The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.
Identifieur interne : 001D94 ( Ncbi/Merge ); précédent : 001D93; suivant : 001D95The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.
Auteurs : R. Salgado [Belgique] ; C. Denkert [Allemagne] ; S. Demaria [États-Unis] ; N. Sirtaine [Belgique] ; F. Klauschen [Allemagne] ; G. Pruneri [Italie] ; S. Wienert [Allemagne] ; G. Van Den Eynden [Belgique] ; F L Baehner [États-Unis] ; F. Penault-Llorca [France] ; E A Perez ; E A Thompson ; W F Symmans [États-Unis] ; A L Richardson [États-Unis] ; J. Brock [États-Unis] ; C. Criscitiello [Italie] ; H. Bailey [États-Unis] ; M. Ignatiadis [Belgique] ; G. Floris [Belgique] ; J. Sparano [États-Unis] ; Z. Kos ; T. Nielsen [Canada] ; D L Rimm ; K H Allison ; J S Reis-Filho [États-Unis] ; S. Loibl [Allemagne] ; C. Sotiriou [Belgique] ; G. Viale [Italie] ; S. Badve [États-Unis] ; S. Adams [États-Unis] ; K. Willard-Gallo [Belgique] ; S. Loi [Australie]Source :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Tumeurs du sein.
- Femelle, Humains, Lymphocytes TIL.
English descriptors
- KwdEn :
- MESH :
- immunology : Breast Neoplasms.
- Female, Humans, Lymphocytes, Tumor-Infiltrating.
Abstract
The morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer (BC) is gaining momentum as evidence strengthens for the clinical relevance of this immunological biomarker. Accumulating evidence suggests that the extent of lymphocytic infiltration in tumor tissue can be assessed as a major parameter by evaluation of hematoxylin and eosin (H&E)-stained tumor sections. TILs have been shown to provide prognostic and potentially predictive value, particularly in triple-negative and human epidermal growth factor receptor 2-overexpressing BC.
DOI: 10.1093/annonc/mdu450
PubMed: 25214542
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Van Den Eynden</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology GZA, TCRU Hospitals and CORE Antwerp University, Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology GZA, TCRU Hospitals and CORE Antwerp University, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Baehner, F L" sort="Baehner, F L" uniqKey="Baehner F" first="F L" last="Baehner">F L Baehner</name><affiliation wicri:level="3"><nlm:affiliation>Genomic Health, Inc., Redwood City, USA University of California San Francisco, San Francisco, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomic Health, Inc., Redwood City, USA University of California San Francisco, San Francisco</wicri:regionArea><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Penault Llorca, F" sort="Penault Llorca, F" uniqKey="Penault Llorca F" first="F" last="Penault-Llorca">F. Penault-Llorca</name><affiliation wicri:level="3"><nlm:affiliation>Clermont-Ferrand Biopathology, University of Auvergne, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Clermont-Ferrand Biopathology, University of Auvergne, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Perez, E A" sort="Perez, E A" uniqKey="Perez E" first="E A" last="Perez">E A Perez</name><affiliation><nlm:affiliation>Division of Haematology/Medical Oncology and.</nlm:affiliation><wicri:noCountry code="no comma">Division of Haematology/Medical Oncology and.</wicri:noCountry></affiliation></author><author><name sortKey="Thompson, E A" sort="Thompson, E A" uniqKey="Thompson E" first="E A" last="Thompson">E A Thompson</name><affiliation><nlm:affiliation>Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville.</nlm:affiliation><wicri:noCountry code="subField">Jacksonville</wicri:noCountry></affiliation></author><author><name sortKey="Symmans, W F" sort="Symmans, W F" uniqKey="Symmans W" first="W F" last="Symmans">W F Symmans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, The UT M.D. Anderson Cancer Center, Boston.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Department of Pathology, The UT M.D. Anderson Cancer Center</wicri:orgArea></affiliation></author><author><name sortKey="Richardson, A L" sort="Richardson, A L" uniqKey="Richardson A" first="A L" last="Richardson">A L Richardson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Brigham and Women's Hospital, Boston Department of Cancer Biology, Dana Farber Cancer Institute, Boston.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Department of Pathology, Brigham and Women's Hospital, Boston Department of Cancer Biology, Dana Farber Cancer Institute</wicri:orgArea></affiliation></author><author><name sortKey="Brock, J" sort="Brock, J" uniqKey="Brock J" first="J" last="Brock">J. Brock</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cancer Biology, Dana Farber Cancer Institute, Boston Department of Cancer Biology, Harvard Medical School, Boston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Biology, Dana Farber Cancer Institute, Boston Department of Cancer Biology, Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Criscitiello, C" sort="Criscitiello, C" uniqKey="Criscitiello C" first="C" last="Criscitiello">C. Criscitiello</name><affiliation wicri:level="3"><nlm:affiliation>Istituto Europeo di Oncologia, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Europeo di Oncologia, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bailey, H" sort="Bailey, H" uniqKey="Bailey H" first="H" last="Bailey">H. Bailey</name><affiliation wicri:level="1"><nlm:affiliation>Genomic Health, Inc., Redwood City, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomic Health, Inc., Redwood City</wicri:regionArea><wicri:noRegion>Redwood City</wicri:noRegion></affiliation></author><author><name sortKey="Ignatiadis, M" sort="Ignatiadis, M" uniqKey="Ignatiadis M" first="M" last="Ignatiadis">M. Ignatiadis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels.</nlm:affiliation><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><wicri:orgArea>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles</wicri:orgArea></affiliation></author><author><name sortKey="Floris, G" sort="Floris, G" uniqKey="Floris G" first="G" last="Floris">G. Floris</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospital Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, University Hospital Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Sparano, J" sort="Sparano, J" uniqKey="Sparano J" first="J" last="Sparano">J. Sparano</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Department of Obstetrics and Gynecology and Women's Health, Albert Einstein Medical Center, Bronx, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Department of Obstetrics and Gynecology and Women's Health, Albert Einstein Medical Center, Bronx</wicri:regionArea><wicri:noRegion>Bronx</wicri:noRegion></affiliation></author><author><name sortKey="Kos, Z" sort="Kos, Z" uniqKey="Kos Z" first="Z" last="Kos">Z. Kos</name><affiliation><nlm:affiliation>Laboratory Medicine Program, University Health Network, University of Toronto, Toronto.</nlm:affiliation><wicri:noCountry code="subField">Toronto</wicri:noCountry></affiliation></author><author><name sortKey="Nielsen, T" sort="Nielsen, T" uniqKey="Nielsen T" first="T" last="Nielsen">T. Nielsen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Rimm, D L" sort="Rimm, D L" uniqKey="Rimm D" first="D L" last="Rimm">D L Rimm</name><affiliation><nlm:affiliation>Department of Pathology, Yale University School of Medicine, New Haven.</nlm:affiliation><wicri:noCountry code="subField">New Haven</wicri:noCountry></affiliation></author><author><name sortKey="Allison, K H" sort="Allison, K H" uniqKey="Allison K" first="K H" last="Allison">K H Allison</name><affiliation><nlm:affiliation>Department of Pathology, Stanford University Medical Centre, Stanford.</nlm:affiliation><wicri:noCountry code="subField">Stanford</wicri:noCountry></affiliation></author><author><name sortKey="Reis Filho, J S" sort="Reis Filho, J S" uniqKey="Reis Filho J" first="J S" last="Reis-Filho">J S Reis-Filho</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Loibl, S" sort="Loibl, S" uniqKey="Loibl S" first="S" last="Loibl">S. Loibl</name><affiliation wicri:level="1"><nlm:affiliation>German Breast Group, Neu-Isenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Breast Group, Neu-Isenburg</wicri:regionArea><wicri:noRegion>Neu-Isenburg</wicri:noRegion><wicri:noRegion>Neu-Isenburg</wicri:noRegion><wicri:noRegion>Neu-Isenburg</wicri:noRegion></affiliation></author><author><name sortKey="Sotiriou, C" sort="Sotiriou, C" uniqKey="Sotiriou C" first="C" last="Sotiriou">C. Sotiriou</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels.</nlm:affiliation><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><wicri:orgArea>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles</wicri:orgArea></affiliation></author><author><name sortKey="Viale, G" sort="Viale, G" uniqKey="Viale G" first="G" last="Viale">G. Viale</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Badve, S" sort="Badve, S" uniqKey="Badve S" first="S" last="Badve">S. Badve</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis</wicri:regionArea><wicri:noRegion>Indianapolis</wicri:noRegion></affiliation></author><author><name sortKey="Adams, S" sort="Adams, S" uniqKey="Adams S" first="S" last="Adams">S. Adams</name><affiliation wicri:level="2"><nlm:affiliation>Perlmutter Cancer Center, New York University Medical School, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Perlmutter Cancer Center, New York University Medical School, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Willard Gallo, K" sort="Willard Gallo, K" uniqKey="Willard Gallo K" first="K" last="Willard-Gallo">K. Willard-Gallo</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Bruxelles</settlement></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Loi, S" sort="Loi, S" uniqKey="Loi S" first="S" last="Loi">S. Loi</name><affiliation wicri:level="4"><nlm:affiliation>Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Victoria, Australia sherene.loi@petermac.org.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25214542</idno><idno type="pmid">25214542</idno><idno type="doi">10.1093/annonc/mdu450</idno><idno type="wicri:Area/PubMed/Corpus">003033</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003033</idno><idno type="wicri:Area/PubMed/Curation">002F52</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002F52</idno><idno type="wicri:Area/PubMed/Checkpoint">002F52</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002F52</idno><idno type="wicri:Area/Ncbi/Merge">001D94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.</title><author><name sortKey="Salgado, R" sort="Salgado, R" uniqKey="Salgado R" first="R" last="Salgado">R. Salgado</name><affiliation wicri:level="1"><nlm:affiliation>Breast Cancer Translational Research Laboratory/Breast International Group, Institut Jules Bordet, Brussels Department of Pathology and TCRU, GZA, Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Breast Cancer Translational Research Laboratory/Breast International Group, Institut Jules Bordet, Brussels Department of Pathology and TCRU, GZA, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Denkert, C" sort="Denkert, C" uniqKey="Denkert C" first="C" last="Denkert">C. Denkert</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pathology, Charité -University Hospital, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Charité -University Hospital, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Demaria, S" sort="Demaria, S" uniqKey="Demaria S" first="S" last="Demaria">S. Demaria</name><affiliation wicri:level="2"><nlm:affiliation>Perlmutter Cancer Center, New York University Medical School, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Perlmutter Cancer Center, New York University Medical School, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Sirtaine, N" sort="Sirtaine, N" uniqKey="Sirtaine N" first="N" last="Sirtaine">N. Sirtaine</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Bruxelles</settlement></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Klauschen, F" sort="Klauschen, F" uniqKey="Klauschen F" first="F" last="Klauschen">F. Klauschen</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pathology, Charité -University Hospital, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Charité -University Hospital, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Pruneri, G" sort="Pruneri, G" uniqKey="Pruneri G" first="G" last="Pruneri">G. Pruneri</name><affiliation wicri:level="3"><nlm:affiliation>European Institute of Oncology (IEO) and University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>European Institute of Oncology (IEO) and University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Wienert, S" sort="Wienert, S" uniqKey="Wienert S" first="S" last="Wienert">S. Wienert</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pathology, Charité -University Hospital, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Charité -University Hospital, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Van Den Eynden, G" sort="Van Den Eynden, G" uniqKey="Van Den Eynden G" first="G" last="Van Den Eynden">G. Van Den Eynden</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology GZA, TCRU Hospitals and CORE Antwerp University, Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology GZA, TCRU Hospitals and CORE Antwerp University, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Baehner, F L" sort="Baehner, F L" uniqKey="Baehner F" first="F L" last="Baehner">F L Baehner</name><affiliation wicri:level="3"><nlm:affiliation>Genomic Health, Inc., Redwood City, USA University of California San Francisco, San Francisco, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomic Health, Inc., Redwood City, USA University of California San Francisco, San Francisco</wicri:regionArea><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Penault Llorca, F" sort="Penault Llorca, F" uniqKey="Penault Llorca F" first="F" last="Penault-Llorca">F. Penault-Llorca</name><affiliation wicri:level="3"><nlm:affiliation>Clermont-Ferrand Biopathology, University of Auvergne, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Clermont-Ferrand Biopathology, University of Auvergne, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Perez, E A" sort="Perez, E A" uniqKey="Perez E" first="E A" last="Perez">E A Perez</name><affiliation><nlm:affiliation>Division of Haematology/Medical Oncology and.</nlm:affiliation><wicri:noCountry code="no comma">Division of Haematology/Medical Oncology and.</wicri:noCountry></affiliation></author><author><name sortKey="Thompson, E A" sort="Thompson, E A" uniqKey="Thompson E" first="E A" last="Thompson">E A Thompson</name><affiliation><nlm:affiliation>Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville.</nlm:affiliation><wicri:noCountry code="subField">Jacksonville</wicri:noCountry></affiliation></author><author><name sortKey="Symmans, W F" sort="Symmans, W F" uniqKey="Symmans W" first="W F" last="Symmans">W F Symmans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, The UT M.D. Anderson Cancer Center, Boston.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Department of Pathology, The UT M.D. Anderson Cancer Center</wicri:orgArea></affiliation></author><author><name sortKey="Richardson, A L" sort="Richardson, A L" uniqKey="Richardson A" first="A L" last="Richardson">A L Richardson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Brigham and Women's Hospital, Boston Department of Cancer Biology, Dana Farber Cancer Institute, Boston.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Department of Pathology, Brigham and Women's Hospital, Boston Department of Cancer Biology, Dana Farber Cancer Institute</wicri:orgArea></affiliation></author><author><name sortKey="Brock, J" sort="Brock, J" uniqKey="Brock J" first="J" last="Brock">J. Brock</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cancer Biology, Dana Farber Cancer Institute, Boston Department of Cancer Biology, Harvard Medical School, Boston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Biology, Dana Farber Cancer Institute, Boston Department of Cancer Biology, Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Criscitiello, C" sort="Criscitiello, C" uniqKey="Criscitiello C" first="C" last="Criscitiello">C. Criscitiello</name><affiliation wicri:level="3"><nlm:affiliation>Istituto Europeo di Oncologia, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Europeo di Oncologia, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bailey, H" sort="Bailey, H" uniqKey="Bailey H" first="H" last="Bailey">H. Bailey</name><affiliation wicri:level="1"><nlm:affiliation>Genomic Health, Inc., Redwood City, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomic Health, Inc., Redwood City</wicri:regionArea><wicri:noRegion>Redwood City</wicri:noRegion></affiliation></author><author><name sortKey="Ignatiadis, M" sort="Ignatiadis, M" uniqKey="Ignatiadis M" first="M" last="Ignatiadis">M. Ignatiadis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels.</nlm:affiliation><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><wicri:orgArea>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles</wicri:orgArea></affiliation></author><author><name sortKey="Floris, G" sort="Floris, G" uniqKey="Floris G" first="G" last="Floris">G. Floris</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospital Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, University Hospital Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Sparano, J" sort="Sparano, J" uniqKey="Sparano J" first="J" last="Sparano">J. Sparano</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Department of Obstetrics and Gynecology and Women's Health, Albert Einstein Medical Center, Bronx, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Department of Obstetrics and Gynecology and Women's Health, Albert Einstein Medical Center, Bronx</wicri:regionArea><wicri:noRegion>Bronx</wicri:noRegion></affiliation></author><author><name sortKey="Kos, Z" sort="Kos, Z" uniqKey="Kos Z" first="Z" last="Kos">Z. Kos</name><affiliation><nlm:affiliation>Laboratory Medicine Program, University Health Network, University of Toronto, Toronto.</nlm:affiliation><wicri:noCountry code="subField">Toronto</wicri:noCountry></affiliation></author><author><name sortKey="Nielsen, T" sort="Nielsen, T" uniqKey="Nielsen T" first="T" last="Nielsen">T. Nielsen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Rimm, D L" sort="Rimm, D L" uniqKey="Rimm D" first="D L" last="Rimm">D L Rimm</name><affiliation><nlm:affiliation>Department of Pathology, Yale University School of Medicine, New Haven.</nlm:affiliation><wicri:noCountry code="subField">New Haven</wicri:noCountry></affiliation></author><author><name sortKey="Allison, K H" sort="Allison, K H" uniqKey="Allison K" first="K H" last="Allison">K H Allison</name><affiliation><nlm:affiliation>Department of Pathology, Stanford University Medical Centre, Stanford.</nlm:affiliation><wicri:noCountry code="subField">Stanford</wicri:noCountry></affiliation></author><author><name sortKey="Reis Filho, J S" sort="Reis Filho, J S" uniqKey="Reis Filho J" first="J S" last="Reis-Filho">J S Reis-Filho</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Loibl, S" sort="Loibl, S" uniqKey="Loibl S" first="S" last="Loibl">S. Loibl</name><affiliation wicri:level="1"><nlm:affiliation>German Breast Group, Neu-Isenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Breast Group, Neu-Isenburg</wicri:regionArea><wicri:noRegion>Neu-Isenburg</wicri:noRegion><wicri:noRegion>Neu-Isenburg</wicri:noRegion><wicri:noRegion>Neu-Isenburg</wicri:noRegion></affiliation></author><author><name sortKey="Sotiriou, C" sort="Sotiriou, C" uniqKey="Sotiriou C" first="C" last="Sotiriou">C. Sotiriou</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels.</nlm:affiliation><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><wicri:orgArea>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles</wicri:orgArea></affiliation></author><author><name sortKey="Viale, G" sort="Viale, G" uniqKey="Viale G" first="G" last="Viale">G. Viale</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Badve, S" sort="Badve, S" uniqKey="Badve S" first="S" last="Badve">S. Badve</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis</wicri:regionArea><wicri:noRegion>Indianapolis</wicri:noRegion></affiliation></author><author><name sortKey="Adams, S" sort="Adams, S" uniqKey="Adams S" first="S" last="Adams">S. Adams</name><affiliation wicri:level="2"><nlm:affiliation>Perlmutter Cancer Center, New York University Medical School, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Perlmutter Cancer Center, New York University Medical School, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Willard Gallo, K" sort="Willard Gallo, K" uniqKey="Willard Gallo K" first="K" last="Willard-Gallo">K. Willard-Gallo</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Bruxelles</settlement></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Loi, S" sort="Loi, S" uniqKey="Loi S" first="S" last="Loi">S. Loi</name><affiliation wicri:level="4"><nlm:affiliation>Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Victoria, Australia sherene.loi@petermac.org.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title><idno type="eISSN">1569-8041</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (immunology)</term><term>Female</term><term>Humans</term><term>Lymphocytes, Tumor-Infiltrating</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Lymphocytes TIL</term><term>Tumeurs du sein (immunologie)</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Lymphocytes, Tumor-Infiltrating</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Lymphocytes TIL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer (BC) is gaining momentum as evidence strengthens for the clinical relevance of this immunological biomarker. Accumulating evidence suggests that the extent of lymphocytic infiltration in tumor tissue can be assessed as a major parameter by evaluation of hematoxylin and eosin (H&E)-stained tumor sections. TILs have been shown to provide prognostic and potentially predictive value, particularly in triple-negative and human epidermal growth factor receptor 2-overexpressing BC.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25214542</PMID><DateCreated><Year>2015</Year><Month>01</Month><Day>24</Day></DateCreated><DateCompleted><Year>2016</Year><Month>02</Month><Day>24</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1569-8041</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Annals of oncology : official journal of the European Society for Medical Oncology</Title><ISOAbbreviation>Ann. Oncol.</ISOAbbreviation></Journal><ArticleTitle>The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.</ArticleTitle><Pagination><MedlinePgn>259-71</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/annonc/mdu450</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer (BC) is gaining momentum as evidence strengthens for the clinical relevance of this immunological biomarker. Accumulating evidence suggests that the extent of lymphocytic infiltration in tumor tissue can be assessed as a major parameter by evaluation of hematoxylin and eosin (H&E)-stained tumor sections. TILs have been shown to provide prognostic and potentially predictive value, particularly in triple-negative and human epidermal growth factor receptor 2-overexpressing BC.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">A standardized methodology for evaluating TILs is now needed as a prerequisite for integrating this parameter in standard histopathological practice, in a research setting as well as in clinical trials. This article reviews current data on the clinical validity and utility of TILs in BC in an effort to foster better knowledge and insight in this rapidly evolving field, and to develop a standardized methodology for visual assessment on H&E sections, acknowledging the future potential of molecular/multiplexed approaches.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The methodology provided is sufficiently detailed to offer a uniformly applied, pragmatic starting point and improve consistency and reproducibility in the measurement of TILs for future studies.</AbstractText><CopyrightInformation>© The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Salgado</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Breast Cancer Translational Research Laboratory/Breast International Group, Institut Jules Bordet, Brussels Department of Pathology and TCRU, GZA, Antwerp, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Denkert</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Pathology, Charité -University Hospital, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demaria</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Perlmutter Cancer Center, New York University Medical School, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sirtaine</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klauschen</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institute of Pathology, Charité -University Hospital, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pruneri</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>European Institute of Oncology (IEO) and University of Milan, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wienert</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Pathology, Charité -University Hospital, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van den Eynden</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Pathology GZA, TCRU Hospitals and CORE Antwerp University, Antwerp, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baehner</LastName><ForeName>F L</ForeName><Initials>FL</Initials><AffiliationInfo><Affiliation>Genomic Health, Inc., Redwood City, USA University of California San Francisco, San Francisco, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Penault-Llorca</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Clermont-Ferrand Biopathology, University of Auvergne, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perez</LastName><ForeName>E A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Division of Haematology/Medical Oncology and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>E A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Symmans</LastName><ForeName>W F</ForeName><Initials>WF</Initials><AffiliationInfo><Affiliation>Department of Pathology, The UT M.D. Anderson Cancer Center, Boston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richardson</LastName><ForeName>A L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Pathology, Brigham and Women's Hospital, Boston Department of Cancer Biology, Dana Farber Cancer Institute, Boston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brock</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Cancer Biology, Dana Farber Cancer Institute, Boston Department of Cancer Biology, Harvard Medical School, Boston, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Criscitiello</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Istituto Europeo di Oncologia, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bailey</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Genomic Health, Inc., Redwood City, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ignatiadis</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Floris</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Pathology, University Hospital Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sparano</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medicine, Department of Obstetrics and Gynecology and Women's Health, Albert Einstein Medical Center, Bronx, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kos</LastName><ForeName>Z</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Laboratory Medicine Program, University Health Network, University of Toronto, Toronto.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nielsen</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rimm</LastName><ForeName>D L</ForeName><Initials>DL</Initials><AffiliationInfo><Affiliation>Department of Pathology, Yale University School of Medicine, New Haven.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allison</LastName><ForeName>K H</ForeName><Initials>KH</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University Medical Centre, Stanford.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reis-Filho</LastName><ForeName>J S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loibl</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>German Breast Group, Neu-Isenburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sotiriou</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viale</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Badve</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adams</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Perlmutter Cancer Center, New York University Medical School, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willard-Gallo</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loi</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Victoria, Australia sherene.loi@petermac.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>International TILs Working Group 2014</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017065">Practice Guideline</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>09</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ann Oncol</MedlineTA><NlmUniqueID>9007735</NlmUniqueID><ISSNLinking>0923-7534</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Ann Oncol. 2015 Nov;26(11):2351</RefSource><PMID Version="1">26347098</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016246" MajorTopicYN="Y">Lymphocytes, Tumor-Infiltrating</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">breast cancer (BC)</Keyword><Keyword MajorTopicYN="N">clinical validity</Keyword><Keyword MajorTopicYN="N">prediction</Keyword><Keyword MajorTopicYN="N">prognosis</Keyword><Keyword MajorTopicYN="N">tumor-infiltrating lymphocytes (TILs)</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25214542</ArticleId><ArticleId IdType="pii">mdu450</ArticleId><ArticleId IdType="doi">10.1093/annonc/mdu450</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>France</li><li>Italie</li><li>États-Unis</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li><li>Berlin</li><li>Californie</li><li>Lombardie</li><li>Massachusetts</li><li>Région de Bruxelles-Capitale</li><li>Victoria (État)</li><li>État de New York</li></region><settlement><li>Berlin</li><li>Boston</li><li>Bruxelles</li><li>Clermont-Ferrand</li><li>Melbourne</li><li>Milan</li><li>San Francisco</li></settlement><orgName><li>Université de Melbourne</li><li>Université libre de Bruxelles</li></orgName></list><tree><noCountry><name sortKey="Allison, K H" sort="Allison, K H" uniqKey="Allison K" first="K H" last="Allison">K H Allison</name><name sortKey="Kos, Z" sort="Kos, Z" uniqKey="Kos Z" first="Z" last="Kos">Z. Kos</name><name sortKey="Perez, E A" sort="Perez, E A" uniqKey="Perez E" first="E A" last="Perez">E A Perez</name><name sortKey="Rimm, D L" sort="Rimm, D L" uniqKey="Rimm D" first="D L" last="Rimm">D L Rimm</name><name sortKey="Thompson, E A" sort="Thompson, E A" uniqKey="Thompson E" first="E A" last="Thompson">E A Thompson</name></noCountry><country name="Belgique"><noRegion><name sortKey="Salgado, R" sort="Salgado, R" uniqKey="Salgado R" first="R" last="Salgado">R. Salgado</name></noRegion><name sortKey="Floris, G" sort="Floris, G" uniqKey="Floris G" first="G" last="Floris">G. Floris</name><name sortKey="Ignatiadis, M" sort="Ignatiadis, M" uniqKey="Ignatiadis M" first="M" last="Ignatiadis">M. Ignatiadis</name><name sortKey="Sirtaine, N" sort="Sirtaine, N" uniqKey="Sirtaine N" first="N" last="Sirtaine">N. Sirtaine</name><name sortKey="Sotiriou, C" sort="Sotiriou, C" uniqKey="Sotiriou C" first="C" last="Sotiriou">C. Sotiriou</name><name sortKey="Van Den Eynden, G" sort="Van Den Eynden, G" uniqKey="Van Den Eynden G" first="G" last="Van Den Eynden">G. Van Den Eynden</name><name sortKey="Willard Gallo, K" sort="Willard Gallo, K" uniqKey="Willard Gallo K" first="K" last="Willard-Gallo">K. Willard-Gallo</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Denkert, C" sort="Denkert, C" uniqKey="Denkert C" first="C" last="Denkert">C. Denkert</name></region><name sortKey="Klauschen, F" sort="Klauschen, F" uniqKey="Klauschen F" first="F" last="Klauschen">F. Klauschen</name><name sortKey="Loibl, S" sort="Loibl, S" uniqKey="Loibl S" first="S" last="Loibl">S. Loibl</name><name sortKey="Wienert, S" sort="Wienert, S" uniqKey="Wienert S" first="S" last="Wienert">S. Wienert</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Demaria, S" sort="Demaria, S" uniqKey="Demaria S" first="S" last="Demaria">S. Demaria</name></region><name sortKey="Adams, S" sort="Adams, S" uniqKey="Adams S" first="S" last="Adams">S. Adams</name><name sortKey="Badve, S" sort="Badve, S" uniqKey="Badve S" first="S" last="Badve">S. Badve</name><name sortKey="Baehner, F L" sort="Baehner, F L" uniqKey="Baehner F" first="F L" last="Baehner">F L Baehner</name><name sortKey="Bailey, H" sort="Bailey, H" uniqKey="Bailey H" first="H" last="Bailey">H. Bailey</name><name sortKey="Brock, J" sort="Brock, J" uniqKey="Brock J" first="J" last="Brock">J. Brock</name><name sortKey="Reis Filho, J S" sort="Reis Filho, J S" uniqKey="Reis Filho J" first="J S" last="Reis-Filho">J S Reis-Filho</name><name sortKey="Richardson, A L" sort="Richardson, A L" uniqKey="Richardson A" first="A L" last="Richardson">A L Richardson</name><name sortKey="Sparano, J" sort="Sparano, J" uniqKey="Sparano J" first="J" last="Sparano">J. Sparano</name><name sortKey="Symmans, W F" sort="Symmans, W F" uniqKey="Symmans W" first="W F" last="Symmans">W F Symmans</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Pruneri, G" sort="Pruneri, G" uniqKey="Pruneri G" first="G" last="Pruneri">G. Pruneri</name></region><name sortKey="Criscitiello, C" sort="Criscitiello, C" uniqKey="Criscitiello C" first="C" last="Criscitiello">C. Criscitiello</name><name sortKey="Viale, G" sort="Viale, G" uniqKey="Viale G" first="G" last="Viale">G. Viale</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Penault Llorca, F" sort="Penault Llorca, F" uniqKey="Penault Llorca F" first="F" last="Penault-Llorca">F. Penault-Llorca</name></region></country><country name="Canada"><noRegion><name sortKey="Nielsen, T" sort="Nielsen, T" uniqKey="Nielsen T" first="T" last="Nielsen">T. Nielsen</name></noRegion></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Loi, S" sort="Loi, S" uniqKey="Loi S" first="S" last="Loi">S. Loi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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