Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling.
Identifieur interne : 003517 ( PubMed/Curation ); précédent : 003516; suivant : 003518Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling.
Auteurs : Peter Kochunov [États-Unis] ; Neda Jahanshad [États-Unis] ; Emma Sprooten [États-Unis] ; Thomas E. Nichols [Royaume-Uni] ; René C. Mandl [Pays-Bas] ; Laura Almasy [États-Unis] ; Tom Booth [Royaume-Uni] ; Rachel M. Brouwer [Pays-Bas] ; Joanne E. Curran [États-Unis] ; Greig I. De Zubicaray [Australie] ; Rali Dimitrova [Royaume-Uni] ; Ravi Duggirala [États-Unis] ; Peter T. Fox [États-Unis] ; L Elliot Hong [États-Unis] ; Bennett A. Landman [États-Unis] ; Hervé Lemaitre [France] ; Lorna M. Lopez [Royaume-Uni] ; Nicholas G. Martin [Australie] ; Katie L. Mcmahon [Australie] ; Braxton D. Mitchell [États-Unis] ; Rene L. Olvera [États-Unis] ; Charles P. Peterson [États-Unis] ; John M. Starr [Royaume-Uni] ; Jessika E. Sussmann [Royaume-Uni] ; Arthur W. Toga [États-Unis] ; Joanna M. Wardlaw [Royaume-Uni] ; Margaret J. Wright [Australie] ; Susan N. Wright [États-Unis] ; Mark E. Bastin [Royaume-Uni] ; Andrew M. Mcintosh [Royaume-Uni] ; Dorret I. Boomsma [Pays-Bas] ; René S. Kahn [Pays-Bas] ; Anouk Den Braber [Pays-Bas] ; Eco J C. De Geus [Pays-Bas] ; Ian J. Deary [Royaume-Uni] ; Hilleke E. Hulshoff Pol [Pays-Bas] ; Douglas E. Williamson [États-Unis] ; John Blangero [États-Unis] ; Dennis Van T Ent [Pays-Bas] ; Paul M. Thompson [États-Unis] ; David C. Glahn [États-Unis]Source :
- NeuroImage [ 1095-9572 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
Abstract
Combining datasets across independent studies can boost statistical power by increasing the numbers of observations and can achieve more accurate estimates of effect sizes. This is especially important for genetic studies where a large number of observations are required to obtain sufficient power to detect and replicate genetic effects. There is a need to develop and evaluate methods for joint-analytical analyses of rich datasets collected in imaging genetics studies. The ENIGMA-DTI consortium is developing and evaluating approaches for obtaining pooled estimates of heritability through meta-and mega-genetic analytical approaches, to estimate the general additive genetic contributions to the intersubject variance in fractional anisotropy (FA) measured from diffusion tensor imaging (DTI). We used the ENIGMA-DTI data harmonization protocol for uniform processing of DTI data from multiple sites. We evaluated this protocol in five family-based cohorts providing data from a total of 2248 children and adults (ages: 9-85) collected with various imaging protocols. We used the imaging genetics analysis tool, SOLAR-Eclipse, to combine twin and family data from Dutch, Australian and Mexican-American cohorts into one large "mega-family". We showed that heritability estimates may vary from one cohort to another. We used two meta-analytical (the sample-size and standard-error weighted) approaches and a mega-genetic analysis to calculate heritability estimates across-population. We performed leave-one-out analysis of the joint estimates of heritability, removing a different cohort each time to understand the estimate variability. Overall, meta- and mega-genetic analyses of heritability produced robust estimates of heritability.
DOI: 10.1016/j.neuroimage.2014.03.033
PubMed: 24657781
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003630
Links to Exploration step
pubmed:24657781Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling.</title><author><name sortKey="Kochunov, Peter" sort="Kochunov, Peter" uniqKey="Kochunov P" first="Peter" last="Kochunov">Peter Kochunov</name><affiliation wicri:level="1"><nlm:affiliation>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: pkochunov@mprc.umaryland.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Jahanshad, Neda" sort="Jahanshad, Neda" uniqKey="Jahanshad N" first="Neda" last="Jahanshad">Neda Jahanshad</name><affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Sprooten, Emma" sort="Sprooten, Emma" uniqKey="Sprooten E" first="Emma" last="Sprooten">Emma Sprooten</name><affiliation wicri:level="1"><nlm:affiliation>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT</wicri:regionArea></affiliation></author><author><name sortKey="Nichols, Thomas E" sort="Nichols, Thomas E" uniqKey="Nichols T" first="Thomas E" last="Nichols">Thomas E. Nichols</name><affiliation wicri:level="1"><nlm:affiliation>Department of Statistics & Warwick Manufacturing Group, The University of Warwick, Coventry, UK; Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Oxford University, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Statistics & Warwick Manufacturing Group, The University of Warwick, Coventry, UK; Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Oxford University</wicri:regionArea></affiliation></author><author><name sortKey="Mandl, Rene C" sort="Mandl, Rene C" uniqKey="Mandl R" first="René C" last="Mandl">René C. Mandl</name><affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Almasy, Laura" sort="Almasy, Laura" uniqKey="Almasy L" first="Laura" last="Almasy">Laura Almasy</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Booth, Tom" sort="Booth, Tom" uniqKey="Booth T" first="Tom" last="Booth">Tom Booth</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Brouwer, Rachel M" sort="Brouwer, Rachel M" uniqKey="Brouwer R" first="Rachel M" last="Brouwer">Rachel M. Brouwer</name><affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Curran, Joanne E" sort="Curran, Joanne E" uniqKey="Curran J" first="Joanne E" last="Curran">Joanne E. Curran</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="De Zubicaray, Greig I" sort="De Zubicaray, Greig I" uniqKey="De Zubicaray G" first="Greig I" last="De Zubicaray">Greig I. De Zubicaray</name><affiliation wicri:level="1"><nlm:affiliation>School of Psychology, University of Queensland, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychology, University of Queensland, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Dimitrova, Rali" sort="Dimitrova, Rali" uniqKey="Dimitrova R" first="Rali" last="Dimitrova">Rali Dimitrova</name><affiliation wicri:level="1"><nlm:affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Duggirala, Ravi" sort="Duggirala, Ravi" uniqKey="Duggirala R" first="Ravi" last="Duggirala">Ravi Duggirala</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Fox, Peter T" sort="Fox, Peter T" uniqKey="Fox P" first="Peter T" last="Fox">Peter T. Fox</name><affiliation wicri:level="1"><nlm:affiliation>Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Hong, L Elliot" sort="Hong, L Elliot" uniqKey="Hong L" first="L Elliot" last="Hong">L Elliot Hong</name><affiliation wicri:level="1"><nlm:affiliation>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Landman, Bennett A" sort="Landman, Bennett A" uniqKey="Landman B" first="Bennett A" last="Landman">Bennett A. Landman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Electrical Engineering, Vanderbilt University, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Electrical Engineering, Vanderbilt University, Nashville, TN</wicri:regionArea></affiliation></author><author><name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaitre">Hervé Lemaitre</name><affiliation wicri:level="1"><nlm:affiliation>U1000 Research Unit Neuroimaging and Psychiatry, INSERM-CEA-Faculté de Médecine Paris-Sud, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>U1000 Research Unit Neuroimaging and Psychiatry, INSERM-CEA-Faculté de Médecine Paris-Sud, Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M" last="Lopez">Lorna M. Lopez</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L" last="Mcmahon">Katie L. Mcmahon</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Advanced Imaging, University of Queensland, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D" last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L" last="Olvera">Rene L. Olvera</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Peterson, Charles P" sort="Peterson, Charles P" uniqKey="Peterson C" first="Charles P" last="Peterson">Charles P. Peterson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M" last="Starr">John M. Starr</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Sussmann, Jessika E" sort="Sussmann, Jessika E" uniqKey="Sussmann J" first="Jessika E" last="Sussmann">Jessika E. Sussmann</name><affiliation wicri:level="1"><nlm:affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W" last="Toga">Arthur W. Toga</name><affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M" last="Wardlaw">Joanna M. Wardlaw</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J" last="Wright">Margaret J. Wright</name><affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Susan N" sort="Wright, Susan N" uniqKey="Wright S" first="Susan N" last="Wright">Susan N. Wright</name><affiliation wicri:level="1"><nlm:affiliation>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E" last="Bastin">Mark E. Bastin</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Mcintosh, Andrew M" sort="Mcintosh, Andrew M" uniqKey="Mcintosh A" first="Andrew M" last="Mcintosh">Andrew M. Mcintosh</name><affiliation wicri:level="1"><nlm:affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Kahn, Rene S" sort="Kahn, Rene S" uniqKey="Kahn R" first="René S" last="Kahn">René S. Kahn</name><affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J C" last="De Geus">Eco J C. De Geus</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J" last="Deary">Ian J. Deary</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Hulshoff Pol, Hilleke E" sort="Hulshoff Pol, Hilleke E" uniqKey="Hulshoff Pol H" first="Hilleke E" last="Hulshoff Pol">Hilleke E. Hulshoff Pol</name><affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Williamson, Douglas E" sort="Williamson, Douglas E" uniqKey="Williamson D" first="Douglas E" last="Williamson">Douglas E. Williamson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Van T Ent, Dennis" sort="Van T Ent, Dennis" uniqKey="Van T Ent D" first="Dennis" last="Van T Ent">Dennis Van T Ent</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M" last="Thompson">Paul M. Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Neurology, Pediatrics, Engineering, Psychiatry, Radiology, & Ophthalmology, University of Southern California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Neurology, Pediatrics, Engineering, Psychiatry, Radiology, & Ophthalmology, University of Southern California, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C" last="Glahn">David C. Glahn</name><affiliation wicri:level="1"><nlm:affiliation>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24657781</idno><idno type="pmid">24657781</idno><idno type="doi">10.1016/j.neuroimage.2014.03.033</idno><idno type="wicri:Area/PubMed/Corpus">003630</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003630</idno><idno type="wicri:Area/PubMed/Curation">003517</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003517</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling.</title><author><name sortKey="Kochunov, Peter" sort="Kochunov, Peter" uniqKey="Kochunov P" first="Peter" last="Kochunov">Peter Kochunov</name><affiliation wicri:level="1"><nlm:affiliation>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: pkochunov@mprc.umaryland.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Jahanshad, Neda" sort="Jahanshad, Neda" uniqKey="Jahanshad N" first="Neda" last="Jahanshad">Neda Jahanshad</name><affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Sprooten, Emma" sort="Sprooten, Emma" uniqKey="Sprooten E" first="Emma" last="Sprooten">Emma Sprooten</name><affiliation wicri:level="1"><nlm:affiliation>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT</wicri:regionArea></affiliation></author><author><name sortKey="Nichols, Thomas E" sort="Nichols, Thomas E" uniqKey="Nichols T" first="Thomas E" last="Nichols">Thomas E. Nichols</name><affiliation wicri:level="1"><nlm:affiliation>Department of Statistics & Warwick Manufacturing Group, The University of Warwick, Coventry, UK; Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Oxford University, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Statistics & Warwick Manufacturing Group, The University of Warwick, Coventry, UK; Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Oxford University</wicri:regionArea></affiliation></author><author><name sortKey="Mandl, Rene C" sort="Mandl, Rene C" uniqKey="Mandl R" first="René C" last="Mandl">René C. Mandl</name><affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Almasy, Laura" sort="Almasy, Laura" uniqKey="Almasy L" first="Laura" last="Almasy">Laura Almasy</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Booth, Tom" sort="Booth, Tom" uniqKey="Booth T" first="Tom" last="Booth">Tom Booth</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Brouwer, Rachel M" sort="Brouwer, Rachel M" uniqKey="Brouwer R" first="Rachel M" last="Brouwer">Rachel M. Brouwer</name><affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Curran, Joanne E" sort="Curran, Joanne E" uniqKey="Curran J" first="Joanne E" last="Curran">Joanne E. Curran</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="De Zubicaray, Greig I" sort="De Zubicaray, Greig I" uniqKey="De Zubicaray G" first="Greig I" last="De Zubicaray">Greig I. De Zubicaray</name><affiliation wicri:level="1"><nlm:affiliation>School of Psychology, University of Queensland, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychology, University of Queensland, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Dimitrova, Rali" sort="Dimitrova, Rali" uniqKey="Dimitrova R" first="Rali" last="Dimitrova">Rali Dimitrova</name><affiliation wicri:level="1"><nlm:affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Duggirala, Ravi" sort="Duggirala, Ravi" uniqKey="Duggirala R" first="Ravi" last="Duggirala">Ravi Duggirala</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Fox, Peter T" sort="Fox, Peter T" uniqKey="Fox P" first="Peter T" last="Fox">Peter T. Fox</name><affiliation wicri:level="1"><nlm:affiliation>Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Hong, L Elliot" sort="Hong, L Elliot" uniqKey="Hong L" first="L Elliot" last="Hong">L Elliot Hong</name><affiliation wicri:level="1"><nlm:affiliation>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Landman, Bennett A" sort="Landman, Bennett A" uniqKey="Landman B" first="Bennett A" last="Landman">Bennett A. Landman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Electrical Engineering, Vanderbilt University, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Electrical Engineering, Vanderbilt University, Nashville, TN</wicri:regionArea></affiliation></author><author><name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaitre">Hervé Lemaitre</name><affiliation wicri:level="1"><nlm:affiliation>U1000 Research Unit Neuroimaging and Psychiatry, INSERM-CEA-Faculté de Médecine Paris-Sud, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>U1000 Research Unit Neuroimaging and Psychiatry, INSERM-CEA-Faculté de Médecine Paris-Sud, Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M" last="Lopez">Lorna M. Lopez</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L" last="Mcmahon">Katie L. Mcmahon</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Advanced Imaging, University of Queensland, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D" last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L" last="Olvera">Rene L. Olvera</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Peterson, Charles P" sort="Peterson, Charles P" uniqKey="Peterson C" first="Charles P" last="Peterson">Charles P. Peterson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M" last="Starr">John M. Starr</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Sussmann, Jessika E" sort="Sussmann, Jessika E" uniqKey="Sussmann J" first="Jessika E" last="Sussmann">Jessika E. Sussmann</name><affiliation wicri:level="1"><nlm:affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W" last="Toga">Arthur W. Toga</name><affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M" last="Wardlaw">Joanna M. Wardlaw</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J" last="Wright">Margaret J. Wright</name><affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Susan N" sort="Wright, Susan N" uniqKey="Wright S" first="Susan N" last="Wright">Susan N. Wright</name><affiliation wicri:level="1"><nlm:affiliation>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E" last="Bastin">Mark E. Bastin</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Mcintosh, Andrew M" sort="Mcintosh, Andrew M" uniqKey="Mcintosh A" first="Andrew M" last="Mcintosh">Andrew M. Mcintosh</name><affiliation wicri:level="1"><nlm:affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Kahn, Rene S" sort="Kahn, Rene S" uniqKey="Kahn R" first="René S" last="Kahn">René S. Kahn</name><affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J C" last="De Geus">Eco J C. De Geus</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J" last="Deary">Ian J. Deary</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Hulshoff Pol, Hilleke E" sort="Hulshoff Pol, Hilleke E" uniqKey="Hulshoff Pol H" first="Hilleke E" last="Hulshoff Pol">Hilleke E. Hulshoff Pol</name><affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Williamson, Douglas E" sort="Williamson, Douglas E" uniqKey="Williamson D" first="Douglas E" last="Williamson">Douglas E. Williamson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea></affiliation></author><author><name sortKey="Van T Ent, Dennis" sort="Van T Ent, Dennis" uniqKey="Van T Ent D" first="Dennis" last="Van T Ent">Dennis Van T Ent</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M" last="Thompson">Paul M. Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Neurology, Pediatrics, Engineering, Psychiatry, Radiology, & Ophthalmology, University of Southern California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Neurology, Pediatrics, Engineering, Psychiatry, Radiology, & Ophthalmology, University of Southern California, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C" last="Glahn">David C. Glahn</name><affiliation wicri:level="1"><nlm:affiliation>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT</wicri:regionArea></affiliation></author></analytic><series><title level="j">NeuroImage</title><idno type="eISSN">1095-9572</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Anisotropy</term><term>Brain</term><term>Child</term><term>Diffusion Tensor Imaging</term><term>Female</term><term>Genetic Variation</term><term>Humans</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Middle Aged</term><term>White Matter</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anisotropie</term><term>Encéphale</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Imagerie par tenseur de diffusion</term><term>Jeune adulte</term><term>Mâle</term><term>Méta-analyse comme sujet</term><term>Substance blanche</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Variation génétique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Anisotropy</term><term>Brain</term><term>Child</term><term>Diffusion Tensor Imaging</term><term>Female</term><term>Genetic Variation</term><term>Humans</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Middle Aged</term><term>White Matter</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anisotropie</term><term>Encéphale</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Imagerie par tenseur de diffusion</term><term>Jeune adulte</term><term>Mâle</term><term>Méta-analyse comme sujet</term><term>Substance blanche</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Variation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Combining datasets across independent studies can boost statistical power by increasing the numbers of observations and can achieve more accurate estimates of effect sizes. This is especially important for genetic studies where a large number of observations are required to obtain sufficient power to detect and replicate genetic effects. There is a need to develop and evaluate methods for joint-analytical analyses of rich datasets collected in imaging genetics studies. The ENIGMA-DTI consortium is developing and evaluating approaches for obtaining pooled estimates of heritability through meta-and mega-genetic analytical approaches, to estimate the general additive genetic contributions to the intersubject variance in fractional anisotropy (FA) measured from diffusion tensor imaging (DTI). We used the ENIGMA-DTI data harmonization protocol for uniform processing of DTI data from multiple sites. We evaluated this protocol in five family-based cohorts providing data from a total of 2248 children and adults (ages: 9-85) collected with various imaging protocols. We used the imaging genetics analysis tool, SOLAR-Eclipse, to combine twin and family data from Dutch, Australian and Mexican-American cohorts into one large "mega-family". We showed that heritability estimates may vary from one cohort to another. We used two meta-analytical (the sample-size and standard-error weighted) approaches and a mega-genetic analysis to calculate heritability estimates across-population. We performed leave-one-out analysis of the joint estimates of heritability, removing a different cohort each time to understand the estimate variability. Overall, meta- and mega-genetic analyses of heritability produced robust estimates of heritability.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24657781</PMID><DateCreated><Year>2014</Year><Month>06</Month><Day>03</Day></DateCreated><DateCompleted><Year>2015</Year><Month>01</Month><Day>12</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9572</ISSN><JournalIssue CitedMedium="Internet"><Volume>95</Volume><PubDate><Year>2014</Year><Month>Jul</Month><Day>15</Day></PubDate></JournalIssue><Title>NeuroImage</Title><ISOAbbreviation>Neuroimage</ISOAbbreviation></Journal><ArticleTitle>Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling.</ArticleTitle><Pagination><MedlinePgn>136-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neuroimage.2014.03.033</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1053-8119(14)00180-3</ELocationID><Abstract><AbstractText>Combining datasets across independent studies can boost statistical power by increasing the numbers of observations and can achieve more accurate estimates of effect sizes. This is especially important for genetic studies where a large number of observations are required to obtain sufficient power to detect and replicate genetic effects. There is a need to develop and evaluate methods for joint-analytical analyses of rich datasets collected in imaging genetics studies. The ENIGMA-DTI consortium is developing and evaluating approaches for obtaining pooled estimates of heritability through meta-and mega-genetic analytical approaches, to estimate the general additive genetic contributions to the intersubject variance in fractional anisotropy (FA) measured from diffusion tensor imaging (DTI). We used the ENIGMA-DTI data harmonization protocol for uniform processing of DTI data from multiple sites. We evaluated this protocol in five family-based cohorts providing data from a total of 2248 children and adults (ages: 9-85) collected with various imaging protocols. We used the imaging genetics analysis tool, SOLAR-Eclipse, to combine twin and family data from Dutch, Australian and Mexican-American cohorts into one large "mega-family". We showed that heritability estimates may vary from one cohort to another. We used two meta-analytical (the sample-size and standard-error weighted) approaches and a mega-genetic analysis to calculate heritability estimates across-population. We performed leave-one-out analysis of the joint estimates of heritability, removing a different cohort each time to understand the estimate variability. Overall, meta- and mega-genetic analyses of heritability produced robust estimates of heritability.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kochunov</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: pkochunov@mprc.umaryland.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jahanshad</LastName><ForeName>Neda</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sprooten</LastName><ForeName>Emma</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nichols</LastName><ForeName>Thomas E</ForeName><Initials>TE</Initials><AffiliationInfo><Affiliation>Department of Statistics & Warwick Manufacturing Group, The University of Warwick, Coventry, UK; Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Oxford University, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mandl</LastName><ForeName>René C</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Almasy</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Booth</LastName><ForeName>Tom</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brouwer</LastName><ForeName>Rachel M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Curran</LastName><ForeName>Joanne E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Zubicaray</LastName><ForeName>Greig I</ForeName><Initials>GI</Initials><AffiliationInfo><Affiliation>School of Psychology, University of Queensland, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dimitrova</LastName><ForeName>Rali</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duggirala</LastName><ForeName>Ravi</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fox</LastName><ForeName>Peter T</ForeName><Initials>PT</Initials><AffiliationInfo><Affiliation>Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hong</LastName><ForeName>L Elliot</ForeName><Initials>LE</Initials><AffiliationInfo><Affiliation>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landman</LastName><ForeName>Bennett A</ForeName><Initials>BA</Initials><AffiliationInfo><Affiliation>Department of Electrical Engineering, Vanderbilt University, Nashville, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lemaitre</LastName><ForeName>Hervé</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>U1000 Research Unit Neuroimaging and Psychiatry, INSERM-CEA-Faculté de Médecine Paris-Sud, Orsay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lopez</LastName><ForeName>Lorna M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Nicholas G</ForeName><Initials>NG</Initials><AffiliationInfo><Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McMahon</LastName><ForeName>Katie L</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitchell</LastName><ForeName>Braxton D</ForeName><Initials>BD</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olvera</LastName><ForeName>Rene L</ForeName><Initials>RL</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peterson</LastName><ForeName>Charles P</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Starr</LastName><ForeName>John M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sussmann</LastName><ForeName>Jessika E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toga</LastName><ForeName>Arthur W</ForeName><Initials>AW</Initials><AffiliationInfo><Affiliation>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wardlaw</LastName><ForeName>Joanna M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wright</LastName><ForeName>Margaret J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wright</LastName><ForeName>Susan N</ForeName><Initials>SN</Initials><AffiliationInfo><Affiliation>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bastin</LastName><ForeName>Mark E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McIntosh</LastName><ForeName>Andrew M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boomsma</LastName><ForeName>Dorret I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kahn</LastName><ForeName>René S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>den Braber</LastName><ForeName>Anouk</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Geus</LastName><ForeName>Eco J C</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deary</LastName><ForeName>Ian J</ForeName><Initials>IJ</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hulshoff Pol</LastName><ForeName>Hilleke E</ForeName><Initials>HE</Initials><AffiliationInfo><Affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Williamson</LastName><ForeName>Douglas E</ForeName><Initials>DE</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blangero</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van 't Ent</LastName><ForeName>Dennis</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>Paul M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Neurology, Pediatrics, Engineering, Psychiatry, Radiology, & Ophthalmology, University of Southern California, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Glahn</LastName><ForeName>David C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P41 EB015922</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>EB007813</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EB007813</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>087727/Z/08/Z</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 EB015611</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01AA016274</GrantID><Acronym>AA</Acronym><Agency>NIAAA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MH083824</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>G1001245</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/K026992/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 MH078111</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>EB008432</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>100309</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 HD050735</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EB008432</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>G0701120</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MH59490</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 MH059490</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>EB008281</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 MH059490</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>G0700704</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>BB/F019394/1</GrantID><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 MH083824</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EB008281</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AA016274</GrantID><Acronym>AA</Acronym><Agency>NIAAA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MH0708143</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D018486">Twin Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>03</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neuroimage</MedlineTA><NlmUniqueID>9215515</NlmUniqueID><ISSNLinking>1053-8119</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Brain Imaging Behav. 2008 Dec 1;2(4):258-263</RefSource><PMID Version="1">20016769</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 2008 Aug;165(8):1024-32</RefSource><PMID Version="1">18558643</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur Arch Psychiatry Clin Neurosci. 2001 Dec;251(6):255-61</RefSource><PMID Version="1">11881838</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Brain Mapp. 2013 Oct;34(10):2688-706</RefSource><PMID Version="1">22522814</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Twin Res Hum Genet. 2012 Jun;15(3):372-83</RefSource><PMID Version="1">22856371</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroinformatics. 2012 Jan;10(1):81-96</RefSource><PMID Version="1">21698393</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2012 May;44(5):545-51</RefSource><PMID Version="1">22504421</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1193-8</RefSource><PMID Version="1">22223662</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2013 Nov 1;81:455-69</RefSource><PMID Version="1">23629049</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Genet. 2010 Mar;40(2):146-56</RefSource><PMID Version="1">20087642</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychiatry Res. 2011 Dec 30;194(3):363-71</RefSource><PMID Version="1">22078796</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2011 Aug 15;70(4):350-6</RefSource><PMID Version="1">21429475</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2010;5(9). pii: e13070. doi: 10.1371/journal.pone.0013070</RefSource><PMID Version="1">20927408</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Brain Mapp. 2013 Sep;34(9):2353-65</RefSource><PMID Version="1">22461372</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Biol. 2005 Oct;77(5):541-59</RefSource><PMID Version="1">16596940</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2001 Dec;4(12):1253-8</RefSource><PMID Version="1">11694885</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Magn Reson B. 1996 Jun;111(3):209-19</RefSource><PMID Version="1">8661285</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Twin Res Hum Genet. 2007 Jun;10(3):423-33</RefSource><PMID Version="1">17564500</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Twin Res Hum Genet. 2012 Jun;15(3):453-67</RefSource><PMID Version="1">22856378</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur Neuropsychopharmacol. 2013 Jan;23(1):19-23</RefSource><PMID Version="1">22819192</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Med Genet B Neuropsychiatr Genet. 2011 Jul;156B(5):561-8</RefSource><PMID Version="1">21557468</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(4):e32316</RefSource><PMID Version="1">22514599</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Psychol. 2008 Sep;79(1):91-102</RefSource><PMID Version="1">18342423</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2011 Nov 15;70(10):969-77</RefSource><PMID Version="1">21549354</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2013 Mar 1;73(5):482-91</RefSource><PMID Version="1">23200529</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Methods. 2010 Mar;50(3):136-46</RefSource><PMID Version="1">19665566</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Adv Genet. 2013;81:1-31</RefSource><PMID Version="1">23419715</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2005 Jan 1;24(1):163-73</RefSource><PMID Version="1">15588607</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroimage Clin. 2013 Apr 05;2:558-68</RefSource><PMID Version="1">24179807</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2010 Nov 15;53(3):1126-34</RefSource><PMID Version="1">20035879</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 1994 Mar;54(3):535-43</RefSource><PMID Version="1">8116623</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2006 Jul 15;31(4):1487-505</RefSource><PMID Version="1">16624579</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Protoc. 2007;2(3):499-503</RefSource><PMID Version="1">17406613</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Twin Res Hum Genet. 2013 Feb;16(1):252-67</RefSource><PMID Version="1">23186620</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Addiction. 2003 Jan;98(1):23-31</RefSource><PMID Version="1">12492752</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychol Bull. 2002 May;128(3):490-529</RefSource><PMID Version="1">12002699</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 2010 Apr;167(4):451-8</RefSource><PMID Version="1">20160006</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Med Genet B Neuropsychiatr Genet. 2012 Jul;159B(5):537-48</RefSource><PMID Version="1">22585743</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2010 Nov 15;53(3):1085-92</RefSource><PMID Version="1">20298793</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 1998 May;62(5):1198-211</RefSource><PMID Version="1">9545414</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1223-8</RefSource><PMID Version="1">20133824</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2010 Jun 2;30(22):7569-74</RefSource><PMID Version="1">20519531</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Twin Res Hum Genet. 2013 Apr;16(2):516-24</RefSource><PMID Version="1">23527678</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Magn Reson Med. 1999 Jul;42(1):127-35</RefSource><PMID Version="1">10398958</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Psychiatry. 2011 Jun;16(6):604-19</RefSource><PMID Version="1">21602829</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2012 May;44(5):552-61</RefSource><PMID Version="1">22504417</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2012 May;44(5):532-8</RefSource><PMID Version="1">22504419</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Brain Mapp. 2007 Jun;28(6):488-501</RefSource><PMID Version="1">17440953</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2002 Apr;15(4):870-8</RefSource><PMID Version="1">11906227</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Integr Neurosci. 2013 Mar 11;7:9</RefSource><PMID Version="1">23483798</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2012;31 Suppl 3:S33-47</RefSource><PMID Version="1">22992380</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2004 May;7(5):473-81</RefSource><PMID Version="1">15114361</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Alzheimers Dis. 2011 Mar 31;2011:490140</RefSource><PMID Version="1">21547229</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2012 Mar 30;335(6076):1634-6</RefSource><PMID Version="1">22461613</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2012 May;44(5):539-44</RefSource><PMID Version="1">22504418</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2010 Nov 15;53(3):1109-16</RefSource><PMID Version="1">20117221</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2013 Sep;38(10):1954-62</RefSource><PMID Version="1">23591167</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Addiction. 2010 Mar;105(3):417-30</RefSource><PMID Version="1">20402985</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2012;29(2):405-29</RefSource><PMID Version="1">22330833</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Alzheimers Dement. 2012 Feb;8(1 Suppl):S1-68</RefSource><PMID Version="1">22047634</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Clin Psychol. 2011;7:63-85</RefSource><PMID Version="1">21219189</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biophys J. 1994 Jan;66(1):259-67</RefSource><PMID Version="1">8130344</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016880" MajorTopicYN="N">Anisotropy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="Y">Brain</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056324" MajorTopicYN="N">Diffusion Tensor Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="Y">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015201" MajorTopicYN="Y">Meta-Analysis as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D066127" MajorTopicYN="Y">White Matter</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS578312</OtherID><OtherID Source="NLM">PMC4043878</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Diffusion tensor imaging (DTI)</Keyword><Keyword MajorTopicYN="N">Heritability</Keyword><Keyword MajorTopicYN="N">Imaging genetics</Keyword><Keyword MajorTopicYN="N">Meta-analysis</Keyword><Keyword MajorTopicYN="N">Multi-site</Keyword><Keyword MajorTopicYN="N">Reliability</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>10</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>02</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>03</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>1</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24657781</ArticleId><ArticleId IdType="pii">S1053-8119(14)00180-3</ArticleId><ArticleId IdType="doi">10.1016/j.neuroimage.2014.03.033</ArticleId><ArticleId IdType="pmc">PMC4043878</ArticleId><ArticleId IdType="mid">NIHMS578312</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003517 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 003517 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:24657781
|texte= Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:24657781" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |