Patient-derived xenograft (PDX) models in basic and translational breast cancer research.
Identifieur interne : 001979 ( Main/Exploration ); précédent : 001978; suivant : 001980Patient-derived xenograft (PDX) models in basic and translational breast cancer research.
Auteurs : Lacey E. Dobrolecki [États-Unis] ; Susie D. Airhart [États-Unis] ; Denis G. Alferez [Royaume-Uni] ; Samuel Aparicio [Canada] ; Fariba Behbod [États-Unis] ; Mohamed Bentires-Alj [Suisse] ; Cathrin Brisken [Suisse] ; Carol J. Bult [États-Unis] ; Shirong Cai [États-Unis] ; Robert B. Clarke [Royaume-Uni] ; Heidi Dowst [États-Unis] ; Matthew J. Ellis [États-Unis] ; Eva Gonzalez-Suarez [Espagne] ; Richard D. Iggo [France] ; Peter Kabos [États-Unis] ; Shunqiang Li [États-Unis] ; Geoffrey J. Lindeman [Australie] ; Elisabetta Marangoni [France] ; Aaron Mccoy [États-Unis] ; Funda Meric-Bernstam [États-Unis] ; Helen Piwnica-Worms [États-Unis] ; Marie-France Poupon [France] ; Jorge Reis-Filho [États-Unis] ; Carol A. Sartorius [États-Unis] ; Valentina Scabia [Suisse] ; George Sflomos [Suisse] ; Yizheng Tu [États-Unis] ; François Vaillant [Australie] ; Jane E. Visvader [Australie] ; Alana Welm [États-Unis] ; Max S. Wicha [États-Unis] ; Michael T. Lewis [États-Unis]Source :
- Cancer metastasis reviews [ 1573-7233 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
Abstract
Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational preclinical research. In breast cancer, to complement the now curated collection of approximately 45 long-established human breast cancer cell lines, a newly formed consortium of academic laboratories, currently from Europe, Australia, and North America, herein summarizes data on over 500 stably transplantable PDX models representing all three clinical subtypes of breast cancer (ER+, HER2+, and "Triple-negative" (TNBC)). Many of these models are well-characterized with respect to genomic, transcriptomic, and proteomic features, metastatic behavior, and treatment response to a variety of standard-of-care and experimental therapeutics. These stably transplantable PDX lines are generally available for dissemination to laboratories conducting translational research, and contact information for each collection is provided. This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, efforts to develop complementary data standards for annotation of PDX characteristics and biology, and progress toward "credentialing" of PDX models as surrogates to represent individual patients for use in preclinical and co-clinical translational research. In addition, this review highlights important unresolved questions, as well as current limitations, that have hampered more efficient generation of PDX lines and more rapid adoption of PDX use in translational breast cancer research.
DOI: 10.1007/s10555-016-9653-x
PubMed: 28025748
Affiliations:
- Australie, Canada, Espagne, France, Royaume-Uni, Suisse, États-Unis
- Angleterre, Aquitaine, Canton de Vaud, Catalogne, Grand Manchester, Nouvelle-Aquitaine, État de New York, Île-de-France
- Barcelone, Bordeaux, Lausanne, Manchester, Paris
- Université de Manchester
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Le document en format XML
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<author><name sortKey="Behbod, Fariba" sort="Behbod, Fariba" uniqKey="Behbod F" first="Fariba" last="Behbod">Fariba Behbod</name>
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<author><name sortKey="Bentires Alj, Mohamed" sort="Bentires Alj, Mohamed" uniqKey="Bentires Alj M" first="Mohamed" last="Bentires-Alj">Mohamed Bentires-Alj</name>
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<author><name sortKey="Brisken, Cathrin" sort="Brisken, Cathrin" uniqKey="Brisken C" first="Cathrin" last="Brisken">Cathrin Brisken</name>
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<author><name sortKey="Bult, Carol J" sort="Bult, Carol J" uniqKey="Bult C" first="Carol J" last="Bult">Carol J. Bult</name>
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<author><name sortKey="Cai, Shirong" sort="Cai, Shirong" uniqKey="Cai S" first="Shirong" last="Cai">Shirong Cai</name>
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<author><name sortKey="Clarke, Robert B" sort="Clarke, Robert B" uniqKey="Clarke R" first="Robert B" last="Clarke">Robert B. Clarke</name>
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<author><name sortKey="Dowst, Heidi" sort="Dowst, Heidi" uniqKey="Dowst H" first="Heidi" last="Dowst">Heidi Dowst</name>
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<author><name sortKey="Ellis, Matthew J" sort="Ellis, Matthew J" uniqKey="Ellis M" first="Matthew J" last="Ellis">Matthew J. Ellis</name>
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<author><name sortKey="Gonzalez Suarez, Eva" sort="Gonzalez Suarez, Eva" uniqKey="Gonzalez Suarez E" first="Eva" last="Gonzalez-Suarez">Eva Gonzalez-Suarez</name>
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<author><name sortKey="Iggo, Richard D" sort="Iggo, Richard D" uniqKey="Iggo R" first="Richard D" last="Iggo">Richard D. Iggo</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U1218, Bergonié Cancer Institute, 229 cours de l'Argonne, 33076, Bordeaux, France.</nlm:affiliation>
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<author><name sortKey="Kabos, Peter" sort="Kabos, Peter" uniqKey="Kabos P" first="Peter" last="Kabos">Peter Kabos</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.</nlm:affiliation>
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<author><name sortKey="Li, Shunqiang" sort="Li, Shunqiang" uniqKey="Li S" first="Shunqiang" last="Li">Shunqiang Li</name>
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<author><name sortKey="Lindeman, Geoffrey J" sort="Lindeman, Geoffrey J" uniqKey="Lindeman G" first="Geoffrey J" last="Lindeman">Geoffrey J. Lindeman</name>
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<author><name sortKey="Marangoni, Elisabetta" sort="Marangoni, Elisabetta" uniqKey="Marangoni E" first="Elisabetta" last="Marangoni">Elisabetta Marangoni</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Translational Research Department, Institut Curie, 26, rue d'Ulm, 75005, Paris</wicri:regionArea>
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<author><name sortKey="Mccoy, Aaron" sort="Mccoy, Aaron" uniqKey="Mccoy A" first="Aaron" last="Mccoy">Aaron Mccoy</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea>
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<author><name sortKey="Meric Bernstam, Funda" sort="Meric Bernstam, Funda" uniqKey="Meric Bernstam F" first="Funda" last="Meric-Bernstam">Funda Meric-Bernstam</name>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Investigational Cancer Therapeutics and Breast Surgical Oncology, UT M. D. Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Investigational Cancer Therapeutics and Breast Surgical Oncology, UT M. D. Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea>
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<author><name sortKey="Piwnica Worms, Helen" sort="Piwnica Worms, Helen" uniqKey="Piwnica Worms H" first="Helen" last="Piwnica-Worms">Helen Piwnica-Worms</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Poupon, Marie France" sort="Poupon, Marie France" uniqKey="Poupon M" first="Marie-France" last="Poupon">Marie-France Poupon</name>
<affiliation wicri:level="1"><nlm:affiliation>Founder and Scientific Advisor, XenTech SA, Genopole, 4 rue Pierre Fontaine, 91000, Evry, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Founder and Scientific Advisor, XenTech SA, Genopole, 4 rue Pierre Fontaine, 91000, Evry</wicri:regionArea>
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<author><name sortKey="Reis Filho, Jorge" sort="Reis Filho, Jorge" uniqKey="Reis Filho J" first="Jorge" last="Reis-Filho">Jorge Reis-Filho</name>
<affiliation wicri:level="2"><nlm:affiliation>Director of Experimental Pathology, Department of Pathology, Affiliate Member, Human Oncology and Pathogenesis Program, and Center for Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Director of Experimental Pathology, Department of Pathology, Affiliate Member, Human Oncology and Pathogenesis Program, and Center for Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
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<author><name sortKey="Sartorius, Carol A" sort="Sartorius, Carol A" uniqKey="Sartorius C" first="Carol A" last="Sartorius">Carol A. Sartorius</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045</wicri:regionArea>
<wicri:noRegion>80045</wicri:noRegion>
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</author>
<author><name sortKey="Scabia, Valentina" sort="Scabia, Valentina" uniqKey="Scabia V" first="Valentina" last="Scabia">Valentina Scabia</name>
<affiliation wicri:level="3"><nlm:affiliation>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
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<author><name sortKey="Sflomos, George" sort="Sflomos, George" uniqKey="Sflomos G" first="George" last="Sflomos">George Sflomos</name>
<affiliation wicri:level="3"><nlm:affiliation>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
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<author><name sortKey="Tu, Yizheng" sort="Tu, Yizheng" uniqKey="Tu Y" first="Yizheng" last="Tu">Yizheng Tu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea>
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</author>
<author><name sortKey="Vaillant, Francois" sort="Vaillant, Francois" uniqKey="Vaillant F" first="François" last="Vaillant">François Vaillant</name>
<affiliation wicri:level="1"><nlm:affiliation>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052</wicri:regionArea>
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</author>
<author><name sortKey="Visvader, Jane E" sort="Visvader, Jane E" uniqKey="Visvader J" first="Jane E" last="Visvader">Jane E. Visvader</name>
<affiliation wicri:level="1"><nlm:affiliation>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052</wicri:regionArea>
<wicri:noRegion>3052</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Welm, Alana" sort="Welm, Alana" uniqKey="Welm A" first="Alana" last="Welm">Alana Welm</name>
<affiliation wicri:level="1"><nlm:affiliation>Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112</wicri:regionArea>
<wicri:noRegion>84112</wicri:noRegion>
</affiliation>
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<author><name sortKey="Wicha, Max S" sort="Wicha, Max S" uniqKey="Wicha M" first="Max S" last="Wicha">Max S. Wicha</name>
<affiliation wicri:level="1"><nlm:affiliation>Madeline and Sidney Forbes Professor of Oncology, Director, Forbes Institute for Cancer Discovery, NCRC 26-335S, SPC 2800 2800 Plymouth Rd, Ann Arbor, MI, 48109-2800, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Madeline and Sidney Forbes Professor of Oncology, Director, Forbes Institute for Cancer Discovery, NCRC 26-335S, SPC 2800 2800 Plymouth Rd, Ann Arbor, MI, 48109-2800</wicri:regionArea>
<wicri:noRegion>48109-2800</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lewis, Michael T" sort="Lewis, Michael T" uniqKey="Lewis M" first="Michael T" last="Lewis">Michael T. Lewis</name>
<affiliation wicri:level="1"><nlm:affiliation>The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030, USA. mtlewis@bcm.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030</wicri:regionArea>
<wicri:noRegion>77030</wicri:noRegion>
</affiliation>
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</titleStmt>
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<country xml:lang="fr">Suisse</country>
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<author><name sortKey="Cai, Shirong" sort="Cai, Shirong" uniqKey="Cai S" first="Shirong" last="Cai">Shirong Cai</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Clarke, Robert B" sort="Clarke, Robert B" uniqKey="Clarke R" first="Robert B" last="Clarke">Robert B. Clarke</name>
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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">Suisse</country>
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<author><name sortKey="Tu, Yizheng" sort="Tu, Yizheng" uniqKey="Tu Y" first="Yizheng" last="Tu">Yizheng Tu</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Vaillant, Francois" sort="Vaillant, Francois" uniqKey="Vaillant F" first="François" last="Vaillant">François Vaillant</name>
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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">États-Unis</country>
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<series><title level="j">Cancer metastasis reviews</title>
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<front><div type="abstract" xml:lang="en">Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational preclinical research. In breast cancer, to complement the now curated collection of approximately 45 long-established human breast cancer cell lines, a newly formed consortium of academic laboratories, currently from Europe, Australia, and North America, herein summarizes data on over 500 stably transplantable PDX models representing all three clinical subtypes of breast cancer (ER+, HER2+, and "Triple-negative" (TNBC)). Many of these models are well-characterized with respect to genomic, transcriptomic, and proteomic features, metastatic behavior, and treatment response to a variety of standard-of-care and experimental therapeutics. These stably transplantable PDX lines are generally available for dissemination to laboratories conducting translational research, and contact information for each collection is provided. This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, efforts to develop complementary data standards for annotation of PDX characteristics and biology, and progress toward "credentialing" of PDX models as surrogates to represent individual patients for use in preclinical and co-clinical translational research. In addition, this review highlights important unresolved questions, as well as current limitations, that have hampered more efficient generation of PDX lines and more rapid adoption of PDX use in translational breast cancer research.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Aquitaine</li>
<li>Canton de Vaud</li>
<li>Catalogne</li>
<li>Grand Manchester</li>
<li>Nouvelle-Aquitaine</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement><li>Barcelone</li>
<li>Bordeaux</li>
<li>Lausanne</li>
<li>Manchester</li>
<li>Paris</li>
</settlement>
<orgName><li>Université de Manchester</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Dobrolecki, Lacey E" sort="Dobrolecki, Lacey E" uniqKey="Dobrolecki L" first="Lacey E" last="Dobrolecki">Lacey E. Dobrolecki</name>
</noRegion>
<name sortKey="Airhart, Susie D" sort="Airhart, Susie D" uniqKey="Airhart S" first="Susie D" last="Airhart">Susie D. Airhart</name>
<name sortKey="Behbod, Fariba" sort="Behbod, Fariba" uniqKey="Behbod F" first="Fariba" last="Behbod">Fariba Behbod</name>
<name sortKey="Bult, Carol J" sort="Bult, Carol J" uniqKey="Bult C" first="Carol J" last="Bult">Carol J. Bult</name>
<name sortKey="Cai, Shirong" sort="Cai, Shirong" uniqKey="Cai S" first="Shirong" last="Cai">Shirong Cai</name>
<name sortKey="Dowst, Heidi" sort="Dowst, Heidi" uniqKey="Dowst H" first="Heidi" last="Dowst">Heidi Dowst</name>
<name sortKey="Ellis, Matthew J" sort="Ellis, Matthew J" uniqKey="Ellis M" first="Matthew J" last="Ellis">Matthew J. Ellis</name>
<name sortKey="Kabos, Peter" sort="Kabos, Peter" uniqKey="Kabos P" first="Peter" last="Kabos">Peter Kabos</name>
<name sortKey="Lewis, Michael T" sort="Lewis, Michael T" uniqKey="Lewis M" first="Michael T" last="Lewis">Michael T. Lewis</name>
<name sortKey="Li, Shunqiang" sort="Li, Shunqiang" uniqKey="Li S" first="Shunqiang" last="Li">Shunqiang Li</name>
<name sortKey="Mccoy, Aaron" sort="Mccoy, Aaron" uniqKey="Mccoy A" first="Aaron" last="Mccoy">Aaron Mccoy</name>
<name sortKey="Meric Bernstam, Funda" sort="Meric Bernstam, Funda" uniqKey="Meric Bernstam F" first="Funda" last="Meric-Bernstam">Funda Meric-Bernstam</name>
<name sortKey="Piwnica Worms, Helen" sort="Piwnica Worms, Helen" uniqKey="Piwnica Worms H" first="Helen" last="Piwnica-Worms">Helen Piwnica-Worms</name>
<name sortKey="Reis Filho, Jorge" sort="Reis Filho, Jorge" uniqKey="Reis Filho J" first="Jorge" last="Reis-Filho">Jorge Reis-Filho</name>
<name sortKey="Sartorius, Carol A" sort="Sartorius, Carol A" uniqKey="Sartorius C" first="Carol A" last="Sartorius">Carol A. Sartorius</name>
<name sortKey="Tu, Yizheng" sort="Tu, Yizheng" uniqKey="Tu Y" first="Yizheng" last="Tu">Yizheng Tu</name>
<name sortKey="Welm, Alana" sort="Welm, Alana" uniqKey="Welm A" first="Alana" last="Welm">Alana Welm</name>
<name sortKey="Wicha, Max S" sort="Wicha, Max S" uniqKey="Wicha M" first="Max S" last="Wicha">Max S. Wicha</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Alferez, Denis G" sort="Alferez, Denis G" uniqKey="Alferez D" first="Denis G" last="Alferez">Denis G. Alferez</name>
</region>
<name sortKey="Clarke, Robert B" sort="Clarke, Robert B" uniqKey="Clarke R" first="Robert B" last="Clarke">Robert B. Clarke</name>
</country>
<country name="Canada"><noRegion><name sortKey="Aparicio, Samuel" sort="Aparicio, Samuel" uniqKey="Aparicio S" first="Samuel" last="Aparicio">Samuel Aparicio</name>
</noRegion>
</country>
<country name="Suisse"><noRegion><name sortKey="Bentires Alj, Mohamed" sort="Bentires Alj, Mohamed" uniqKey="Bentires Alj M" first="Mohamed" last="Bentires-Alj">Mohamed Bentires-Alj</name>
</noRegion>
<name sortKey="Brisken, Cathrin" sort="Brisken, Cathrin" uniqKey="Brisken C" first="Cathrin" last="Brisken">Cathrin Brisken</name>
<name sortKey="Scabia, Valentina" sort="Scabia, Valentina" uniqKey="Scabia V" first="Valentina" last="Scabia">Valentina Scabia</name>
<name sortKey="Sflomos, George" sort="Sflomos, George" uniqKey="Sflomos G" first="George" last="Sflomos">George Sflomos</name>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Gonzalez Suarez, Eva" sort="Gonzalez Suarez, Eva" uniqKey="Gonzalez Suarez E" first="Eva" last="Gonzalez-Suarez">Eva Gonzalez-Suarez</name>
</region>
</country>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Iggo, Richard D" sort="Iggo, Richard D" uniqKey="Iggo R" first="Richard D" last="Iggo">Richard D. Iggo</name>
</region>
<name sortKey="Marangoni, Elisabetta" sort="Marangoni, Elisabetta" uniqKey="Marangoni E" first="Elisabetta" last="Marangoni">Elisabetta Marangoni</name>
<name sortKey="Poupon, Marie France" sort="Poupon, Marie France" uniqKey="Poupon M" first="Marie-France" last="Poupon">Marie-France Poupon</name>
</country>
<country name="Australie"><noRegion><name sortKey="Lindeman, Geoffrey J" sort="Lindeman, Geoffrey J" uniqKey="Lindeman G" first="Geoffrey J" last="Lindeman">Geoffrey J. Lindeman</name>
</noRegion>
<name sortKey="Vaillant, Francois" sort="Vaillant, Francois" uniqKey="Vaillant F" first="François" last="Vaillant">François Vaillant</name>
<name sortKey="Visvader, Jane E" sort="Visvader, Jane E" uniqKey="Visvader J" first="Jane E" last="Visvader">Jane E. Visvader</name>
</country>
</tree>
</affiliations>
</record>
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