A L" uniqKey="Richardson A" first="A L" last="Richardson">A L Richardson</name><name sortKey="Sparano, J" sort="Sparano, J" uniqKey="Sparano J" first="J" last="Sparano">J. Sparano</name><name sortKey="Symmans, W F" sort="Symmans, W F" uniqKey="Symmans W" first="W F" last="Symmans">W F Symmans</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Pruneri, G" sort="Pruneri, G" uniqKey="Pruneri G" first="G" last="Pruneri">G. Pruneri</name></region><name sortKey="Criscitiello, C" sort="Criscitiello, C" uniqKey="Criscitiello C" first="C" last="Criscitiello">C. Criscitiello</name><name sortKey="Viale, G" sort="Viale, G" uniqKey="Viale G" first="G" last="Viale">G. Viale</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Penault Llorca, F" sort="Penault Llorca, F" uniqKey="Penault Llorca F" first="F" last="Penault-Llorca">F. Penault-Llorca</name></region></country><country name="Canada"><noRegion><name sortKey="Nielsen, T" sort="Nielsen, T" uniqKey="Nielsen T" first="T" last="Nielsen">T. Nielsen</name></noRegion></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Loi, S" sort="Loi, S" uniqKey="Loi S" first="S" last="Loi">S. Loi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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