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Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus

Identifieur interne : 008E67 ( Main/Merge ); précédent : 008E66; suivant : 008E68

Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus

Auteurs : Dedee F. Murrell ; Sarah Dick ; A. R. Ahmed ; Masayuki Amagia ; Maria A. Barnadas ; Luca Borradori ; Jean-Claude Bystryn ; Giuseppe Cianchini ; Luis Diaz ; David Fivenson ; Russell Hall ; Karen E. Harman ; Takashi Hashimoto ; Michael Hertl ; Nico Hunzelmann ; Pilar Iranzo ; Pascal Joly ; Marcel F. Jonkman ; Yasuo Kitajima ; Neil J. Korman ; Linda K. Martin ; Daniel Mimouni ; Animesh A. Sinha ; David Sirois ; Detlef Zillikens ; Victoria P. Werth

Source :

RBID : PMC:2829665

Abstract

Our scientific knowledge of pemphigus has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define effective therapies in pemphigus. A major obstacle in comparing therapeutic outcomes between centers is the lack of generally accepted definitions and measurements for the clinical evaluation of pemphigus patients. Common terms and endpoints of pemphigus are needed so that experts in the field can accurately measure and assess disease extent, activity, severity, and therapeutic response, and thus facilitate and advance clinical trials This consensus statement from the International Pemphigus Committee represents two years of collaborative efforts to attain mutually acceptable common definitions for pemphigus. These should assist in development of consistent reporting of outcomes in future studies.


Url:
DOI: 10.1016/j.jaad.2008.01.012
PubMed: 18339444
PubMed Central: 2829665

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PMC:2829665

Le document en format XML

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<p id="P1">Our scientific knowledge of pemphigus has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define effective therapies in pemphigus. A major obstacle in comparing therapeutic outcomes between centers is the lack of generally accepted definitions and measurements for the clinical evaluation of pemphigus patients. Common terms and endpoints of pemphigus are needed so that experts in the field can accurately measure and assess disease extent, activity, severity, and therapeutic response, and thus facilitate and advance clinical trials This consensus statement from the International Pemphigus Committee represents two years of collaborative efforts to attain mutually acceptable common definitions for pemphigus. These should assist in development of consistent reporting of outcomes in future studies.</p>
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