STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.
Identifieur interne : 002B98 ( PubMed/Curation ); précédent : 002B97; suivant : 002B99STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.
Auteurs : Robert P. Wilson [Australie] ; Megan L. Ives [Australie] ; Geetha Rao [Australie] ; Anthony Lau [Australie] ; Kathryn Payne [Australie] ; Masao Kobayashi ; Peter D. Arkwright [Royaume-Uni] ; Jane Peake [Australie] ; Melanie Wong [Australie] ; Stephen Adelstein [Australie] ; Joanne M. Smart [Australie] ; Martyn A. French [Australie] ; David A. Fulcher [Australie] ; Capucine Picard [France] ; Jacinta Bustamante [France] ; Stephanie Boisson-Dupuis [États-Unis] ; Paul Gray [Australie] ; Polina Stepensky [Israël] ; Klaus Warnatz [Allemagne] ; Alexandra F. Freeman [États-Unis] ; Jamie Rossjohn [Royaume-Uni] ; James Mccluskey [Australie] ; Steven M. Holland [États-Unis] ; Jean-Laurent Casanova [États-Unis] ; Gulbu Uzel [États-Unis] ; Cindy S. Ma [Australie] ; Stuart G. Tangye [Australie] ; Elissa K. Deenick [Australie]Source :
- The Journal of experimental medicine [ 1540-9538 ] ; 2015.
Descripteurs français
- KwdFr :
- Agranulocytes (cytologie), Cellules tueuses naturelles (cytologie), Cytokines (métabolisme), Cytométrie en flux, Facteur de nécrose tumorale alpha (métabolisme), Facteur de transcription STAT-3 (métabolisme), Humains, Interféron gamma (métabolisme), Interleukine-17 (métabolisme), Interleukine-23 (métabolisme), Interleukines (métabolisme), Lymphocytes (cytologie), Lymphocytes T (cytologie), Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires (métabolisme), Mutation, Polymorphisme de nucléotide simple, Récepteur lymphocytaire T antigène, gamma-delta (métabolisme), Récepteurs aux interleukines (métabolisme), Récepteurs à l'interleukine-12 (métabolisme), Récepteurs à l'interleukine-21 (métabolisme), Séparation cellulaire, Transduction du signal.
- MESH :
- cytologie : Agranulocytes, Cellules tueuses naturelles, Lymphocytes, Lymphocytes T.
- métabolisme : Cytokines, Facteur de nécrose tumorale alpha, Facteur de transcription STAT-3, Interféron gamma, Interleukine-17, Interleukine-23, Interleukines, Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires, Récepteur lymphocytaire T antigène, gamma-delta, Récepteurs aux interleukines, Récepteurs à l'interleukine-12, Récepteurs à l'interleukine-21.
- Cytométrie en flux, Humains, Mutation, Polymorphisme de nucléotide simple, Séparation cellulaire, Transduction du signal.
English descriptors
- KwdEn :
- Cell Separation, Cytokines (metabolism), Flow Cytometry, Humans, Interferon-gamma (metabolism), Interleukin-17 (metabolism), Interleukin-23 (metabolism), Interleukins (metabolism), Killer Cells, Natural (cytology), Leukocytes, Mononuclear (cytology), Lymphocytes (cytology), Mutation, Nuclear Receptor Subfamily 1, Group F, Member 3 (metabolism), Polymorphism, Single Nucleotide, Receptors, Antigen, T-Cell, gamma-delta (metabolism), Receptors, Interleukin (metabolism), Receptors, Interleukin-12 (metabolism), Receptors, Interleukin-21 (metabolism), STAT3 Transcription Factor (metabolism), Signal Transduction, T-Lymphocytes (cytology), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , metabolism : Cytokines, Interferon-gamma, Interleukin-17, Interleukin-23, Interleukins, Nuclear Receptor Subfamily 1, Group F, Member 3, Receptors, Antigen, T-Cell, gamma-delta, Receptors, Interleukin, Receptors, Interleukin-12, Receptors, Interleukin-21, STAT3 Transcription Factor, Tumor Necrosis Factor-alpha.
- cytology : Killer Cells, Natural, Leukocytes, Mononuclear, Lymphocytes, T-Lymphocytes.
- Cell Separation, Flow Cytometry, Humans, Mutation, Polymorphism, Single Nucleotide, Signal Transduction.
Abstract
Unconventional T cells such as γδ T cells, natural killer T cells (NKT cells) and mucosal-associated invariant T cells (MAIT cells) are a major component of the immune system; however, the cytokine signaling pathways that control their development and function in humans are unknown. Primary immunodeficiencies caused by single gene mutations provide a unique opportunity to investigate the role of specific molecules in regulating human lymphocyte development and function. We found that individuals with loss-of-function mutations in STAT3 had reduced numbers of peripheral blood MAIT and NKT but not γδ T cells. Analysis of STAT3 mosaic individuals revealed that this effect was cell intrinsic. Surprisingly, the residual STAT3-deficient MAIT cells expressed normal levels of the transcription factor RORγt. Despite this, they displayed a deficiency in secretion of IL-17A and IL-17F, but were able to secrete normal levels of cytokines such as IFNγ and TNF. The deficiency in MAIT and NKT cells in STAT3-deficient patients was mirrored by loss-of-function mutations in IL12RB1 and IL21R, respectively. Thus, these results reveal for the first time the essential role of STAT3 signaling downstream of IL-23R and IL-21R in controlling human MAIT and NKT cell numbers.
DOI: 10.1084/jem.20141992
PubMed: 25941256
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Masao Kobayashi<affiliation><nlm:affiliation>Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan 739-8511.</nlm:affiliation><wicri:noCountry code="subField">Japan 739-8511</wicri:noCountry></affiliation>Le document en format XML
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Ives</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052</wicri:regionArea></affiliation></author><author><name sortKey="Rao, Geetha" sort="Rao, Geetha" uniqKey="Rao G" first="Geetha" last="Rao">Geetha Rao</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010</wicri:regionArea></affiliation></author><author><name sortKey="Lau, Anthony" sort="Lau, Anthony" uniqKey="Lau A" first="Anthony" last="Lau">Anthony Lau</name><affiliation wicri:level="1"><nlm:affiliation>University of Bath, Bath BA2 7AY, England, UK Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Bath, Bath BA2 7AY, England, UK Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010</wicri:regionArea></affiliation></author><author><name sortKey="Payne, Kathryn" sort="Payne, Kathryn" uniqKey="Payne K" first="Kathryn" last="Payne">Kathryn Payne</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010</wicri:regionArea></affiliation></author><author><name sortKey="Kobayashi, Masao" sort="Kobayashi, Masao" uniqKey="Kobayashi M" first="Masao" last="Kobayashi">Masao Kobayashi</name><affiliation><nlm:affiliation>Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan 739-8511.</nlm:affiliation><wicri:noCountry code="subField">Japan 739-8511</wicri:noCountry></affiliation></author><author><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D" last="Arkwright">Peter D. Arkwright</name><affiliation wicri:level="1"><nlm:affiliation>University of Manchester, Royal Manchester Children's Hospital, Manchester M13 9WL, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Manchester, Royal Manchester Children's Hospital, Manchester M13 9WL, England</wicri:regionArea></affiliation></author><author><name sortKey="Peake, Jane" sort="Peake, Jane" uniqKey="Peake J" first="Jane" last="Peake">Jane Peake</name><affiliation wicri:level="1"><nlm:affiliation>Department of Paediatrics and Child Health, Royal Children's Hospital Brisbane, Brisbane, QLD 4006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Paediatrics and Child Health, Royal Children's Hospital Brisbane, Brisbane, QLD 4006</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Melanie" sort="Wong, Melanie" uniqKey="Wong M" first="Melanie" last="Wong">Melanie Wong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergy and Immunology, Children's Hospital at Westmead, Westmead, Sydney, NSW 2145, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Allergy and Immunology, Children's Hospital at Westmead, Westmead, Sydney, NSW 2145</wicri:regionArea></affiliation></author><author><name sortKey="Adelstein, Stephen" sort="Adelstein, Stephen" uniqKey="Adelstein S" first="Stephen" last="Adelstein">Stephen Adelstein</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Immunology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2050, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Clinical Immunology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2050</wicri:regionArea></affiliation></author><author><name sortKey="Smart, Joanne M" sort="Smart, Joanne M" uniqKey="Smart J" first="Joanne M" last="Smart">Joanne M. Smart</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergy and Immunology, Royal Children's Hospital Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Allergy and Immunology, Royal Children's Hospital Melbourne, Parkville, VIC 3052</wicri:regionArea></affiliation></author><author><name sortKey="French, Martyn A" sort="French, Martyn A" uniqKey="French M" first="Martyn A" last="French">Martyn A. French</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Immunology, Royal Perth Hospital, Perth, WA 6000, Australia School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Clinical Immunology, Royal Perth Hospital, Perth, WA 6000, Australia School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, WA 6009</wicri:regionArea></affiliation></author><author><name sortKey="Fulcher, David A" sort="Fulcher, David A" uniqKey="Fulcher D" first="David A" last="Fulcher">David A. Fulcher</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Sydney, NSW 2006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Immunology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Sydney, NSW 2006</wicri:regionArea></affiliation></author><author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Study Center for Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Study Center for Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Study Center for Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Study Center for Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stephanie" last="Boisson-Dupuis">Stephanie Boisson-Dupuis</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Gray, Paul" sort="Gray, Paul" uniqKey="Gray P" first="Paul" last="Gray">Paul Gray</name><affiliation wicri:level="1"><nlm:affiliation>St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052</wicri:regionArea></affiliation></author><author><name sortKey="Stepensky, Polina" sort="Stepensky, Polina" uniqKey="Stepensky P" first="Polina" last="Stepensky">Polina Stepensky</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Hematology-Oncology and Bone Marrow Transplantation, Hadassah Medical Center, Hebrew University Medical Center, Jerusalem 91120, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Pediatric Hematology-Oncology and Bone Marrow Transplantation, Hadassah Medical Center, Hebrew University Medical Center, Jerusalem 91120</wicri:regionArea></affiliation></author><author><name sortKey="Warnatz, Klaus" sort="Warnatz, Klaus" uniqKey="Warnatz K" first="Klaus" last="Warnatz">Klaus Warnatz</name><affiliation wicri:level="1"><nlm:affiliation>Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, 79106 Freiburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, 79106 Freiburg</wicri:regionArea></affiliation></author><author><name sortKey="Freeman, Alexandra F" sort="Freeman, Alexandra F" uniqKey="Freeman A" first="Alexandra F" last="Freeman">Alexandra F. Freeman</name><affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.</nlm:affiliation><wicri:noCountry code="subField">MD 20892</wicri:noCountry></affiliation></author><author><name sortKey="Rossjohn, Jamie" sort="Rossjohn, Jamie" uniqKey="Rossjohn J" first="Jamie" last="Rossjohn">Jamie Rossjohn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences and Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia Department of Biochemistry and Molecular Biology, School of Biomedical Sciences and Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences and Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia Department of Biochemistry and Molecular Biology, School of Biomedical Sciences and Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales</wicri:regionArea></affiliation></author><author><name sortKey="Mccluskey, James" sort="Mccluskey, James" uniqKey="Mccluskey J" first="James" last="Mccluskey">James Mccluskey</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000</wicri:regionArea></affiliation></author><author><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M" last="Holland">Steven M. Holland</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris, France St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065 Howard Hughes Medical Institute, New York, NY 10065.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris, France St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065 Howard Hughes Medical Institute, New York</wicri:cityArea></affiliation></author><author><name sortKey="Uzel, Gulbu" sort="Uzel, Gulbu" uniqKey="Uzel G" first="Gulbu" last="Uzel">Gulbu Uzel</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Ma, Cindy S" sort="Ma, Cindy S" uniqKey="Ma C" first="Cindy S" last="Ma">Cindy S. Ma</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052</wicri:regionArea></affiliation></author><author><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G" last="Tangye">Stuart G. Tangye</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia e.deenick@garvan.org.au s.tangye@garvan.org.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052</wicri:regionArea></affiliation></author><author><name sortKey="Deenick, Elissa K" sort="Deenick, Elissa K" uniqKey="Deenick E" first="Elissa K" last="Deenick">Elissa K. Deenick</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia e.deenick@garvan.org.au s.tangye@garvan.org.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25941256</idno><idno type="pmid">25941256</idno><idno type="doi">10.1084/jem.20141992</idno><idno type="wicri:Area/PubMed/Corpus">002C72</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002C72</idno><idno type="wicri:Area/PubMed/Curation">002B98</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002B98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.</title><author><name sortKey="Wilson, Robert P" sort="Wilson, Robert P" uniqKey="Wilson R" first="Robert P" last="Wilson">Robert P. Wilson</name><affiliation wicri:level="1"><nlm:affiliation>University of Bath, Bath BA2 7AY, England, UK Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Bath, Bath BA2 7AY, England, UK Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010</wicri:regionArea></affiliation></author><author><name sortKey="Ives, Megan L" sort="Ives, Megan L" uniqKey="Ives M" first="Megan L" last="Ives">Megan L. Ives</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052</wicri:regionArea></affiliation></author><author><name sortKey="Rao, Geetha" sort="Rao, Geetha" uniqKey="Rao G" first="Geetha" last="Rao">Geetha Rao</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010</wicri:regionArea></affiliation></author><author><name sortKey="Lau, Anthony" sort="Lau, Anthony" uniqKey="Lau A" first="Anthony" last="Lau">Anthony Lau</name><affiliation wicri:level="1"><nlm:affiliation>University of Bath, Bath BA2 7AY, England, UK Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Bath, Bath BA2 7AY, England, UK Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010</wicri:regionArea></affiliation></author><author><name sortKey="Payne, Kathryn" sort="Payne, Kathryn" uniqKey="Payne K" first="Kathryn" last="Payne">Kathryn Payne</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010</wicri:regionArea></affiliation></author><author><name sortKey="Kobayashi, Masao" sort="Kobayashi, Masao" uniqKey="Kobayashi M" first="Masao" last="Kobayashi">Masao Kobayashi</name><affiliation><nlm:affiliation>Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan 739-8511.</nlm:affiliation><wicri:noCountry code="subField">Japan 739-8511</wicri:noCountry></affiliation></author><author><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D" last="Arkwright">Peter D. Arkwright</name><affiliation wicri:level="1"><nlm:affiliation>University of Manchester, Royal Manchester Children's Hospital, Manchester M13 9WL, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Manchester, Royal Manchester Children's Hospital, Manchester M13 9WL, England</wicri:regionArea></affiliation></author><author><name sortKey="Peake, Jane" sort="Peake, Jane" uniqKey="Peake J" first="Jane" last="Peake">Jane Peake</name><affiliation wicri:level="1"><nlm:affiliation>Department of Paediatrics and Child Health, Royal Children's Hospital Brisbane, Brisbane, QLD 4006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Paediatrics and Child Health, Royal Children's Hospital Brisbane, Brisbane, QLD 4006</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Melanie" sort="Wong, Melanie" uniqKey="Wong M" first="Melanie" last="Wong">Melanie Wong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergy and Immunology, Children's Hospital at Westmead, Westmead, Sydney, NSW 2145, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Allergy and Immunology, Children's Hospital at Westmead, Westmead, Sydney, NSW 2145</wicri:regionArea></affiliation></author><author><name sortKey="Adelstein, Stephen" sort="Adelstein, Stephen" uniqKey="Adelstein S" first="Stephen" last="Adelstein">Stephen Adelstein</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Immunology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2050, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Clinical Immunology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2050</wicri:regionArea></affiliation></author><author><name sortKey="Smart, Joanne M" sort="Smart, Joanne M" uniqKey="Smart J" first="Joanne M" last="Smart">Joanne M. Smart</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergy and Immunology, Royal Children's Hospital Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Allergy and Immunology, Royal Children's Hospital Melbourne, Parkville, VIC 3052</wicri:regionArea></affiliation></author><author><name sortKey="French, Martyn A" sort="French, Martyn A" uniqKey="French M" first="Martyn A" last="French">Martyn A. French</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Immunology, Royal Perth Hospital, Perth, WA 6000, Australia School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Clinical Immunology, Royal Perth Hospital, Perth, WA 6000, Australia School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, WA 6009</wicri:regionArea></affiliation></author><author><name sortKey="Fulcher, David A" sort="Fulcher, David A" uniqKey="Fulcher D" first="David A" last="Fulcher">David A. Fulcher</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Sydney, NSW 2006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Immunology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Sydney, NSW 2006</wicri:regionArea></affiliation></author><author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Study Center for Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Study Center for Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Study Center for Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Study Center for Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stephanie" last="Boisson-Dupuis">Stephanie Boisson-Dupuis</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Gray, Paul" sort="Gray, Paul" uniqKey="Gray P" first="Paul" last="Gray">Paul Gray</name><affiliation wicri:level="1"><nlm:affiliation>St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052</wicri:regionArea></affiliation></author><author><name sortKey="Stepensky, Polina" sort="Stepensky, Polina" uniqKey="Stepensky P" first="Polina" last="Stepensky">Polina Stepensky</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Hematology-Oncology and Bone Marrow Transplantation, Hadassah Medical Center, Hebrew University Medical Center, Jerusalem 91120, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Pediatric Hematology-Oncology and Bone Marrow Transplantation, Hadassah Medical Center, Hebrew University Medical Center, Jerusalem 91120</wicri:regionArea></affiliation></author><author><name sortKey="Warnatz, Klaus" sort="Warnatz, Klaus" uniqKey="Warnatz K" first="Klaus" last="Warnatz">Klaus Warnatz</name><affiliation wicri:level="1"><nlm:affiliation>Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, 79106 Freiburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, 79106 Freiburg</wicri:regionArea></affiliation></author><author><name sortKey="Freeman, Alexandra F" sort="Freeman, Alexandra F" uniqKey="Freeman A" first="Alexandra F" last="Freeman">Alexandra F. Freeman</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Rossjohn, Jamie" sort="Rossjohn, Jamie" uniqKey="Rossjohn J" first="Jamie" last="Rossjohn">Jamie Rossjohn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences and Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia Department of Biochemistry and Molecular Biology, School of Biomedical Sciences and Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences and Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia Department of Biochemistry and Molecular Biology, School of Biomedical Sciences and Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales</wicri:regionArea></affiliation></author><author><name sortKey="Mccluskey, James" sort="Mccluskey, James" uniqKey="Mccluskey J" first="James" last="Mccluskey">James Mccluskey</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000</wicri:regionArea></affiliation></author><author><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M" last="Holland">Steven M. Holland</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris, France St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065 Howard Hughes Medical Institute, New York, NY 10065.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris, France St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065 Howard Hughes Medical Institute, New York</wicri:cityArea></affiliation></author><author><name sortKey="Uzel, Gulbu" sort="Uzel, Gulbu" uniqKey="Uzel G" first="Gulbu" last="Uzel">Gulbu Uzel</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Ma, Cindy S" sort="Ma, Cindy S" uniqKey="Ma C" first="Cindy S" last="Ma">Cindy S. Ma</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052</wicri:regionArea></affiliation></author><author><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G" last="Tangye">Stuart G. Tangye</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia e.deenick@garvan.org.au s.tangye@garvan.org.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052</wicri:regionArea></affiliation></author><author><name sortKey="Deenick, Elissa K" sort="Deenick, Elissa K" uniqKey="Deenick E" first="Elissa K" last="Deenick">Elissa K. Deenick</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia e.deenick@garvan.org.au s.tangye@garvan.org.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of experimental medicine</title><idno type="eISSN">1540-9538</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Separation</term><term>Cytokines (metabolism)</term><term>Flow Cytometry</term><term>Humans</term><term>Interferon-gamma (metabolism)</term><term>Interleukin-17 (metabolism)</term><term>Interleukin-23 (metabolism)</term><term>Interleukins (metabolism)</term><term>Killer Cells, Natural (cytology)</term><term>Leukocytes, Mononuclear (cytology)</term><term>Lymphocytes (cytology)</term><term>Mutation</term><term>Nuclear Receptor Subfamily 1, Group F, Member 3 (metabolism)</term><term>Polymorphism, Single Nucleotide</term><term>Receptors, Antigen, T-Cell, gamma-delta (metabolism)</term><term>Receptors, Interleukin (metabolism)</term><term>Receptors, Interleukin-12 (metabolism)</term><term>Receptors, Interleukin-21 (metabolism)</term><term>STAT3 Transcription Factor (metabolism)</term><term>Signal Transduction</term><term>T-Lymphocytes (cytology)</term><term>Tumor Necrosis Factor-alpha (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agranulocytes (cytologie)</term><term>Cellules tueuses naturelles (cytologie)</term><term>Cytokines (métabolisme)</term><term>Cytométrie en flux</term><term>Facteur de nécrose tumorale alpha (métabolisme)</term><term>Facteur de transcription STAT-3 (métabolisme)</term><term>Humains</term><term>Interféron gamma (métabolisme)</term><term>Interleukine-17 (métabolisme)</term><term>Interleukine-23 (métabolisme)</term><term>Interleukines (métabolisme)</term><term>Lymphocytes (cytologie)</term><term>Lymphocytes T (cytologie)</term><term>Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires (métabolisme)</term><term>Mutation</term><term>Polymorphisme de nucléotide simple</term><term>Récepteur lymphocytaire T antigène, gamma-delta (métabolisme)</term><term>Récepteurs aux interleukines (métabolisme)</term><term>Récepteurs à l'interleukine-12 (métabolisme)</term><term>Récepteurs à l'interleukine-21 (métabolisme)</term><term>Séparation cellulaire</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Interferon-gamma</term><term>Interleukin-17</term><term>Interleukin-23</term><term>Interleukins</term><term>Nuclear Receptor Subfamily 1, Group F, Member 3</term><term>Receptors, Antigen, T-Cell, gamma-delta</term><term>Receptors, Interleukin</term><term>Receptors, Interleukin-12</term><term>Receptors, Interleukin-21</term><term>STAT3 Transcription Factor</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Agranulocytes</term><term>Cellules tueuses naturelles</term><term>Lymphocytes</term><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Killer Cells, Natural</term><term>Leukocytes, Mononuclear</term><term>Lymphocytes</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term><term>Facteur de nécrose tumorale alpha</term><term>Facteur de transcription STAT-3</term><term>Interféron gamma</term><term>Interleukine-17</term><term>Interleukine-23</term><term>Interleukines</term><term>Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires</term><term>Récepteur lymphocytaire T antigène, gamma-delta</term><term>Récepteurs aux interleukines</term><term>Récepteurs à l'interleukine-12</term><term>Récepteurs à l'interleukine-21</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Separation</term><term>Flow Cytometry</term><term>Humans</term><term>Mutation</term><term>Polymorphism, Single Nucleotide</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cytométrie en flux</term><term>Humains</term><term>Mutation</term><term>Polymorphisme de nucléotide simple</term><term>Séparation cellulaire</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Unconventional T cells such as γδ T cells, natural killer T cells (NKT cells) and mucosal-associated invariant T cells (MAIT cells) are a major component of the immune system; however, the cytokine signaling pathways that control their development and function in humans are unknown. Primary immunodeficiencies caused by single gene mutations provide a unique opportunity to investigate the role of specific molecules in regulating human lymphocyte development and function. We found that individuals with loss-of-function mutations in STAT3 had reduced numbers of peripheral blood MAIT and NKT but not γδ T cells. Analysis of STAT3 mosaic individuals revealed that this effect was cell intrinsic. Surprisingly, the residual STAT3-deficient MAIT cells expressed normal levels of the transcription factor RORγt. Despite this, they displayed a deficiency in secretion of IL-17A and IL-17F, but were able to secrete normal levels of cytokines such as IFNγ and TNF. The deficiency in MAIT and NKT cells in STAT3-deficient patients was mirrored by loss-of-function mutations in IL12RB1 and IL21R, respectively. Thus, these results reveal for the first time the essential role of STAT3 signaling downstream of IL-23R and IL-21R in controlling human MAIT and NKT cell numbers.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25941256</PMID><DateCreated><Year>2015</Year><Month>06</Month><Day>02</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>10</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1540-9538</ISSN><JournalIssue CitedMedium="Internet"><Volume>212</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>Jun</Month><Day>01</Day></PubDate></JournalIssue><Title>The Journal of experimental medicine</Title><ISOAbbreviation>J. Exp. Med.</ISOAbbreviation></Journal><ArticleTitle>STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.</ArticleTitle><Pagination><MedlinePgn>855-64</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1084/jem.20141992</ELocationID><Abstract><AbstractText>Unconventional T cells such as γδ T cells, natural killer T cells (NKT cells) and mucosal-associated invariant T cells (MAIT cells) are a major component of the immune system; however, the cytokine signaling pathways that control their development and function in humans are unknown. Primary immunodeficiencies caused by single gene mutations provide a unique opportunity to investigate the role of specific molecules in regulating human lymphocyte development and function. We found that individuals with loss-of-function mutations in STAT3 had reduced numbers of peripheral blood MAIT and NKT but not γδ T cells. Analysis of STAT3 mosaic individuals revealed that this effect was cell intrinsic. Surprisingly, the residual STAT3-deficient MAIT cells expressed normal levels of the transcription factor RORγt. Despite this, they displayed a deficiency in secretion of IL-17A and IL-17F, but were able to secrete normal levels of cytokines such as IFNγ and TNF. The deficiency in MAIT and NKT cells in STAT3-deficient patients was mirrored by loss-of-function mutations in IL12RB1 and IL21R, respectively. Thus, these results reveal for the first time the essential role of STAT3 signaling downstream of IL-23R and IL-21R in controlling human MAIT and NKT cell numbers.</AbstractText><CopyrightInformation>© 2015 Wilson et al.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>Robert P</ForeName><Initials>RP</Initials><AffiliationInfo><Affiliation>University of Bath, Bath BA2 7AY, England, UK Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ives</LastName><ForeName>Megan L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rao</LastName><ForeName>Geetha</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lau</LastName><ForeName>Anthony</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Bath, Bath BA2 7AY, England, UK Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Payne</LastName><ForeName>Kathryn</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kobayashi</LastName><ForeName>Masao</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan 739-8511.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arkwright</LastName><ForeName>Peter D</ForeName><Initials>PD</Initials><AffiliationInfo><Affiliation>University of Manchester, Royal Manchester Children's Hospital, Manchester M13 9WL, England, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peake</LastName><ForeName>Jane</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Paediatrics and Child Health, Royal Children's Hospital Brisbane, Brisbane, QLD 4006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Melanie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Allergy and Immunology, Children's Hospital at Westmead, Westmead, Sydney, NSW 2145, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adelstein</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Clinical Immunology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2050, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smart</LastName><ForeName>Joanne M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Allergy and Immunology, Royal Children's Hospital Melbourne, Parkville, VIC 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>French</LastName><ForeName>Martyn A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Clinical Immunology, Royal Perth Hospital, Perth, WA 6000, Australia School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, WA 6009, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fulcher</LastName><ForeName>David A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Department of Immunology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Sydney, NSW 2006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Picard</LastName><ForeName>Capucine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Study Center for Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bustamante</LastName><ForeName>Jacinta</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Study Center for Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boisson-Dupuis</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gray</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stepensky</LastName><ForeName>Polina</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Pediatric Hematology-Oncology and Bone Marrow Transplantation, Hadassah Medical Center, Hebrew University Medical Center, Jerusalem 91120, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Warnatz</LastName><ForeName>Klaus</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Center for Chronic Immunodeficiency, University Medical Center Freiburg, University of Freiburg, 79106 Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Freeman</LastName><ForeName>Alexandra F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rossjohn</LastName><ForeName>Jamie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences and Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia Department of Biochemistry and Molecular Biology, School of Biomedical Sciences and Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCluskey</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holland</LastName><ForeName>Steven M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casanova</LastName><ForeName>Jean-Laurent</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research (INSERM) U1163 and Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France Imagine Institute, Paris Descartes University, 75015 Paris, France St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065 Howard Hughes Medical Institute, New York, NY 10065.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uzel</LastName><ForeName>Gulbu</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Cindy S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tangye</LastName><ForeName>Stuart G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia e.deenick@garvan.org.au s.tangye@garvan.org.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deenick</LastName><ForeName>Elissa K</ForeName><Initials>EK</Initials><AffiliationInfo><Affiliation>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia St. Vincent's Clinical School and School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia e.deenick@garvan.org.au s.tangye@garvan.org.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>UL1 RR024143</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Exp Med</MedlineTA><NlmUniqueID>2985109R</NlmUniqueID><ISSNLinking>0022-1007</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C508438">IL12RB1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C515500">IL23R protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020381">Interleukin-17</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053759">Interleukin-23</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007378">Interleukins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D057132">Nuclear Receptor Subfamily 1, Group F, Member 3</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C539900">RORC protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016692">Receptors, Antigen, T-Cell, gamma-delta</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018123">Receptors, Interleukin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053707">Receptors, Interleukin-12</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053655">Receptors, Interleukin-21</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050796">STAT3 Transcription Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C494086">STAT3 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C416243">interleukin-21</NameOfSubstance></Chemical><Chemical><RegistryNumber>82115-62-6</RegistryNumber><NameOfSubstance UI="D007371">Interferon-gamma</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Blood. 2009 Jun 25;113(26):6611-8</RefSource><PMID Version="1">19395673</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2008 Sep 19;29(3):391-403</RefSource><PMID Version="1">18703361</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2010 May 28;32(5):605-15</RefSource><PMID Version="1">20493732</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2010 Jun 15;184(12):7268-80</RefSource><PMID Version="1">20483730</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2010 Jul;10(7):467-78</RefSource><PMID Version="1">20539306</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2010 Jul;10(7):479-89</RefSource><PMID Version="1">20559326</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Medicine (Baltimore). 2010 Nov;89(6):381-402</RefSource><PMID Version="1">21057261</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2011 Jan 27;117(4):1250-9</RefSource><PMID Version="1">21084709</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2011 Apr 1;332(6025):65-8</RefSource><PMID Version="1">21350122</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2011 Jul 21;118(3):586-93</RefSource><PMID Version="1">21606479</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(9):e24441</RefSource><PMID Version="1">21915328</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2011 Nov 23;35(5):806-18</RefSource><PMID Version="1">22118528</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Medicine (Baltimore). 2012 Jul;91(4):e1-19</RefSource><PMID Version="1">22751495</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Immunol. 2012 Sep;42(9):2246-54</RefSource><PMID Version="1">22949323</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2012 Dec;12(12):845-57</RefSource><PMID Version="1">23154222</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2012 Nov 29;491(7426):717-23</RefSource><PMID Version="1">23051753</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Microbiol. 2013 Jan;11(1):14-9</RefSource><PMID Version="1">23178389</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2013 Mar 11;210(3):433-43</RefSource><PMID Version="1">23440042</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Immunol. 2013 Apr;25(2):161-7</RefSource><PMID Version="1">23402834</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Immunol. 2013 Apr;25(2):174-80</RefSource><PMID Version="1">23422835</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Allergy Clin Immunol. 2013 Jun;131(6):1586-93</RefSource><PMID Version="1">23623265</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Allergy Clin Immunol. 2013 Aug;132(2):400-11.e9</RefSource><PMID Version="1">23830147</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2013 Oct 21;210(11):2305-20</RefSource><PMID Version="1">24101382</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2013 Nov 18;210(12):2739-53</RefSource><PMID Version="1">24218138</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Immunol. 2014;32:121-55</RefSource><PMID Version="1">24387714</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2014 May 15;509(7500):361-5</RefSource><PMID Version="1">24695216</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Immunol. 2014 Jun;28:49-57</RefSource><PMID Version="1">24594518</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Haematologica. 2015 Feb;100(2):e72-6</RefSource><PMID Version="1">25398835</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 1990 May 1;171(5):1597-612</RefSource><PMID Version="1">2185330</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1996 Nov 1;157(9):4222-9</RefSource><PMID Version="1">8892660</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2004 Dec 11-17;364(9451):2113-21</RefSource><PMID Version="1">15589309</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2006 Sep 22;126(6):1121-33</RefSource><PMID Version="1">16990136</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2007 Jun;8(6):639-46</RefSource><PMID Version="1">17486092</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2007 Sep;8(9):950-7</RefSource><PMID Version="1">17676044</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2007 Aug 30;448(7157):1058-62</RefSource><PMID Version="1">17676033</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2007 Oct 18;357(16):1608-19</RefSource><PMID Version="1">17881745</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2008 Apr 15;180(8):5167-71</RefSource><PMID Version="1">18390697</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2008 Apr 10;452(7188):773-6</RefSource><PMID Version="1">18337720</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2008 Jul 7;205(7):1543-50</RefSource><PMID Version="1">18591412</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2008 Jul 7;205(7):1551-7</RefSource><PMID Version="1">18591410</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11287-92</RefSource><PMID Version="1">18685112</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2008 Sep;9(9):1055-64</RefSource><PMID Version="1">18660811</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2010 May;120(5):1762-73</RefSource><PMID Version="1">20364087</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D002469" MajorTopicYN="N">Cell Separation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005434" MajorTopicYN="N">Flow Cytometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020381" MajorTopicYN="N">Interleukin-17</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053759" MajorTopicYN="N">Interleukin-23</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007378" MajorTopicYN="N">Interleukins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007694" MajorTopicYN="N">Killer Cells, Natural</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007963" MajorTopicYN="N">Leukocytes, Mononuclear</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008214" MajorTopicYN="N">Lymphocytes</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057132" MajorTopicYN="N">Nuclear Receptor Subfamily 1, Group F, Member 3</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016692" MajorTopicYN="N">Receptors, Antigen, T-Cell, gamma-delta</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018123" MajorTopicYN="N">Receptors, Interleukin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053707" MajorTopicYN="N">Receptors, Interleukin-12</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053655" MajorTopicYN="N">Receptors, Interleukin-21</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050796" MajorTopicYN="N">STAT3 Transcription Factor</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4451129</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>10</Month><Day>21</Day></PubMedPubDate><PubMedPubDate 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