AustralieFrV1, Istex, Checkpoint, bibRecord, 001F30

Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice

Identifieur interne : 001F30 ( Istex/Checkpoint ); précédent : 001F29; suivant : 001F31

Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice

Auteurs : Catherine J. Lees [Australie] ; Vasso Apostolopoulos [Australie] ; Bruce Acres [France] ; Ian Ramshaw [Australie] ; Alistair Ramsay [Australie] ; Chin.-Swee Ong [Australie] ; Ian F. C Mckenzie [Australie]

Source :

Vaccine [ 0264-410X ] ; 2000.

RBID : ISTEX:0436D241201D03E24ACFA04DF57DB24A63713B39

Descripteurs français

Wicri :
- topic : Vaccin.

English descriptors

KwdEn :
- Apostolopoulos, Control muc1, Ctlp, Ctlp frequencies, Ctlp frequency, Cytotoxic, Fusion protein, Human muc1, Immune, Immune responses, Immunisation, Immunised, Immunol, Inbred, Lees, Lysis, Mannan, Mice immunised, Mouse, Muc1, Muc1 ctlp frequency, Murine, Palpable tumors, Precursor, Recombinant, Single injection, Transgenic, Transgenic mice, Tumor cells, Tumor challenge, Tumor growth, Tumor protection, Tumour, Vaccine, Vaccinia, Vaccinia virus.
Teeft :
- Apostolopoulos, Control muc1, Ctlp, Ctlp frequencies, Ctlp frequency, Cytotoxic, Fusion protein, Human muc1, Immune, Immune responses, Immunisation, Immunised, Immunol, Inbred, Lees, Lysis, Mannan, Mice immunised, Mouse, Muc1, Muc1 ctlp frequency, Murine, Palpable tumors, Precursor, Recombinant, Single injection, Transgenic, Transgenic mice, Tumor cells, Tumor challenge, Tumor growth, Tumor protection, Tumour, Vaccine, Vaccinia, Vaccinia virus.

Abstract

Abstract: Mice immunised with oxidised mannan-MUC1 fusion protein (M-FP) develop MHC restricted CD8+ cytotoxic T cells. We now demonstrate that in MUC1/HLA-A2 transgenic mice, IL-12 gives enhanced CTL, CTLp and tumor protection. CTLp in MUC1 transgenic mice with M-FP were 1/55,000, and with IL-12, this increased to 1/19,000, with improved tumor protection. Thus, IL-12 is important for effective CTL responses to MUC1 in transgenic mice.

Url:

https://api.istex.fr/document/0436D241201D03E24ACFA04DF57DB24A63713B39/fulltext/pdf

DOI: 10.1016/S0264-410X(00)00065-7

Affiliations:

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ISTEX:0436D241201D03E24ACFA04DF57DB24A63713B39

Le document en format XML

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<term>Immune responses</term>
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<front><div type="abstract" xml:lang="en">Abstract: Mice immunised with oxidised mannan-MUC1 fusion protein (M-FP) develop MHC restricted CD8+ cytotoxic T cells. We now demonstrate that in MUC1/HLA-A2 transgenic mice, IL-12 gives enhanced CTL, CTLp and tumor protection. CTLp in MUC1 transgenic mice with M-FP were 1/55,000, and with IL-12, this increased to 1/19,000, with improved tumor protection. Thus, IL-12 is important for effective CTL responses to MUC1 in transgenic mice.</div>
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Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice

Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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