Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
Identifieur interne : 002B67 ( Main/Merge ); précédent : 002B66; suivant : 002B68Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
Auteurs : Adrian Cortes [Australie] ; Sara L. Pulit [Pays-Bas] ; Paul J. Leo [Australie] ; Jenny J. Pointon [Royaume-Uni] ; Philip C. Robinson [Australie] ; Michael H. Weisman [États-Unis] ; Michael Ward [États-Unis] ; Lianne S. Gensler [États-Unis] ; Xiaodong Zhou [États-Unis] ; Henri-Jean Garchon [France] ; Gilles Chiocchia [France] ; Johannes Nossent [Australie] ; Benedicte A. Lie [Norvège] ; Ystein F Rre [Norvège] ; Jaakko Tuomilehto [Finlande, Autriche, Arabie saoudite] ; Kari Laiho [Finlande] ; Linda A. Bradbury [Australie] ; Dirk Elewaut [Belgique] ; Ruben Burgos-Vargas [Mexique] ; Simon Stebbings [Nouvelle-Zélande] ; Louise Appleton [Royaume-Uni] ; Claire Farrah [Royaume-Uni] ; Jonathan Lau [Royaume-Uni] ; Nigil Haroon [Canada] ; Juan Mulero [Espagne] ; Francisco J. Blanco [Espagne] ; Miguel A. Gonzalez-Gay [Espagne] ; C. Lopez-Larrea [Espagne] ; Paul Bowness [Royaume-Uni] ; Karl Gaffney [Royaume-Uni] ; Hill Gaston [Royaume-Uni] ; Dafna D. Gladman [Canada] ; Proton Rahman [Canada] ; Walter P. Maksymowych [Canada] ; J. Bart A. Crusius [Pays-Bas] ; Irene E. Van Der Horst-Bruinsma [Pays-Bas] ; Raphael Valle-O Ate [Colombie] ; Consuelo Romero-Sánchez [Colombie] ; Inger Myrnes Hansen [Norvège] ; Fernando M. Pimentel-Santos [Portugal] ; Robert D. Inman [Canada] ; Javier Martin [Espagne] ; Maxime Breban [France] ; Bryan Paul Wordsworth [Royaume-Uni] ; John D. Reveille [États-Unis] ; David M. Evans [Australie, Royaume-Uni] ; Paul I. W. De Bakker [Pays-Bas] ; Matthew A. Brown [Australie]Source :
- Nature Communications [ 2041-1723 ] ; 2015.
Descripteurs français
- KwdFr :
- Aminopeptidases (génétique), Antigène HLA-B27 (génétique), Antigène HLA-B40 (génétique), Antigènes mineurs d'histocompatibilité, Complexe majeur d'histocompatibilité, Humains, Pelvispondylite rhumatismale (étiologie), Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Épistasie, Études cas-témoins.
- MESH :
- génétique : Aminopeptidases, Antigène HLA-B27, Antigène HLA-B40.
- étiologie : Pelvispondylite rhumatismale.
- Antigènes mineurs d'histocompatibilité, Complexe majeur d'histocompatibilité, Humains, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Épistasie, Études cas-témoins.
English descriptors
- KwdEn :
- Aminopeptidases (genetics), Case-Control Studies, Epistasis, Genetic, Genetic Predisposition to Disease, HLA-B27 Antigen (genetics), HLA-B40 Antigen (genetics), Humans, Major Histocompatibility Complex, Minor Histocompatibility Antigens, Polymorphism, Single Nucleotide, Spondylitis, Ankylosing (etiology).
- MESH :
Abstract
Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which
Url:
DOI: 10.1038/ncomms8146
PubMed: 25994336
PubMed Central: 4443427
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PMC:4443427Le document en format XML
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Pulit</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht</institution>, Utrecht 3584,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leo, Paul J" sort="Leo, Paul J" uniqKey="Leo P" first="Paul J." last="Leo">Paul J. Leo</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>University of Queensland Diamantina Institute, Princess Alexandra Hospital</institution>, Brisbane 4102,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pointon, Jenny J" sort="Pointon, Jenny J" uniqKey="Pointon J" first="Jenny J." last="Pointon">Jenny J. Pointon</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre</institution>, Headington, Oxford OX3 7LD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Robinson, Philip C" sort="Robinson, Philip C" uniqKey="Robinson P" first="Philip C." last="Robinson">Philip C. Robinson</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>University of Queensland Diamantina Institute, Princess Alexandra Hospital</institution>, Brisbane 4102,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H." last="Weisman">Michael H. Weisman</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Medicine/Rheumatology, Cedars-Sinai Medical Center</institution>, Los Angeles, California 90048,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ward, Michael" sort="Ward, Michael" uniqKey="Ward M" first="Michael" last="Ward">Michael Ward</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health</institution>, Bethesda, Maryland 20892-1468,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gensler, Lianne S" sort="Gensler, Lianne S" uniqKey="Gensler L" first="Lianne S." last="Gensler">Lianne S. Gensler</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Medicine/Rheumatology, University of California</institution>, San Francisco, California 94143,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Xiaodong" sort="Zhou, Xiaodong" uniqKey="Zhou X" first="Xiaodong" last="Zhou">Xiaodong Zhou</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston</institution>, Houston, Texas 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garchon, Henri Jean" sort="Garchon, Henri Jean" uniqKey="Garchon H" first="Henri-Jean" last="Garchon">Henri-Jean Garchon</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex</institution>, Saint-Quentn-En-Yvelines 78180,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Genetics Division, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines</institution>, Boulogne-Billancourt 78180,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chiocchia, Gilles" sort="Chiocchia, Gilles" uniqKey="Chiocchia G" first="Gilles" last="Chiocchia">Gilles Chiocchia</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex</institution>, Saint-Quentn-En-Yvelines 78180,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nossent, Johannes" sort="Nossent, Johannes" uniqKey="Nossent J" first="Johannes" last="Nossent">Johannes Nossent</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>School of Medicine, University of Western Australia</institution>, Perth, WA 6009,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Department of Rheumatology, Sir Charles Gairdner Hospital</institution>, Perth, WA 6009,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lie, Benedicte A" sort="Lie, Benedicte A" uniqKey="Lie B" first="Benedicte A." last="Lie">Benedicte A. Lie</name><affiliation wicri:level="1"><nlm:aff id="a12"><institution>Department of Medical Genetics, University of Oslo and Oslo University Hospital</institution>, Oslo 0310,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Immunology, Oslo University Hospital</institution>, Oslo 0310,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="F Rre, Ystein" sort="F Rre, Ystein" uniqKey="F Rre " first=" Ystein" last="F Rre"> Ystein F Rre</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Rheumatology, Oslo University Hospital, and University of Oslo</institution>, Oslo 0310,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Department of Chronic Disease Prevention, National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a16"><institution>Centre for Vascular Prevention, Danube-University Krems</institution>, 3500 Krems,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Diabetes Research Group, King Abdulaziz University</institution>, 21589 Jeddah,<country>Saudi Arabia</country></nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laiho, Kari" sort="Laiho, Kari" uniqKey="Laiho K" first="Kari" last="Laiho">Kari Laiho</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Department of Medicine, Paijat-Hame Central Hospital</institution>, Lahti,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bradbury, Linda A" sort="Bradbury, Linda A" uniqKey="Bradbury L" first="Linda A." last="Bradbury">Linda A. Bradbury</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>University of Queensland Diamantina Institute, Princess Alexandra Hospital</institution>, Brisbane 4102,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Elewaut, Dirk" sort="Elewaut, Dirk" uniqKey="Elewaut D" first="Dirk" last="Elewaut">Dirk Elewaut</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Department of Rheumatology, Gent University Hospital</institution>, Gent 9052,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a20"><institution>VIB Inflammation Research Center, Ghent University</institution>, Gent 9052,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Ruben" last="Burgos-Vargas">Ruben Burgos-Vargas</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>Department of Rheumatology, Hospital General de Mexico and Universidad Nacional Autonoma de Mexico</institution>, Mexico City 06726,<country>Mexico</country></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stebbings, Simon" sort="Stebbings, Simon" uniqKey="Stebbings S" first="Simon" last="Stebbings">Simon Stebbings</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Department of Medicine, Dunedin School of Medicine, University of Otago</institution>, Dunedin 9016,<country>New Zealand</country></nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Appleton, Louise" sort="Appleton, Louise" uniqKey="Appleton L" first="Louise" last="Appleton">Louise Appleton</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre</institution>, Headington, Oxford OX3 7LD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Farrah, Claire" sort="Farrah, Claire" uniqKey="Farrah C" first="Claire" last="Farrah">Claire Farrah</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre</institution>, Headington, Oxford OX3 7LD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lau, Jonathan" sort="Lau, Jonathan" uniqKey="Lau J" first="Jonathan" last="Lau">Jonathan Lau</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre</institution>, Headington, Oxford OX3 7LD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haroon, Nigil" sort="Haroon, Nigil" uniqKey="Haroon N" first="Nigil" last="Haroon">Nigil Haroon</name><affiliation wicri:level="1"><nlm:aff id="a23"><institution>Division of Rheumatology, Toronto Western Hospital, University of Toronto</institution>, Toronto M5T2S8,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mulero, Juan" sort="Mulero, Juan" uniqKey="Mulero J" first="Juan" last="Mulero">Juan Mulero</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Rheumatology, Hospital Puerta de Hierro</institution>, Madrid 28222,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blanco, Francisco J" sort="Blanco, Francisco J" uniqKey="Blanco F" first="Francisco J." last="Blanco">Francisco J. Blanco</name><affiliation wicri:level="1"><nlm:aff id="a25"><institution>Department of Rheumatology, Complejo Hospitalario La Coruña, INIBIC</institution>, La Coruña 15006,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Gay, Miguel A" sort="Gonzalez Gay, Miguel A" uniqKey="Gonzalez Gay M" first="Miguel A." last="Gonzalez-Gay">Miguel A. Gonzalez-Gay</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Department of Rheumatology, Hospital Marques de Valcecillas, IFIMAV</institution>, Santander 39008,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lopez Larrea, C" sort="Lopez Larrea, C" uniqKey="Lopez Larrea C" first="C" last="Lopez-Larrea">C. Lopez-Larrea</name><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Department of Immunology, Hospital Universitario Central de Asturias</institution>, Oviedo 33011,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a28"><institution>Fundación Renal ‘Iñigo Álvarez de Toledo'</institution>, Madrid 33011,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bowness, Paul" sort="Bowness, Paul" uniqKey="Bowness P" first="Paul" last="Bowness">Paul Bowness</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre</institution>, Headington, Oxford OX3 7LD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaffney, Karl" sort="Gaffney, Karl" uniqKey="Gaffney K" first="Karl" last="Gaffney">Karl Gaffney</name><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Department of Rheumatology, Norfolk and Norwich University Hospital</institution>, Norwich NR4 7UY,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaston, Hill" sort="Gaston, Hill" uniqKey="Gaston H" first="Hill" last="Gaston">Hill Gaston</name><affiliation wicri:level="1"><nlm:aff id="a30"><institution>Department of Medicine, University of Cambridge, Addenbrookes Hospital</institution>, Cambridge CB2 0SP,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gladman, Dafna D" sort="Gladman, Dafna D" uniqKey="Gladman D" first="Dafna D." last="Gladman">Dafna D. Gladman</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>Division of Rheumatology, University of Toronto</institution>, Toronto, ON M4N 3M5,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Toronto Western Research Institute</institution>, Toronto ON M4N 3M5,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="a33"><institution>Psoriatic Arthritis Program, University Health Network, Toronto ON M4N 3M5, Canada</institution></nlm:aff></affiliation></author><author><name sortKey="Rahman, Proton" sort="Rahman, Proton" uniqKey="Rahman P" first="Proton" last="Rahman">Proton Rahman</name><affiliation wicri:level="1"><nlm:aff id="a34"><institution>Memorial University of Newfoundland</institution>, Newfoundland NL A1B 3X9,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maksymowych, Walter P" sort="Maksymowych, Walter P" uniqKey="Maksymowych W" first="Walter P." last="Maksymowych">Walter P. Maksymowych</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Department of Medicine, University of Alberta</institution>, Alberta T6G 2R7,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Crusius, J Bart A" sort="Crusius, J Bart A" uniqKey="Crusius J" first="J. Bart A." last="Crusius">J. Bart A. Crusius</name><affiliation wicri:level="1"><nlm:aff id="a36"><institution>Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, VU University Medical Center</institution>, Amsterdam 1081 BT,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Horst Bruinsma, Irene E" sort="Van Der Horst Bruinsma, Irene E" uniqKey="Van Der Horst Bruinsma I" first="Irene E." last="Van Der Horst-Bruinsma">Irene E. Van Der Horst-Bruinsma</name><affiliation wicri:level="1"><nlm:aff id="a37"><institution>Department of Rheumatology, VU University Medical Centre</institution>, Amsterdam 1081 BT,<country>Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Valle O Ate, Raphael" sort="Valle O Ate, Raphael" uniqKey="Valle O Ate R" first="Raphael" last="Valle-O Ate">Raphael Valle-O Ate</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana</institution>,<country>Transversal 3 # 49-00, Bogotá, NA, Colombia</country></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>The University of Chicago Medicine, 5841 South Maryland Avenue, MC 2115 Chicago</wicri:regionArea><wicri:noRegion>MC 2115 Chicago</wicri:noRegion></affiliation></author><author><name sortKey="Romero Sanchez, Consuelo" sort="Romero Sanchez, Consuelo" uniqKey="Romero Sanchez C" first="Consuelo" last="Romero-Sánchez">Consuelo Romero-Sánchez</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana</institution>,<country>Transversal 3 # 49-00, Bogotá, NA, Colombia</country></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>The University of Chicago Medicine, 5841 South Maryland Avenue, MC 2115 Chicago</wicri:regionArea><wicri:noRegion>MC 2115 Chicago</wicri:noRegion></affiliation></author><author><name sortKey="Hansen, Inger Myrnes" sort="Hansen, Inger Myrnes" uniqKey="Hansen I" first="Inger Myrnes" last="Hansen">Inger Myrnes Hansen</name><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Helgelandssykehuset, 8613</institution> Mo i Rana,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pimentel Santos, Fernando M" sort="Pimentel Santos, Fernando M" uniqKey="Pimentel Santos F" first="Fernando M." last="Pimentel-Santos">Fernando M. Pimentel-Santos</name><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Chronic Diseases Research Centre (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa</institution>, Lisboa 1169-056,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Inman, Robert D" sort="Inman, Robert D" uniqKey="Inman R" first="Robert D." last="Inman">Robert D. Inman</name><affiliation wicri:level="1"><nlm:aff id="a23"><institution>Division of Rheumatology, Toronto Western Hospital, University of Toronto</institution>, Toronto M5T2S8,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Javier" sort="Martin, Javier" uniqKey="Martin J" first="Javier" last="Martin">Javier Martin</name><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones–Científicas</institution>, Granada 18100,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Breban, Maxime" sort="Breban, Maxime" uniqKey="Breban M" first="Maxime" last="Breban">Maxime Breban</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex</institution>, Saint-Quentn-En-Yvelines 78180,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a42"><institution>Division of Rheumatology, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines</institution>, Boulogne-Billancourt 92100,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wordsworth, Bryan Paul" sort="Wordsworth, Bryan Paul" uniqKey="Wordsworth B" first="Bryan Paul" last="Wordsworth">Bryan Paul Wordsworth</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre</institution>, Headington, Oxford OX3 7LD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reveille, John D" sort="Reveille, John D" uniqKey="Reveille J" first="John D." last="Reveille">John D. Reveille</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston</institution>, Houston, Texas 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>University of Queensland Diamantina Institute, Princess Alexandra Hospital</institution>, Brisbane 4102,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a43"><institution>MRC Integrative Epidemiology Unit, University of Bristol</institution>, Bristol,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a44"><institution>School of Social and Community Medicine, University of Bristol</institution>, Bristol,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht</institution>, Utrecht 3584,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</institution>, Utrecht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A." last="Brown">Matthew A. Brown</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>University of Queensland Diamantina Institute, Princess Alexandra Hospital</institution>, Brisbane 4102,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25994336</idno><idno type="pmc">4443427</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443427</idno><idno type="RBID">PMC:4443427</idno><idno type="doi">10.1038/ncomms8146</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000740</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000740</idno><idno type="wicri:Area/Pmc/Curation">000739</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000739</idno><idno type="wicri:Area/Pmc/Checkpoint">000E76</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E76</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002D51</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002D51</idno><idno type="wicri:Area/PubMed/Curation">002C76</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002C76</idno><idno type="wicri:Area/PubMed/Checkpoint">002C76</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002C76</idno><idno type="wicri:Area/Ncbi/Merge">002596</idno><idno type="wicri:Area/Ncbi/Curation">002596</idno><idno type="wicri:Area/Ncbi/Checkpoint">002596</idno><idno type="wicri:Area/Main/Merge">002B67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with <italic>ERAP1</italic></title><author><name sortKey="Cortes, Adrian" sort="Cortes, Adrian" uniqKey="Cortes A" first="Adrian" last="Cortes">Adrian Cortes</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>University of Queensland Diamantina Institute, Princess Alexandra Hospital</institution>, Brisbane 4102,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pulit, Sara L" sort="Pulit, Sara L" uniqKey="Pulit S" first="Sara L." last="Pulit">Sara L. Pulit</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht</institution>, Utrecht 3584,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leo, Paul J" sort="Leo, Paul J" uniqKey="Leo P" first="Paul J." last="Leo">Paul J. Leo</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>University of Queensland Diamantina Institute, Princess Alexandra Hospital</institution>, Brisbane 4102,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pointon, Jenny J" sort="Pointon, Jenny J" uniqKey="Pointon J" first="Jenny J." last="Pointon">Jenny J. Pointon</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre</institution>, Headington, Oxford OX3 7LD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Robinson, Philip C" sort="Robinson, Philip C" uniqKey="Robinson P" first="Philip C." last="Robinson">Philip C. Robinson</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>University of Queensland Diamantina Institute, Princess Alexandra Hospital</institution>, Brisbane 4102,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H." last="Weisman">Michael H. Weisman</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Medicine/Rheumatology, Cedars-Sinai Medical Center</institution>, Los Angeles, California 90048,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ward, Michael" sort="Ward, Michael" uniqKey="Ward M" first="Michael" last="Ward">Michael Ward</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health</institution>, Bethesda, Maryland 20892-1468,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gensler, Lianne S" sort="Gensler, Lianne S" uniqKey="Gensler L" first="Lianne S." last="Gensler">Lianne S. Gensler</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Medicine/Rheumatology, University of California</institution>, San Francisco, California 94143,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Xiaodong" sort="Zhou, Xiaodong" uniqKey="Zhou X" first="Xiaodong" last="Zhou">Xiaodong Zhou</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston</institution>, Houston, Texas 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garchon, Henri Jean" sort="Garchon, Henri Jean" uniqKey="Garchon H" first="Henri-Jean" last="Garchon">Henri-Jean Garchon</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex</institution>, Saint-Quentn-En-Yvelines 78180,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Genetics Division, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines</institution>, Boulogne-Billancourt 78180,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chiocchia, Gilles" sort="Chiocchia, Gilles" uniqKey="Chiocchia G" first="Gilles" last="Chiocchia">Gilles Chiocchia</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex</institution>, Saint-Quentn-En-Yvelines 78180,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nossent, Johannes" sort="Nossent, Johannes" uniqKey="Nossent J" first="Johannes" last="Nossent">Johannes Nossent</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>School of Medicine, University of Western Australia</institution>, Perth, WA 6009,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Department of Rheumatology, Sir Charles Gairdner Hospital</institution>, Perth, WA 6009,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lie, Benedicte A" sort="Lie, Benedicte A" uniqKey="Lie B" first="Benedicte A." last="Lie">Benedicte A. Lie</name><affiliation wicri:level="1"><nlm:aff id="a12"><institution>Department of Medical Genetics, University of Oslo and Oslo University Hospital</institution>, Oslo 0310,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Immunology, Oslo University Hospital</institution>, Oslo 0310,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="F Rre, Ystein" sort="F Rre, Ystein" uniqKey="F Rre " first=" Ystein" last="F Rre"> Ystein F Rre</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Rheumatology, Oslo University Hospital, and University of Oslo</institution>, Oslo 0310,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Department of Chronic Disease Prevention, National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a16"><institution>Centre for Vascular Prevention, Danube-University Krems</institution>, 3500 Krems,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Diabetes Research Group, King Abdulaziz University</institution>, 21589 Jeddah,<country>Saudi Arabia</country></nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laiho, Kari" sort="Laiho, Kari" uniqKey="Laiho K" first="Kari" last="Laiho">Kari Laiho</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Department of Medicine, Paijat-Hame Central Hospital</institution>, Lahti,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bradbury, Linda A" sort="Bradbury, Linda A" uniqKey="Bradbury L" first="Linda A." last="Bradbury">Linda A. Bradbury</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>University of Queensland Diamantina Institute, Princess Alexandra Hospital</institution>, Brisbane 4102,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Elewaut, Dirk" sort="Elewaut, Dirk" uniqKey="Elewaut D" first="Dirk" last="Elewaut">Dirk Elewaut</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Department of Rheumatology, Gent University Hospital</institution>, Gent 9052,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a20"><institution>VIB Inflammation Research Center, Ghent University</institution>, Gent 9052,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Ruben" last="Burgos-Vargas">Ruben Burgos-Vargas</name><affiliation wicri:level="1"><nlm:aff id="a21"><institution>Department of Rheumatology, Hospital General de Mexico and Universidad Nacional Autonoma de Mexico</institution>, Mexico City 06726,<country>Mexico</country></nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stebbings, Simon" sort="Stebbings, Simon" uniqKey="Stebbings S" first="Simon" last="Stebbings">Simon Stebbings</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Department of Medicine, Dunedin School of Medicine, University of Otago</institution>, Dunedin 9016,<country>New Zealand</country></nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Appleton, Louise" sort="Appleton, Louise" uniqKey="Appleton L" first="Louise" last="Appleton">Louise Appleton</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre</institution>, Headington, Oxford OX3 7LD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Farrah, Claire" sort="Farrah, Claire" uniqKey="Farrah C" first="Claire" last="Farrah">Claire Farrah</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre</institution>, Headington, Oxford OX3 7LD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lau, Jonathan" sort="Lau, Jonathan" uniqKey="Lau J" first="Jonathan" last="Lau">Jonathan Lau</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre</institution>, Headington, Oxford OX3 7LD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haroon, Nigil" sort="Haroon, Nigil" uniqKey="Haroon N" first="Nigil" last="Haroon">Nigil Haroon</name><affiliation wicri:level="1"><nlm:aff id="a23"><institution>Division of Rheumatology, Toronto Western Hospital, University of Toronto</institution>, Toronto M5T2S8,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mulero, Juan" sort="Mulero, Juan" uniqKey="Mulero J" first="Juan" last="Mulero">Juan Mulero</name><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Rheumatology, Hospital Puerta de Hierro</institution>, Madrid 28222,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blanco, Francisco J" sort="Blanco, Francisco J" uniqKey="Blanco F" first="Francisco J." last="Blanco">Francisco J. Blanco</name><affiliation wicri:level="1"><nlm:aff id="a25"><institution>Department of Rheumatology, Complejo Hospitalario La Coruña, INIBIC</institution>, La Coruña 15006,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Gay, Miguel A" sort="Gonzalez Gay, Miguel A" uniqKey="Gonzalez Gay M" first="Miguel A." last="Gonzalez-Gay">Miguel A. Gonzalez-Gay</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Department of Rheumatology, Hospital Marques de Valcecillas, IFIMAV</institution>, Santander 39008,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lopez Larrea, C" sort="Lopez Larrea, C" uniqKey="Lopez Larrea C" first="C" last="Lopez-Larrea">C. Lopez-Larrea</name><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Department of Immunology, Hospital Universitario Central de Asturias</institution>, Oviedo 33011,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a28"><institution>Fundación Renal ‘Iñigo Álvarez de Toledo'</institution>, Madrid 33011,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bowness, Paul" sort="Bowness, Paul" uniqKey="Bowness P" first="Paul" last="Bowness">Paul Bowness</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre</institution>, Headington, Oxford OX3 7LD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaffney, Karl" sort="Gaffney, Karl" uniqKey="Gaffney K" first="Karl" last="Gaffney">Karl Gaffney</name><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Department of Rheumatology, Norfolk and Norwich University Hospital</institution>, Norwich NR4 7UY,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaston, Hill" sort="Gaston, Hill" uniqKey="Gaston H" first="Hill" last="Gaston">Hill Gaston</name><affiliation wicri:level="1"><nlm:aff id="a30"><institution>Department of Medicine, University of Cambridge, Addenbrookes Hospital</institution>, Cambridge CB2 0SP,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gladman, Dafna D" sort="Gladman, Dafna D" uniqKey="Gladman D" first="Dafna D." last="Gladman">Dafna D. Gladman</name><affiliation wicri:level="1"><nlm:aff id="a31"><institution>Division of Rheumatology, University of Toronto</institution>, Toronto, ON M4N 3M5,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Toronto Western Research Institute</institution>, Toronto ON M4N 3M5,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="a33"><institution>Psoriatic Arthritis Program, University Health Network, Toronto ON M4N 3M5, Canada</institution></nlm:aff></affiliation></author><author><name sortKey="Rahman, Proton" sort="Rahman, Proton" uniqKey="Rahman P" first="Proton" last="Rahman">Proton Rahman</name><affiliation wicri:level="1"><nlm:aff id="a34"><institution>Memorial University of Newfoundland</institution>, Newfoundland NL A1B 3X9,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maksymowych, Walter P" sort="Maksymowych, Walter P" uniqKey="Maksymowych W" first="Walter P." last="Maksymowych">Walter P. Maksymowych</name><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Department of Medicine, University of Alberta</institution>, Alberta T6G 2R7,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Crusius, J Bart A" sort="Crusius, J Bart A" uniqKey="Crusius J" first="J. Bart A." last="Crusius">J. Bart A. Crusius</name><affiliation wicri:level="1"><nlm:aff id="a36"><institution>Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, VU University Medical Center</institution>, Amsterdam 1081 BT,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Horst Bruinsma, Irene E" sort="Van Der Horst Bruinsma, Irene E" uniqKey="Van Der Horst Bruinsma I" first="Irene E." last="Van Der Horst-Bruinsma">Irene E. Van Der Horst-Bruinsma</name><affiliation wicri:level="1"><nlm:aff id="a37"><institution>Department of Rheumatology, VU University Medical Centre</institution>, Amsterdam 1081 BT,<country>Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Valle O Ate, Raphael" sort="Valle O Ate, Raphael" uniqKey="Valle O Ate R" first="Raphael" last="Valle-O Ate">Raphael Valle-O Ate</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana</institution>,<country>Transversal 3 # 49-00, Bogotá, NA, Colombia</country></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>The University of Chicago Medicine, 5841 South Maryland Avenue, MC 2115 Chicago</wicri:regionArea><wicri:noRegion>MC 2115 Chicago</wicri:noRegion></affiliation></author><author><name sortKey="Romero Sanchez, Consuelo" sort="Romero Sanchez, Consuelo" uniqKey="Romero Sanchez C" first="Consuelo" last="Romero-Sánchez">Consuelo Romero-Sánchez</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana</institution>,<country>Transversal 3 # 49-00, Bogotá, NA, Colombia</country></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>The University of Chicago Medicine, 5841 South Maryland Avenue, MC 2115 Chicago</wicri:regionArea><wicri:noRegion>MC 2115 Chicago</wicri:noRegion></affiliation></author><author><name sortKey="Hansen, Inger Myrnes" sort="Hansen, Inger Myrnes" uniqKey="Hansen I" first="Inger Myrnes" last="Hansen">Inger Myrnes Hansen</name><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Helgelandssykehuset, 8613</institution> Mo i Rana,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pimentel Santos, Fernando M" sort="Pimentel Santos, Fernando M" uniqKey="Pimentel Santos F" first="Fernando M." last="Pimentel-Santos">Fernando M. Pimentel-Santos</name><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Chronic Diseases Research Centre (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa</institution>, Lisboa 1169-056,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Inman, Robert D" sort="Inman, Robert D" uniqKey="Inman R" first="Robert D." last="Inman">Robert D. Inman</name><affiliation wicri:level="1"><nlm:aff id="a23"><institution>Division of Rheumatology, Toronto Western Hospital, University of Toronto</institution>, Toronto M5T2S8,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Javier" sort="Martin, Javier" uniqKey="Martin J" first="Javier" last="Martin">Javier Martin</name><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones–Científicas</institution>, Granada 18100,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Breban, Maxime" sort="Breban, Maxime" uniqKey="Breban M" first="Maxime" last="Breban">Maxime Breban</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex</institution>, Saint-Quentn-En-Yvelines 78180,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a42"><institution>Division of Rheumatology, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines</institution>, Boulogne-Billancourt 92100,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wordsworth, Bryan Paul" sort="Wordsworth, Bryan Paul" uniqKey="Wordsworth B" first="Bryan Paul" last="Wordsworth">Bryan Paul Wordsworth</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre</institution>, Headington, Oxford OX3 7LD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reveille, John D" sort="Reveille, John D" uniqKey="Reveille J" first="John D." last="Reveille">John D. Reveille</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston</institution>, Houston, Texas 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>University of Queensland Diamantina Institute, Princess Alexandra Hospital</institution>, Brisbane 4102,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a43"><institution>MRC Integrative Epidemiology Unit, University of Bristol</institution>, Bristol,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a44"><institution>School of Social and Community Medicine, University of Bristol</institution>, Bristol,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht</institution>, Utrecht 3584,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</institution>, Utrecht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A." last="Brown">Matthew A. Brown</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>University of Queensland Diamantina Institute, Princess Alexandra Hospital</institution>, Brisbane 4102,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminopeptidases (genetics)</term><term>Case-Control Studies</term><term>Epistasis, Genetic</term><term>Genetic Predisposition to Disease</term><term>HLA-B27 Antigen (genetics)</term><term>HLA-B40 Antigen (genetics)</term><term>Humans</term><term>Major Histocompatibility Complex</term><term>Minor Histocompatibility Antigens</term><term>Polymorphism, Single Nucleotide</term><term>Spondylitis, Ankylosing (etiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aminopeptidases (génétique)</term><term>Antigène HLA-B27 (génétique)</term><term>Antigène HLA-B40 (génétique)</term><term>Antigènes mineurs d'histocompatibilité</term><term>Complexe majeur d'histocompatibilité</term><term>Humains</term><term>Pelvispondylite rhumatismale (étiologie)</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Épistasie</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Aminopeptidases</term><term>HLA-B27 Antigen</term><term>HLA-B40 Antigen</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Spondylitis, Ankylosing</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Aminopeptidases</term><term>Antigène HLA-B27</term><term>Antigène HLA-B40</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Pelvispondylite rhumatismale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Epistasis, Genetic</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Major Histocompatibility Complex</term><term>Minor Histocompatibility Antigens</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Antigènes mineurs d'histocompatibilité</term><term>Complexe majeur d'histocompatibilité</term><term>Humains</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Épistasie</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which <italic>HLA-B*27</italic> is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid residues within HLA proteins, and tested these for association to AS status. Here we show that in addition to effects due to <italic>HLA-B*27</italic> alleles, several other <italic>HLA-B</italic> alleles also affect susceptibility. After controlling for the associated haplotypes in <italic>HLA-B</italic>, we observe independent associations with variants in the <italic>HLA-A</italic>, <italic>HLA-DPB1</italic> and <italic>HLA-DRB1</italic> loci. We also demonstrate that the <italic>ERAP1</italic> SNP rs30187 association is not restricted only to carriers of <italic>HLA-B*27</italic> but also found in <italic>HLA-B*40:01</italic> carriers independently of HLA-B*27 genotype.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Brown, M A" uniqKey="Brown M">M. A. Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brewerton, D A" uniqKey="Brewerton D">D. A. Brewerton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caffrey, M F" uniqKey="Caffrey M">M. F. Caffrey</name></author><author><name sortKey="James, D C" uniqKey="James D">D. C. James</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schlosstein, L" uniqKey="Schlosstein L">L. Schlosstein</name></author><author><name sortKey="Terasaki, P I" uniqKey="Terasaki P">P. I. Terasaki</name></author><author><name sortKey="Bluestone, R" uniqKey="Bluestone R">R. Bluestone</name></author><author><name sortKey="Pearson, C M" uniqKey="Pearson C">C. M. Pearson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burton, P R" uniqKey="Burton P">P. R. Burton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reveille, J D" uniqKey="Reveille J">J. D. Reveille</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Evans, D M" uniqKey="Evans D">D. M. Evans</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Benjamin, R" uniqKey="Benjamin R">R. Benjamin</name></author><author><name sortKey="Parham, P" uniqKey="Parham P">P. Parham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kenna, T J" uniqKey="Kenna T">T. J. 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