Patient-derived xenograft (PDX) models in basic and translational breast cancer research.
Identifieur interne : 004094 ( Ncbi/Curation ); précédent : 004093; suivant : 004095Patient-derived xenograft (PDX) models in basic and translational breast cancer research.
Auteurs : Lacey E. Dobrolecki [États-Unis] ; Susie D. Airhart [États-Unis] ; Denis G. Alferez [Royaume-Uni] ; Samuel Aparicio [Canada] ; Fariba Behbod [États-Unis] ; Mohamed Bentires-Alj [Suisse] ; Cathrin Brisken [Suisse] ; Carol J. Bult [États-Unis] ; Shirong Cai [États-Unis] ; Robert B. Clarke [Royaume-Uni] ; Heidi Dowst [États-Unis] ; Matthew J. Ellis [États-Unis] ; Eva Gonzalez-Suarez [Espagne] ; Richard D. Iggo [France] ; Peter Kabos [États-Unis] ; Shunqiang Li [États-Unis] ; Geoffrey J. Lindeman [Australie] ; Elisabetta Marangoni [France] ; Aaron Mccoy [États-Unis] ; Funda Meric-Bernstam [États-Unis] ; Helen Piwnica-Worms [États-Unis] ; Marie-France Poupon [France] ; Jorge Reis-Filho [États-Unis] ; Carol A. Sartorius [États-Unis] ; Valentina Scabia [Suisse] ; George Sflomos [Suisse] ; Yizheng Tu [États-Unis] ; François Vaillant [Australie] ; Jane E. Visvader [Australie] ; Alana Welm [États-Unis] ; Max S. Wicha [États-Unis] ; Michael T. Lewis [États-Unis]Source :
- Cancer metastasis reviews [ 1573-7233 ] ; 2016.
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Abstract
Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational preclinical research. In breast cancer, to complement the now curated collection of approximately 45 long-established human breast cancer cell lines, a newly formed consortium of academic laboratories, currently from Europe, Australia, and North America, herein summarizes data on over 500 stably transplantable PDX models representing all three clinical subtypes of breast cancer (ER+, HER2+, and "Triple-negative" (TNBC)). Many of these models are well-characterized with respect to genomic, transcriptomic, and proteomic features, metastatic behavior, and treatment response to a variety of standard-of-care and experimental therapeutics. These stably transplantable PDX lines are generally available for dissemination to laboratories conducting translational research, and contact information for each collection is provided. This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, efforts to develop complementary data standards for annotation of PDX characteristics and biology, and progress toward "credentialing" of PDX models as surrogates to represent individual patients for use in preclinical and co-clinical translational research. In addition, this review highlights important unresolved questions, as well as current limitations, that have hampered more efficient generation of PDX lines and more rapid adoption of PDX use in translational breast cancer research.
DOI: 10.1007/s10555-016-9653-x
PubMed: 28025748
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Bult</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, ME, 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, ME, 04609</wicri:regionArea><wicri:noRegion>04609</wicri:noRegion></affiliation></author><author><name sortKey="Cai, Shirong" sort="Cai, Shirong" uniqKey="Cai S" first="Shirong" last="Cai">Shirong Cai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Clarke, Robert B" sort="Clarke, Robert B" uniqKey="Clarke R" first="Robert B" last="Clarke">Robert B. Clarke</name><affiliation wicri:level="4"><nlm:affiliation>Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M21 4QL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M21 4QL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Dowst, Heidi" sort="Dowst, Heidi" uniqKey="Dowst H" first="Heidi" last="Dowst">Heidi Dowst</name><affiliation wicri:level="1"><nlm:affiliation>Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Ellis, Matthew J" sort="Ellis, Matthew J" uniqKey="Ellis M" first="Matthew J" last="Ellis">Matthew J. Ellis</name><affiliation wicri:level="1"><nlm:affiliation>The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Suarez, Eva" sort="Gonzalez Suarez, Eva" uniqKey="Gonzalez Suarez E" first="Eva" last="Gonzalez-Suarez">Eva Gonzalez-Suarez</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program, PEBC, Bellvitge Institute for Biomedical Research, IDIBELL, Av. Gran Via de L'Hospitalet, 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program, PEBC, Bellvitge Institute for Biomedical Research, IDIBELL, Av. Gran Via de L'Hospitalet, 199-203, 08908 L'Hospitalet de Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Iggo, Richard D" sort="Iggo, Richard D" uniqKey="Iggo R" first="Richard D" last="Iggo">Richard D. Iggo</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U1218, Bergonié Cancer Institute, 229 cours de l'Argonne, 33076, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1218, Bergonié Cancer Institute, 229 cours de l'Argonne, 33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Kabos, Peter" sort="Kabos, Peter" uniqKey="Kabos P" first="Peter" last="Kabos">Peter Kabos</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045</wicri:regionArea><wicri:noRegion>80045</wicri:noRegion></affiliation></author><author><name sortKey="Li, Shunqiang" sort="Li, Shunqiang" uniqKey="Li S" first="Shunqiang" last="Li">Shunqiang Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Washington University, St. Louis, MO, 63130, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Washington University, St. Louis, MO, 63130</wicri:regionArea><wicri:noRegion>63130</wicri:noRegion></affiliation></author><author><name sortKey="Lindeman, Geoffrey J" sort="Lindeman, Geoffrey J" uniqKey="Lindeman G" first="Geoffrey J" last="Lindeman">Geoffrey J. Lindeman</name><affiliation wicri:level="1"><nlm:affiliation>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Marangoni, Elisabetta" sort="Marangoni, Elisabetta" uniqKey="Marangoni E" first="Elisabetta" last="Marangoni">Elisabetta Marangoni</name><affiliation wicri:level="3"><nlm:affiliation>Translational Research Department, Institut Curie, 26, rue d'Ulm, 75005, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Translational Research Department, Institut Curie, 26, rue d'Ulm, 75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Mccoy, Aaron" sort="Mccoy, Aaron" uniqKey="Mccoy A" first="Aaron" last="Mccoy">Aaron Mccoy</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Meric Bernstam, Funda" sort="Meric Bernstam, Funda" uniqKey="Meric Bernstam F" first="Funda" last="Meric-Bernstam">Funda Meric-Bernstam</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Investigational Cancer Therapeutics and Breast Surgical Oncology, UT M. D. Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Investigational Cancer Therapeutics and Breast Surgical Oncology, UT M. D. Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Piwnica Worms, Helen" sort="Piwnica Worms, Helen" uniqKey="Piwnica Worms H" first="Helen" last="Piwnica-Worms">Helen Piwnica-Worms</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Poupon, Marie France" sort="Poupon, Marie France" uniqKey="Poupon M" first="Marie-France" last="Poupon">Marie-France Poupon</name><affiliation wicri:level="1"><nlm:affiliation>Founder and Scientific Advisor, XenTech SA, Genopole, 4 rue Pierre Fontaine, 91000, Evry, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Founder and Scientific Advisor, XenTech SA, Genopole, 4 rue Pierre Fontaine, 91000, Evry</wicri:regionArea><wicri:noRegion>91000, Evry</wicri:noRegion><wicri:noRegion>91000, Evry</wicri:noRegion></affiliation></author><author><name sortKey="Reis Filho, Jorge" sort="Reis Filho, Jorge" uniqKey="Reis Filho J" first="Jorge" last="Reis-Filho">Jorge Reis-Filho</name><affiliation wicri:level="2"><nlm:affiliation>Director of Experimental Pathology, Department of Pathology, Affiliate Member, Human Oncology and Pathogenesis Program, and Center for Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Director of Experimental Pathology, Department of Pathology, Affiliate Member, Human Oncology and Pathogenesis Program, and Center for Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Sartorius, Carol A" sort="Sartorius, Carol A" uniqKey="Sartorius C" first="Carol A" last="Sartorius">Carol A. Sartorius</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045</wicri:regionArea><wicri:noRegion>80045</wicri:noRegion></affiliation></author><author><name sortKey="Scabia, Valentina" sort="Scabia, Valentina" uniqKey="Scabia V" first="Valentina" last="Scabia">Valentina Scabia</name><affiliation wicri:level="3"><nlm:affiliation>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Sflomos, George" sort="Sflomos, George" uniqKey="Sflomos G" first="George" last="Sflomos">George Sflomos</name><affiliation wicri:level="3"><nlm:affiliation>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Tu, Yizheng" sort="Tu, Yizheng" uniqKey="Tu Y" first="Yizheng" last="Tu">Yizheng Tu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Vaillant, Francois" sort="Vaillant, Francois" uniqKey="Vaillant F" first="François" last="Vaillant">François Vaillant</name><affiliation wicri:level="1"><nlm:affiliation>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Visvader, Jane E" sort="Visvader, Jane E" uniqKey="Visvader J" first="Jane E" last="Visvader">Jane E. Visvader</name><affiliation wicri:level="1"><nlm:affiliation>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Welm, Alana" sort="Welm, Alana" uniqKey="Welm A" first="Alana" last="Welm">Alana Welm</name><affiliation wicri:level="1"><nlm:affiliation>Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112</wicri:regionArea><wicri:noRegion>84112</wicri:noRegion></affiliation></author><author><name sortKey="Wicha, Max S" sort="Wicha, Max S" uniqKey="Wicha M" first="Max S" last="Wicha">Max S. Wicha</name><affiliation wicri:level="1"><nlm:affiliation>Madeline and Sidney Forbes Professor of Oncology, Director, Forbes Institute for Cancer Discovery, NCRC 26-335S, SPC 2800 2800 Plymouth Rd, Ann Arbor, MI, 48109-2800, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Madeline and Sidney Forbes Professor of Oncology, Director, Forbes Institute for Cancer Discovery, NCRC 26-335S, SPC 2800 2800 Plymouth Rd, Ann Arbor, MI, 48109-2800</wicri:regionArea><wicri:noRegion>48109-2800</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, Michael T" sort="Lewis, Michael T" uniqKey="Lewis M" first="Michael T" last="Lewis">Michael T. Lewis</name><affiliation wicri:level="1"><nlm:affiliation>The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030, USA. mtlewis@bcm.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:28025748</idno><idno type="pmid">28025748</idno><idno type="doi">10.1007/s10555-016-9653-x</idno><idno type="wicri:Area/PubMed/Corpus">001401</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001401</idno><idno type="wicri:Area/PubMed/Curation">001379</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001379</idno><idno type="wicri:Area/PubMed/Checkpoint">001379</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001379</idno><idno type="wicri:Area/Ncbi/Merge">004094</idno><idno type="wicri:Area/Ncbi/Curation">004094</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Patient-derived xenograft (PDX) models in basic and translational breast cancer research.</title><author><name sortKey="Dobrolecki, Lacey E" sort="Dobrolecki, Lacey E" uniqKey="Dobrolecki L" first="Lacey E" last="Dobrolecki">Lacey E. Dobrolecki</name><affiliation wicri:level="1"><nlm:affiliation>The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Airhart, Susie D" sort="Airhart, Susie D" uniqKey="Airhart S" first="Susie D" last="Airhart">Susie D. Airhart</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, ME, 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, ME, 04609</wicri:regionArea><wicri:noRegion>04609</wicri:noRegion></affiliation></author><author><name sortKey="Alferez, Denis G" sort="Alferez, Denis G" uniqKey="Alferez D" first="Denis G" last="Alferez">Denis G. Alferez</name><affiliation wicri:level="4"><nlm:affiliation>Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M21 4QL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M21 4QL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Aparicio, Samuel" sort="Aparicio, Samuel" uniqKey="Aparicio S" first="Samuel" last="Aparicio">Samuel Aparicio</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, BC Cancer Agency, 675 W10th Avenue, Vancouver, V6R 3A6, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, BC Cancer Agency, 675 W10th Avenue, Vancouver, V6R 3A6</wicri:regionArea><wicri:noRegion>V6R 3A6</wicri:noRegion></affiliation></author><author><name sortKey="Behbod, Fariba" sort="Behbod, Fariba" uniqKey="Behbod F" first="Fariba" last="Behbod">Fariba Behbod</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University of Kansas Medical Center, |3901 Rainbow Blvd, WHE 1005B, Kansas City, KS, 66160, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Kansas Medical Center, |3901 Rainbow Blvd, WHE 1005B, Kansas City, KS, 66160</wicri:regionArea><wicri:noRegion>66160</wicri:noRegion></affiliation></author><author><name sortKey="Bentires Alj, Mohamed" sort="Bentires Alj, Mohamed" uniqKey="Bentires Alj M" first="Mohamed" last="Bentires-Alj">Mohamed Bentires-Alj</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedicine, University of Basel, University Hospital Basel, Lab 306, Hebelstrasse 20, CH-4031, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Biomedicine, University of Basel, University Hospital Basel, Lab 306, Hebelstrasse 20, CH-4031, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Brisken, Cathrin" sort="Brisken, Cathrin" uniqKey="Brisken C" first="Cathrin" last="Brisken">Cathrin Brisken</name><affiliation wicri:level="3"><nlm:affiliation>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Bult, Carol J" sort="Bult, Carol J" uniqKey="Bult C" first="Carol J" last="Bult">Carol J. Bult</name><affiliation wicri:level="1"><nlm:affiliation>The Jackson Laboratory, Bar Harbor, ME, 04609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Jackson Laboratory, Bar Harbor, ME, 04609</wicri:regionArea><wicri:noRegion>04609</wicri:noRegion></affiliation></author><author><name sortKey="Cai, Shirong" sort="Cai, Shirong" uniqKey="Cai S" first="Shirong" last="Cai">Shirong Cai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Clarke, Robert B" sort="Clarke, Robert B" uniqKey="Clarke R" first="Robert B" last="Clarke">Robert B. Clarke</name><affiliation wicri:level="4"><nlm:affiliation>Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M21 4QL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M21 4QL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Dowst, Heidi" sort="Dowst, Heidi" uniqKey="Dowst H" first="Heidi" last="Dowst">Heidi Dowst</name><affiliation wicri:level="1"><nlm:affiliation>Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Ellis, Matthew J" sort="Ellis, Matthew J" uniqKey="Ellis M" first="Matthew J" last="Ellis">Matthew J. Ellis</name><affiliation wicri:level="1"><nlm:affiliation>The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Suarez, Eva" sort="Gonzalez Suarez, Eva" uniqKey="Gonzalez Suarez E" first="Eva" last="Gonzalez-Suarez">Eva Gonzalez-Suarez</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program, PEBC, Bellvitge Institute for Biomedical Research, IDIBELL, Av. Gran Via de L'Hospitalet, 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program, PEBC, Bellvitge Institute for Biomedical Research, IDIBELL, Av. Gran Via de L'Hospitalet, 199-203, 08908 L'Hospitalet de Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Iggo, Richard D" sort="Iggo, Richard D" uniqKey="Iggo R" first="Richard D" last="Iggo">Richard D. Iggo</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U1218, Bergonié Cancer Institute, 229 cours de l'Argonne, 33076, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1218, Bergonié Cancer Institute, 229 cours de l'Argonne, 33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Kabos, Peter" sort="Kabos, Peter" uniqKey="Kabos P" first="Peter" last="Kabos">Peter Kabos</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045</wicri:regionArea><wicri:noRegion>80045</wicri:noRegion></affiliation></author><author><name sortKey="Li, Shunqiang" sort="Li, Shunqiang" uniqKey="Li S" first="Shunqiang" last="Li">Shunqiang Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Washington University, St. Louis, MO, 63130, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Washington University, St. Louis, MO, 63130</wicri:regionArea><wicri:noRegion>63130</wicri:noRegion></affiliation></author><author><name sortKey="Lindeman, Geoffrey J" sort="Lindeman, Geoffrey J" uniqKey="Lindeman G" first="Geoffrey J" last="Lindeman">Geoffrey J. Lindeman</name><affiliation wicri:level="1"><nlm:affiliation>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Marangoni, Elisabetta" sort="Marangoni, Elisabetta" uniqKey="Marangoni E" first="Elisabetta" last="Marangoni">Elisabetta Marangoni</name><affiliation wicri:level="3"><nlm:affiliation>Translational Research Department, Institut Curie, 26, rue d'Ulm, 75005, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Translational Research Department, Institut Curie, 26, rue d'Ulm, 75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Mccoy, Aaron" sort="Mccoy, Aaron" uniqKey="Mccoy A" first="Aaron" last="Mccoy">Aaron Mccoy</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Meric Bernstam, Funda" sort="Meric Bernstam, Funda" uniqKey="Meric Bernstam F" first="Funda" last="Meric-Bernstam">Funda Meric-Bernstam</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Investigational Cancer Therapeutics and Breast Surgical Oncology, UT M. D. Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Investigational Cancer Therapeutics and Breast Surgical Oncology, UT M. D. Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Piwnica Worms, Helen" sort="Piwnica Worms, Helen" uniqKey="Piwnica Worms H" first="Helen" last="Piwnica-Worms">Helen Piwnica-Worms</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Poupon, Marie France" sort="Poupon, Marie France" uniqKey="Poupon M" first="Marie-France" last="Poupon">Marie-France Poupon</name><affiliation wicri:level="1"><nlm:affiliation>Founder and Scientific Advisor, XenTech SA, Genopole, 4 rue Pierre Fontaine, 91000, Evry, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Founder and Scientific Advisor, XenTech SA, Genopole, 4 rue Pierre Fontaine, 91000, Evry</wicri:regionArea><wicri:noRegion>91000, Evry</wicri:noRegion><wicri:noRegion>91000, Evry</wicri:noRegion></affiliation></author><author><name sortKey="Reis Filho, Jorge" sort="Reis Filho, Jorge" uniqKey="Reis Filho J" first="Jorge" last="Reis-Filho">Jorge Reis-Filho</name><affiliation wicri:level="2"><nlm:affiliation>Director of Experimental Pathology, Department of Pathology, Affiliate Member, Human Oncology and Pathogenesis Program, and Center for Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Director of Experimental Pathology, Department of Pathology, Affiliate Member, Human Oncology and Pathogenesis Program, and Center for Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Sartorius, Carol A" sort="Sartorius, Carol A" uniqKey="Sartorius C" first="Carol A" last="Sartorius">Carol A. Sartorius</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045</wicri:regionArea><wicri:noRegion>80045</wicri:noRegion></affiliation></author><author><name sortKey="Scabia, Valentina" sort="Scabia, Valentina" uniqKey="Scabia V" first="Valentina" last="Scabia">Valentina Scabia</name><affiliation wicri:level="3"><nlm:affiliation>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Sflomos, George" sort="Sflomos, George" uniqKey="Sflomos G" first="George" last="Sflomos">George Sflomos</name><affiliation wicri:level="3"><nlm:affiliation>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Tu, Yizheng" sort="Tu, Yizheng" uniqKey="Tu Y" first="Yizheng" last="Tu">Yizheng Tu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author><author><name sortKey="Vaillant, Francois" sort="Vaillant, Francois" uniqKey="Vaillant F" first="François" last="Vaillant">François Vaillant</name><affiliation wicri:level="1"><nlm:affiliation>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Visvader, Jane E" sort="Visvader, Jane E" uniqKey="Visvader J" first="Jane E" last="Visvader">Jane E. Visvader</name><affiliation wicri:level="1"><nlm:affiliation>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Welm, Alana" sort="Welm, Alana" uniqKey="Welm A" first="Alana" last="Welm">Alana Welm</name><affiliation wicri:level="1"><nlm:affiliation>Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112</wicri:regionArea><wicri:noRegion>84112</wicri:noRegion></affiliation></author><author><name sortKey="Wicha, Max S" sort="Wicha, Max S" uniqKey="Wicha M" first="Max S" last="Wicha">Max S. Wicha</name><affiliation wicri:level="1"><nlm:affiliation>Madeline and Sidney Forbes Professor of Oncology, Director, Forbes Institute for Cancer Discovery, NCRC 26-335S, SPC 2800 2800 Plymouth Rd, Ann Arbor, MI, 48109-2800, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Madeline and Sidney Forbes Professor of Oncology, Director, Forbes Institute for Cancer Discovery, NCRC 26-335S, SPC 2800 2800 Plymouth Rd, Ann Arbor, MI, 48109-2800</wicri:regionArea><wicri:noRegion>48109-2800</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, Michael T" sort="Lewis, Michael T" uniqKey="Lewis M" first="Michael T" last="Lewis">Michael T. Lewis</name><affiliation wicri:level="1"><nlm:affiliation>The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030, USA. mtlewis@bcm.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030</wicri:regionArea><wicri:noRegion>77030</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cancer metastasis reviews</title><idno type="eISSN">1573-7233</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Breast Neoplasms (pathology)</term><term>Disease Models, Animal</term><term>Female</term><term>Heterografts</term><term>Humans</term><term>Mice, Inbred NOD</term><term>Mice, SCID</term><term>Neoplasm Transplantation</term><term>Translational Medical Research</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Hétérogreffes</term><term>Modèles animaux de maladie humaine</term><term>Recherche médicale translationnelle</term><term>Souris SCID</term><term>Souris de lignée NOD</term><term>Transplantation tumorale</term><term>Tumeurs du sein (anatomopathologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Heterografts</term><term>Humans</term><term>Mice, Inbred NOD</term><term>Mice, SCID</term><term>Neoplasm Transplantation</term><term>Translational Medical Research</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Hétérogreffes</term><term>Modèles animaux de maladie humaine</term><term>Recherche médicale translationnelle</term><term>Souris SCID</term><term>Souris de lignée NOD</term><term>Transplantation tumorale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational preclinical research. In breast cancer, to complement the now curated collection of approximately 45 long-established human breast cancer cell lines, a newly formed consortium of academic laboratories, currently from Europe, Australia, and North America, herein summarizes data on over 500 stably transplantable PDX models representing all three clinical subtypes of breast cancer (ER+, HER2+, and "Triple-negative" (TNBC)). Many of these models are well-characterized with respect to genomic, transcriptomic, and proteomic features, metastatic behavior, and treatment response to a variety of standard-of-care and experimental therapeutics. These stably transplantable PDX lines are generally available for dissemination to laboratories conducting translational research, and contact information for each collection is provided. This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, efforts to develop complementary data standards for annotation of PDX characteristics and biology, and progress toward "credentialing" of PDX models as surrogates to represent individual patients for use in preclinical and co-clinical translational research. In addition, this review highlights important unresolved questions, as well as current limitations, that have hampered more efficient generation of PDX lines and more rapid adoption of PDX use in translational breast cancer research.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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