Clinical evaluation of alfaxalone to induce and maintain anaesthesia in cats undergoing neutering procedures.
Identifieur interne : 003B76 ( Main/Merge ); précédent : 003B75; suivant : 003B77Clinical evaluation of alfaxalone to induce and maintain anaesthesia in cats undergoing neutering procedures.
Auteurs : Thierry Beths [Australie] ; Gwenola Touzot-Jourde [France] ; Gabrielle Musk [Australie] ; Kirby Pasloske [Australie]Source :
- Journal of feline medicine and surgery [ 1532-2750 ] ; 2014.
Descripteurs français
- KwdFr :
- Analyse des gaz du sang (médecine vétérinaire), Anesthésie (médecine vétérinaire), Anesthésie intraveineuse (), Anesthésie intraveineuse (médecine vétérinaire), Animaux, Chats, Femelle, Fréquence respiratoire, Maladies des chats (), Mâle, Prégnanediones (administration et posologie), Respiration (), Rythme cardiaque (), Résultat thérapeutique, Réveil anesthésique, Surveillance peropératoire (médecine vétérinaire).
- MESH :
- administration et posologie : Prégnanediones.
- médecine vétérinaire : Analyse des gaz du sang, Anesthésie, Anesthésie intraveineuse, Surveillance peropératoire.
- Anesthésie intraveineuse, Animaux, Chats, Femelle, Fréquence respiratoire, Maladies des chats, Mâle, Respiration, Rythme cardiaque, Résultat thérapeutique, Réveil anesthésique.
English descriptors
- KwdEn :
- Anesthesia (veterinary), Anesthesia Recovery Period, Anesthesia, Intravenous (methods), Anesthesia, Intravenous (veterinary), Animals, Blood Gas Analysis (veterinary), Cat Diseases (surgery), Cats, Female, Heart Rate (drug effects), Male, Monitoring, Intraoperative (veterinary), Pregnanediones (administration & dosage), Respiration (drug effects), Respiratory Rate, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Pregnanediones.
- drug effects : Heart Rate, Respiration.
- methods : Anesthesia, Intravenous.
- surgery : Cat Diseases.
- veterinary : Anesthesia, Anesthesia, Intravenous, Blood Gas Analysis, Monitoring, Intraoperative.
- Anesthesia Recovery Period, Animals, Cats, Female, Male, Respiratory Rate, Treatment Outcome.
Abstract
This study looked at the use and efficacy of alfaxalone for total intravenous anaesthesia (TIVA) in cats. Following intramuscular medetomidine (20 μg/kg) and morphine (0.3 mg/kg) premedication, anaesthesia was induced and maintained with intravenous alfaxalone. Patients were breathing 100% oxygen. Heart rate (HR), respiratory rate (RR), end-tidal carbon dioxide, oxygen saturation of haemoglobin and indirect arterial blood pressure via Doppler (DAP) were recorded every 5 mins. Thirty-four cats (10 males and 24 females), between the age of 6 and 18 months, and weighing between 1.8 and 5.3 kg, and undergoing neutering procedures were included in this study. The results are presented as median (min, max) values. The time to first spontaneous movement (TS) was >30 mins in 19 cats, of which 12 received atipamezole for reversal of the effects of medetomidine. The TS was 53 (43, 130) mins in these 12 cats and 50 (40, 72) mins in the other seven cats. The body temperature in those 19 cats was significantly lower than the other cats (P = 0.05). The alfaxalone induction dose and maintenance infusion rate were1.7 (0.7, 3.0) mg/kg and 0.18 (0.06, 0.25) mg/kg/min, respectively. The HR, RR and DAP were 145 (68, 235) beats/min, 17 (5, 40) breaths/min and 110 (58, 210) mmHg, respectively. Apnoea was not observed in any cat. In conclusion, alfaxalone TIVA in combination with medetomidine and morphine premedication was effective in feral and domestic cats for the performance of neutering surgery; low body temperature might have resulted in longer recoveries in some cats.
DOI: 10.1177/1098612X13514420
PubMed: 24305470
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pubmed:24305470Le document en format XML
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<term>Anesthesia Recovery Period</term>
<term>Anesthesia, Intravenous (methods)</term>
<term>Anesthesia, Intravenous (veterinary)</term>
<term>Animals</term>
<term>Blood Gas Analysis (veterinary)</term>
<term>Cat Diseases (surgery)</term>
<term>Cats</term>
<term>Female</term>
<term>Heart Rate (drug effects)</term>
<term>Male</term>
<term>Monitoring, Intraoperative (veterinary)</term>
<term>Pregnanediones (administration & dosage)</term>
<term>Respiration (drug effects)</term>
<term>Respiratory Rate</term>
<term>Treatment Outcome</term>
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<term>Anesthésie (médecine vétérinaire)</term>
<term>Anesthésie intraveineuse ()</term>
<term>Anesthésie intraveineuse (médecine vétérinaire)</term>
<term>Animaux</term>
<term>Chats</term>
<term>Femelle</term>
<term>Fréquence respiratoire</term>
<term>Maladies des chats ()</term>
<term>Mâle</term>
<term>Prégnanediones (administration et posologie)</term>
<term>Respiration ()</term>
<term>Rythme cardiaque ()</term>
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<term>Réveil anesthésique</term>
<term>Surveillance peropératoire (médecine vétérinaire)</term>
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<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Prégnanediones</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Heart Rate</term>
<term>Respiration</term>
</keywords>
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<term>Anesthésie</term>
<term>Anesthésie intraveineuse</term>
<term>Surveillance peropératoire</term>
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</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Anesthesia</term>
<term>Anesthesia, Intravenous</term>
<term>Blood Gas Analysis</term>
<term>Monitoring, Intraoperative</term>
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<term>Cats</term>
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<term>Respiratory Rate</term>
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<term>Chats</term>
<term>Femelle</term>
<term>Fréquence respiratoire</term>
<term>Maladies des chats</term>
<term>Mâle</term>
<term>Respiration</term>
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<front><div type="abstract" xml:lang="en">This study looked at the use and efficacy of alfaxalone for total intravenous anaesthesia (TIVA) in cats. Following intramuscular medetomidine (20 μg/kg) and morphine (0.3 mg/kg) premedication, anaesthesia was induced and maintained with intravenous alfaxalone. Patients were breathing 100% oxygen. Heart rate (HR), respiratory rate (RR), end-tidal carbon dioxide, oxygen saturation of haemoglobin and indirect arterial blood pressure via Doppler (DAP) were recorded every 5 mins. Thirty-four cats (10 males and 24 females), between the age of 6 and 18 months, and weighing between 1.8 and 5.3 kg, and undergoing neutering procedures were included in this study. The results are presented as median (min, max) values. The time to first spontaneous movement (TS) was >30 mins in 19 cats, of which 12 received atipamezole for reversal of the effects of medetomidine. The TS was 53 (43, 130) mins in these 12 cats and 50 (40, 72) mins in the other seven cats. The body temperature in those 19 cats was significantly lower than the other cats (P = 0.05). The alfaxalone induction dose and maintenance infusion rate were1.7 (0.7, 3.0) mg/kg and 0.18 (0.06, 0.25) mg/kg/min, respectively. The HR, RR and DAP were 145 (68, 235) beats/min, 17 (5, 40) breaths/min and 110 (58, 210) mmHg, respectively. Apnoea was not observed in any cat. In conclusion, alfaxalone TIVA in combination with medetomidine and morphine premedication was effective in feral and domestic cats for the performance of neutering surgery; low body temperature might have resulted in longer recoveries in some cats.</div>
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