AustralieFrV1, Main, Merge, bibRecord, 003725

Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: comparing meta and mega analytical approaches for data pooling

Identifieur interne : 003725 ( Main/Merge ); précédent : 003724; suivant : 003726

Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: comparing meta and mega analytical approaches for data pooling

Auteurs : Peter Kochunov [États-Unis] ; Neda Jahanshad [États-Unis] ; Emma Sprooten [États-Unis] ; Thomas E. Nichols [Royaume-Uni] ; René C. Mandl [Pays-Bas] ; Laura Almasy [États-Unis] ; Tom Booth [Royaume-Uni] ; Rachel M. Brouwer [Pays-Bas] ; Joanne E. Curran [États-Unis] ; Greig I. De Zubicaray [Australie] ; Rali Dimitrova [Royaume-Uni] ; Ravi Duggirala [États-Unis] ; Peter T. Fox [États-Unis] ; L. Elliot Hong [États-Unis] ; Bennett A. Landman [États-Unis] ; Hervé Lemaitre [France] ; Lorna Lopez [Royaume-Uni] ; Nicholas G. Martin [Australie] ; Katie L. Mcmahon [Australie] ; Braxton D. Mitchell [États-Unis] ; Rene L. Olvera [États-Unis] ; Charles P. Peterson [États-Unis] ; John M. Starr [Royaume-Uni] ; Jessika E. Sussmann [Royaume-Uni] ; Arthur W. Toga [États-Unis] ; Joanna M. Wardlaw [Royaume-Uni] ; Margaret J. Wright [Australie] ; Susan N. Wright [États-Unis] ; Mark E. Bastin [Royaume-Uni] ; Andrew M. Mcintosh [Royaume-Uni] ; Dorret I. Boomsma [Pays-Bas] ; René S. Kahn [Pays-Bas] ; Anouk Den Braber [Pays-Bas] ; Eco Jc De Geus [Pays-Bas] ; Ian J. Deary [Royaume-Uni] ; Hilleke E. Hulshoff Pol [Pays-Bas] ; Douglas E. Williamson [États-Unis] ; John Blangero [États-Unis] ; Dennis Van Ent ; Paul M. Thompson [États-Unis] ; David C. Glahn [États-Unis]

Source :

NeuroImage [ 1053-8119 ] ; 2014.

RBID : PMC:4043878

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anisotropie, Encéphale, Enfant, Femelle, Humains, Imagerie par tenseur de diffusion, Jeune adulte, Mâle, Méta-analyse comme sujet, Substance blanche, Sujet âgé, Sujet âgé de 80 ans ou plus, Variation génétique.
MESH :
- Adolescent, Adulte, Adulte d'âge moyen, Anisotropie, Encéphale, Enfant, Femelle, Humains, Imagerie par tenseur de diffusion, Jeune adulte, Mâle, Méta-analyse comme sujet, Substance blanche, Sujet âgé, Sujet âgé de 80 ans ou plus, Variation génétique.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Anisotropy, Brain, Child, Diffusion Tensor Imaging, Female, Genetic Variation, Humans, Male, Meta-Analysis as Topic, Middle Aged, White Matter, Young Adult.
MESH :
- Adolescent, Adult, Aged, Aged, 80 and over, Anisotropy, Brain, Child, Diffusion Tensor Imaging, Female, Genetic Variation, Humans, Male, Meta-Analysis as Topic, Middle Aged, White Matter, Young Adult.

Abstract

Combining datasets across independent studies can boost statistical power by increasing the numbers of observations and can achieve more accurate estimates of effect sizes. This is especially important for genetic studies where a large number of observations are required to obtain sufficient power to detect and replicate genetic effects. There is a need to develop and evaluate methods for joint-analytical analyses of rich datasets collected in imaging genetics studies. The ENIGMA-DTI consortium is developing and evaluating approaches for obtaining pooled estimates of heritability through meta-and mega-genetic analytical approaches, to estimate the general additive genetic contributions to the intersubject variance in fractional anisotropy (FA) measured from diffusion tensor imaging (DTI). We used the ENIGMA-DTI data harmonization protocol for uniform processing of DTI data from multiple sites. We evaluated this protocol in five family-based cohorts providing data from a total of 2248 children and adults (ages: 9–85) collected with various imaging protocols. We used the imaging genetics analysis tool, SOLAR-Eclipse, to combine twin and family data from Dutch, Australian and Mexican-American cohorts into one large “mega-family”. We showed that heritability estimates may vary from one cohort to another. We used two meta-analytical (the sample-size and standard-error weighted) approaches and a mega-genetic analysis to calculate heritability estimates across-population. We performed leave-one-out analysis of the joint estimates of heritability, removing a different cohort each time to understand the estimate variability. Overall, meta- and mega-genetic analyses of heritability produced robust estimates of heritability.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043878

DOI: 10.1016/j.neuroimage.2014.03.033
PubMed: 24657781
PubMed Central: 4043878

Links to Exploration step

PMC:4043878

Le document en format XML

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<author><name sortKey="De Zubicaray, Greig I" sort="De Zubicaray, Greig I" uniqKey="De Zubicaray G" first="Greig I." last="De Zubicaray">Greig I. De Zubicaray</name>
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<author><name sortKey="Fox, Peter T" sort="Fox, Peter T" uniqKey="Fox P" first="Peter T." last="Fox">Peter T. Fox</name>
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<author><name sortKey="Hong, L Elliot" sort="Hong, L Elliot" uniqKey="Hong L" first="L. Elliot" last="Hong">L. Elliot Hong</name>
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<author><name sortKey="Landman, Bennett A" sort="Landman, Bennett A" uniqKey="Landman B" first="Bennett A." last="Landman">Bennett A. Landman</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Department of Electrical Engineering, Vanderbilt University, Nashville, TN, USA</nlm:aff>
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<author><name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaitre">Hervé Lemaitre</name>
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<author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L." last="Mcmahon">Katie L. Mcmahon</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Center for Advanced Imaging, University of Queensland, Brisbane, Australia</nlm:aff>
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<author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA</nlm:aff>
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<wicri:regionArea>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea>
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<author><name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L." last="Olvera">Rene L. Olvera</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea>
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<author><name sortKey="Peterson, Charles P" sort="Peterson, Charles P" uniqKey="Peterson C" first="Charles P." last="Peterson">Charles P. Peterson</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea>
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<author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
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<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
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<affiliation wicri:level="4"><nlm:aff id="A19">Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
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<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
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<author><name sortKey="Sussmann, Jessika E" sort="Sussmann, Jessika E" uniqKey="Sussmann J" first="Jessika E." last="Sussmann">Jessika E. Sussmann</name>
<affiliation wicri:level="4"><nlm:aff id="A10">Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea>
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<author><name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W." last="Toga">Arthur W. Toga</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Imaging Genetics Center, Institute of Neuroimaging Informatics, USC Keck School of Medicine, Los Angeles, CA, USA</nlm:aff>
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<wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging Informatics, USC Keck School of Medicine, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M." last="Wardlaw">Joanna M. Wardlaw</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff>
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<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
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<affiliation wicri:level="4"><nlm:aff id="A14">Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</nlm:aff>
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<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name>
<affiliation wicri:level="1"><nlm:aff id="A15">QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea>
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<author><name sortKey="Wright, Susan N" sort="Wright, Susan N" uniqKey="Wright S" first="Susan N." last="Wright">Susan N. Wright</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
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<author><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
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<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
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<affiliation wicri:level="4"><nlm:aff id="A14">Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</nlm:aff>
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<orgName type="university">Université d'Édimbourg</orgName>
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</author>
<author><name sortKey="Mcintosh, Andrew M" sort="Mcintosh, Andrew M" uniqKey="Mcintosh A" first="Andrew M." last="Mcintosh">Andrew M. Mcintosh</name>
<affiliation wicri:level="4"><nlm:aff id="A10">Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
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<author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name>
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<wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea>
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<author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name>
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<wicri:regionArea>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: comparing meta and mega analytical approaches for data pooling</title>
<author><name sortKey="Kochunov, Peter" sort="Kochunov, Peter" uniqKey="Kochunov P" first="Peter" last="Kochunov">Peter Kochunov</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging Informatics, USC Keck School of Medicine, Los Angeles, CA</wicri:regionArea>
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<author><name sortKey="Sprooten, Emma" sort="Sprooten, Emma" uniqKey="Sprooten E" first="Emma" last="Sprooten">Emma Sprooten</name>
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<wicri:regionArea>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="A4">Department of Statistics & Warwick Manufacturing Group, The University of Warwick, Coventry, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Statistics & Warwick Manufacturing Group, The University of Warwick, Coventry</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A5">Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Oxford University, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Oxford University</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Mandl, Rene C" sort="Mandl, Rene C" uniqKey="Mandl R" first="René C." last="Mandl">René C. Mandl</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea>
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<author><name sortKey="Almasy, Laura" sort="Almasy, Laura" uniqKey="Almasy L" first="Laura" last="Almasy">Laura Almasy</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Booth, Tom" sort="Booth, Tom" uniqKey="Booth T" first="Tom" last="Booth">Tom Booth</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
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<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Brouwer, Rachel M" sort="Brouwer, Rachel M" uniqKey="Brouwer R" first="Rachel M." last="Brouwer">Rachel M. Brouwer</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Curran, Joanne E" sort="Curran, Joanne E" uniqKey="Curran J" first="Joanne E." last="Curran">Joanne E. Curran</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Zubicaray, Greig I" sort="De Zubicaray, Greig I" uniqKey="De Zubicaray G" first="Greig I." last="De Zubicaray">Greig I. De Zubicaray</name>
<affiliation wicri:level="1"><nlm:aff id="A9">School of Psychology, University of Queensland, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychology, University of Queensland, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dimitrova, Rali" sort="Dimitrova, Rali" uniqKey="Dimitrova R" first="Rali" last="Dimitrova">Rali Dimitrova</name>
<affiliation wicri:level="4"><nlm:aff id="A10">Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Duggirala, Ravi" sort="Duggirala, Ravi" uniqKey="Duggirala R" first="Ravi" last="Duggirala">Ravi Duggirala</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fox, Peter T" sort="Fox, Peter T" uniqKey="Fox P" first="Peter T." last="Fox">Peter T. Fox</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hong, L Elliot" sort="Hong, L Elliot" uniqKey="Hong L" first="L. Elliot" last="Hong">L. Elliot Hong</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Landman, Bennett A" sort="Landman, Bennett A" uniqKey="Landman B" first="Bennett A." last="Landman">Bennett A. Landman</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Department of Electrical Engineering, Vanderbilt University, Nashville, TN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Electrical Engineering, Vanderbilt University, Nashville, TN</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaitre">Hervé Lemaitre</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>U1000 Research Unit Neuroimaging and Psychiatry, INSERM-CEA-Faculté de Médecine Paris-Sud. Orsay</wicri:regionArea>
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<wicri:noRegion>INSERM-CEA-Faculté de Médecine Paris-Sud. Orsay</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lopez, Lorna" sort="Lopez, Lorna" uniqKey="Lopez L" first="Lorna" last="Lopez">Lorna Lopez</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L." last="Mcmahon">Katie L. Mcmahon</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Center for Advanced Imaging, University of Queensland, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Center for Advanced Imaging, University of Queensland, Brisbane</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L." last="Olvera">Rene L. Olvera</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peterson, Charles P" sort="Peterson, Charles P" uniqKey="Peterson C" first="Charles P." last="Peterson">Charles P. Peterson</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A19">Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Sussmann, Jessika E" sort="Sussmann, Jessika E" uniqKey="Sussmann J" first="Jessika E." last="Sussmann">Jessika E. Sussmann</name>
<affiliation wicri:level="4"><nlm:aff id="A10">Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK</nlm:aff>
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<wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W." last="Toga">Arthur W. Toga</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging Informatics, USC Keck School of Medicine, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M." last="Wardlaw">Joanna M. Wardlaw</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A14">Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</nlm:aff>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name>
<affiliation wicri:level="1"><nlm:aff id="A15">QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wright, Susan N" sort="Wright, Susan N" uniqKey="Wright S" first="Susan N." last="Wright">Susan N. Wright</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A14">Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</nlm:aff>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Mcintosh, Andrew M" sort="Mcintosh, Andrew M" uniqKey="Mcintosh A" first="Andrew M." last="Mcintosh">Andrew M. Mcintosh</name>
<affiliation wicri:level="4"><nlm:aff id="A10">Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Department of Biological Psychology, VU University, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kahn, Rene S" sort="Kahn, Rene S" uniqKey="Kahn R" first="René S." last="Kahn">René S. Kahn</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Department of Biological Psychology, VU University, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Geus, Eco Jc" sort="De Geus, Eco Jc" uniqKey="De Geus E" first="Eco Jc" last="De Geus">Eco Jc De Geus</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Department of Biological Psychology, VU University, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Hulshoff Pol, Hilleke E" sort="Hulshoff Pol, Hilleke E" uniqKey="Hulshoff Pol H" first="Hilleke E." last="Hulshoff Pol">Hilleke E. Hulshoff Pol</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Williamson, Douglas E" sort="Williamson, Douglas E" uniqKey="Williamson D" first="Douglas E." last="Williamson">Douglas E. Williamson</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Ent, Dennis" sort="Van Ent, Dennis" uniqKey="Van Ent D" first="Dennis" last="Van Ent">Dennis Van Ent</name>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Imaging Genetics Center, Institute of Neuroimaging Informatics, USC Keck School of Medicine, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging Informatics, USC Keck School of Medicine, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C." last="Glahn">David C. Glahn</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">NeuroImage</title>
<idno type="ISSN">1053-8119</idno>
<idno type="eISSN">1095-9572</idno>
<imprint><date when="2014">2014</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Anisotropy</term>
<term>Brain</term>
<term>Child</term>
<term>Diffusion Tensor Imaging</term>
<term>Female</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Male</term>
<term>Meta-Analysis as Topic</term>
<term>Middle Aged</term>
<term>White Matter</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anisotropie</term>
<term>Encéphale</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par tenseur de diffusion</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Méta-analyse comme sujet</term>
<term>Substance blanche</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Variation génétique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Anisotropy</term>
<term>Brain</term>
<term>Child</term>
<term>Diffusion Tensor Imaging</term>
<term>Female</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Male</term>
<term>Meta-Analysis as Topic</term>
<term>Middle Aged</term>
<term>White Matter</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anisotropie</term>
<term>Encéphale</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par tenseur de diffusion</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Méta-analyse comme sujet</term>
<term>Substance blanche</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Variation génétique</term>
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<front><div type="abstract" xml:lang="en"><p id="P2">Combining datasets across independent studies can boost statistical power by increasing the numbers of observations and can achieve more accurate estimates of effect sizes. This is especially important for genetic studies where a large number of observations are required to obtain sufficient power to detect and replicate genetic effects. There is a need to develop and evaluate methods for joint-analytical analyses of rich datasets collected in imaging genetics studies. The ENIGMA-DTI consortium is developing and evaluating approaches for obtaining pooled estimates of heritability through meta-and mega-genetic analytical approaches, to estimate the general additive genetic contributions to the intersubject variance in fractional anisotropy (FA) measured from diffusion tensor imaging (DTI). We used the ENIGMA-DTI data harmonization protocol for uniform processing of DTI data from multiple sites. We evaluated this protocol in five family-based cohorts providing data from a total of 2248 children and adults (ages: 9–85) collected with various imaging protocols. We used the imaging genetics analysis tool, SOLAR-Eclipse, to combine twin and family data from Dutch, Australian and Mexican-American cohorts into one large “mega-family”. We showed that heritability estimates may vary from one cohort to another. We used two meta-analytical (the sample-size and standard-error weighted) approaches and a mega-genetic analysis to calculate heritability estimates across-population. We performed leave-one-out analysis of the joint estimates of heritability, removing a different cohort each time to understand the estimate variability. Overall, meta- and mega-genetic analyses of heritability produced robust estimates of heritability.</p>
</div>
</front>
</TEI>
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Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: comparing meta and mega analytical approaches for data pooling

Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: comparing meta and mega analytical approaches for data pooling

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