STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function
Identifieur interne : 002854 ( Main/Merge ); précédent : 002853; suivant : 002855STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function
Auteurs : Robert P. Wilson ; Megan L. Ives ; Geetha Rao ; Anthony Lau ; Kathryn Payne ; Masao Kobayashi ; Peter D. Arkwright ; Jane Peake ; Melanie Wong ; Stephen Adelstein ; Joanne M. Smart ; Martyn A. French ; David A. Fulcher ; Capucine Picard ; Jacinta Bustamante ; Stephanie Boisson-Dupuis ; Paul Gray ; Polina Stepensky ; Klaus Warnatz ; Alexandra F. Freeman ; Jamie Rossjohn ; James Mccluskey ; Steven M. Holland ; Jean-Laurent Casanova ; Gulbu Uzel ; Cindy S. Ma ; Stuart G. Tangye ; Elissa K. DeenickSource :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 2015.
Descripteurs français
- KwdFr :
- Agranulocytes (cytologie), Cellules tueuses naturelles (cytologie), Cytokines (métabolisme), Cytométrie en flux, Facteur de nécrose tumorale alpha (métabolisme), Facteur de transcription STAT-3 (métabolisme), Humains, Interféron gamma (métabolisme), Interleukine-17 (métabolisme), Interleukine-23 (métabolisme), Interleukines (métabolisme), Lymphocytes (cytologie), Lymphocytes T (cytologie), Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires (métabolisme), Mutation, Polymorphisme de nucléotide simple, Récepteur lymphocytaire T antigène, gamma-delta (métabolisme), Récepteurs aux interleukines (métabolisme), Récepteurs à l'interleukine-12 (métabolisme), Récepteurs à l'interleukine-21 (métabolisme), Séparation cellulaire, Transduction du signal.
- MESH :
- cytologie : Agranulocytes, Cellules tueuses naturelles, Lymphocytes, Lymphocytes T.
- métabolisme : Cytokines, Facteur de nécrose tumorale alpha, Facteur de transcription STAT-3, Interféron gamma, Interleukine-17, Interleukine-23, Interleukines, Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires, Récepteur lymphocytaire T antigène, gamma-delta, Récepteurs aux interleukines, Récepteurs à l'interleukine-12, Récepteurs à l'interleukine-21.
- Cytométrie en flux, Humains, Mutation, Polymorphisme de nucléotide simple, Séparation cellulaire, Transduction du signal.
English descriptors
- KwdEn :
- Cell Separation, Cytokines (metabolism), Flow Cytometry, Humans, Interferon-gamma (metabolism), Interleukin-17 (metabolism), Interleukin-23 (metabolism), Interleukins (metabolism), Killer Cells, Natural (cytology), Leukocytes, Mononuclear (cytology), Lymphocytes (cytology), Mutation, Nuclear Receptor Subfamily 1, Group F, Member 3 (metabolism), Polymorphism, Single Nucleotide, Receptors, Antigen, T-Cell, gamma-delta (metabolism), Receptors, Interleukin (metabolism), Receptors, Interleukin-12 (metabolism), Receptors, Interleukin-21 (metabolism), STAT3 Transcription Factor (metabolism), Signal Transduction, T-Lymphocytes (cytology), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , metabolism : Cytokines, Interferon-gamma, Interleukin-17, Interleukin-23, Interleukins, Nuclear Receptor Subfamily 1, Group F, Member 3, Receptors, Antigen, T-Cell, gamma-delta, Receptors, Interleukin, Receptors, Interleukin-12, Receptors, Interleukin-21, STAT3 Transcription Factor, Tumor Necrosis Factor-alpha.
- cytology : Killer Cells, Natural, Leukocytes, Mononuclear, Lymphocytes, T-Lymphocytes.
- Cell Separation, Flow Cytometry, Humans, Mutation, Polymorphism, Single Nucleotide, Signal Transduction.
Abstract
Wilson et al. show that individuals with loss-of-function mutations in
Url:
DOI: 10.1084/jem.20141992
PubMed: 25941256
PubMed Central: 4451129
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PMC:4451129Le document en format XML
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Ives</name><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>St. Vincent’s Clinical School</institution></nlm:aff></affiliation></author><author><name sortKey="Rao, Geetha" sort="Rao, Geetha" uniqKey="Rao G" first="Geetha" last="Rao">Geetha Rao</name><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Lau, Anthony" sort="Lau, Anthony" uniqKey="Lau A" first="Anthony" last="Lau">Anthony Lau</name><affiliation><nlm:aff id="aff1"><institution>University of Bath, Bath BA2 7AY, England, UK</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Payne, Kathryn" sort="Payne, Kathryn" uniqKey="Payne K" first="Kathryn" last="Payne">Kathryn Payne</name><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Kobayashi, Masao" sort="Kobayashi, Masao" uniqKey="Kobayashi M" first="Masao" last="Kobayashi">Masao Kobayashi</name><affiliation><nlm:aff id="aff4"><institution>Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan 739-8511</institution></nlm:aff></affiliation></author><author><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D." last="Arkwright">Peter D. Arkwright</name><affiliation><nlm:aff id="aff5"><institution>University of Manchester, Royal Manchester Children’s Hospital, Manchester M13 9WL, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Peake, Jane" sort="Peake, Jane" uniqKey="Peake J" first="Jane" last="Peake">Jane Peake</name><affiliation><nlm:aff id="aff6"><institution>Department of Paediatrics and Child Health, Royal Children’s Hospital Brisbane, Brisbane, QLD 4006, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Wong, Melanie" sort="Wong, Melanie" uniqKey="Wong M" first="Melanie" last="Wong">Melanie Wong</name><affiliation><nlm:aff id="aff7"><institution>Department of Allergy and Immunology, Children’s Hospital at Westmead, Westmead, Sydney, NSW 2145, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Adelstein, Stephen" sort="Adelstein, Stephen" uniqKey="Adelstein S" first="Stephen" last="Adelstein">Stephen Adelstein</name><affiliation><nlm:aff id="aff8"><institution>Department of Clinical Immunology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2050, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Smart, Joanne M" sort="Smart, Joanne M" uniqKey="Smart J" first="Joanne M." last="Smart">Joanne M. Smart</name><affiliation><nlm:aff id="aff9"><institution>Department of Allergy and Immunology, Royal Children’s Hospital Melbourne, Parkville, VIC 3052, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="French, Martyn A" sort="French, Martyn A" uniqKey="French M" first="Martyn A." last="French">Martyn A. French</name><affiliation><nlm:aff id="aff10"><institution>Department of Clinical Immunology, Royal Perth Hospital, Perth, WA 6000, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff11"><institution>School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, WA 6009, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Fulcher, David A" sort="Fulcher, David A" uniqKey="Fulcher D" first="David A." last="Fulcher">David A. Fulcher</name><affiliation><nlm:aff id="aff12"><institution>Department of Immunology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Sydney, NSW 2006, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><affiliation><nlm:aff wicri:cut=" and" id="aff13"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff14"><institution>Study Center for Primary Immunodeficiencies, Assistance Publique–Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff15"><institution>Imagine Institute, Paris Descartes University, 75015 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><affiliation><nlm:aff wicri:cut=" and" id="aff13"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff14"><institution>Study Center for Primary Immunodeficiencies, Assistance Publique–Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff15"><institution>Imagine Institute, Paris Descartes University, 75015 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stephanie" last="Boisson-Dupuis">Stephanie Boisson-Dupuis</name><affiliation><nlm:aff wicri:cut=" and" id="aff13"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff16"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution></nlm:aff></affiliation></author><author><name sortKey="Gray, Paul" sort="Gray, Paul" uniqKey="Gray P" first="Paul" last="Gray">Paul Gray</name><affiliation><nlm:aff id="aff3"><institution>School of Women’s and Children’s Health, University of New South Wales, Sydney, NSW 2052, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Stepensky, Polina" sort="Stepensky, Polina" uniqKey="Stepensky P" first="Polina" last="Stepensky">Polina Stepensky</name><affiliation><nlm:aff id="aff17"><institution>Department of Pediatric Hematology-Oncology and Bone Marrow Transplantation, Hadassah Medical Center, Hebrew University Medical Center, Jerusalem 91120, Israel</institution></nlm:aff></affiliation></author><author><name sortKey="Warnatz, Klaus" sort="Warnatz, Klaus" uniqKey="Warnatz K" first="Klaus" last="Warnatz">Klaus Warnatz</name><affiliation><nlm:aff id="aff18"><institution>Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, 79106 Freiburg, Germany</institution></nlm:aff></affiliation></author><author><name sortKey="Freeman, Alexandra F" sort="Freeman, Alexandra F" uniqKey="Freeman A" first="Alexandra F." last="Freeman">Alexandra F. Freeman</name><affiliation><nlm:aff id="aff19"><institution>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892</institution></nlm:aff></affiliation></author><author><name sortKey="Rossjohn, Jamie" sort="Rossjohn, Jamie" uniqKey="Rossjohn J" first="Jamie" last="Rossjohn">Jamie Rossjohn</name><affiliation><nlm:aff wicri:cut=" and" id="aff20"><institution>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff20"><institution>Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff21"><institution>Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Mccluskey, James" sort="Mccluskey, James" uniqKey="Mccluskey J" first="James" last="Mccluskey">James Mccluskey</name><affiliation><nlm:aff id="aff22"><institution>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M." last="Holland">Steven M. Holland</name><affiliation><nlm:aff id="aff19"><institution>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892</institution></nlm:aff></affiliation></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><affiliation><nlm:aff wicri:cut=" and" id="aff13"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff13"><institution>Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff15"><institution>Imagine Institute, Paris Descartes University, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff16"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff23"><institution>Howard Hughes Medical Institute, New York, NY 10065</institution></nlm:aff></affiliation></author><author><name sortKey="Uzel, Gulbu" sort="Uzel, Gulbu" uniqKey="Uzel G" first="Gulbu" last="Uzel">Gulbu Uzel</name><affiliation><nlm:aff id="aff19"><institution>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892</institution></nlm:aff></affiliation></author><author><name sortKey="Ma, Cindy S" sort="Ma, Cindy S" uniqKey="Ma C" first="Cindy S." last="Ma">Cindy S. Ma</name><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>St. Vincent’s Clinical School</institution></nlm:aff></affiliation></author><author><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. Tangye</name><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>St. Vincent’s Clinical School</institution></nlm:aff></affiliation></author><author><name sortKey="Deenick, Elissa K" sort="Deenick, Elissa K" uniqKey="Deenick E" first="Elissa K." last="Deenick">Elissa K. Deenick</name><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>St. Vincent’s Clinical School</institution></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25941256</idno><idno type="pmc">4451129</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451129</idno><idno type="RBID">PMC:4451129</idno><idno type="doi">10.1084/jem.20141992</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000289</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000289</idno><idno type="wicri:Area/Pmc/Curation">000289</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000289</idno><idno type="wicri:Area/Pmc/Checkpoint">000D28</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D28</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002C72</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002C72</idno><idno type="wicri:Area/PubMed/Curation">002B98</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002B98</idno><idno type="wicri:Area/PubMed/Checkpoint">002B98</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002B98</idno><idno type="wicri:Area/Ncbi/Merge">002532</idno><idno type="wicri:Area/Ncbi/Curation">002532</idno><idno type="wicri:Area/Ncbi/Checkpoint">002532</idno><idno type="wicri:doubleKey">0022-1007:2015:Wilson R:stat:is:a</idno><idno type="wicri:Area/Main/Merge">002854</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function</title><author><name sortKey="Wilson, Robert P" sort="Wilson, Robert P" uniqKey="Wilson R" first="Robert P." last="Wilson">Robert P. Wilson</name><affiliation><nlm:aff id="aff1"><institution>University of Bath, Bath BA2 7AY, England, UK</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Ives, Megan L" sort="Ives, Megan L" uniqKey="Ives M" first="Megan L." last="Ives">Megan L. Ives</name><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>St. Vincent’s Clinical School</institution></nlm:aff></affiliation></author><author><name sortKey="Rao, Geetha" sort="Rao, Geetha" uniqKey="Rao G" first="Geetha" last="Rao">Geetha Rao</name><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Lau, Anthony" sort="Lau, Anthony" uniqKey="Lau A" first="Anthony" last="Lau">Anthony Lau</name><affiliation><nlm:aff id="aff1"><institution>University of Bath, Bath BA2 7AY, England, UK</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Payne, Kathryn" sort="Payne, Kathryn" uniqKey="Payne K" first="Kathryn" last="Payne">Kathryn Payne</name><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Kobayashi, Masao" sort="Kobayashi, Masao" uniqKey="Kobayashi M" first="Masao" last="Kobayashi">Masao Kobayashi</name><affiliation><nlm:aff id="aff4"><institution>Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan 739-8511</institution></nlm:aff></affiliation></author><author><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D." last="Arkwright">Peter D. Arkwright</name><affiliation><nlm:aff id="aff5"><institution>University of Manchester, Royal Manchester Children’s Hospital, Manchester M13 9WL, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Peake, Jane" sort="Peake, Jane" uniqKey="Peake J" first="Jane" last="Peake">Jane Peake</name><affiliation><nlm:aff id="aff6"><institution>Department of Paediatrics and Child Health, Royal Children’s Hospital Brisbane, Brisbane, QLD 4006, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Wong, Melanie" sort="Wong, Melanie" uniqKey="Wong M" first="Melanie" last="Wong">Melanie Wong</name><affiliation><nlm:aff id="aff7"><institution>Department of Allergy and Immunology, Children’s Hospital at Westmead, Westmead, Sydney, NSW 2145, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Adelstein, Stephen" sort="Adelstein, Stephen" uniqKey="Adelstein S" first="Stephen" last="Adelstein">Stephen Adelstein</name><affiliation><nlm:aff id="aff8"><institution>Department of Clinical Immunology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2050, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Smart, Joanne M" sort="Smart, Joanne M" uniqKey="Smart J" first="Joanne M." last="Smart">Joanne M. Smart</name><affiliation><nlm:aff id="aff9"><institution>Department of Allergy and Immunology, Royal Children’s Hospital Melbourne, Parkville, VIC 3052, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="French, Martyn A" sort="French, Martyn A" uniqKey="French M" first="Martyn A." last="French">Martyn A. French</name><affiliation><nlm:aff id="aff10"><institution>Department of Clinical Immunology, Royal Perth Hospital, Perth, WA 6000, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff11"><institution>School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, WA 6009, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Fulcher, David A" sort="Fulcher, David A" uniqKey="Fulcher D" first="David A." last="Fulcher">David A. Fulcher</name><affiliation><nlm:aff id="aff12"><institution>Department of Immunology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Sydney, NSW 2006, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><affiliation><nlm:aff wicri:cut=" and" id="aff13"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff14"><institution>Study Center for Primary Immunodeficiencies, Assistance Publique–Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff15"><institution>Imagine Institute, Paris Descartes University, 75015 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><affiliation><nlm:aff wicri:cut=" and" id="aff13"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff14"><institution>Study Center for Primary Immunodeficiencies, Assistance Publique–Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff15"><institution>Imagine Institute, Paris Descartes University, 75015 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stephanie" last="Boisson-Dupuis">Stephanie Boisson-Dupuis</name><affiliation><nlm:aff wicri:cut=" and" id="aff13"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff16"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution></nlm:aff></affiliation></author><author><name sortKey="Gray, Paul" sort="Gray, Paul" uniqKey="Gray P" first="Paul" last="Gray">Paul Gray</name><affiliation><nlm:aff id="aff3"><institution>School of Women’s and Children’s Health, University of New South Wales, Sydney, NSW 2052, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Stepensky, Polina" sort="Stepensky, Polina" uniqKey="Stepensky P" first="Polina" last="Stepensky">Polina Stepensky</name><affiliation><nlm:aff id="aff17"><institution>Department of Pediatric Hematology-Oncology and Bone Marrow Transplantation, Hadassah Medical Center, Hebrew University Medical Center, Jerusalem 91120, Israel</institution></nlm:aff></affiliation></author><author><name sortKey="Warnatz, Klaus" sort="Warnatz, Klaus" uniqKey="Warnatz K" first="Klaus" last="Warnatz">Klaus Warnatz</name><affiliation><nlm:aff id="aff18"><institution>Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, 79106 Freiburg, Germany</institution></nlm:aff></affiliation></author><author><name sortKey="Freeman, Alexandra F" sort="Freeman, Alexandra F" uniqKey="Freeman A" first="Alexandra F." last="Freeman">Alexandra F. 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Ma</name><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>St. Vincent’s Clinical School</institution></nlm:aff></affiliation></author><author><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. Tangye</name><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>St. Vincent’s Clinical School</institution></nlm:aff></affiliation></author><author><name sortKey="Deenick, Elissa K" sort="Deenick, Elissa K" uniqKey="Deenick E" first="Elissa K." last="Deenick">Elissa K. Deenick</name><affiliation><nlm:aff id="aff2"><institution>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>St. Vincent’s Clinical School</institution></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Experimental Medicine</title><idno type="ISSN">0022-1007</idno><idno type="eISSN">1540-9538</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Separation</term><term>Cytokines (metabolism)</term><term>Flow Cytometry</term><term>Humans</term><term>Interferon-gamma (metabolism)</term><term>Interleukin-17 (metabolism)</term><term>Interleukin-23 (metabolism)</term><term>Interleukins (metabolism)</term><term>Killer Cells, Natural (cytology)</term><term>Leukocytes, Mononuclear (cytology)</term><term>Lymphocytes (cytology)</term><term>Mutation</term><term>Nuclear Receptor Subfamily 1, Group F, Member 3 (metabolism)</term><term>Polymorphism, Single Nucleotide</term><term>Receptors, Antigen, T-Cell, gamma-delta (metabolism)</term><term>Receptors, Interleukin (metabolism)</term><term>Receptors, Interleukin-12 (metabolism)</term><term>Receptors, Interleukin-21 (metabolism)</term><term>STAT3 Transcription Factor (metabolism)</term><term>Signal Transduction</term><term>T-Lymphocytes (cytology)</term><term>Tumor Necrosis Factor-alpha (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agranulocytes (cytologie)</term><term>Cellules tueuses naturelles (cytologie)</term><term>Cytokines (métabolisme)</term><term>Cytométrie en flux</term><term>Facteur de nécrose tumorale alpha (métabolisme)</term><term>Facteur de transcription STAT-3 (métabolisme)</term><term>Humains</term><term>Interféron gamma (métabolisme)</term><term>Interleukine-17 (métabolisme)</term><term>Interleukine-23 (métabolisme)</term><term>Interleukines (métabolisme)</term><term>Lymphocytes (cytologie)</term><term>Lymphocytes T (cytologie)</term><term>Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires (métabolisme)</term><term>Mutation</term><term>Polymorphisme de nucléotide simple</term><term>Récepteur lymphocytaire T antigène, gamma-delta (métabolisme)</term><term>Récepteurs aux interleukines (métabolisme)</term><term>Récepteurs à l'interleukine-12 (métabolisme)</term><term>Récepteurs à l'interleukine-21 (métabolisme)</term><term>Séparation cellulaire</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Interferon-gamma</term><term>Interleukin-17</term><term>Interleukin-23</term><term>Interleukins</term><term>Nuclear Receptor Subfamily 1, Group F, Member 3</term><term>Receptors, Antigen, T-Cell, gamma-delta</term><term>Receptors, Interleukin</term><term>Receptors, Interleukin-12</term><term>Receptors, Interleukin-21</term><term>STAT3 Transcription Factor</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Agranulocytes</term><term>Cellules tueuses naturelles</term><term>Lymphocytes</term><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Killer Cells, Natural</term><term>Leukocytes, Mononuclear</term><term>Lymphocytes</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term><term>Facteur de nécrose tumorale alpha</term><term>Facteur de transcription STAT-3</term><term>Interféron gamma</term><term>Interleukine-17</term><term>Interleukine-23</term><term>Interleukines</term><term>Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires</term><term>Récepteur lymphocytaire T antigène, gamma-delta</term><term>Récepteurs aux interleukines</term><term>Récepteurs à l'interleukine-12</term><term>Récepteurs à l'interleukine-21</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Separation</term><term>Flow Cytometry</term><term>Humans</term><term>Mutation</term><term>Polymorphism, Single Nucleotide</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cytométrie en flux</term><term>Humains</term><term>Mutation</term><term>Polymorphisme de nucléotide simple</term><term>Séparation cellulaire</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Wilson et al. show that individuals with loss-of-function mutations in <italic>STAT3</italic> have reduced numbers of peripheral blood MAIT and NKT cells, but not γδ T cells. 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Boniface</name></author><author><name sortKey="Chan, J R" uniqKey="Chan J">J.R. Chan</name></author><author><name sortKey="Mckenzie, B S" uniqKey="Mckenzie B">B.S. McKenzie</name></author><author><name sortKey="Blumenschein, W M" uniqKey="Blumenschein W">W.M. Blumenschein</name></author><author><name sortKey="Mattson, J D" uniqKey="Mattson J">J.D. Mattson</name></author><author><name sortKey="Basham, B" uniqKey="Basham B">B. Basham</name></author><author><name sortKey="Smith, K" uniqKey="Smith K">K. Smith</name></author><author><name sortKey="Chen, T" uniqKey="Chen T">T. Chen</name></author><author><name sortKey="Morel, F" uniqKey="Morel F">F. Morel</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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