Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
Identifieur interne : 002361 ( Main/Exploration ); précédent : 002360; suivant : 002362Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
Auteurs : Christine Kowalczyk-Quintas [Suisse] ; Sonia Schuepbach-Mallepell [Suisse] ; Michele Vigolo [Suisse] ; Laure Willen [Suisse] ; Aubry Tardivel [Suisse] ; Cristian R. Smulski [Suisse] ; Timothy S. Zheng [États-Unis] ; Jennifer Gommerman [Canada] ; Henry Hess [Allemagne] ; Jacques-Eric Gottenberg [France] ; Fabienne Mackay ; Olivier Donzé [Suisse] ; Pascal Schneider [Suisse]Source :
- The Journal of biological chemistry [ 1083-351X ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Anticorps (immunologie), Anticorps (pharmacologie), Déplétion lymphocytaire (), Facteur d'activation des lymphocytes B (antagonistes et inhibiteurs), Facteur d'activation des lymphocytes B (génétique), Facteur d'activation des lymphocytes B (immunologie), Hyperplasie, Immunoglobuline G (immunologie), Immunoglobuline G (pharmacologie), Lymphocytes B (anatomopathologie), Lymphocytes B (immunologie), Souris, Souris knockout, Survie cellulaire ().
- MESH :
- anatomopathologie : Lymphocytes B.
- antagonistes et inhibiteurs : Facteur d'activation des lymphocytes B.
- génétique : Facteur d'activation des lymphocytes B.
- immunologie : Anticorps, Facteur d'activation des lymphocytes B, Immunoglobuline G, Lymphocytes B.
- pharmacologie : Anticorps, Immunoglobuline G.
- Animaux, Déplétion lymphocytaire, Hyperplasie, Souris, Souris knockout, Survie cellulaire.
English descriptors
- KwdEn :
- Animals, Antibodies (immunology), Antibodies (pharmacology), B-Cell Activating Factor (antagonists & inhibitors), B-Cell Activating Factor (genetics), B-Cell Activating Factor (immunology), B-Lymphocytes (immunology), B-Lymphocytes (pathology), Cell Survival (drug effects), Hyperplasia, Immunoglobulin G (immunology), Immunoglobulin G (pharmacology), Lymphocyte Depletion (methods), Mice, Mice, Knockout.
- MESH :
- chemical , antagonists & inhibitors : B-Cell Activating Factor.
- chemical , genetics : B-Cell Activating Factor.
- chemical , immunology : Antibodies, B-Cell Activating Factor, Immunoglobulin G.
- chemical , pharmacology : Antibodies, Immunoglobulin G.
- drug effects : Cell Survival.
- immunology : B-Lymphocytes.
- methods : Lymphocyte Depletion.
- pathology : B-Lymphocytes.
- Animals, Hyperplasia, Mice, Mice, Knockout.
Abstract
B cell activating factor of the TNF family (BAFF), also known as B lymphocyte stimulator, is a ligand required for the generation and maintenance of B lymphocytes. In this study, the ability of different monoclonal antibodies to recognize, inhibit, or activate mouse BAFF was investigated. One of them, a mouse IgG1 named Sandy-2, prevented the binding of BAFF to all of its receptors, BAFF receptor, transmembrane activator and calcium modulating ligand interactor, and B cell maturation antigen, at a stoichiometric ratio; blocked the activity of mouse BAFF on a variety of cell-based reporter assays; and antagonized the prosurvival action of BAFF on primary mouse B cells in vitro A single administration of Sandy-2 in mice induced B cell depletion within 2 weeks, down to levels close to those observed in BAFF-deficient mice. This depletion could then be maintained with a chronic treatment. Sandy-2 and a previously described rat IgG1 antibody, 5A8, also formed a pair suitable for the sensitive detection of endogenous circulating BAFF by ELISA or using a homogenous assay. Interestingly, 5A8 and Sandy-5 displayed activities opposite to that of Sandy-2 by stimulating recombinant BAFF in vitro and endogenous BAFF in vivo These tools will prove useful for the detection and functional manipulation of endogenous mouse BAFF and provide an alternative to the widely used BAFF receptor-Fc decoy receptor for the specific depletion of BAFF in mice.
DOI: 10.1074/jbc.M116.725929
PubMed: 27451394
Affiliations:
- Allemagne, Canada, France, Suisse, États-Unis
- Alsace (région administrative), District de Darmstadt, Grand Est, Hesse (Land), Massachusetts, Ontario
- Darmstadt, Strasbourg, Toronto
- Université de Toronto
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001969
- to stream PubMed, to step Curation: 001945
- to stream PubMed, to step Checkpoint: 001945
- to stream Ncbi, to step Merge: 003893
- to stream Ncbi, to step Curation: 003893
- to stream Ncbi, to step Checkpoint: 003893
- to stream Main, to step Merge: 002360
- to stream Main, to step Curation: 002361
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.</title>
<author><name sortKey="Kowalczyk Quintas, Christine" sort="Kowalczyk Quintas, Christine" uniqKey="Kowalczyk Quintas C" first="Christine" last="Kowalczyk-Quintas">Christine Kowalczyk-Quintas</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schuepbach Mallepell, Sonia" sort="Schuepbach Mallepell, Sonia" uniqKey="Schuepbach Mallepell S" first="Sonia" last="Schuepbach-Mallepell">Sonia Schuepbach-Mallepell</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vigolo, Michele" sort="Vigolo, Michele" uniqKey="Vigolo M" first="Michele" last="Vigolo">Michele Vigolo</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Willen, Laure" sort="Willen, Laure" uniqKey="Willen L" first="Laure" last="Willen">Laure Willen</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tardivel, Aubry" sort="Tardivel, Aubry" uniqKey="Tardivel A" first="Aubry" last="Tardivel">Aubry Tardivel</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smulski, Cristian R" sort="Smulski, Cristian R" uniqKey="Smulski C" first="Cristian R" last="Smulski">Cristian R. Smulski</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Timothy S" sort="Zheng, Timothy S" uniqKey="Zheng T" first="Timothy S" last="Zheng">Timothy S. Zheng</name>
<affiliation wicri:level="2"><nlm:affiliation>Biogen, Cambridge, Massachusetts 02142.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Biogen, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gommerman, Jennifer" sort="Gommerman, Jennifer" uniqKey="Gommerman J" first="Jennifer" last="Gommerman">Jennifer Gommerman</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hess, Henry" sort="Hess, Henry" uniqKey="Hess H" first="Henry" last="Hess">Henry Hess</name>
<affiliation wicri:level="3"><nlm:affiliation>Merck KGaA, D-64293 Darmstadt, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Merck KGaA, D-64293 Darmstadt</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Darmstadt</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM UMR S1109, University of Strasbourg, 67085 Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR S1109, University of Strasbourg, 67085 Strasbourg</wicri:regionArea>
<wicri:noRegion>67085 Strasbourg</wicri:noRegion>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mackay, Fabienne" sort="Mackay, Fabienne" uniqKey="Mackay F" first="Fabienne" last="Mackay">Fabienne Mackay</name>
<affiliation><nlm:affiliation>Department of Immunology, Monash University, Melbourne 3004, Australia, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Donze, Olivier" sort="Donze, Olivier" uniqKey="Donze O" first="Olivier" last="Donzé">Olivier Donzé</name>
<affiliation wicri:level="1"><nlm:affiliation>Adipogen Life Sciences, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Adipogen Life Sciences, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schneider, Pascal" sort="Schneider, Pascal" uniqKey="Schneider P" first="Pascal" last="Schneider">Pascal Schneider</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland, pascal.schneider@unil.ch.</nlm:affiliation>
<country wicri:rule="url">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland</wicri:regionArea>
<wicri:noRegion>Switzerland</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27451394</idno>
<idno type="pmid">27451394</idno>
<idno type="doi">10.1074/jbc.M116.725929</idno>
<idno type="wicri:Area/PubMed/Corpus">001969</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001969</idno>
<idno type="wicri:Area/PubMed/Curation">001945</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001945</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001945</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001945</idno>
<idno type="wicri:Area/Ncbi/Merge">003893</idno>
<idno type="wicri:Area/Ncbi/Curation">003893</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003893</idno>
<idno type="wicri:Area/Main/Merge">002360</idno>
<idno type="wicri:Area/Main/Curation">002361</idno>
<idno type="wicri:Area/Main/Exploration">002361</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.</title>
<author><name sortKey="Kowalczyk Quintas, Christine" sort="Kowalczyk Quintas, Christine" uniqKey="Kowalczyk Quintas C" first="Christine" last="Kowalczyk-Quintas">Christine Kowalczyk-Quintas</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schuepbach Mallepell, Sonia" sort="Schuepbach Mallepell, Sonia" uniqKey="Schuepbach Mallepell S" first="Sonia" last="Schuepbach-Mallepell">Sonia Schuepbach-Mallepell</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vigolo, Michele" sort="Vigolo, Michele" uniqKey="Vigolo M" first="Michele" last="Vigolo">Michele Vigolo</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Willen, Laure" sort="Willen, Laure" uniqKey="Willen L" first="Laure" last="Willen">Laure Willen</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tardivel, Aubry" sort="Tardivel, Aubry" uniqKey="Tardivel A" first="Aubry" last="Tardivel">Aubry Tardivel</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smulski, Cristian R" sort="Smulski, Cristian R" uniqKey="Smulski C" first="Cristian R" last="Smulski">Cristian R. Smulski</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Timothy S" sort="Zheng, Timothy S" uniqKey="Zheng T" first="Timothy S" last="Zheng">Timothy S. Zheng</name>
<affiliation wicri:level="2"><nlm:affiliation>Biogen, Cambridge, Massachusetts 02142.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Biogen, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gommerman, Jennifer" sort="Gommerman, Jennifer" uniqKey="Gommerman J" first="Jennifer" last="Gommerman">Jennifer Gommerman</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hess, Henry" sort="Hess, Henry" uniqKey="Hess H" first="Henry" last="Hess">Henry Hess</name>
<affiliation wicri:level="3"><nlm:affiliation>Merck KGaA, D-64293 Darmstadt, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Merck KGaA, D-64293 Darmstadt</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Darmstadt</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM UMR S1109, University of Strasbourg, 67085 Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR S1109, University of Strasbourg, 67085 Strasbourg</wicri:regionArea>
<wicri:noRegion>67085 Strasbourg</wicri:noRegion>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mackay, Fabienne" sort="Mackay, Fabienne" uniqKey="Mackay F" first="Fabienne" last="Mackay">Fabienne Mackay</name>
<affiliation><nlm:affiliation>Department of Immunology, Monash University, Melbourne 3004, Australia, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Donze, Olivier" sort="Donze, Olivier" uniqKey="Donze O" first="Olivier" last="Donzé">Olivier Donzé</name>
<affiliation wicri:level="1"><nlm:affiliation>Adipogen Life Sciences, CH-1066 Epalinges, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Adipogen Life Sciences, CH-1066 Epalinges</wicri:regionArea>
<wicri:noRegion>CH-1066 Epalinges</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schneider, Pascal" sort="Schneider, Pascal" uniqKey="Schneider P" first="Pascal" last="Schneider">Pascal Schneider</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland, pascal.schneider@unil.ch.</nlm:affiliation>
<country wicri:rule="url">Suisse</country>
<wicri:regionArea>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland</wicri:regionArea>
<wicri:noRegion>Switzerland</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of biological chemistry</title>
<idno type="eISSN">1083-351X</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies (immunology)</term>
<term>Antibodies (pharmacology)</term>
<term>B-Cell Activating Factor (antagonists & inhibitors)</term>
<term>B-Cell Activating Factor (genetics)</term>
<term>B-Cell Activating Factor (immunology)</term>
<term>B-Lymphocytes (immunology)</term>
<term>B-Lymphocytes (pathology)</term>
<term>Cell Survival (drug effects)</term>
<term>Hyperplasia</term>
<term>Immunoglobulin G (immunology)</term>
<term>Immunoglobulin G (pharmacology)</term>
<term>Lymphocyte Depletion (methods)</term>
<term>Mice</term>
<term>Mice, Knockout</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps (immunologie)</term>
<term>Anticorps (pharmacologie)</term>
<term>Déplétion lymphocytaire ()</term>
<term>Facteur d'activation des lymphocytes B (antagonistes et inhibiteurs)</term>
<term>Facteur d'activation des lymphocytes B (génétique)</term>
<term>Facteur d'activation des lymphocytes B (immunologie)</term>
<term>Hyperplasie</term>
<term>Immunoglobuline G (immunologie)</term>
<term>Immunoglobuline G (pharmacologie)</term>
<term>Lymphocytes B (anatomopathologie)</term>
<term>Lymphocytes B (immunologie)</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Survie cellulaire ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>B-Cell Activating Factor</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>B-Cell Activating Factor</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies</term>
<term>B-Cell Activating Factor</term>
<term>Immunoglobulin G</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antibodies</term>
<term>Immunoglobulin G</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphocytes B</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Facteur d'activation des lymphocytes B</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur d'activation des lymphocytes B</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps</term>
<term>Facteur d'activation des lymphocytes B</term>
<term>Immunoglobuline G</term>
<term>Lymphocytes B</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Lymphocyte Depletion</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>B-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anticorps</term>
<term>Immunoglobuline G</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Hyperplasia</term>
<term>Mice</term>
<term>Mice, Knockout</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Déplétion lymphocytaire</term>
<term>Hyperplasie</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Survie cellulaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">B cell activating factor of the TNF family (BAFF), also known as B lymphocyte stimulator, is a ligand required for the generation and maintenance of B lymphocytes. In this study, the ability of different monoclonal antibodies to recognize, inhibit, or activate mouse BAFF was investigated. One of them, a mouse IgG1 named Sandy-2, prevented the binding of BAFF to all of its receptors, BAFF receptor, transmembrane activator and calcium modulating ligand interactor, and B cell maturation antigen, at a stoichiometric ratio; blocked the activity of mouse BAFF on a variety of cell-based reporter assays; and antagonized the prosurvival action of BAFF on primary mouse B cells in vitro A single administration of Sandy-2 in mice induced B cell depletion within 2 weeks, down to levels close to those observed in BAFF-deficient mice. This depletion could then be maintained with a chronic treatment. Sandy-2 and a previously described rat IgG1 antibody, 5A8, also formed a pair suitable for the sensitive detection of endogenous circulating BAFF by ELISA or using a homogenous assay. Interestingly, 5A8 and Sandy-5 displayed activities opposite to that of Sandy-2 by stimulating recombinant BAFF in vitro and endogenous BAFF in vivo These tools will prove useful for the detection and functional manipulation of endogenous mouse BAFF and provide an alternative to the widely used BAFF receptor-Fc decoy receptor for the specific depletion of BAFF in mice.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Canada</li>
<li>France</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>District de Darmstadt</li>
<li>Grand Est</li>
<li>Hesse (Land)</li>
<li>Massachusetts</li>
<li>Ontario</li>
</region>
<settlement><li>Darmstadt</li>
<li>Strasbourg</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Mackay, Fabienne" sort="Mackay, Fabienne" uniqKey="Mackay F" first="Fabienne" last="Mackay">Fabienne Mackay</name>
</noCountry>
<country name="Suisse"><noRegion><name sortKey="Kowalczyk Quintas, Christine" sort="Kowalczyk Quintas, Christine" uniqKey="Kowalczyk Quintas C" first="Christine" last="Kowalczyk-Quintas">Christine Kowalczyk-Quintas</name>
</noRegion>
<name sortKey="Donze, Olivier" sort="Donze, Olivier" uniqKey="Donze O" first="Olivier" last="Donzé">Olivier Donzé</name>
<name sortKey="Schneider, Pascal" sort="Schneider, Pascal" uniqKey="Schneider P" first="Pascal" last="Schneider">Pascal Schneider</name>
<name sortKey="Schuepbach Mallepell, Sonia" sort="Schuepbach Mallepell, Sonia" uniqKey="Schuepbach Mallepell S" first="Sonia" last="Schuepbach-Mallepell">Sonia Schuepbach-Mallepell</name>
<name sortKey="Smulski, Cristian R" sort="Smulski, Cristian R" uniqKey="Smulski C" first="Cristian R" last="Smulski">Cristian R. Smulski</name>
<name sortKey="Tardivel, Aubry" sort="Tardivel, Aubry" uniqKey="Tardivel A" first="Aubry" last="Tardivel">Aubry Tardivel</name>
<name sortKey="Vigolo, Michele" sort="Vigolo, Michele" uniqKey="Vigolo M" first="Michele" last="Vigolo">Michele Vigolo</name>
<name sortKey="Willen, Laure" sort="Willen, Laure" uniqKey="Willen L" first="Laure" last="Willen">Laure Willen</name>
</country>
<country name="États-Unis"><region name="Massachusetts"><name sortKey="Zheng, Timothy S" sort="Zheng, Timothy S" uniqKey="Zheng T" first="Timothy S" last="Zheng">Timothy S. Zheng</name>
</region>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Gommerman, Jennifer" sort="Gommerman, Jennifer" uniqKey="Gommerman J" first="Jennifer" last="Gommerman">Jennifer Gommerman</name>
</region>
</country>
<country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Hess, Henry" sort="Hess, Henry" uniqKey="Hess H" first="Henry" last="Hess">Henry Hess</name>
</region>
</country>
<country name="France"><region name="Grand Est"><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002361 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002361 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:27451394 |texte= Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27451394" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |