AustralieFrV1, Main, Merge, bibRecord, 00E613

The γδ T Lymphocytes of the Perinatal Murine Thymus

Identifieur interne : 00E613 ( Main/Merge ); précédent : 00E612; suivant : 00E614

The γδ T Lymphocytes of the Perinatal Murine Thymus

Auteurs : Michelle I. Zorbas [Australie, France] ; Roland Scollay [Australie]

Source :

Developmental Immunology [ 1044-6672 ] ; 1995.

RBID : PMC:2275952

Abstract

We have previously shown that the adult thymus contains three subsets of γδ T cells that can be defined by the expression of Thy-1 and heat-stable antigen (HSA). In this study, the number of cells in each of these thymic γδ populations was investigated at different stages throughout life. In adult mice, the populations stayed relatively constant, however, in contrast, there were major variations in them early in development. It was shown that only two of the γδ populations were present in the prenatal thymus, a major population of Thy-1⁺ HSA^- cells, and a smaller population of Thy-1⁺ HSA^- cells. However, after birth, most of the Thy-1⁺ HSA^-cells appear to loose the Thy-1 antigen, forming the third population of HSA^- Thy-1^-cells. The adult configuration of populations appeared to be established within the first week after birth. Therefore, whereas the γδ populations stayed relatively constant from this time point onwards, there were major variations early in development. Throughout life, most γδ thymocytes are CD4^- CD8^-, however, in the neonatal thymus, there are some CD4⁺ and CD8⁺ γδ thymocytes, and these are contained in the Thy-1⁺ HSA^- population.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275952

DOI: 10.1155/1995/57536
PubMed: 9700359
PubMed Central: 2275952

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: 000718
to stream Pmc, to step Curation: 000717
to stream Pmc, to step Checkpoint: 002D92
to stream Ncbi, to step Merge: 005246
to stream Ncbi, to step Curation: 005246
to stream Ncbi, to step Checkpoint: 005246

Links to Exploration step

PMC:2275952

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The γδ T Lymphocytes of the Perinatal Murine Thymus</title>
<author><name sortKey="Zorbas, Michelle I" sort="Zorbas, Michelle I" uniqKey="Zorbas M" first="Michelle I." last="Zorbas">Michelle I. Zorbas</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Walter and Eliza Hall Institute of Medical Research</addr-line>
<addr-line>Post Office Royal Melbourne Hospital</addr-line>
<addr-line>Victoria</addr-line>
<addr-line>3050</addr-line>
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>INSERM U345 CHU Necker</addr-line>
<addr-line>156 rue de Vaugirard</addr-line>
<addr-line>Paris Cedex 15</addr-line>
<addr-line>75730</addr-line>
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Scollay, Roland" sort="Scollay, Roland" uniqKey="Scollay R" first="Roland" last="Scollay">Roland Scollay</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>The Centenary Institute of Cancer Medicine and Cell Biology</addr-line>
<addr-line>Locked Bag No. 6</addr-line>
<addr-line>Newtown</addr-line>
<addr-line>NSW 2042</addr-line>
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">9700359</idno>
<idno type="pmc">2275952</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275952</idno>
<idno type="RBID">PMC:2275952</idno>
<idno type="doi">10.1155/1995/57536</idno>
<date when="1995">1995</date>
<idno type="wicri:Area/Pmc/Corpus">000718</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000718</idno>
<idno type="wicri:Area/Pmc/Curation">000717</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000717</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002D92</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002D92</idno>
<idno type="wicri:Area/Ncbi/Merge">005246</idno>
<idno type="wicri:Area/Ncbi/Curation">005246</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">005246</idno>
<idno type="wicri:doubleKey">1044-6672:1995:Zorbas M:the:t:lymphocytes</idno>
<idno type="wicri:Area/Main/Merge">00E613</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The γδ T Lymphocytes of the Perinatal Murine Thymus</title>
<author><name sortKey="Zorbas, Michelle I" sort="Zorbas, Michelle I" uniqKey="Zorbas M" first="Michelle I." last="Zorbas">Michelle I. Zorbas</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Walter and Eliza Hall Institute of Medical Research</addr-line>
<addr-line>Post Office Royal Melbourne Hospital</addr-line>
<addr-line>Victoria</addr-line>
<addr-line>3050</addr-line>
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>INSERM U345 CHU Necker</addr-line>
<addr-line>156 rue de Vaugirard</addr-line>
<addr-line>Paris Cedex 15</addr-line>
<addr-line>75730</addr-line>
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Scollay, Roland" sort="Scollay, Roland" uniqKey="Scollay R" first="Roland" last="Scollay">Roland Scollay</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>The Centenary Institute of Cancer Medicine and Cell Biology</addr-line>
<addr-line>Locked Bag No. 6</addr-line>
<addr-line>Newtown</addr-line>
<addr-line>NSW 2042</addr-line>
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Developmental Immunology</title>
<idno type="ISSN">1044-6672</idno>
<imprint><date when="1995">1995</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>We have previously shown that the adult thymus contains three subsets of γδ T cells that
can be defined by the expression of Thy-1 and heat-stable antigen (HSA). In this study, the
number of cells in each of these thymic γδ populations was investigated at different stages
throughout life. In adult mice, the populations stayed relatively constant, however, in
contrast, there were major variations in them early in development. It was shown that only
two of the γδ populations were present in the prenatal thymus, a major population of
Thy-1<sup>+</sup>
 HSA<sup>-</sup>
 cells, and a smaller population of Thy-1<sup>+</sup>
 HSA<sup>-</sup> cells. However, after birth,
most of the Thy-1<sup>+</sup>
 HSA<sup>-</sup>cells appear to loose the Thy-1 antigen, forming the third
population of HSA<sup>-</sup>
 Thy-1<sup>-</sup>cells. The adult configuration of populations appeared to be
established within the first week after birth. Therefore, whereas the γδ populations stayed
relatively constant from this time point onwards, there were major variations early in
development. Throughout life, most γδ thymocytes are CD4<sup>-</sup>
 CD8<sup>-</sup>, however, in the
neonatal thymus, there are some CD4<sup>+</sup>
 and CD8<sup>+</sup> γδ thymocytes, and these are contained
in the Thy-1<sup>+</sup>
 HSA<sup>-</sup>
 population.</p>
</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00E613 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 00E613 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     PMC:2275952
   |texte=   The γδ T Lymphocytes of the Perinatal Murine Thymus
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i   -Sk "pubmed:9700359" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

The γδ T Lymphocytes of the Perinatal Murine Thymus

The γδ T Lymphocytes of the Perinatal Murine Thymus

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki