Clinical evaluation of alfaxalone to induce and maintain anaesthesia in cats undergoing neutering procedures.
Identifieur interne : 001627 ( Ncbi/Merge ); précédent : 001626; suivant : 001628Clinical evaluation of alfaxalone to induce and maintain anaesthesia in cats undergoing neutering procedures.
Auteurs : Thierry Beths [Australie] ; Gwenola Touzot-Jourde [France] ; Gabrielle Musk [Australie] ; Kirby Pasloske [Australie]Source :
- Journal of feline medicine and surgery [ 1532-2750 ] ; 2014.
Descripteurs français
- KwdFr :
- Analyse des gaz du sang (médecine vétérinaire), Anesthésie (médecine vétérinaire), Anesthésie intraveineuse (), Anesthésie intraveineuse (médecine vétérinaire), Animaux, Chats, Femelle, Fréquence respiratoire, Maladies des chats (), Mâle, Prégnanediones (administration et posologie), Respiration (), Rythme cardiaque (), Résultat thérapeutique, Réveil anesthésique, Surveillance peropératoire (médecine vétérinaire).
- MESH :
- administration et posologie : Prégnanediones.
- médecine vétérinaire : Analyse des gaz du sang, Anesthésie, Anesthésie intraveineuse, Surveillance peropératoire.
- Anesthésie intraveineuse, Animaux, Chats, Femelle, Fréquence respiratoire, Maladies des chats, Mâle, Respiration, Rythme cardiaque, Résultat thérapeutique, Réveil anesthésique.
English descriptors
- KwdEn :
- Anesthesia (veterinary), Anesthesia Recovery Period, Anesthesia, Intravenous (methods), Anesthesia, Intravenous (veterinary), Animals, Blood Gas Analysis (veterinary), Cat Diseases (surgery), Cats, Female, Heart Rate (drug effects), Male, Monitoring, Intraoperative (veterinary), Pregnanediones (administration & dosage), Respiration (drug effects), Respiratory Rate, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Pregnanediones.
- drug effects : Heart Rate, Respiration.
- methods : Anesthesia, Intravenous.
- surgery : Cat Diseases.
- veterinary : Anesthesia, Anesthesia, Intravenous, Blood Gas Analysis, Monitoring, Intraoperative.
- Anesthesia Recovery Period, Animals, Cats, Female, Male, Respiratory Rate, Treatment Outcome.
Abstract
This study looked at the use and efficacy of alfaxalone for total intravenous anaesthesia (TIVA) in cats. Following intramuscular medetomidine (20 μg/kg) and morphine (0.3 mg/kg) premedication, anaesthesia was induced and maintained with intravenous alfaxalone. Patients were breathing 100% oxygen. Heart rate (HR), respiratory rate (RR), end-tidal carbon dioxide, oxygen saturation of haemoglobin and indirect arterial blood pressure via Doppler (DAP) were recorded every 5 mins. Thirty-four cats (10 males and 24 females), between the age of 6 and 18 months, and weighing between 1.8 and 5.3 kg, and undergoing neutering procedures were included in this study. The results are presented as median (min, max) values. The time to first spontaneous movement (TS) was >30 mins in 19 cats, of which 12 received atipamezole for reversal of the effects of medetomidine. The TS was 53 (43, 130) mins in these 12 cats and 50 (40, 72) mins in the other seven cats. The body temperature in those 19 cats was significantly lower than the other cats (P = 0.05). The alfaxalone induction dose and maintenance infusion rate were1.7 (0.7, 3.0) mg/kg and 0.18 (0.06, 0.25) mg/kg/min, respectively. The HR, RR and DAP were 145 (68, 235) beats/min, 17 (5, 40) breaths/min and 110 (58, 210) mmHg, respectively. Apnoea was not observed in any cat. In conclusion, alfaxalone TIVA in combination with medetomidine and morphine premedication was effective in feral and domestic cats for the performance of neutering surgery; low body temperature might have resulted in longer recoveries in some cats.
DOI: 10.1177/1098612X13514420
PubMed: 24305470
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Anaesthesia Unit, ONIRIS National Veterinary School, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Surgery - Anaesthesia Unit, ONIRIS National Veterinary School, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Musk, Gabrielle" sort="Musk, Gabrielle" uniqKey="Musk G" first="Gabrielle" last="Musk">Gabrielle Musk</name><affiliation wicri:level="1"><nlm:affiliation>College of Veterinary Medicine, Murdoch University, Murdoch, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>College of Veterinary Medicine, Murdoch University, Murdoch, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Pasloske, Kirby" sort="Pasloske, Kirby" uniqKey="Pasloske K" first="Kirby" last="Pasloske">Kirby Pasloske</name><affiliation wicri:level="1"><nlm:affiliation>Research and Development, Jurox Pty Ltd, Rutherford, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Research and Development, Jurox Pty Ltd, Rutherford, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of feline medicine and surgery</title><idno type="eISSN">1532-2750</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anesthesia (veterinary)</term><term>Anesthesia Recovery Period</term><term>Anesthesia, Intravenous (methods)</term><term>Anesthesia, Intravenous (veterinary)</term><term>Animals</term><term>Blood Gas Analysis (veterinary)</term><term>Cat Diseases (surgery)</term><term>Cats</term><term>Female</term><term>Heart Rate (drug effects)</term><term>Male</term><term>Monitoring, Intraoperative (veterinary)</term><term>Pregnanediones (administration & dosage)</term><term>Respiration (drug effects)</term><term>Respiratory Rate</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse des gaz du sang (médecine vétérinaire)</term><term>Anesthésie (médecine vétérinaire)</term><term>Anesthésie intraveineuse ()</term><term>Anesthésie intraveineuse (médecine vétérinaire)</term><term>Animaux</term><term>Chats</term><term>Femelle</term><term>Fréquence respiratoire</term><term>Maladies des chats ()</term><term>Mâle</term><term>Prégnanediones (administration et posologie)</term><term>Respiration ()</term><term>Rythme cardiaque ()</term><term>Résultat thérapeutique</term><term>Réveil anesthésique</term><term>Surveillance peropératoire (médecine vétérinaire)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Pregnanediones</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Prégnanediones</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Heart Rate</term><term>Respiration</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Anesthesia, Intravenous</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Analyse des gaz du sang</term><term>Anesthésie</term><term>Anesthésie intraveineuse</term><term>Surveillance peropératoire</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Cat Diseases</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Anesthesia</term><term>Anesthesia, Intravenous</term><term>Blood Gas Analysis</term><term>Monitoring, Intraoperative</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Anesthesia Recovery Period</term><term>Animals</term><term>Cats</term><term>Female</term><term>Male</term><term>Respiratory Rate</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Anesthésie intraveineuse</term><term>Animaux</term><term>Chats</term><term>Femelle</term><term>Fréquence respiratoire</term><term>Maladies des chats</term><term>Mâle</term><term>Respiration</term><term>Rythme cardiaque</term><term>Résultat thérapeutique</term><term>Réveil anesthésique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study looked at the use and efficacy of alfaxalone for total intravenous anaesthesia (TIVA) in cats. Following intramuscular medetomidine (20 μg/kg) and morphine (0.3 mg/kg) premedication, anaesthesia was induced and maintained with intravenous alfaxalone. Patients were breathing 100% oxygen. Heart rate (HR), respiratory rate (RR), end-tidal carbon dioxide, oxygen saturation of haemoglobin and indirect arterial blood pressure via Doppler (DAP) were recorded every 5 mins. Thirty-four cats (10 males and 24 females), between the age of 6 and 18 months, and weighing between 1.8 and 5.3 kg, and undergoing neutering procedures were included in this study. The results are presented as median (min, max) values. The time to first spontaneous movement (TS) was >30 mins in 19 cats, of which 12 received atipamezole for reversal of the effects of medetomidine. The TS was 53 (43, 130) mins in these 12 cats and 50 (40, 72) mins in the other seven cats. The body temperature in those 19 cats was significantly lower than the other cats (P = 0.05). The alfaxalone induction dose and maintenance infusion rate were1.7 (0.7, 3.0) mg/kg and 0.18 (0.06, 0.25) mg/kg/min, respectively. The HR, RR and DAP were 145 (68, 235) beats/min, 17 (5, 40) breaths/min and 110 (58, 210) mmHg, respectively. Apnoea was not observed in any cat. In conclusion, alfaxalone TIVA in combination with medetomidine and morphine premedication was effective in feral and domestic cats for the performance of neutering surgery; low body temperature might have resulted in longer recoveries in some cats.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24305470</PMID><DateCreated><Year>2014</Year><Month>11</Month><Day>21</Day></DateCreated><DateCompleted><Year>2015</Year><Month>07</Month><Day>13</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-2750</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>8</Issue><PubDate><Year>2014</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Journal of feline medicine and surgery</Title><ISOAbbreviation>J. Feline Med. Surg.</ISOAbbreviation></Journal><ArticleTitle>Clinical evaluation of alfaxalone to induce and maintain anaesthesia in cats undergoing neutering procedures.</ArticleTitle><Pagination><MedlinePgn>609-15</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1177/1098612X13514420</ELocationID><Abstract><AbstractText>This study looked at the use and efficacy of alfaxalone for total intravenous anaesthesia (TIVA) in cats. Following intramuscular medetomidine (20 μg/kg) and morphine (0.3 mg/kg) premedication, anaesthesia was induced and maintained with intravenous alfaxalone. Patients were breathing 100% oxygen. Heart rate (HR), respiratory rate (RR), end-tidal carbon dioxide, oxygen saturation of haemoglobin and indirect arterial blood pressure via Doppler (DAP) were recorded every 5 mins. Thirty-four cats (10 males and 24 females), between the age of 6 and 18 months, and weighing between 1.8 and 5.3 kg, and undergoing neutering procedures were included in this study. The results are presented as median (min, max) values. The time to first spontaneous movement (TS) was >30 mins in 19 cats, of which 12 received atipamezole for reversal of the effects of medetomidine. The TS was 53 (43, 130) mins in these 12 cats and 50 (40, 72) mins in the other seven cats. The body temperature in those 19 cats was significantly lower than the other cats (P = 0.05). The alfaxalone induction dose and maintenance infusion rate were1.7 (0.7, 3.0) mg/kg and 0.18 (0.06, 0.25) mg/kg/min, respectively. The HR, RR and DAP were 145 (68, 235) beats/min, 17 (5, 40) breaths/min and 110 (58, 210) mmHg, respectively. Apnoea was not observed in any cat. In conclusion, alfaxalone TIVA in combination with medetomidine and morphine premedication was effective in feral and domestic cats for the performance of neutering surgery; low body temperature might have resulted in longer recoveries in some cats.</AbstractText><CopyrightInformation>© ISFM and AAFP 2013.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Beths</LastName><ForeName>Thierry</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Faculty of Veterinary Science, Melbourne University Veterinary Hospital, Werribee, VIC, Australia thierry.beths@unimelb.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Touzot-Jourde</LastName><ForeName>Gwenola</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Surgery - Anaesthesia Unit, ONIRIS National Veterinary School, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Musk</LastName><ForeName>Gabrielle</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>College of Veterinary Medicine, Murdoch University, Murdoch, WA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pasloske</LastName><ForeName>Kirby</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Research and Development, Jurox Pty Ltd, Rutherford, NSW, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>12</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Feline Med Surg</MedlineTA><NlmUniqueID>100897329</NlmUniqueID><ISSNLinking>1098-612X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011277">Pregnanediones</NameOfSubstance></Chemical><Chemical><RegistryNumber>BD07M97B2A</RegistryNumber><NameOfSubstance UI="C006477">alphaxalone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000758" MajorTopicYN="N">Anesthesia</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000762" MajorTopicYN="N">Anesthesia Recovery Period</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000771" MajorTopicYN="N">Anesthesia, Intravenous</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001784" MajorTopicYN="N">Blood Gas Analysis</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002371" MajorTopicYN="N">Cat Diseases</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002415" MajorTopicYN="N">Cats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006339" MajorTopicYN="N">Heart Rate</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016343" MajorTopicYN="N">Monitoring, Intraoperative</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011277" MajorTopicYN="N">Pregnanediones</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012119" MajorTopicYN="N">Respiration</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056152" MajorTopicYN="N">Respiratory Rate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>12</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>12</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24305470</ArticleId><ArticleId IdType="pii">1098612X13514420</ArticleId><ArticleId IdType="doi">10.1177/1098612X13514420</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Pays de la Loire</li></region><settlement><li>Nantes</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Beths, Thierry" sort="Beths, Thierry" uniqKey="Beths T" first="Thierry" last="Beths">Thierry Beths</name></noRegion><name sortKey="Musk, Gabrielle" sort="Musk, Gabrielle" uniqKey="Musk G" first="Gabrielle" last="Musk">Gabrielle Musk</name><name sortKey="Pasloske, Kirby" sort="Pasloske, Kirby" uniqKey="Pasloske K" first="Kirby" last="Pasloske">Kirby Pasloske</name></country><country name="France"><region name="Pays de la Loire"><name sortKey="Touzot Jourde, Gwenola" sort="Touzot Jourde, Gwenola" uniqKey="Touzot Jourde G" first="Gwenola" last="Touzot-Jourde">Gwenola Touzot-Jourde</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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