Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts.
Identifieur interne : 003688 ( Main/Merge ); précédent : 003687; suivant : 003689Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts.
Auteurs : Benoit Le Goff [France] ; Sofie Singbrant [Australie] ; Brett A. Tonkin [Australie] ; T John Martin [Australie] ; Evange Romas [Australie] ; Natalie A. Sims [Australie] ; Nicole C. Walsh [Australie]Source :
- Cytokine [ 1096-0023 ] ; 2014.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Animaux, Facteur de nécrose tumorale alpha (métabolisme), Fibroblastes (métabolisme), Humains, Interleukine-1 bêta (génétique), Interleukine-1 bêta (métabolisme), Ligand de RANK (génétique), Ligand de RANK (métabolisme), Membrane synoviale (anatomopathologie), Oncostatine M (métabolisme), Ostéoprotégérine (génétique), Ostéoprotégérine (métabolisme), Polyarthrite rhumatoïde (anatomopathologie), Polyarthrite rhumatoïde (génétique), Récepteurs à l'interleukine-1 (métabolisme), Récepteurs à l'oncostatine M (déficit), Récepteurs à l'oncostatine M (métabolisme), Régulation de l'expression des gènes, Souris de lignée C57BL.
- MESH :
- anatomopathologie : Membrane synoviale, Polyarthrite rhumatoïde.
- déficit : Récepteurs à l'oncostatine M.
- génétique : ARN messager, Interleukine-1 bêta, Ligand de RANK, Ostéoprotégérine, Polyarthrite rhumatoïde.
- métabolisme : ARN messager, Facteur de nécrose tumorale alpha, Fibroblastes, Interleukine-1 bêta, Ligand de RANK, Oncostatine M, Ostéoprotégérine, Récepteurs à l'interleukine-1, Récepteurs à l'oncostatine M.
- Animaux, Humains, Régulation de l'expression des gènes, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals, Arthritis, Rheumatoid (genetics), Arthritis, Rheumatoid (pathology), Fibroblasts (metabolism), Gene Expression Regulation, Humans, Interleukin-1beta (genetics), Interleukin-1beta (metabolism), Mice, Inbred C57BL, Oncostatin M (metabolism), Osteoprotegerin (genetics), Osteoprotegerin (metabolism), RANK Ligand (genetics), RANK Ligand (metabolism), RNA, Messenger (genetics), RNA, Messenger (metabolism), Receptors, Interleukin-1 (metabolism), Receptors, Oncostatin M (deficiency), Receptors, Oncostatin M (metabolism), Synovial Membrane (pathology), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , deficiency : Receptors, Oncostatin M.
- chemical , genetics : Interleukin-1beta, Osteoprotegerin, RANK Ligand, RNA, Messenger.
- genetics : Arthritis, Rheumatoid.
- metabolism : Fibroblasts, Interleukin-1beta, Oncostatin M, Osteoprotegerin, RANK Ligand, RNA, Messenger, Receptors, Interleukin-1, Receptors, Oncostatin M, Tumor Necrosis Factor-alpha.
- pathology : Arthritis, Rheumatoid, Synovial Membrane.
- Animals, Gene Expression Regulation, Humans, Mice, Inbred C57BL.
Abstract
To identify how the gp130-signaling cytokine oncostatin M (OSM), acting alone or in concert with IL-1β or TNFα, affects synovial fibroblast expression of genes relevant to inflammation and bone erosion in inflammatory arthritis.
DOI: 10.1016/j.cyto.2014.04.001
PubMed: 24767864
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pubmed:24767864Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Arthritis, Rheumatoid (genetics)</term>
<term>Arthritis, Rheumatoid (pathology)</term>
<term>Fibroblasts (metabolism)</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Interleukin-1beta (genetics)</term>
<term>Interleukin-1beta (metabolism)</term>
<term>Mice, Inbred C57BL</term>
<term>Oncostatin M (metabolism)</term>
<term>Osteoprotegerin (genetics)</term>
<term>Osteoprotegerin (metabolism)</term>
<term>RANK Ligand (genetics)</term>
<term>RANK Ligand (metabolism)</term>
<term>RNA, Messenger (genetics)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Receptors, Interleukin-1 (metabolism)</term>
<term>Receptors, Oncostatin M (deficiency)</term>
<term>Receptors, Oncostatin M (metabolism)</term>
<term>Synovial Membrane (pathology)</term>
<term>Tumor Necrosis Factor-alpha (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term>
<term>ARN messager (métabolisme)</term>
<term>Animaux</term>
<term>Facteur de nécrose tumorale alpha (métabolisme)</term>
<term>Fibroblastes (métabolisme)</term>
<term>Humains</term>
<term>Interleukine-1 bêta (génétique)</term>
<term>Interleukine-1 bêta (métabolisme)</term>
<term>Ligand de RANK (génétique)</term>
<term>Ligand de RANK (métabolisme)</term>
<term>Membrane synoviale (anatomopathologie)</term>
<term>Oncostatine M (métabolisme)</term>
<term>Ostéoprotégérine (génétique)</term>
<term>Ostéoprotégérine (métabolisme)</term>
<term>Polyarthrite rhumatoïde (anatomopathologie)</term>
<term>Polyarthrite rhumatoïde (génétique)</term>
<term>Récepteurs à l'interleukine-1 (métabolisme)</term>
<term>Récepteurs à l'oncostatine M (déficit)</term>
<term>Récepteurs à l'oncostatine M (métabolisme)</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris de lignée C57BL</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Receptors, Oncostatin M</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Interleukin-1beta</term>
<term>Osteoprotegerin</term>
<term>RANK Ligand</term>
<term>RNA, Messenger</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Membrane synoviale</term>
<term>Polyarthrite rhumatoïde</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Récepteurs à l'oncostatine M</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arthritis, Rheumatoid</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term>
<term>Interleukine-1 bêta</term>
<term>Ligand de RANK</term>
<term>Ostéoprotégérine</term>
<term>Polyarthrite rhumatoïde</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fibroblasts</term>
<term>Interleukin-1beta</term>
<term>Oncostatin M</term>
<term>Osteoprotegerin</term>
<term>RANK Ligand</term>
<term>RNA, Messenger</term>
<term>Receptors, Interleukin-1</term>
<term>Receptors, Oncostatin M</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term>
<term>Facteur de nécrose tumorale alpha</term>
<term>Fibroblastes</term>
<term>Interleukine-1 bêta</term>
<term>Ligand de RANK</term>
<term>Oncostatine M</term>
<term>Ostéoprotégérine</term>
<term>Récepteurs à l'interleukine-1</term>
<term>Récepteurs à l'oncostatine M</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Arthritis, Rheumatoid</term>
<term>Synovial Membrane</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Mice, Inbred C57BL</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris de lignée C57BL</term>
</keywords>
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<front><div type="abstract" xml:lang="en">To identify how the gp130-signaling cytokine oncostatin M (OSM), acting alone or in concert with IL-1β or TNFα, affects synovial fibroblast expression of genes relevant to inflammation and bone erosion in inflammatory arthritis.</div>
</front>
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