Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice
Identifieur interne : 00CE11 ( Main/Merge ); précédent : 00CE10; suivant : 00CE12Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice
Auteurs : Catherine J. Lees [Australie] ; Vasso Apostolopoulos [Australie] ; Bruce Acres [France] ; Ian Ramshaw [Australie] ; Alistair Ramsay [Australie] ; Chin.-Swee Ong [Australie] ; Ian F. C Mckenzie [Australie]Source :
- Vaccine [ 0264-410X ] ; 2000.
Descripteurs français
- Wicri :
- topic : Vaccin.
English descriptors
- KwdEn :
- Apostolopoulos, Control muc1, Ctlp, Ctlp frequencies, Ctlp frequency, Cytotoxic, Fusion protein, Human muc1, Immune, Immune responses, Immunisation, Immunised, Immunol, Inbred, Lees, Lysis, Mannan, Mice immunised, Mouse, Muc1, Muc1 ctlp frequency, Murine, Palpable tumors, Precursor, Recombinant, Single injection, Transgenic, Transgenic mice, Tumor cells, Tumor challenge, Tumor growth, Tumor protection, Tumour, Vaccine, Vaccinia, Vaccinia virus.
- Teeft :
- Apostolopoulos, Control muc1, Ctlp, Ctlp frequencies, Ctlp frequency, Cytotoxic, Fusion protein, Human muc1, Immune, Immune responses, Immunisation, Immunised, Immunol, Inbred, Lees, Lysis, Mannan, Mice immunised, Mouse, Muc1, Muc1 ctlp frequency, Murine, Palpable tumors, Precursor, Recombinant, Single injection, Transgenic, Transgenic mice, Tumor cells, Tumor challenge, Tumor growth, Tumor protection, Tumour, Vaccine, Vaccinia, Vaccinia virus.
Abstract
Abstract: Mice immunised with oxidised mannan-MUC1 fusion protein (M-FP) develop MHC restricted CD8+ cytotoxic T cells. We now demonstrate that in MUC1/HLA-A2 transgenic mice, IL-12 gives enhanced CTL, CTLp and tumor protection. CTLp in MUC1 transgenic mice with M-FP were 1/55,000, and with IL-12, this increased to 1/19,000, with improved tumor protection. Thus, IL-12 is important for effective CTL responses to MUC1 in transgenic mice.
Url:
DOI: 10.1016/S0264-410X(00)00065-7
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<front><div type="abstract" xml:lang="en">Abstract: Mice immunised with oxidised mannan-MUC1 fusion protein (M-FP) develop MHC restricted CD8+ cytotoxic T cells. We now demonstrate that in MUC1/HLA-A2 transgenic mice, IL-12 gives enhanced CTL, CTLp and tumor protection. CTLp in MUC1 transgenic mice with M-FP were 1/55,000, and with IL-12, this increased to 1/19,000, with improved tumor protection. Thus, IL-12 is important for effective CTL responses to MUC1 in transgenic mice.</div>
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