Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling.
Identifieur interne : 003517 ( PubMed/Curation ); précédent : 003516; suivant : 003518Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling.
Auteurs : Peter Kochunov [États-Unis] ; Neda Jahanshad [États-Unis] ; Emma Sprooten [États-Unis] ; Thomas E. Nichols [Royaume-Uni] ; René C. Mandl [Pays-Bas] ; Laura Almasy [États-Unis] ; Tom Booth [Royaume-Uni] ; Rachel M. Brouwer [Pays-Bas] ; Joanne E. Curran [États-Unis] ; Greig I. De Zubicaray [Australie] ; Rali Dimitrova [Royaume-Uni] ; Ravi Duggirala [États-Unis] ; Peter T. Fox [États-Unis] ; L Elliot Hong [États-Unis] ; Bennett A. Landman [États-Unis] ; Hervé Lemaitre [France] ; Lorna M. Lopez [Royaume-Uni] ; Nicholas G. Martin [Australie] ; Katie L. Mcmahon [Australie] ; Braxton D. Mitchell [États-Unis] ; Rene L. Olvera [États-Unis] ; Charles P. Peterson [États-Unis] ; John M. Starr [Royaume-Uni] ; Jessika E. Sussmann [Royaume-Uni] ; Arthur W. Toga [États-Unis] ; Joanna M. Wardlaw [Royaume-Uni] ; Margaret J. Wright [Australie] ; Susan N. Wright [États-Unis] ; Mark E. Bastin [Royaume-Uni] ; Andrew M. Mcintosh [Royaume-Uni] ; Dorret I. Boomsma [Pays-Bas] ; René S. Kahn [Pays-Bas] ; Anouk Den Braber [Pays-Bas] ; Eco J C. De Geus [Pays-Bas] ; Ian J. Deary [Royaume-Uni] ; Hilleke E. Hulshoff Pol [Pays-Bas] ; Douglas E. Williamson [États-Unis] ; John Blangero [États-Unis] ; Dennis Van T Ent [Pays-Bas] ; Paul M. Thompson [États-Unis] ; David C. Glahn [États-Unis]Source :
- NeuroImage [ 1095-9572 ] ; 2014.
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Abstract
Combining datasets across independent studies can boost statistical power by increasing the numbers of observations and can achieve more accurate estimates of effect sizes. This is especially important for genetic studies where a large number of observations are required to obtain sufficient power to detect and replicate genetic effects. There is a need to develop and evaluate methods for joint-analytical analyses of rich datasets collected in imaging genetics studies. The ENIGMA-DTI consortium is developing and evaluating approaches for obtaining pooled estimates of heritability through meta-and mega-genetic analytical approaches, to estimate the general additive genetic contributions to the intersubject variance in fractional anisotropy (FA) measured from diffusion tensor imaging (DTI). We used the ENIGMA-DTI data harmonization protocol for uniform processing of DTI data from multiple sites. We evaluated this protocol in five family-based cohorts providing data from a total of 2248 children and adults (ages: 9-85) collected with various imaging protocols. We used the imaging genetics analysis tool, SOLAR-Eclipse, to combine twin and family data from Dutch, Australian and Mexican-American cohorts into one large "mega-family". We showed that heritability estimates may vary from one cohort to another. We used two meta-analytical (the sample-size and standard-error weighted) approaches and a mega-genetic analysis to calculate heritability estimates across-population. We performed leave-one-out analysis of the joint estimates of heritability, removing a different cohort each time to understand the estimate variability. Overall, meta- and mega-genetic analyses of heritability produced robust estimates of heritability.
DOI: 10.1016/j.neuroimage.2014.03.033
PubMed: 24657781
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<author><name sortKey="Jahanshad, Neda" sort="Jahanshad, Neda" uniqKey="Jahanshad N" first="Neda" last="Jahanshad">Neda Jahanshad</name>
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<author><name sortKey="Nichols, Thomas E" sort="Nichols, Thomas E" uniqKey="Nichols T" first="Thomas E" last="Nichols">Thomas E. Nichols</name>
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<author><name sortKey="Mandl, Rene C" sort="Mandl, Rene C" uniqKey="Mandl R" first="René C" last="Mandl">René C. Mandl</name>
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<author><name sortKey="Almasy, Laura" sort="Almasy, Laura" uniqKey="Almasy L" first="Laura" last="Almasy">Laura Almasy</name>
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<author><name sortKey="Booth, Tom" sort="Booth, Tom" uniqKey="Booth T" first="Tom" last="Booth">Tom Booth</name>
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<author><name sortKey="Brouwer, Rachel M" sort="Brouwer, Rachel M" uniqKey="Brouwer R" first="Rachel M" last="Brouwer">Rachel M. Brouwer</name>
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<author><name sortKey="Curran, Joanne E" sort="Curran, Joanne E" uniqKey="Curran J" first="Joanne E" last="Curran">Joanne E. Curran</name>
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<author><name sortKey="De Zubicaray, Greig I" sort="De Zubicaray, Greig I" uniqKey="De Zubicaray G" first="Greig I" last="De Zubicaray">Greig I. De Zubicaray</name>
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<author><name sortKey="Dimitrova, Rali" sort="Dimitrova, Rali" uniqKey="Dimitrova R" first="Rali" last="Dimitrova">Rali Dimitrova</name>
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<author><name sortKey="Duggirala, Ravi" sort="Duggirala, Ravi" uniqKey="Duggirala R" first="Ravi" last="Duggirala">Ravi Duggirala</name>
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<author><name sortKey="Fox, Peter T" sort="Fox, Peter T" uniqKey="Fox P" first="Peter T" last="Fox">Peter T. Fox</name>
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<author><name sortKey="Hong, L Elliot" sort="Hong, L Elliot" uniqKey="Hong L" first="L Elliot" last="Hong">L Elliot Hong</name>
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<author><name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaitre">Hervé Lemaitre</name>
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<author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M" last="Lopez">Lorna M. Lopez</name>
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<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
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<author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L" last="Mcmahon">Katie L. Mcmahon</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.</nlm:affiliation>
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<author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D" last="Mitchell">Braxton D. Mitchell</name>
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<author><name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L" last="Olvera">Rene L. Olvera</name>
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<author><name sortKey="Peterson, Charles P" sort="Peterson, Charles P" uniqKey="Peterson C" first="Charles P" last="Peterson">Charles P. Peterson</name>
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<author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M" last="Starr">John M. Starr</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sussmann, Jessika E" sort="Sussmann, Jessika E" uniqKey="Sussmann J" first="Jessika E" last="Sussmann">Jessika E. Sussmann</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</nlm:affiliation>
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<author><name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W" last="Toga">Arthur W. Toga</name>
<affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M" last="Wardlaw">Joanna M. Wardlaw</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</wicri:regionArea>
</affiliation>
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<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J" last="Wright">Margaret J. Wright</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wright, Susan N" sort="Wright, Susan N" uniqKey="Wright S" first="Susan N" last="Wright">Susan N. Wright</name>
<affiliation wicri:level="1"><nlm:affiliation>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea>
</affiliation>
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<author><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E" last="Bastin">Mark E. Bastin</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcintosh, Andrew M" sort="Mcintosh, Andrew M" uniqKey="Mcintosh A" first="Andrew M" last="Mcintosh">Andrew M. Mcintosh</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kahn, Rene S" sort="Kahn, Rene S" uniqKey="Kahn R" first="René S" last="Kahn">René S. Kahn</name>
<affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J C" last="De Geus">Eco J C. De Geus</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J" last="Deary">Ian J. Deary</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hulshoff Pol, Hilleke E" sort="Hulshoff Pol, Hilleke E" uniqKey="Hulshoff Pol H" first="Hilleke E" last="Hulshoff Pol">Hilleke E. Hulshoff Pol</name>
<affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Williamson, Douglas E" sort="Williamson, Douglas E" uniqKey="Williamson D" first="Douglas E" last="Williamson">Douglas E. Williamson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van T Ent, Dennis" sort="Van T Ent, Dennis" uniqKey="Van T Ent D" first="Dennis" last="Van T Ent">Dennis Van T Ent</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M" last="Thompson">Paul M. Thompson</name>
<affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Neurology, Pediatrics, Engineering, Psychiatry, Radiology, & Ophthalmology, University of Southern California, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Neurology, Pediatrics, Engineering, Psychiatry, Radiology, & Ophthalmology, University of Southern California, Los Angeles, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C" last="Glahn">David C. Glahn</name>
<affiliation wicri:level="1"><nlm:affiliation>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT</wicri:regionArea>
</affiliation>
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</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling.</title>
<author><name sortKey="Kochunov, Peter" sort="Kochunov, Peter" uniqKey="Kochunov P" first="Peter" last="Kochunov">Peter Kochunov</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Jahanshad, Neda" sort="Jahanshad, Neda" uniqKey="Jahanshad N" first="Neda" last="Jahanshad">Neda Jahanshad</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sprooten, Emma" sort="Sprooten, Emma" uniqKey="Sprooten E" first="Emma" last="Sprooten">Emma Sprooten</name>
<affiliation wicri:level="1"><nlm:affiliation>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA.</nlm:affiliation>
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<author><name sortKey="Nichols, Thomas E" sort="Nichols, Thomas E" uniqKey="Nichols T" first="Thomas E" last="Nichols">Thomas E. Nichols</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Statistics & Warwick Manufacturing Group, The University of Warwick, Coventry, UK; Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Oxford University, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Statistics & Warwick Manufacturing Group, The University of Warwick, Coventry, UK; Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Oxford University</wicri:regionArea>
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</author>
<author><name sortKey="Mandl, Rene C" sort="Mandl, Rene C" uniqKey="Mandl R" first="René C" last="Mandl">René C. Mandl</name>
<affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea>
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</author>
<author><name sortKey="Almasy, Laura" sort="Almasy, Laura" uniqKey="Almasy L" first="Laura" last="Almasy">Laura Almasy</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Booth, Tom" sort="Booth, Tom" uniqKey="Booth T" first="Tom" last="Booth">Tom Booth</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brouwer, Rachel M" sort="Brouwer, Rachel M" uniqKey="Brouwer R" first="Rachel M" last="Brouwer">Rachel M. Brouwer</name>
<affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Curran, Joanne E" sort="Curran, Joanne E" uniqKey="Curran J" first="Joanne E" last="Curran">Joanne E. Curran</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea>
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</author>
<author><name sortKey="De Zubicaray, Greig I" sort="De Zubicaray, Greig I" uniqKey="De Zubicaray G" first="Greig I" last="De Zubicaray">Greig I. De Zubicaray</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Psychology, University of Queensland, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychology, University of Queensland, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dimitrova, Rali" sort="Dimitrova, Rali" uniqKey="Dimitrova R" first="Rali" last="Dimitrova">Rali Dimitrova</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Duggirala, Ravi" sort="Duggirala, Ravi" uniqKey="Duggirala R" first="Ravi" last="Duggirala">Ravi Duggirala</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fox, Peter T" sort="Fox, Peter T" uniqKey="Fox P" first="Peter T" last="Fox">Peter T. Fox</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea>
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<author><name sortKey="Hong, L Elliot" sort="Hong, L Elliot" uniqKey="Hong L" first="L Elliot" last="Hong">L Elliot Hong</name>
<affiliation wicri:level="1"><nlm:affiliation>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea>
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<author><name sortKey="Landman, Bennett A" sort="Landman, Bennett A" uniqKey="Landman B" first="Bennett A" last="Landman">Bennett A. Landman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Electrical Engineering, Vanderbilt University, Nashville, TN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Electrical Engineering, Vanderbilt University, Nashville, TN</wicri:regionArea>
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<author><name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaitre">Hervé Lemaitre</name>
<affiliation wicri:level="1"><nlm:affiliation>U1000 Research Unit Neuroimaging and Psychiatry, INSERM-CEA-Faculté de Médecine Paris-Sud, Orsay, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>U1000 Research Unit Neuroimaging and Psychiatry, INSERM-CEA-Faculté de Médecine Paris-Sud, Orsay</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M" last="Lopez">Lorna M. Lopez</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L" last="Mcmahon">Katie L. Mcmahon</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Advanced Imaging, University of Queensland, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D" last="Mitchell">Braxton D. Mitchell</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L" last="Olvera">Rene L. Olvera</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peterson, Charles P" sort="Peterson, Charles P" uniqKey="Peterson C" first="Charles P" last="Peterson">Charles P. Peterson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M" last="Starr">John M. Starr</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sussmann, Jessika E" sort="Sussmann, Jessika E" uniqKey="Sussmann J" first="Jessika E" last="Sussmann">Jessika E. Sussmann</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea>
</affiliation>
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<author><name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W" last="Toga">Arthur W. Toga</name>
<affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M" last="Wardlaw">Joanna M. Wardlaw</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</wicri:regionArea>
</affiliation>
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<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J" last="Wright">Margaret J. Wright</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea>
</affiliation>
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<author><name sortKey="Wright, Susan N" sort="Wright, Susan N" uniqKey="Wright S" first="Susan N" last="Wright">Susan N. Wright</name>
<affiliation wicri:level="1"><nlm:affiliation>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea>
</affiliation>
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<author><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E" last="Bastin">Mark E. Bastin</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</wicri:regionArea>
</affiliation>
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<author><name sortKey="Mcintosh, Andrew M" sort="Mcintosh, Andrew M" uniqKey="Mcintosh A" first="Andrew M" last="Mcintosh">Andrew M. Mcintosh</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kahn, Rene S" sort="Kahn, Rene S" uniqKey="Kahn R" first="René S" last="Kahn">René S. Kahn</name>
<affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J C" last="De Geus">Eco J C. De Geus</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J" last="Deary">Ian J. Deary</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hulshoff Pol, Hilleke E" sort="Hulshoff Pol, Hilleke E" uniqKey="Hulshoff Pol H" first="Hilleke E" last="Hulshoff Pol">Hilleke E. Hulshoff Pol</name>
<affiliation wicri:level="1"><nlm:affiliation>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Williamson, Douglas E" sort="Williamson, Douglas E" uniqKey="Williamson D" first="Douglas E" last="Williamson">Douglas E. Williamson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van T Ent, Dennis" sort="Van T Ent, Dennis" uniqKey="Van T Ent D" first="Dennis" last="Van T Ent">Dennis Van T Ent</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M" last="Thompson">Paul M. Thompson</name>
<affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Neurology, Pediatrics, Engineering, Psychiatry, Radiology, & Ophthalmology, University of Southern California, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Neurology, Pediatrics, Engineering, Psychiatry, Radiology, & Ophthalmology, University of Southern California, Los Angeles, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C" last="Glahn">David C. Glahn</name>
<affiliation wicri:level="1"><nlm:affiliation>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT</wicri:regionArea>
</affiliation>
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<series><title level="j">NeuroImage</title>
<idno type="eISSN">1095-9572</idno>
<imprint><date when="2014" type="published">2014</date>
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<front><div type="abstract" xml:lang="en">Combining datasets across independent studies can boost statistical power by increasing the numbers of observations and can achieve more accurate estimates of effect sizes. This is especially important for genetic studies where a large number of observations are required to obtain sufficient power to detect and replicate genetic effects. There is a need to develop and evaluate methods for joint-analytical analyses of rich datasets collected in imaging genetics studies. The ENIGMA-DTI consortium is developing and evaluating approaches for obtaining pooled estimates of heritability through meta-and mega-genetic analytical approaches, to estimate the general additive genetic contributions to the intersubject variance in fractional anisotropy (FA) measured from diffusion tensor imaging (DTI). We used the ENIGMA-DTI data harmonization protocol for uniform processing of DTI data from multiple sites. We evaluated this protocol in five family-based cohorts providing data from a total of 2248 children and adults (ages: 9-85) collected with various imaging protocols. We used the imaging genetics analysis tool, SOLAR-Eclipse, to combine twin and family data from Dutch, Australian and Mexican-American cohorts into one large "mega-family". We showed that heritability estimates may vary from one cohort to another. We used two meta-analytical (the sample-size and standard-error weighted) approaches and a mega-genetic analysis to calculate heritability estimates across-population. We performed leave-one-out analysis of the joint estimates of heritability, removing a different cohort each time to understand the estimate variability. Overall, meta- and mega-genetic analyses of heritability produced robust estimates of heritability.</div>
</front>
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<DateCreated><Year>2014</Year>
<Month>06</Month>
<Day>03</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>01</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9572</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>95</Volume>
<PubDate><Year>2014</Year>
<Month>Jul</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>NeuroImage</Title>
<ISOAbbreviation>Neuroimage</ISOAbbreviation>
</Journal>
<ArticleTitle>Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling.</ArticleTitle>
<Pagination><MedlinePgn>136-50</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neuroimage.2014.03.033</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S1053-8119(14)00180-3</ELocationID>
<Abstract><AbstractText>Combining datasets across independent studies can boost statistical power by increasing the numbers of observations and can achieve more accurate estimates of effect sizes. This is especially important for genetic studies where a large number of observations are required to obtain sufficient power to detect and replicate genetic effects. There is a need to develop and evaluate methods for joint-analytical analyses of rich datasets collected in imaging genetics studies. The ENIGMA-DTI consortium is developing and evaluating approaches for obtaining pooled estimates of heritability through meta-and mega-genetic analytical approaches, to estimate the general additive genetic contributions to the intersubject variance in fractional anisotropy (FA) measured from diffusion tensor imaging (DTI). We used the ENIGMA-DTI data harmonization protocol for uniform processing of DTI data from multiple sites. We evaluated this protocol in five family-based cohorts providing data from a total of 2248 children and adults (ages: 9-85) collected with various imaging protocols. We used the imaging genetics analysis tool, SOLAR-Eclipse, to combine twin and family data from Dutch, Australian and Mexican-American cohorts into one large "mega-family". We showed that heritability estimates may vary from one cohort to another. We used two meta-analytical (the sample-size and standard-error weighted) approaches and a mega-genetic analysis to calculate heritability estimates across-population. We performed leave-one-out analysis of the joint estimates of heritability, removing a different cohort each time to understand the estimate variability. Overall, meta- and mega-genetic analyses of heritability produced robust estimates of heritability.</AbstractText>
<CopyrightInformation>Copyright © 2014 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
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<ForeName>Peter</ForeName>
<Initials>P</Initials>
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<Initials>TE</Initials>
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