Study of the effect of ceramic Ta2O5 nanoparticle distribution on cellular dose enhancement in a kilovoltage photon field.
Identifieur interne : 003C03 ( Ncbi/Checkpoint ); précédent : 003C02; suivant : 003C04Study of the effect of ceramic Ta2O5 nanoparticle distribution on cellular dose enhancement in a kilovoltage photon field.
Auteurs : Sally Mckinnon [Australie] ; Elette Engels [Australie] ; Moeava Tehei [Australie] ; Konstantin Konstantinov [Australie] ; Stéphanie Corde [Australie] ; Sianne Oktaria [Australie] ; Sebastien Incerti [France] ; Michael Lerch [Australie] ; Anatoly Rosenfeld [Australie] ; Susanna Guatelli [Australie]Source :
- Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [ 1724-191X ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Céramiques, Dosimétrie en radiothérapie, Humains, Lignée cellulaire tumorale, Modèles biologiques, Méthode de Monte-Carlo, Nanoparticules métalliques (), Nanoparticules métalliques (effets des radiations), Nanoparticules métalliques (usage thérapeutique), Oxydes, Photons (usage thérapeutique), Phénomènes biophysiques, Rats, Simulation numérique, Survie cellulaire (effets des radiations), Tantale, Transfert linéique d'énergie, Tumeurs (radiothérapie).
- MESH :
- effets des radiations : Nanoparticules métalliques, Survie cellulaire.
- radiothérapie : Tumeurs.
- usage thérapeutique : Nanoparticules métalliques, Photons.
- Animaux, Céramiques, Dosimétrie en radiothérapie, Humains, Lignée cellulaire tumorale, Modèles biologiques, Méthode de Monte-Carlo, Nanoparticules métalliques, Oxydes, Phénomènes biophysiques, Rats, Simulation numérique, Tantale, Transfert linéique d'énergie.
English descriptors
- KwdEn :
- Animals, Biophysical Phenomena, Cell Line, Tumor, Cell Survival (radiation effects), Ceramics, Computer Simulation, Humans, Linear Energy Transfer, Metal Nanoparticles (chemistry), Metal Nanoparticles (radiation effects), Metal Nanoparticles (therapeutic use), Models, Biological, Monte Carlo Method, Neoplasms (radiotherapy), Oxides, Photons (therapeutic use), Radiotherapy Dosage, Rats, Tantalum.
- MESH :
- chemical : Oxides, Tantalum.
- chemistry : Metal Nanoparticles.
- radiation effects : Cell Survival, Metal Nanoparticles.
- radiotherapy : Neoplasms.
- therapeutic use : Metal Nanoparticles, Photons.
- Animals, Biophysical Phenomena, Cell Line, Tumor, Ceramics, Computer Simulation, Humans, Linear Energy Transfer, Models, Biological, Monte Carlo Method, Radiotherapy Dosage, Rats.
Abstract
The application of nanoparticles (NPs) in radiotherapy is an increasingly attractive technique to improve clinical outcomes. The internalisation of NPs within the tumour cells enables an increased radiation dose to critical cellular structures. The purpose of this study is to investigate, by means of Geant4 simulations, the dose enhancement within a cell population irradiated with a 150kVp photon field in the presence of a varying concentration of tantalum pentoxide (Ta2O5) NP aggregates, experimentally observed to form shells within tumour cells. This scenario is compared to the more traditionally simulated homogeneous solution of NP material in water with the same weight fraction of Ta2O5, as well as to a cell population without NPs present. The production of secondary electrons is enhanced by increased photoelectric effect interactions within the high-Z material and this is examined in terms of their kinetic energy spectra and linear energy transfer (LET) with various NP distributions compared to water. Our results indicate that the shell formation scenario limits the dose enhancement at 150kVp. The underlying mechanism for this limit is discussed.
DOI: 10.1016/j.ejmp.2016.09.006
PubMed: 27666955
Affiliations:
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pubmed:27666955Le document en format XML
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<term>Biophysical Phenomena</term>
<term>Cell Line, Tumor</term>
<term>Cell Survival (radiation effects)</term>
<term>Ceramics</term>
<term>Computer Simulation</term>
<term>Humans</term>
<term>Linear Energy Transfer</term>
<term>Metal Nanoparticles (chemistry)</term>
<term>Metal Nanoparticles (radiation effects)</term>
<term>Metal Nanoparticles (therapeutic use)</term>
<term>Models, Biological</term>
<term>Monte Carlo Method</term>
<term>Neoplasms (radiotherapy)</term>
<term>Oxides</term>
<term>Photons (therapeutic use)</term>
<term>Radiotherapy Dosage</term>
<term>Rats</term>
<term>Tantalum</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Céramiques</term>
<term>Dosimétrie en radiothérapie</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Modèles biologiques</term>
<term>Méthode de Monte-Carlo</term>
<term>Nanoparticules métalliques ()</term>
<term>Nanoparticules métalliques (effets des radiations)</term>
<term>Nanoparticules métalliques (usage thérapeutique)</term>
<term>Oxydes</term>
<term>Photons (usage thérapeutique)</term>
<term>Phénomènes biophysiques</term>
<term>Rats</term>
<term>Simulation numérique</term>
<term>Survie cellulaire (effets des radiations)</term>
<term>Tantale</term>
<term>Transfert linéique d'énergie</term>
<term>Tumeurs (radiothérapie)</term>
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<term>Tantalum</term>
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<term>Survie cellulaire</term>
</keywords>
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<term>Metal Nanoparticles</term>
</keywords>
<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs</term>
</keywords>
<keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Metal Nanoparticles</term>
<term>Photons</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Nanoparticules métalliques</term>
<term>Photons</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Biophysical Phenomena</term>
<term>Cell Line, Tumor</term>
<term>Ceramics</term>
<term>Computer Simulation</term>
<term>Humans</term>
<term>Linear Energy Transfer</term>
<term>Models, Biological</term>
<term>Monte Carlo Method</term>
<term>Radiotherapy Dosage</term>
<term>Rats</term>
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<term>Céramiques</term>
<term>Dosimétrie en radiothérapie</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Modèles biologiques</term>
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<front><div type="abstract" xml:lang="en">The application of nanoparticles (NPs) in radiotherapy is an increasingly attractive technique to improve clinical outcomes. The internalisation of NPs within the tumour cells enables an increased radiation dose to critical cellular structures. The purpose of this study is to investigate, by means of Geant4 simulations, the dose enhancement within a cell population irradiated with a 150kVp photon field in the presence of a varying concentration of tantalum pentoxide (Ta2O5) NP aggregates, experimentally observed to form shells within tumour cells. This scenario is compared to the more traditionally simulated homogeneous solution of NP material in water with the same weight fraction of Ta2O5, as well as to a cell population without NPs present. The production of secondary electrons is enhanced by increased photoelectric effect interactions within the high-Z material and this is examined in terms of their kinetic energy spectra and linear energy transfer (LET) with various NP distributions compared to water. Our results indicate that the shell formation scenario limits the dose enhancement at 150kVp. The underlying mechanism for this limit is discussed.</div>
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<name sortKey="Engels, Elette" sort="Engels, Elette" uniqKey="Engels E" first="Elette" last="Engels">Elette Engels</name>
<name sortKey="Guatelli, Susanna" sort="Guatelli, Susanna" uniqKey="Guatelli S" first="Susanna" last="Guatelli">Susanna Guatelli</name>
<name sortKey="Konstantinov, Konstantin" sort="Konstantinov, Konstantin" uniqKey="Konstantinov K" first="Konstantin" last="Konstantinov">Konstantin Konstantinov</name>
<name sortKey="Lerch, Michael" sort="Lerch, Michael" uniqKey="Lerch M" first="Michael" last="Lerch">Michael Lerch</name>
<name sortKey="Oktaria, Sianne" sort="Oktaria, Sianne" uniqKey="Oktaria S" first="Sianne" last="Oktaria">Sianne Oktaria</name>
<name sortKey="Rosenfeld, Anatoly" sort="Rosenfeld, Anatoly" uniqKey="Rosenfeld A" first="Anatoly" last="Rosenfeld">Anatoly Rosenfeld</name>
<name sortKey="Tehei, Moeava" sort="Tehei, Moeava" uniqKey="Tehei M" first="Moeava" last="Tehei">Moeava Tehei</name>
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<country name="France"><noRegion><name sortKey="Incerti, Sebastien" sort="Incerti, Sebastien" uniqKey="Incerti S" first="Sebastien" last="Incerti">Sebastien Incerti</name>
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