Obesity-Associated Alterations in Glucose Metabolism Are Reversed by Chronic Bilateral Stimulation of the Abdominal Vagus Nerve.
Identifieur interne : 000703 ( Main/Exploration ); précédent : 000702; suivant : 000704Obesity-Associated Alterations in Glucose Metabolism Are Reversed by Chronic Bilateral Stimulation of the Abdominal Vagus Nerve.
Auteurs : Charles-Henri Malbert [France] ; Chloé Picq [France] ; Jean-Louis Divoux [France] ; Christine Henry [France] ; Michael Horowitz [Australie]Source :
- Diabetes [ 1939-327X ] ; 2017.
Descripteurs français
- KwdFr :
- Abdomen, Animaux, Encéphale (imagerie diagnostique), Encéphale (métabolisme), Foie (imagerie diagnostique), Foie (métabolisme), Glucose (métabolisme), Glycémie (métabolisme), Insulinorésistance, Muscles squelettiques (imagerie diagnostique), Muscles squelettiques (métabolisme), Métabolisme énergétique, Obésité (métabolisme), Poids du corps, Porc miniature, Stimulation du nerf vague, Suidae, Technique du clamp glycémique, Tomographie par émission de positons.
- MESH :
- imagerie diagnostique : Encéphale, Foie, Muscles squelettiques.
- métabolisme : Encéphale, Foie, Glucose, Glycémie, Muscles squelettiques, Obésité.
- Abdomen, Animaux, Insulinorésistance, Métabolisme énergétique, Poids du corps, Porc miniature, Stimulation du nerf vague, Suidae, Technique du clamp glycémique, Tomographie par émission de positons.
English descriptors
- KwdEn :
- Abdomen, Animals, Blood Glucose (metabolism), Body Weight, Brain (diagnostic imaging), Brain (metabolism), Energy Metabolism, Glucose (metabolism), Glucose Clamp Technique, Insulin Resistance, Liver (diagnostic imaging), Liver (metabolism), Muscle, Skeletal (diagnostic imaging), Muscle, Skeletal (metabolism), Obesity (metabolism), Positron-Emission Tomography, Swine, Swine, Miniature, Vagus Nerve Stimulation.
- MESH :
- chemical , metabolism : Blood Glucose, Glucose.
- diagnostic imaging : Brain, Liver, Muscle, Skeletal.
- metabolism : Brain, Liver, Muscle, Skeletal, Obesity.
- Abdomen, Animals, Body Weight, Energy Metabolism, Glucose Clamp Technique, Insulin Resistance, Positron-Emission Tomography, Swine, Swine, Miniature, Vagus Nerve Stimulation.
Abstract
Acute vagal stimulation modifies glucose and insulin metabolism, but the effect of chronic bilateral vagal stimulation is not known. Our aim was to quantify the changes in whole-body and organ-specific insulin sensitivities 12 weeks after permanent, bilateral, vagal stimulation performed at the abdominal level in adult mini-pigs. In 15 adult mini-pigs, stimulating electrodes were placed around the dorsal and ventral vagi using laparoscopy and connected to a dual-channel stimulator placed subcutaneously. Animals were divided into three groups based on stimulation and body weight (i.e., lean nonstimulated, obese nonstimulated, and obese stimulated). Twelve weeks after surgery, glucose uptake and insulin sensitivity were measured using positron emission tomography during an isoglycemic clamp. Mean whole-body insulin sensitivity was lower by 34% (P < 0.01) and the hepatic glucose uptake rate was lower by 33% (P < 0.01) in obese-nonstimulated mini-pigs but was no different in obese-stimulated compared with lean mini-pigs. An improvement in skeletal glucose uptake rate was also observed in obese-stimulated compared with obese-nonstimulated groups (P < 0.01). Vagal stimulation was associated with increased glucose metabolism in the cingulate and prefrontal brain areas. We conclude that chronic vagal stimulation improves insulin sensitivity substantially in diet-induced obesity by both peripheral and central mechanisms.
DOI: 10.2337/db16-0847
PubMed: 28082456
Affiliations:
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sort="Malbert, Charles Henri" uniqKey="Malbert C" first="Charles-Henri" last="Malbert">Charles-Henri Malbert</name><affiliation wicri:level="1"><nlm:affiliation>Ani-Scans, Department of Nutrition, French National Institute for Agricultural Research, Saint-Gilles, France charles-henri.malbert@inra.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Ani-Scans, Department of Nutrition, French National Institute for Agricultural Research, Saint-Gilles</wicri:regionArea><wicri:noRegion>Saint-Gilles</wicri:noRegion><wicri:noRegion>Saint-Gilles</wicri:noRegion></affiliation></author><author><name sortKey="Picq, Chloe" sort="Picq, Chloe" uniqKey="Picq C" first="Chloé" last="Picq">Chloé Picq</name><affiliation wicri:level="1"><nlm:affiliation>Axonic, Vallauris Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Axonic, Vallauris Cedex</wicri:regionArea><wicri:noRegion>Vallauris Cedex</wicri:noRegion><wicri:noRegion>Vallauris Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Divoux, Jean Louis" sort="Divoux, Jean Louis" uniqKey="Divoux J" first="Jean-Louis" last="Divoux">Jean-Louis Divoux</name><affiliation wicri:level="1"><nlm:affiliation>Axonic, Vallauris Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Axonic, Vallauris Cedex</wicri:regionArea><wicri:noRegion>Vallauris Cedex</wicri:noRegion><wicri:noRegion>Vallauris Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Henry, Christine" sort="Henry, Christine" uniqKey="Henry C" first="Christine" last="Henry">Christine Henry</name><affiliation wicri:level="1"><nlm:affiliation>LivaNova, Sorin CRM SAS, Clamart, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>LivaNova, Sorin CRM SAS, Clamart</wicri:regionArea><wicri:noRegion>Clamart</wicri:noRegion><wicri:noRegion>Clamart</wicri:noRegion></affiliation></author><author><name sortKey="Horowitz, Michael" sort="Horowitz, Michael" uniqKey="Horowitz M" first="Michael" last="Horowitz">Michael Horowitz</name><affiliation wicri:level="1"><nlm:affiliation>Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author></analytic><series><title level="j">Diabetes</title><idno type="eISSN">1939-327X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abdomen</term><term>Animals</term><term>Blood Glucose (metabolism)</term><term>Body Weight</term><term>Brain (diagnostic imaging)</term><term>Brain (metabolism)</term><term>Energy Metabolism</term><term>Glucose (metabolism)</term><term>Glucose Clamp Technique</term><term>Insulin Resistance</term><term>Liver (diagnostic imaging)</term><term>Liver (metabolism)</term><term>Muscle, Skeletal (diagnostic imaging)</term><term>Muscle, Skeletal (metabolism)</term><term>Obesity (metabolism)</term><term>Positron-Emission Tomography</term><term>Swine</term><term>Swine, Miniature</term><term>Vagus Nerve Stimulation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Abdomen</term><term>Animaux</term><term>Encéphale (imagerie diagnostique)</term><term>Encéphale (métabolisme)</term><term>Foie (imagerie diagnostique)</term><term>Foie (métabolisme)</term><term>Glucose (métabolisme)</term><term>Glycémie (métabolisme)</term><term>Insulinorésistance</term><term>Muscles squelettiques (imagerie diagnostique)</term><term>Muscles squelettiques (métabolisme)</term><term>Métabolisme énergétique</term><term>Obésité (métabolisme)</term><term>Poids du corps</term><term>Porc miniature</term><term>Stimulation du nerf vague</term><term>Suidae</term><term>Technique du clamp glycémique</term><term>Tomographie par émission de positons</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term><term>Glucose</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term><term>Liver</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Encéphale</term><term>Foie</term><term>Muscles squelettiques</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Liver</term><term>Muscle, Skeletal</term><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Encéphale</term><term>Foie</term><term>Glucose</term><term>Glycémie</term><term>Muscles squelettiques</term><term>Obésité</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Abdomen</term><term>Animals</term><term>Body Weight</term><term>Energy Metabolism</term><term>Glucose Clamp Technique</term><term>Insulin Resistance</term><term>Positron-Emission Tomography</term><term>Swine</term><term>Swine, Miniature</term><term>Vagus Nerve Stimulation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Abdomen</term><term>Animaux</term><term>Insulinorésistance</term><term>Métabolisme énergétique</term><term>Poids du corps</term><term>Porc miniature</term><term>Stimulation du nerf vague</term><term>Suidae</term><term>Technique du clamp glycémique</term><term>Tomographie par émission de positons</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acute vagal stimulation modifies glucose and insulin metabolism, but the effect of chronic bilateral vagal stimulation is not known. Our aim was to quantify the changes in whole-body and organ-specific insulin sensitivities 12 weeks after permanent, bilateral, vagal stimulation performed at the abdominal level in adult mini-pigs. In 15 adult mini-pigs, stimulating electrodes were placed around the dorsal and ventral vagi using laparoscopy and connected to a dual-channel stimulator placed subcutaneously. Animals were divided into three groups based on stimulation and body weight (i.e., lean nonstimulated, obese nonstimulated, and obese stimulated). Twelve weeks after surgery, glucose uptake and insulin sensitivity were measured using positron emission tomography during an isoglycemic clamp. Mean whole-body insulin sensitivity was lower by 34% (P < 0.01) and the hepatic glucose uptake rate was lower by 33% (P < 0.01) in obese-nonstimulated mini-pigs but was no different in obese-stimulated compared with lean mini-pigs. An improvement in skeletal glucose uptake rate was also observed in obese-stimulated compared with obese-nonstimulated groups (P < 0.01). Vagal stimulation was associated with increased glucose metabolism in the cingulate and prefrontal brain areas. We conclude that chronic vagal stimulation improves insulin sensitivity substantially in diet-induced obesity by both peripheral and central mechanisms.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Malbert, Charles Henri" sort="Malbert, Charles Henri" uniqKey="Malbert C" first="Charles-Henri" last="Malbert">Charles-Henri Malbert</name></noRegion><name sortKey="Divoux, Jean Louis" sort="Divoux, Jean Louis" uniqKey="Divoux J" first="Jean-Louis" last="Divoux">Jean-Louis Divoux</name><name sortKey="Henry, Christine" sort="Henry, Christine" uniqKey="Henry C" first="Christine" last="Henry">Christine Henry</name><name sortKey="Picq, Chloe" sort="Picq, Chloe" uniqKey="Picq C" first="Chloé" last="Picq">Chloé Picq</name></country><country name="Australie"><noRegion><name sortKey="Horowitz, Michael" sort="Horowitz, Michael" uniqKey="Horowitz M" first="Michael" last="Horowitz">Michael Horowitz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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