The γδ T Lymphocytes of the Perinatal Murine Thymus
Identifieur interne : 005246 ( Ncbi/Merge ); précédent : 005245; suivant : 005247The γδ T Lymphocytes of the Perinatal Murine Thymus
Auteurs : Michelle I. Zorbas [Australie, France] ; Roland Scollay [Australie]Source :
- Developmental Immunology [ 1044-6672 ] ; 1995.
Abstract
We have previously shown that the adult thymus contains three subsets of γδ T cells that can be defined by the expression of Thy-1 and heat-stable antigen (HSA). In this study, the number of cells in each of these thymic γδ populations was investigated at different stages throughout life. In adult mice, the populations stayed relatively constant, however, in contrast, there were major variations in them early in development. It was shown that only two of the γδ populations were present in the prenatal thymus, a major population of Thy-1+ HSA- cells, and a smaller population of Thy-1+ HSA- cells. However, after birth, most of the Thy-1+ HSA-cells appear to loose the Thy-1 antigen, forming the third population of HSA- Thy-1-cells. The adult configuration of populations appeared to be established within the first week after birth. Therefore, whereas the γδ populations stayed relatively constant from this time point onwards, there were major variations early in development. Throughout life, most γδ thymocytes are CD4- CD8-, however, in the neonatal thymus, there are some CD4+ and CD8+ γδ thymocytes, and these are contained in the Thy-1+ HSA- population.
Url:
DOI: 10.1155/1995/57536
PubMed: 9700359
PubMed Central: 2275952
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<author><name sortKey="Zorbas, Michelle I" sort="Zorbas, Michelle I" uniqKey="Zorbas M" first="Michelle I." last="Zorbas">Michelle I. Zorbas</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Walter and Eliza Hall Institute of Medical Research</addr-line>
<addr-line>Post Office Royal Melbourne Hospital</addr-line>
<addr-line>Victoria</addr-line>
<addr-line>3050</addr-line>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>INSERM U345 CHU Necker</addr-line>
<addr-line>156 rue de Vaugirard</addr-line>
<addr-line>Paris Cedex 15</addr-line>
<addr-line>75730</addr-line>
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<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Scollay, Roland" sort="Scollay, Roland" uniqKey="Scollay R" first="Roland" last="Scollay">Roland Scollay</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>The Centenary Institute of Cancer Medicine and Cell Biology</addr-line>
<addr-line>Locked Bag No. 6</addr-line>
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<addr-line>NSW 2042</addr-line>
<country>Australia</country>
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<addr-line>Post Office Royal Melbourne Hospital</addr-line>
<addr-line>Victoria</addr-line>
<addr-line>3050</addr-line>
<country>Australia</country>
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<country xml:lang="fr">Australie</country>
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<addr-line>156 rue de Vaugirard</addr-line>
<addr-line>Paris Cedex 15</addr-line>
<addr-line>75730</addr-line>
<country>France</country>
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<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Scollay, Roland" sort="Scollay, Roland" uniqKey="Scollay R" first="Roland" last="Scollay">Roland Scollay</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>The Centenary Institute of Cancer Medicine and Cell Biology</addr-line>
<addr-line>Locked Bag No. 6</addr-line>
<addr-line>Newtown</addr-line>
<addr-line>NSW 2042</addr-line>
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<series><title level="j">Developmental Immunology</title>
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<front><div type="abstract" xml:lang="en"><p>We have previously shown that the adult thymus contains three subsets of γδ T cells that
can be defined by the expression of Thy-1 and heat-stable antigen (HSA). In this study, the
number of cells in each of these thymic γδ populations was investigated at different stages
throughout life. In adult mice, the populations stayed relatively constant, however, in
contrast, there were major variations in them early in development. It was shown that only
two of the γδ populations were present in the prenatal thymus, a major population of
Thy-1<sup>+</sup>
HSA<sup>-</sup>
cells, and a smaller population of Thy-1<sup>+</sup>
HSA<sup>-</sup>
cells. However, after birth,
most of the Thy-1<sup>+</sup>
HSA<sup>-</sup>
cells appear to loose the Thy-1 antigen, forming the third
population of HSA<sup>-</sup>
Thy-1<sup>-</sup>
cells. The adult configuration of populations appeared to be
established within the first week after birth. Therefore, whereas the γδ populations stayed
relatively constant from this time point onwards, there were major variations early in
development. Throughout life, most γδ thymocytes are CD4<sup>-</sup>
CD8<sup>-</sup>
, however, in the
neonatal thymus, there are some CD4<sup>+</sup>
and CD8<sup>+</sup>
γδ thymocytes, and these are contained
in the Thy-1<sup>+</sup>
HSA<sup>-</sup>
population.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Dev Immunol</journal-id>
<journal-title>Developmental Immunology</journal-title>
<issn pub-type="ppub">1044-6672</issn>
<publisher><publisher-name>Hindawi Publishing Corporation</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">9700359</article-id>
<article-id pub-id-type="pmc">2275952</article-id>
<article-id pub-id-type="pii">S1740252295575365</article-id>
<article-id pub-id-type="doi">10.1155/1995/57536</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The γδ T Lymphocytes of the Perinatal Murine Thymus</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Zorbas</surname>
<given-names>Michelle I.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Scollay</surname>
<given-names>Roland</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>The Walter and Eliza Hall Institute of Medical Research</addr-line>
<addr-line>Post Office Royal Melbourne Hospital</addr-line>
<addr-line>Victoria</addr-line>
<addr-line>3050</addr-line>
<country>Australia</country>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>The Centenary Institute of Cancer Medicine and Cell Biology</addr-line>
<addr-line>Locked Bag No. 6</addr-line>
<addr-line>Newtown</addr-line>
<addr-line>NSW 2042</addr-line>
<country>Australia</country>
</aff>
<aff id="aff3"><label>3</label>
<addr-line>INSERM U345 CHU Necker</addr-line>
<addr-line>156 rue de Vaugirard</addr-line>
<addr-line>Paris Cedex 15</addr-line>
<addr-line>75730</addr-line>
<country>France</country>
</aff>
<pub-date pub-type="ppub"><year>1995</year>
</pub-date>
<volume>4</volume>
<issue>2</issue>
<fpage>93</fpage>
<lpage>100</lpage>
<history><date date-type="received"><day>20</day>
<month>5</month>
<year>1994</year>
</date>
<date date-type="accepted"><day>24</day>
<month>8</month>
<year>1994</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 1995 Hindawi Publishing Corporation.</copyright-statement>
<copyright-year>1995</copyright-year>
<copyright-holder>Hindawi Publishing Corporation</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/"><p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p>
</license>
</permissions>
<abstract><p>We have previously shown that the adult thymus contains three subsets of γδ T cells that
can be defined by the expression of Thy-1 and heat-stable antigen (HSA). In this study, the
number of cells in each of these thymic γδ populations was investigated at different stages
throughout life. In adult mice, the populations stayed relatively constant, however, in
contrast, there were major variations in them early in development. It was shown that only
two of the γδ populations were present in the prenatal thymus, a major population of
Thy-1<sup>+</sup>
HSA<sup>-</sup>
cells, and a smaller population of Thy-1<sup>+</sup>
HSA<sup>-</sup>
cells. However, after birth,
most of the Thy-1<sup>+</sup>
HSA<sup>-</sup>
cells appear to loose the Thy-1 antigen, forming the third
population of HSA<sup>-</sup>
Thy-1<sup>-</sup>
cells. The adult configuration of populations appeared to be
established within the first week after birth. Therefore, whereas the γδ populations stayed
relatively constant from this time point onwards, there were major variations early in
development. Throughout life, most γδ thymocytes are CD4<sup>-</sup>
CD8<sup>-</sup>
, however, in the
neonatal thymus, there are some CD4<sup>+</sup>
and CD8<sup>+</sup>
γδ thymocytes, and these are contained
in the Thy-1<sup>+</sup>
HSA<sup>-</sup>
population.</p>
</abstract>
<kwd-group><kwd>γδ lymphocytes</kwd>
<kwd>heat-stable antigen</kwd>
<kwd>lymphocyte development</kwd>
<kwd>mouse thymus</kwd>
<kwd>Thy-1</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
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<tree><country name="Australie"><noRegion><name sortKey="Zorbas, Michelle I" sort="Zorbas, Michelle I" uniqKey="Zorbas M" first="Michelle I." last="Zorbas">Michelle I. Zorbas</name>
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<name sortKey="Scollay, Roland" sort="Scollay, Roland" uniqKey="Scollay R" first="Roland" last="Scollay">Roland Scollay</name>
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<country name="France"><noRegion><name sortKey="Zorbas, Michelle I" sort="Zorbas, Michelle I" uniqKey="Zorbas M" first="Michelle I." last="Zorbas">Michelle I. Zorbas</name>
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