Study of the effect of ceramic Ta2O5 nanoparticle distribution on cellular dose enhancement in a kilovoltage photon field.
Identifieur interne : 001695 ( Main/Merge ); précédent : 001694; suivant : 001696Study of the effect of ceramic Ta2O5 nanoparticle distribution on cellular dose enhancement in a kilovoltage photon field.
Auteurs : Sally Mckinnon [Australie] ; Elette Engels [Australie] ; Moeava Tehei [Australie] ; Konstantin Konstantinov [Australie] ; Stéphanie Corde [Australie] ; Sianne Oktaria [Australie] ; Sebastien Incerti [France] ; Michael Lerch [Australie] ; Anatoly Rosenfeld [Australie] ; Susanna Guatelli [Australie]Source :
- Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [ 1724-191X ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Céramiques, Dosimétrie en radiothérapie, Humains, Lignée cellulaire tumorale, Modèles biologiques, Méthode de Monte-Carlo, Nanoparticules métalliques (), Nanoparticules métalliques (effets des radiations), Nanoparticules métalliques (usage thérapeutique), Oxydes, Photons (usage thérapeutique), Phénomènes biophysiques, Rats, Simulation numérique, Survie cellulaire (effets des radiations), Tantale, Transfert linéique d'énergie, Tumeurs (radiothérapie).
- MESH :
- effets des radiations : Nanoparticules métalliques, Survie cellulaire.
- radiothérapie : Tumeurs.
- usage thérapeutique : Nanoparticules métalliques, Photons.
- Animaux, Céramiques, Dosimétrie en radiothérapie, Humains, Lignée cellulaire tumorale, Modèles biologiques, Méthode de Monte-Carlo, Nanoparticules métalliques, Oxydes, Phénomènes biophysiques, Rats, Simulation numérique, Tantale, Transfert linéique d'énergie.
English descriptors
- KwdEn :
- Animals, Biophysical Phenomena, Cell Line, Tumor, Cell Survival (radiation effects), Ceramics, Computer Simulation, Humans, Linear Energy Transfer, Metal Nanoparticles (chemistry), Metal Nanoparticles (radiation effects), Metal Nanoparticles (therapeutic use), Models, Biological, Monte Carlo Method, Neoplasms (radiotherapy), Oxides, Photons (therapeutic use), Radiotherapy Dosage, Rats, Tantalum.
- MESH :
- chemical : Oxides, Tantalum.
- chemistry : Metal Nanoparticles.
- radiation effects : Cell Survival, Metal Nanoparticles.
- radiotherapy : Neoplasms.
- therapeutic use : Metal Nanoparticles, Photons.
- Animals, Biophysical Phenomena, Cell Line, Tumor, Ceramics, Computer Simulation, Humans, Linear Energy Transfer, Models, Biological, Monte Carlo Method, Radiotherapy Dosage, Rats.
Abstract
The application of nanoparticles (NPs) in radiotherapy is an increasingly attractive technique to improve clinical outcomes. The internalisation of NPs within the tumour cells enables an increased radiation dose to critical cellular structures. The purpose of this study is to investigate, by means of Geant4 simulations, the dose enhancement within a cell population irradiated with a 150kVp photon field in the presence of a varying concentration of tantalum pentoxide (Ta2O5) NP aggregates, experimentally observed to form shells within tumour cells. This scenario is compared to the more traditionally simulated homogeneous solution of NP material in water with the same weight fraction of Ta2O5, as well as to a cell population without NPs present. The production of secondary electrons is enhanced by increased photoelectric effect interactions within the high-Z material and this is examined in terms of their kinetic energy spectra and linear energy transfer (LET) with various NP distributions compared to water. Our results indicate that the shell formation scenario limits the dose enhancement at 150kVp. The underlying mechanism for this limit is discussed.
DOI: 10.1016/j.ejmp.2016.09.006
PubMed: 27666955
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Institute for Superconducting and Electronic Materials, University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Corde, Stephanie" sort="Corde, Stephanie" uniqKey="Corde S" first="Stéphanie" last="Corde">Stéphanie Corde</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Radiation Oncology Department, Prince of Wales Hospital, Randwick, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Radiation Oncology Department, Prince of Wales Hospital, Randwick, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Oktaria, Sianne" sort="Oktaria, Sianne" uniqKey="Oktaria S" first="Sianne" last="Oktaria">Sianne Oktaria</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia; Centre for Medical and Molecular Bioscience, University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia; Centre for Medical and Molecular Bioscience, University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Incerti, Sebastien" sort="Incerti, Sebastien" uniqKey="Incerti S" first="Sebastien" last="Incerti">Sebastien Incerti</name><affiliation wicri:level="1"><nlm:affiliation>CNRS/IN2P3, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan, France; Université Bordeaux, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS/IN2P3, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan, France; Université Bordeaux, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan</wicri:regionArea><wicri:noRegion>33175 Gradignan</wicri:noRegion><wicri:noRegion>33175 Gradignan</wicri:noRegion></affiliation></author><author><name sortKey="Lerch, Michael" sort="Lerch, Michael" uniqKey="Lerch M" first="Michael" last="Lerch">Michael Lerch</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Rosenfeld, Anatoly" sort="Rosenfeld, Anatoly" uniqKey="Rosenfeld A" first="Anatoly" last="Rosenfeld">Anatoly Rosenfeld</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Guatelli, Susanna" sort="Guatelli, Susanna" uniqKey="Guatelli S" first="Susanna" last="Guatelli">Susanna Guatelli</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia. Electronic address: susanna@uow.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27666955</idno><idno type="pmid">27666955</idno><idno type="doi">10.1016/j.ejmp.2016.09.006</idno><idno type="wicri:Area/PubMed/Corpus">001810</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001810</idno><idno type="wicri:Area/PubMed/Curation">001787</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001787</idno><idno type="wicri:Area/PubMed/Checkpoint">001787</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001787</idno><idno type="wicri:Area/Ncbi/Merge">003C03</idno><idno type="wicri:Area/Ncbi/Curation">003C03</idno><idno type="wicri:Area/Ncbi/Checkpoint">003C03</idno><idno type="wicri:Area/Main/Merge">001695</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Study of the effect of ceramic Ta2O5 nanoparticle distribution on cellular dose enhancement in a kilovoltage photon field.</title><author><name sortKey="Mckinnon, Sally" sort="Mckinnon, Sally" uniqKey="Mckinnon S" first="Sally" last="Mckinnon">Sally Mckinnon</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Engels, Elette" sort="Engels, Elette" uniqKey="Engels E" first="Elette" last="Engels">Elette Engels</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Tehei, Moeava" sort="Tehei, Moeava" uniqKey="Tehei M" first="Moeava" last="Tehei">Moeava Tehei</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia; Centre for Medical and Molecular Bioscience, University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia; Centre for Medical and Molecular Bioscience, University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Konstantinov, Konstantin" sort="Konstantinov, Konstantin" uniqKey="Konstantinov K" first="Konstantin" last="Konstantinov">Konstantin Konstantinov</name><affiliation wicri:level="1"><nlm:affiliation>Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia; Institute for Superconducting and Electronic Materials, University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia; Institute for Superconducting and Electronic Materials, University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Corde, Stephanie" sort="Corde, Stephanie" uniqKey="Corde S" first="Stéphanie" last="Corde">Stéphanie Corde</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Radiation Oncology Department, Prince of Wales Hospital, Randwick, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Radiation Oncology Department, Prince of Wales Hospital, Randwick, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Oktaria, Sianne" sort="Oktaria, Sianne" uniqKey="Oktaria S" first="Sianne" last="Oktaria">Sianne Oktaria</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia; Centre for Medical and Molecular Bioscience, University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia; Centre for Medical and Molecular Bioscience, University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Incerti, Sebastien" sort="Incerti, Sebastien" uniqKey="Incerti S" first="Sebastien" last="Incerti">Sebastien Incerti</name><affiliation wicri:level="1"><nlm:affiliation>CNRS/IN2P3, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan, France; Université Bordeaux, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS/IN2P3, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan, France; Université Bordeaux, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR-5797, chemin du solarium, 33175 Gradignan</wicri:regionArea><wicri:noRegion>33175 Gradignan</wicri:noRegion><wicri:noRegion>33175 Gradignan</wicri:noRegion></affiliation></author><author><name sortKey="Lerch, Michael" sort="Lerch, Michael" uniqKey="Lerch M" first="Michael" last="Lerch">Michael Lerch</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Rosenfeld, Anatoly" sort="Rosenfeld, Anatoly" uniqKey="Rosenfeld A" first="Anatoly" last="Rosenfeld">Anatoly Rosenfeld</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Guatelli, Susanna" sort="Guatelli, Susanna" uniqKey="Guatelli S" first="Susanna" last="Guatelli">Susanna Guatelli</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW, Australia. Electronic address: susanna@uow.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics (CMRP), University of Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author></analytic><series><title level="j">Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)</title><idno type="eISSN">1724-191X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biophysical Phenomena</term><term>Cell Line, Tumor</term><term>Cell Survival (radiation effects)</term><term>Ceramics</term><term>Computer Simulation</term><term>Humans</term><term>Linear Energy Transfer</term><term>Metal Nanoparticles (chemistry)</term><term>Metal Nanoparticles (radiation effects)</term><term>Metal Nanoparticles (therapeutic use)</term><term>Models, Biological</term><term>Monte Carlo Method</term><term>Neoplasms (radiotherapy)</term><term>Oxides</term><term>Photons (therapeutic use)</term><term>Radiotherapy Dosage</term><term>Rats</term><term>Tantalum</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Céramiques</term><term>Dosimétrie en radiothérapie</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Modèles biologiques</term><term>Méthode de Monte-Carlo</term><term>Nanoparticules métalliques ()</term><term>Nanoparticules métalliques (effets des radiations)</term><term>Nanoparticules métalliques (usage thérapeutique)</term><term>Oxydes</term><term>Photons (usage thérapeutique)</term><term>Phénomènes biophysiques</term><term>Rats</term><term>Simulation numérique</term><term>Survie cellulaire (effets des radiations)</term><term>Tantale</term><term>Transfert linéique d'énergie</term><term>Tumeurs (radiothérapie)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Oxides</term><term>Tantalum</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Metal Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Nanoparticules métalliques</term><term>Survie cellulaire</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Cell Survival</term><term>Metal Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Metal Nanoparticles</term><term>Photons</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Nanoparticules métalliques</term><term>Photons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biophysical Phenomena</term><term>Cell Line, Tumor</term><term>Ceramics</term><term>Computer Simulation</term><term>Humans</term><term>Linear Energy Transfer</term><term>Models, Biological</term><term>Monte Carlo Method</term><term>Radiotherapy Dosage</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Céramiques</term><term>Dosimétrie en radiothérapie</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Modèles biologiques</term><term>Méthode de Monte-Carlo</term><term>Nanoparticules métalliques</term><term>Oxydes</term><term>Phénomènes biophysiques</term><term>Rats</term><term>Simulation numérique</term><term>Tantale</term><term>Transfert linéique d'énergie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The application of nanoparticles (NPs) in radiotherapy is an increasingly attractive technique to improve clinical outcomes. The internalisation of NPs within the tumour cells enables an increased radiation dose to critical cellular structures. The purpose of this study is to investigate, by means of Geant4 simulations, the dose enhancement within a cell population irradiated with a 150kVp photon field in the presence of a varying concentration of tantalum pentoxide (Ta2O5) NP aggregates, experimentally observed to form shells within tumour cells. This scenario is compared to the more traditionally simulated homogeneous solution of NP material in water with the same weight fraction of Ta2O5, as well as to a cell population without NPs present. The production of secondary electrons is enhanced by increased photoelectric effect interactions within the high-Z material and this is examined in terms of their kinetic energy spectra and linear energy transfer (LET) with various NP distributions compared to water. Our results indicate that the shell formation scenario limits the dose enhancement at 150kVp. The underlying mechanism for this limit is discussed.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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