Ontogeny and water temperature influences the antiviral response of the Pacific oyster, Crassostrea gigas.
Identifieur interne : 003687 ( Main/Merge ); précédent : 003686; suivant : 003688Ontogeny and water temperature influences the antiviral response of the Pacific oyster, Crassostrea gigas.
Auteurs : Timothy J. Green [Australie] ; Caroline Montagnani [France] ; Kirsten Benkendorff [Australie] ; Nick Robinson [Norvège] ; Peter Speck [Australie]Source :
- Fish & shellfish immunology [ 1095-9947 ] ; 2014.
Descripteurs français
- KwdFr :
- ARN (), ARN (génétique), Analyse multivariée, Animaux, Crassostrea (immunologie), Crassostrea (virologie), Facteur de différenciation myéloïde-88 (immunologie), Facteur-1 de régulation d'interféron (immunologie), Herpesviridae (immunologie), Infections à Herpesviridae (immunologie), Infections à Herpesviridae (virologie), Poly I-C (pharmacologie), Protéines I-kappa B (immunologie), Protéines proto-oncogènes c-rel (immunologie), RT-PCR, Récepteurs de type Toll (immunologie), Régulation positive (immunologie), Réplication virale (immunologie), Température.
- MESH :
- génétique : ARN.
- immunologie : Crassostrea, Facteur de différenciation myéloïde-88, Facteur-1 de régulation d'interféron, Herpesviridae, Infections à Herpesviridae, Protéines I-kappa B, Protéines proto-oncogènes c-rel, Récepteurs de type Toll, Régulation positive, Réplication virale.
- pharmacologie : Poly I-C.
- virologie : Crassostrea, Infections à Herpesviridae.
- ARN, Analyse multivariée, Animaux, RT-PCR, Température.
English descriptors
- KwdEn :
- Animals, Crassostrea (immunology), Crassostrea (virology), Herpesviridae (immunology), Herpesviridae Infections (immunology), Herpesviridae Infections (virology), I-kappa B Proteins (immunology), Interferon Regulatory Factor-1 (immunology), Multivariate Analysis, Myeloid Differentiation Factor 88 (immunology), Poly I-C (pharmacology), Proto-Oncogene Proteins c-rel (immunology), RNA (chemistry), RNA (genetics), Reverse Transcriptase Polymerase Chain Reaction, Temperature, Toll-Like Receptors (immunology), Up-Regulation (immunology), Virus Replication (immunology).
- MESH :
- chemical , chemistry : RNA.
- chemical , genetics : RNA.
- chemical , immunology : I-kappa B Proteins, Interferon Regulatory Factor-1, Myeloid Differentiation Factor 88, Proto-Oncogene Proteins c-rel, Toll-Like Receptors.
- immunology : Crassostrea, Herpesviridae, Herpesviridae Infections, Up-Regulation, Virus Replication.
- chemical , pharmacology : Poly I-C.
- virology : Crassostrea, Herpesviridae Infections.
- Animals, Multivariate Analysis, Reverse Transcriptase Polymerase Chain Reaction, Temperature.
Abstract
Disease is caused by a complex interaction between the pathogen, environment, and the physiological status of the host. Determining how host ontogeny interacts with water temperature to influence the antiviral response of the Pacific oysters, Crassostrea gigas, is a major goal in understanding why juvenile Pacific oysters are dying during summer as a result of the global emergence of a new genotype of the Ostreid herpesvirus, termed OsHV-1 μvar. We measured the effect of temperature (12 vs 22 °C) on the antiviral response of adult and juvenile C. gigas injected with poly I:C. Poly I:C up-regulated the expression of numerous immune genes, including TLR, MyD88, IκB-1, Rel, IRF, MDA5, STING, SOC, PKR, Viperin and Mpeg1. At 22 °C, these immune genes showed significant up-regulation in juvenile and adult oysters, but the majority of these genes were up-regulated 12 h post-injection for juveniles compared to 26 h for adults. At 12 °C, the response of these genes was completely inhibited in juveniles and delayed in adults. Temperature and age had no effect on hemolymph antiviral activity against herpes simplex virus (HSV-1). These results suggest that oysters rely on a cellular response to minimise viral replication, involving recognition of virus-associated molecular patterns to induce host cells into an antiviral state, as opposed to producing broad-spectrum antiviral compounds. This cellular response, measured by antiviral gene expression of circulating hemocytes, was influenced by temperature and oyster age. We speculate whether the vigorous antiviral response of juveniles at 22 °C results in an immune-mediated disorder causing mortality.
DOI: 10.1016/j.fsi.2013.10.026
PubMed: 24200990
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ontogeny and water temperature influences the antiviral response of the Pacific oyster, Crassostrea gigas.</title><author><name sortKey="Green, Timothy J" sort="Green, Timothy J" uniqKey="Green T" first="Timothy J" last="Green">Timothy J. Green</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences and Australian Seafood Cooperative Research Centre, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia. Electronic address: tim.green@flinders.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biological Sciences and Australian Seafood Cooperative Research Centre, Flinders University, GPO Box 2100, Adelaide, SA 5001</wicri:regionArea><wicri:noRegion>SA 5001</wicri:noRegion></affiliation></author><author><name sortKey="Montagnani, Caroline" sort="Montagnani, Caroline" uniqKey="Montagnani C" first="Caroline" last="Montagnani">Caroline Montagnani</name><affiliation wicri:level="4"><nlm:affiliation>Ifremer, UMR 5119 Ecology of Coastal Marine Systems, Université Montpellier 2, Place Eugène Bataillon, CC80, 30495 Montpellier cedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Ifremer, UMR 5119 Ecology of Coastal Marine Systems, Université Montpellier 2, Place Eugène Bataillon, CC80, 30495 Montpellier cedex 05</wicri:regionArea><wicri:noRegion>30495 Montpellier cedex 05</wicri:noRegion><orgName type="university">Université Montpellier 2</orgName><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation></author><author><name sortKey="Benkendorff, Kirsten" sort="Benkendorff, Kirsten" uniqKey="Benkendorff K" first="Kirsten" last="Benkendorff">Kirsten Benkendorff</name><affiliation wicri:level="1"><nlm:affiliation>Marine Ecology Research Centre, Southern Cross University, P.O. Box 157, Lismore, NSW 2480, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Marine Ecology Research Centre, Southern Cross University, P.O. Box 157, Lismore, NSW 2480</wicri:regionArea><wicri:noRegion>NSW 2480</wicri:noRegion></affiliation></author><author><name sortKey="Robinson, Nick" sort="Robinson, Nick" uniqKey="Robinson N" first="Nick" last="Robinson">Nick Robinson</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences and Australian Seafood Cooperative Research Centre, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia; Nofima, P.O. Box 210, N-1431 Ås, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>School of Biological Sciences and Australian Seafood Cooperative Research Centre, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia; Nofima, P.O. 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Green</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences and Australian Seafood Cooperative Research Centre, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia. Electronic address: tim.green@flinders.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biological Sciences and Australian Seafood Cooperative Research Centre, Flinders University, GPO Box 2100, Adelaide, SA 5001</wicri:regionArea><wicri:noRegion>SA 5001</wicri:noRegion></affiliation></author><author><name sortKey="Montagnani, Caroline" sort="Montagnani, Caroline" uniqKey="Montagnani C" first="Caroline" last="Montagnani">Caroline Montagnani</name><affiliation wicri:level="4"><nlm:affiliation>Ifremer, UMR 5119 Ecology of Coastal Marine Systems, Université Montpellier 2, Place Eugène Bataillon, CC80, 30495 Montpellier cedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Ifremer, UMR 5119 Ecology of Coastal Marine Systems, Université Montpellier 2, Place Eugène Bataillon, CC80, 30495 Montpellier cedex 05</wicri:regionArea><wicri:noRegion>30495 Montpellier cedex 05</wicri:noRegion><orgName type="university">Université Montpellier 2</orgName><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation></author><author><name sortKey="Benkendorff, Kirsten" sort="Benkendorff, Kirsten" uniqKey="Benkendorff K" first="Kirsten" last="Benkendorff">Kirsten Benkendorff</name><affiliation wicri:level="1"><nlm:affiliation>Marine Ecology Research Centre, Southern Cross University, P.O. Box 157, Lismore, NSW 2480, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Marine Ecology Research Centre, Southern Cross University, P.O. Box 157, Lismore, NSW 2480</wicri:regionArea><wicri:noRegion>NSW 2480</wicri:noRegion></affiliation></author><author><name sortKey="Robinson, Nick" sort="Robinson, Nick" uniqKey="Robinson N" first="Nick" last="Robinson">Nick Robinson</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences and Australian Seafood Cooperative Research Centre, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia; Nofima, P.O. Box 210, N-1431 Ås, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>School of Biological Sciences and Australian Seafood Cooperative Research Centre, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia; Nofima, P.O. Box 210, N-1431 Ås</wicri:regionArea><wicri:noRegion>N-1431 Ås</wicri:noRegion></affiliation></author><author><name sortKey="Speck, Peter" sort="Speck, Peter" uniqKey="Speck P" first="Peter" last="Speck">Peter Speck</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences and Australian Seafood Cooperative Research Centre, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biological Sciences and Australian Seafood Cooperative Research Centre, Flinders University, GPO Box 2100, Adelaide, SA 5001</wicri:regionArea><wicri:noRegion>SA 5001</wicri:noRegion></affiliation></author></analytic><series><title level="j">Fish & shellfish immunology</title><idno type="eISSN">1095-9947</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Crassostrea (immunology)</term><term>Crassostrea (virology)</term><term>Herpesviridae (immunology)</term><term>Herpesviridae Infections (immunology)</term><term>Herpesviridae Infections (virology)</term><term>I-kappa B Proteins (immunology)</term><term>Interferon Regulatory Factor-1 (immunology)</term><term>Multivariate Analysis</term><term>Myeloid Differentiation Factor 88 (immunology)</term><term>Poly I-C (pharmacology)</term><term>Proto-Oncogene Proteins c-rel (immunology)</term><term>RNA (chemistry)</term><term>RNA (genetics)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Temperature</term><term>Toll-Like Receptors (immunology)</term><term>Up-Regulation (immunology)</term><term>Virus Replication (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN ()</term><term>ARN (génétique)</term><term>Analyse multivariée</term><term>Animaux</term><term>Crassostrea (immunologie)</term><term>Crassostrea (virologie)</term><term>Facteur de différenciation myéloïde-88 (immunologie)</term><term>Facteur-1 de régulation d'interféron (immunologie)</term><term>Herpesviridae (immunologie)</term><term>Infections à Herpesviridae (immunologie)</term><term>Infections à Herpesviridae (virologie)</term><term>Poly I-C (pharmacologie)</term><term>Protéines I-kappa B (immunologie)</term><term>Protéines proto-oncogènes c-rel (immunologie)</term><term>RT-PCR</term><term>Récepteurs de type Toll (immunologie)</term><term>Régulation positive (immunologie)</term><term>Réplication virale (immunologie)</term><term>Température</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>RNA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>I-kappa B Proteins</term><term>Interferon Regulatory Factor-1</term><term>Myeloid Differentiation Factor 88</term><term>Proto-Oncogene Proteins c-rel</term><term>Toll-Like Receptors</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Crassostrea</term><term>Facteur de différenciation myéloïde-88</term><term>Facteur-1 de régulation d'interféron</term><term>Herpesviridae</term><term>Infections à Herpesviridae</term><term>Protéines I-kappa B</term><term>Protéines proto-oncogènes c-rel</term><term>Récepteurs de type Toll</term><term>Régulation positive</term><term>Réplication virale</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Crassostrea</term><term>Herpesviridae</term><term>Herpesviridae Infections</term><term>Up-Regulation</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Poly I-C</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Poly I-C</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Crassostrea</term><term>Infections à Herpesviridae</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Crassostrea</term><term>Herpesviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Multivariate Analysis</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Temperature</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ARN</term><term>Analyse multivariée</term><term>Animaux</term><term>RT-PCR</term><term>Température</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Disease is caused by a complex interaction between the pathogen, environment, and the physiological status of the host. Determining how host ontogeny interacts with water temperature to influence the antiviral response of the Pacific oysters, Crassostrea gigas, is a major goal in understanding why juvenile Pacific oysters are dying during summer as a result of the global emergence of a new genotype of the Ostreid herpesvirus, termed OsHV-1 μvar. We measured the effect of temperature (12 vs 22 °C) on the antiviral response of adult and juvenile C. gigas injected with poly I:C. Poly I:C up-regulated the expression of numerous immune genes, including TLR, MyD88, IκB-1, Rel, IRF, MDA5, STING, SOC, PKR, Viperin and Mpeg1. At 22 °C, these immune genes showed significant up-regulation in juvenile and adult oysters, but the majority of these genes were up-regulated 12 h post-injection for juveniles compared to 26 h for adults. At 12 °C, the response of these genes was completely inhibited in juveniles and delayed in adults. Temperature and age had no effect on hemolymph antiviral activity against herpes simplex virus (HSV-1). These results suggest that oysters rely on a cellular response to minimise viral replication, involving recognition of virus-associated molecular patterns to induce host cells into an antiviral state, as opposed to producing broad-spectrum antiviral compounds. This cellular response, measured by antiviral gene expression of circulating hemocytes, was influenced by temperature and oyster age. We speculate whether the vigorous antiviral response of juveniles at 22 °C results in an immune-mediated disorder causing mortality.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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