A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease
Identifieur interne : 003D06 ( Main/Merge ); précédent : 003D05; suivant : 003D07A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease
Auteurs : Frank Jessen [Allemagne] ; Rebecca E. Amariglio [États-Unis] ; Martin Van Boxtel [Pays-Bas] ; Monique Breteler [Allemagne] ; Mathieu Ceccaldi [France] ; Gaël Chételat [France] ; Bruno Dubois [France] ; Carole Dufouil [France] ; Kathryn A. Ellis [Australie] ; Wiesje M. Van Der Flier [Pays-Bas] ; Lidia Glodzik [États-Unis] ; Argonde C. Van Harten [Pays-Bas] ; Mony J. De Leon [États-Unis] ; Pauline Mchugh [États-Unis] ; Michelle M. Mielke [États-Unis] ; Jose Luis Molinuevo [Espagne] ; Lisa Mosconi [États-Unis] ; Ricardo S. Osorio [États-Unis] ; Audrey Perrotin [France] ; Ronald C. Petersen [États-Unis] ; Laura A. Rabin [États-Unis] ; Lorena Rami [Espagne] ; Barry Reisberg [États-Unis] ; Dorene M. Rentz [États-Unis] ; Perminder S. Sachdev [Australie] ; Vincent De La Sayette [France] ; Andrew J. Saykin [États-Unis] ; Philip Scheltens [Pays-Bas] ; Melanie B. Shulman [États-Unis] ; Melissa J. Slavin [Australie] ; Reisa A. Sperling [États-Unis] ; Robert Stewart [Royaume-Uni] ; Olga Uspenskaya [France] ; Bruno Vellas [France] ; Pieter Jelle Visser [Pays-Bas] ; Michael Wagner [Allemagne]Source :
- Alzheimer's & dementia : the journal of the Alzheimer's Association [ 1552-5260 ] ; 2014.
Descripteurs français
- KwdFr :
- Femelle, Humains, Maladie d'Alzheimer (physiopathologie), Mâle, Symptômes prodromiques, Terminologie comme sujet, Tests neuropsychologiques, Troubles de la cognition (diagnostic), Troubles de la cognition (physiopathologie), Âge de début, Échelles d'évaluation en psychiatrie, Évolution de la maladie.
- MESH :
English descriptors
- KwdEn :
- MESH :
- diagnosis : Cognition Disorders.
- physiopathology : Alzheimer Disease, Cognition Disorders.
- Age of Onset, Disease Progression, Female, Humans, Male, Neuropsychological Tests, Prodromal Symptoms, Psychiatric Status Rating Scales, Terminology as Topic.
Abstract
There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer’s disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD
Url:
DOI: 10.1016/j.jalz.2014.01.001
PubMed: 24798886
PubMed Central: 4317324
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PMC:4317324Le document en format XML
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<author><name sortKey="Mchugh, Pauline" sort="Mchugh, Pauline" uniqKey="Mchugh P" first="Pauline" last="Mchugh">Pauline Mchugh</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, New York University Langone Medical Center, New York, NY</wicri:regionArea>
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<author><name sortKey="Mielke, Michelle M" sort="Mielke, Michelle M" uniqKey="Mielke M" first="Michelle M." last="Mielke">Michelle M. Mielke</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, MN</wicri:regionArea>
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<author><name sortKey="Molinuevo, Jose Luis" sort="Molinuevo, Jose Luis" uniqKey="Molinuevo J" first="Jose Luis" last="Molinuevo">Jose Luis Molinuevo</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, New York University Langone Medical Center, New York, NY</wicri:regionArea>
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<author><name sortKey="Osorio, Ricardo S" sort="Osorio, Ricardo S" uniqKey="Osorio R" first="Ricardo S." last="Osorio">Ricardo S. Osorio</name>
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<author><name sortKey="Perrotin, Audrey" sort="Perrotin, Audrey" uniqKey="Perrotin A" first="Audrey" last="Perrotin">Audrey Perrotin</name>
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<affiliation wicri:level="4"><nlm:aff id="A8">Université de Caen Basse-Normandie, UMR-S1077, Caen, France</nlm:aff>
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<affiliation wicri:level="3"><nlm:aff id="A10">CHU de Caen, U1077, Caen, France</nlm:aff>
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<author><name sortKey="Rabin, Laura A" sort="Rabin, Laura A" uniqKey="Rabin L" first="Laura A." last="Rabin">Laura A. Rabin</name>
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<affiliation wicri:level="2"><nlm:aff id="A20">The Graduate Center of The City University of New York, New York, NY, USA</nlm:aff>
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<author><name sortKey="Rami, Lorena" sort="Rami, Lorena" uniqKey="Rami L" first="Lorena" last="Rami">Lorena Rami</name>
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<country xml:lang="fr">Espagne</country>
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<author><name sortKey="Reisberg, Barry" sort="Reisberg, Barry" uniqKey="Reisberg B" first="Barry" last="Reisberg">Barry Reisberg</name>
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<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="2"><nlm:aff id="A21">Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY</wicri:regionArea>
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<author><name sortKey="Rentz, Dorene M" sort="Rentz, Dorene M" uniqKey="Rentz D" first="Dorene M." last="Rentz">Dorene M. Rentz</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Harvard Medical School, Brigham and Women’s Hospital, Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Harvard Medical School, Brigham and Women’s Hospital, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
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<author><name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S." last="Sachdev">Perminder S. Sachdev</name>
<affiliation wicri:level="3"><nlm:aff id="A22">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
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<author><name sortKey="De La Sayette, Vincent" sort="De La Sayette, Vincent" uniqKey="De La Sayette V" first="Vincent" last="De La Sayette">Vincent De La Sayette</name>
<affiliation wicri:level="3"><nlm:aff id="A7">INSERM, U1077, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U1077, Caen</wicri:regionArea>
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<settlement type="city">Caen</settlement>
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<wicri:regionArea>Ecole Pratique des Hautes Etudes, UMR-S1077, Caen</wicri:regionArea>
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</placeName>
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<author><name sortKey="Shulman, Melanie B" sort="Shulman, Melanie B" uniqKey="Shulman M" first="Melanie B." last="Shulman">Melanie B. Shulman</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, New York University Langone Medical Center, New York, NY</wicri:regionArea>
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</placeName>
</affiliation>
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<author><name sortKey="Slavin, Melissa J" sort="Slavin, Melissa J" uniqKey="Slavin M" first="Melissa J." last="Slavin">Melissa J. Slavin</name>
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<wicri:regionArea>Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney</wicri:regionArea>
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</placeName>
</affiliation>
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<author><name sortKey="Sperling, Reisa A" sort="Sperling, Reisa A" uniqKey="Sperling R" first="Reisa A." last="Sperling">Reisa A. Sperling</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Harvard Medical School, Brigham and Women’s Hospital, Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Harvard Medical School, Brigham and Women’s Hospital, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
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</placeName>
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</author>
<author><name sortKey="Stewart, Robert" sort="Stewart, Robert" uniqKey="Stewart R" first="Robert" last="Stewart">Robert Stewart</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychiatry, King’s College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
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</placeName>
</affiliation>
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<wicri:regionArea>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A14">Alzheimer Center, Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff>
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<wicri:regionArea>Alzheimer Center, Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam</wicri:regionArea>
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<author><name sortKey="Wagner, Michael" sort="Wagner, Michael" uniqKey="Wagner M" first="Michael" last="Wagner">Michael Wagner</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease</title>
<author><name sortKey="Jessen, Frank" sort="Jessen, Frank" uniqKey="Jessen F" first="Frank" last="Jessen">Frank Jessen</name>
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</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Clinical Treatment and Research Center for Neurodegenerative Disease (KBFZ), University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinical Treatment and Research Center for Neurodegenerative Disease (KBFZ), University of Bonn, Bonn</wicri:regionArea>
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<affiliation wicri:level="3"><nlm:aff id="A3">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
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<author><name sortKey="Amariglio, Rebecca E" sort="Amariglio, Rebecca E" uniqKey="Amariglio R" first="Rebecca E." last="Amariglio">Rebecca E. Amariglio</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Harvard Medical School, Brigham and Women’s Hospital, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Van Boxtel, Martin" sort="Van Boxtel, Martin" uniqKey="Van Boxtel M" first="Martin" last="Van Boxtel">Martin Van Boxtel</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Breteler, Monique" sort="Breteler, Monique" uniqKey="Breteler M" first="Monique" last="Breteler">Monique Breteler</name>
<affiliation wicri:level="3"><nlm:aff id="A3">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ceccaldi, Mathieu" sort="Ceccaldi, Mathieu" uniqKey="Ceccaldi M" first="Mathieu" last="Ceccaldi">Mathieu Ceccaldi</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Institut des Neurosciences des Systèmes, Université de Marseille, Marseille</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U1077, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
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<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A8">Université de Caen Basse-Normandie, UMR-S1077, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Caen Basse-Normandie, UMR-S1077, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
<settlement type="city">Caen</settlement>
</placeName>
<orgName type="university">Université de Caen Basse-Normandie</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A9">Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Ecole Pratique des Hautes Etudes, UMR-S1077, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A10">CHU de Caen, U1077, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Caen, U1077, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name>
<affiliation wicri:level="4"><nlm:aff id="A11">Université Pierre et Marie Curie, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Pierre et Marie Curie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Pierre-et-Marie-Curie</orgName>
</affiliation>
</author>
<author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="3"><nlm:aff id="A12">INSERM U708, Neuroepidemiology, CIC-EC7 and Bordeaux University, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U708, Neuroepidemiology, CIC-EC7 and Bordeaux University, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ellis, Kathryn A" sort="Ellis, Kathryn A" uniqKey="Ellis K" first="Kathryn A." last="Ellis">Kathryn A. Ellis</name>
<affiliation wicri:level="4"><nlm:aff id="A13">Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Van Der Flier, Wiesje M" sort="Van Der Flier, Wiesje M" uniqKey="Van Der Flier W" first="Wiesje M." last="Van Der Flier">Wiesje M. Van Der Flier</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Alzheimer Center, Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Glodzik, Lidia" sort="Glodzik, Lidia" uniqKey="Glodzik L" first="Lidia" last="Glodzik">Lidia Glodzik</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, New York University Langone Medical Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Harten, Argonde C" sort="Van Harten, Argonde C" uniqKey="Van Harten A" first="Argonde C." last="Van Harten">Argonde C. Van Harten</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Alzheimer Center, Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Alzheimer Center, Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Leon, Mony J" sort="De Leon, Mony J" uniqKey="De Leon M" first="Mony J." last="De Leon">Mony J. De Leon</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, New York University Langone Medical Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mchugh, Pauline" sort="Mchugh, Pauline" uniqKey="Mchugh P" first="Pauline" last="Mchugh">Pauline Mchugh</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, New York University Langone Medical Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mielke, Michelle M" sort="Mielke, Michelle M" uniqKey="Mielke M" first="Michelle M." last="Mielke">Michelle M. Mielke</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Molinuevo, Jose Luis" sort="Molinuevo, Jose Luis" uniqKey="Molinuevo J" first="Jose Luis" last="Molinuevo">Jose Luis Molinuevo</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Alzheimer’s Disease and Other Cognitive Disorders Unit, IDIBAPS, Hospital Clinic, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
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<author><name sortKey="Mosconi, Lisa" sort="Mosconi, Lisa" uniqKey="Mosconi L" first="Lisa" last="Mosconi">Lisa Mosconi</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, New York University Langone Medical Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Osorio, Ricardo S" sort="Osorio, Ricardo S" uniqKey="Osorio R" first="Ricardo S." last="Osorio">Ricardo S. Osorio</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, New York University Langone Medical Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perrotin, Audrey" sort="Perrotin, Audrey" uniqKey="Perrotin A" first="Audrey" last="Perrotin">Audrey Perrotin</name>
<affiliation wicri:level="3"><nlm:aff id="A7">INSERM, U1077, Caen, France</nlm:aff>
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<wicri:regionArea>Université de Caen Basse-Normandie, UMR-S1077, Caen</wicri:regionArea>
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<settlement type="city">Caen</settlement>
<settlement type="city">Caen</settlement>
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<orgName type="university">Université de Caen Basse-Normandie</orgName>
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<affiliation wicri:level="3"><nlm:aff id="A9">Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Ecole Pratique des Hautes Etudes, UMR-S1077, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A10">CHU de Caen, U1077, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Caen, U1077, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
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<author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C." last="Petersen">Ronald C. Petersen</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rabin, Laura A" sort="Rabin, Laura A" uniqKey="Rabin L" first="Laura A." last="Rabin">Laura A. Rabin</name>
<affiliation wicri:level="2"><nlm:aff id="A19">Brooklyn College of The City University of New York, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brooklyn College of The City University of New York, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A20">The Graduate Center of The City University of New York, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Graduate Center of The City University of New York, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rami, Lorena" sort="Rami, Lorena" uniqKey="Rami L" first="Lorena" last="Rami">Lorena Rami</name>
<affiliation wicri:level="3"><nlm:aff id="A17">Alzheimer’s Disease and Other Cognitive Disorders Unit, IDIBAPS, Hospital Clinic, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Alzheimer’s Disease and Other Cognitive Disorders Unit, IDIBAPS, Hospital Clinic, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reisberg, Barry" sort="Reisberg, Barry" uniqKey="Reisberg B" first="Barry" last="Reisberg">Barry Reisberg</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, New York University Langone Medical Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A21">Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rentz, Dorene M" sort="Rentz, Dorene M" uniqKey="Rentz D" first="Dorene M." last="Rentz">Dorene M. Rentz</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Harvard Medical School, Brigham and Women’s Hospital, Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Harvard Medical School, Brigham and Women’s Hospital, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S." last="Sachdev">Perminder S. Sachdev</name>
<affiliation wicri:level="3"><nlm:aff id="A22">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De La Sayette, Vincent" sort="De La Sayette, Vincent" uniqKey="De La Sayette V" first="Vincent" last="De La Sayette">Vincent De La Sayette</name>
<affiliation wicri:level="3"><nlm:aff id="A7">INSERM, U1077, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U1077, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A8">Université de Caen Basse-Normandie, UMR-S1077, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Caen Basse-Normandie, UMR-S1077, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
<settlement type="city">Caen</settlement>
</placeName>
<orgName type="university">Université de Caen Basse-Normandie</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A9">Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Ecole Pratique des Hautes Etudes, UMR-S1077, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A10">CHU de Caen, U1077, Caen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Caen, U1077, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Saykin, Andrew J" sort="Saykin, Andrew J" uniqKey="Saykin A" first="Andrew J." last="Saykin">Andrew J. Saykin</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scheltens, Philip" sort="Scheltens, Philip" uniqKey="Scheltens P" first="Philip" last="Scheltens">Philip Scheltens</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Alzheimer Center, Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Alzheimer Center, Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shulman, Melanie B" sort="Shulman, Melanie B" uniqKey="Shulman M" first="Melanie B." last="Shulman">Melanie B. Shulman</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, New York University Langone Medical Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Slavin, Melissa J" sort="Slavin, Melissa J" uniqKey="Slavin M" first="Melissa J." last="Slavin">Melissa J. Slavin</name>
<affiliation wicri:level="3"><nlm:aff id="A24">Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sperling, Reisa A" sort="Sperling, Reisa A" uniqKey="Sperling R" first="Reisa A." last="Sperling">Reisa A. Sperling</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Harvard Medical School, Brigham and Women’s Hospital, Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Harvard Medical School, Brigham and Women’s Hospital, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stewart, Robert" sort="Stewart, Robert" uniqKey="Stewart R" first="Robert" last="Stewart">Robert Stewart</name>
<affiliation wicri:level="3"><nlm:aff id="A25">Institute of Psychiatry, King’s College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychiatry, King’s College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Uspenskaya, Olga" sort="Uspenskaya, Olga" uniqKey="Uspenskaya O" first="Olga" last="Uspenskaya">Olga Uspenskaya</name>
<affiliation wicri:level="3"><nlm:aff id="A26">Alzheimer’s Institute, Groupe Hospitalier Pitié-Salpêtrière, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Alzheimer’s Institute, Groupe Hospitalier Pitié-Salpêtrière, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name>
<affiliation wicri:level="3"><nlm:aff id="A27">Department of Internal Medicine and Geriatrics, Toulouse University Hospital, UMR INSERM 1027, University Paul Sabatier, Toulouse, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Internal Medicine and Geriatrics, Toulouse University Hospital, UMR INSERM 1027, University Paul Sabatier, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Visser, Pieter Jelle" sort="Visser, Pieter Jelle" uniqKey="Visser P" first="Pieter Jelle" last="Visser">Pieter Jelle Visser</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A14">Alzheimer Center, Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Alzheimer Center, Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wagner, Michael" sort="Wagner, Michael" uniqKey="Wagner M" first="Michael" last="Wagner">Michael Wagner</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Psychiatry, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Clinical Treatment and Research Center for Neurodegenerative Disease (KBFZ), University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinical Treatment and Research Center for Neurodegenerative Disease (KBFZ), University of Bonn, Bonn</wicri:regionArea>
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<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
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</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
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<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
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<series><title level="j">Alzheimer's & dementia : the journal of the Alzheimer's Association</title>
<idno type="ISSN">1552-5260</idno>
<idno type="eISSN">1552-5279</idno>
<imprint><date when="2014">2014</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term>
<term>Alzheimer Disease (physiopathology)</term>
<term>Cognition Disorders (diagnosis)</term>
<term>Cognition Disorders (physiopathology)</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Neuropsychological Tests</term>
<term>Prodromal Symptoms</term>
<term>Psychiatric Status Rating Scales</term>
<term>Terminology as Topic</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term>
<term>Humains</term>
<term>Maladie d'Alzheimer (physiopathologie)</term>
<term>Mâle</term>
<term>Symptômes prodromiques</term>
<term>Terminologie comme sujet</term>
<term>Tests neuropsychologiques</term>
<term>Troubles de la cognition (diagnostic)</term>
<term>Troubles de la cognition (physiopathologie)</term>
<term>Âge de début</term>
<term>Échelles d'évaluation en psychiatrie</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Maladie d'Alzheimer</term>
<term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Alzheimer Disease</term>
<term>Cognition Disorders</term>
</keywords>
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<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Neuropsychological Tests</term>
<term>Prodromal Symptoms</term>
<term>Psychiatric Status Rating Scales</term>
<term>Terminology as Topic</term>
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<term>Humains</term>
<term>Mâle</term>
<term>Symptômes prodromiques</term>
<term>Terminologie comme sujet</term>
<term>Tests neuropsychologiques</term>
<term>Âge de début</term>
<term>Échelles d'évaluation en psychiatrie</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer’s disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD <italic>plus</italic>
.</p>
</div>
</front>
</TEI>
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