Dual-Action Cancer Therapy with Targeted Porous Silicon Nanovectors.
Identifieur interne : 000D97 ( PubMed/Checkpoint ); précédent : 000D96; suivant : 000D98Dual-Action Cancer Therapy with Targeted Porous Silicon Nanovectors.
Auteurs : Anna Cifuentes-Rius [Australie] ; Angela Ivask [Australie] ; Ester Sporleder [Australie] ; Ishdeep Kaur [Australie] ; Yasmin Assan [Australie] ; Shasha Rao [Australie] ; David Warther [France] ; Clive A. Prestidge [Australie] ; Jean-Olivier Durand [France] ; Nicolas H. Voelcker [Australie]Source :
- Small (Weinheim an der Bergstrasse, Germany) [ 1613-6829 ] ; 2017.
Abstract
There is a pressing need to develop more effective therapeutics to fight cancer. An idyllic chemotherapeutic is expected to overcome drug resistance of tumors and minimize harmful side effects to healthy tissues. Antibody-functionalized porous silicon nanoparticles loaded with a combination of chemotherapy drug and gold nanoclusters (AuNCs) are developed. These nanocarriers are observed to selectively deliver both payloads, the chemotherapy drug and AuNCs, to human B cells. The accumulation of AuNCs to target cells and subsequent exposure to an external electromagnetic field in the microwave region render them more susceptible to the codelivered drug. This approach represents a targeted two-stage delivery nanocarrier that benefits from a dual therapeutic action that results in enhanced cytotoxicity.
DOI: 10.1002/smll.201701201
PubMed: 28570785
Affiliations:
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5095</wicri:regionArea><wicri:noRegion>5095</wicri:noRegion></affiliation></author><author><name sortKey="Ivask, Angela" sort="Ivask, Angela" uniqKey="Ivask A" first="Angela" last="Ivask">Angela Ivask</name><affiliation wicri:level="1"><nlm:affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095</wicri:regionArea><wicri:noRegion>5095</wicri:noRegion></affiliation></author><author><name sortKey="Sporleder, Ester" sort="Sporleder, Ester" uniqKey="Sporleder E" first="Ester" last="Sporleder">Ester Sporleder</name><affiliation wicri:level="1"><nlm:affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095</wicri:regionArea><wicri:noRegion>5095</wicri:noRegion></affiliation></author><author><name sortKey="Kaur, Ishdeep" sort="Kaur, Ishdeep" uniqKey="Kaur I" first="Ishdeep" last="Kaur">Ishdeep Kaur</name><affiliation wicri:level="1"><nlm:affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095</wicri:regionArea><wicri:noRegion>5095</wicri:noRegion></affiliation></author><author><name sortKey="Assan, Yasmin" sort="Assan, Yasmin" uniqKey="Assan Y" first="Yasmin" last="Assan">Yasmin Assan</name><affiliation wicri:level="1"><nlm:affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095</wicri:regionArea><wicri:noRegion>5095</wicri:noRegion></affiliation></author><author><name sortKey="Rao, Shasha" sort="Rao, Shasha" uniqKey="Rao S" first="Shasha" last="Rao">Shasha Rao</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy and Medical Sciences, University of South Australia, City East Campus, Adelaide, SA, 5000, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Pharmacy and Medical Sciences, University of South Australia, City East Campus, Adelaide, SA, 5000</wicri:regionArea><wicri:noRegion>5000</wicri:noRegion></affiliation></author><author><name sortKey="Warther, David" sort="Warther, David" uniqKey="Warther D" first="David" last="Warther">David Warther</name><affiliation wicri:level="1"><nlm:affiliation>Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM-UM1cc, 1701, Place Eugène Bataillon, F-34095, Montpelliercedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM-UM1cc, 1701, Place Eugène Bataillon, F-34095, Montpelliercedex 05</wicri:regionArea><wicri:noRegion>34095, Montpelliercedex 05</wicri:noRegion><wicri:noRegion>34095, Montpelliercedex 05</wicri:noRegion></affiliation></author><author><name sortKey="Prestidge, Clive A" sort="Prestidge, Clive A" uniqKey="Prestidge C" first="Clive A" last="Prestidge">Clive A. Prestidge</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy and Medical Sciences, University of South Australia, City East Campus, Adelaide, SA, 5000, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Pharmacy and Medical Sciences, University of South Australia, City East Campus, Adelaide, SA, 5000</wicri:regionArea><wicri:noRegion>5000</wicri:noRegion></affiliation></author><author><name sortKey="Durand, Jean Olivier" sort="Durand, Jean Olivier" uniqKey="Durand J" first="Jean-Olivier" last="Durand">Jean-Olivier Durand</name><affiliation wicri:level="1"><nlm:affiliation>Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM-UM1cc, 1701, Place Eugène Bataillon, F-34095, Montpelliercedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM-UM1cc, 1701, Place Eugène Bataillon, F-34095, Montpelliercedex 05</wicri:regionArea><wicri:noRegion>34095, Montpelliercedex 05</wicri:noRegion><wicri:noRegion>34095, Montpelliercedex 05</wicri:noRegion></affiliation></author><author><name sortKey="Voelcker, Nicolas H" sort="Voelcker, Nicolas H" uniqKey="Voelcker N" first="Nicolas H" last="Voelcker">Nicolas H. Voelcker</name><affiliation wicri:level="1"><nlm:affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095</wicri:regionArea><wicri:noRegion>5095</wicri:noRegion></affiliation></author></analytic><series><title level="j">Small (Weinheim an der Bergstrasse, Germany)</title><idno type="eISSN">1613-6829</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is a pressing need to develop more effective therapeutics to fight cancer. An idyllic chemotherapeutic is expected to overcome drug resistance of tumors and minimize harmful side effects to healthy tissues. Antibody-functionalized porous silicon nanoparticles loaded with a combination of chemotherapy drug and gold nanoclusters (AuNCs) are developed. These nanocarriers are observed to selectively deliver both payloads, the chemotherapy drug and AuNCs, to human B cells. The accumulation of AuNCs to target cells and subsequent exposure to an external electromagnetic field in the microwave region render them more susceptible to the codelivered drug. This approach represents a targeted two-stage delivery nanocarrier that benefits from a dual therapeutic action that results in enhanced cytotoxicity.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28570785</PMID><DateCreated><Year>2017</Year><Month>06</Month><Day>01</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1613-6829</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>29</Issue><PubDate><Year>2017</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Small (Weinheim an der Bergstrasse, Germany)</Title><ISOAbbreviation>Small</ISOAbbreviation></Journal><ArticleTitle>Dual-Action Cancer Therapy with Targeted Porous Silicon Nanovectors.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1002/smll.201701201</ELocationID><Abstract><AbstractText>There is a pressing need to develop more effective therapeutics to fight cancer. An idyllic chemotherapeutic is expected to overcome drug resistance of tumors and minimize harmful side effects to healthy tissues. Antibody-functionalized porous silicon nanoparticles loaded with a combination of chemotherapy drug and gold nanoclusters (AuNCs) are developed. These nanocarriers are observed to selectively deliver both payloads, the chemotherapy drug and AuNCs, to human B cells. The accumulation of AuNCs to target cells and subsequent exposure to an external electromagnetic field in the microwave region render them more susceptible to the codelivered drug. This approach represents a targeted two-stage delivery nanocarrier that benefits from a dual therapeutic action that results in enhanced cytotoxicity.</AbstractText><CopyrightInformation>© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cifuentes-Rius</LastName><ForeName>Anna</ForeName><Initials>A</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-9478-2239</Identifier><AffiliationInfo><Affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ivask</LastName><ForeName>Angela</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sporleder</LastName><ForeName>Ester</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaur</LastName><ForeName>Ishdeep</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Assan</LastName><ForeName>Yasmin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rao</LastName><ForeName>Shasha</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>School of Pharmacy and Medical Sciences, University of South Australia, City East Campus, Adelaide, SA, 5000, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Warther</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM-UM1cc, 1701, Place Eugène Bataillon, F-34095, Montpelliercedex 05, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prestidge</LastName><ForeName>Clive A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>School of Pharmacy and Medical Sciences, University of South Australia, City East Campus, Adelaide, SA, 5000, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Durand</LastName><ForeName>Jean-Olivier</ForeName><Initials>JO</Initials><AffiliationInfo><Affiliation>Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM-UM1cc, 1701, Place Eugène Bataillon, F-34095, Montpelliercedex 05, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Voelcker</LastName><ForeName>Nicolas H</ForeName><Initials>NH</Initials><AffiliationInfo><Affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>06</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Small</MedlineTA><NlmUniqueID>101235338</NlmUniqueID><ISSNLinking>1613-6810</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">cancer</Keyword><Keyword MajorTopicYN="N">cytotoxicity</Keyword><Keyword MajorTopicYN="N">drug delivery</Keyword><Keyword MajorTopicYN="N">nanoparticles</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>04</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28570785</ArticleId><ArticleId IdType="doi">10.1002/smll.201701201</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Cifuentes Rius, Anna" sort="Cifuentes Rius, Anna" uniqKey="Cifuentes Rius A" first="Anna" last="Cifuentes-Rius">Anna Cifuentes-Rius</name></noRegion><name sortKey="Assan, Yasmin" sort="Assan, Yasmin" uniqKey="Assan Y" first="Yasmin" last="Assan">Yasmin Assan</name><name sortKey="Ivask, Angela" sort="Ivask, Angela" uniqKey="Ivask A" first="Angela" last="Ivask">Angela Ivask</name><name sortKey="Kaur, Ishdeep" sort="Kaur, Ishdeep" uniqKey="Kaur I" first="Ishdeep" last="Kaur">Ishdeep Kaur</name><name sortKey="Prestidge, Clive A" sort="Prestidge, Clive A" uniqKey="Prestidge C" first="Clive A" last="Prestidge">Clive A. Prestidge</name><name sortKey="Rao, Shasha" sort="Rao, Shasha" uniqKey="Rao S" first="Shasha" last="Rao">Shasha Rao</name><name sortKey="Sporleder, Ester" sort="Sporleder, Ester" uniqKey="Sporleder E" first="Ester" last="Sporleder">Ester Sporleder</name><name sortKey="Voelcker, Nicolas H" sort="Voelcker, Nicolas H" uniqKey="Voelcker N" first="Nicolas H" last="Voelcker">Nicolas H. Voelcker</name></country><country name="France"><noRegion><name sortKey="Warther, David" sort="Warther, David" uniqKey="Warther D" first="David" last="Warther">David Warther</name></noRegion><name sortKey="Durand, Jean Olivier" sort="Durand, Jean Olivier" uniqKey="Durand J" first="Jean-Olivier" last="Durand">Jean-Olivier Durand</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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