AustralieFrV1, Main, Exploration, bibRecordById, pubmed:25017103

Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.

Identifieur interne : 003359 ( Main/Exploration ); précédent : 003358; suivant : 003360

Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.

Auteurs : Hans D. Daetwyler [Australie] ; Aurélien Capitan [France] ; Hubert Pausch [Allemagne] ; Paul Stothard [Canada] ; Rianne Van Binsbergen [Pays-Bas] ; Rasmus F. Br Ndum [Danemark] ; Xiaoping Liao [Canada] ; Anis Djari [France] ; Sabrina C. Rodriguez [France] ; Cécile Grohs [France] ; Diane Esquerré [France] ; Olivier Bouchez [France] ; Marie-Noëlle Rossignol [France] ; Christophe Klopp [France] ; Dominique Rocha [France] ; Sébastien Fritz [France] ; André Eggen [France] ; Phil J. Bowman [Australie] ; David Coote [Australie] ; Amanda J. Chamberlain [Australie] ; Charlotte Anderson [Australie] ; Curt P. Vantassell [États-Unis] ; Ina Hulsegge [Pays-Bas] ; Mike E. Goddard [Australie] ; Bernt Guldbrandtsen [Danemark] ; Mogens S. Lund [Danemark] ; Roel F. Veerkamp [Pays-Bas] ; Didier A. Boichard [France] ; Ruedi Fries [Allemagne] ; Ben J. Hayes [Australie]

Source :

Nature genetics [ 1546-1718 ] ; 2014.

RBID : pubmed:25017103

Descripteurs français

KwdFr :
- Animaux, Bovins (génétique), Données de séquences moléculaires, Génome, Génotype, Mâle, Polymorphisme de nucléotide simple, Similitude de séquences d'acides aminés, Séquence d'acides aminés, Étude d'association pangénomique ().
MESH :
- génétique : Bovins.
- Animaux, Données de séquences moléculaires, Génome, Génotype, Mâle, Polymorphisme de nucléotide simple, Similitude de séquences d'acides aminés, Séquence d'acides aminés, Étude d'association pangénomique.

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Cattle (genetics), Genome, Genome-Wide Association Study (methods), Genotype, Male, Molecular Sequence Data, Polymorphism, Single Nucleotide, Sequence Homology, Amino Acid.
MESH :
- genetics : Cattle.
- methods : Genome-Wide Association Study.
- Amino Acid Sequence, Animals, Genome, Genotype, Male, Molecular Sequence Data, Polymorphism, Single Nucleotide, Sequence Homology, Amino Acid.

Abstract

The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle.

DOI: 10.1038/ng.3034
PubMed: 25017103

Affiliations:

Allemagne, Australie, Canada, Danemark, France, Pays-Bas, États-Unis
Maryland, Victoria (État), Île-de-France
Melbourne, Paris
Université de Melbourne

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.</title>
<author><name sortKey="Daetwyler, Hans D" sort="Daetwyler, Hans D" uniqKey="Daetwyler H" first="Hans D" last="Daetwyler">Hans D. Daetwyler</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Capitan, Aurelien" sort="Capitan, Aurelien" uniqKey="Capitan A" first="Aurélien" last="Capitan">Aurélien Capitan</name>
<affiliation wicri:level="3"><nlm:affiliation>1] Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France. [2] Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>1] Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France. [2] Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pausch, Hubert" sort="Pausch, Hubert" uniqKey="Pausch H" first="Hubert" last="Pausch">Hubert Pausch</name>
<affiliation wicri:level="1"><nlm:affiliation>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan</wicri:regionArea>
<wicri:noRegion>Freising-Weihenstephan</wicri:noRegion>
<wicri:noRegion>Freising-Weihenstephan</wicri:noRegion>
<wicri:noRegion>Freising-Weihenstephan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stothard, Paul" sort="Stothard, Paul" uniqKey="Stothard P" first="Paul" last="Stothard">Paul Stothard</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Binsbergen, Rianne" sort="Van Binsbergen, Rianne" uniqKey="Van Binsbergen R" first="Rianne" last="Van Binsbergen">Rianne Van Binsbergen</name>
<affiliation wicri:level="1"><nlm:affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen</wicri:regionArea>
<wicri:noRegion>Wageningen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Br Ndum, Rasmus F" sort="Br Ndum, Rasmus F" uniqKey="Br Ndum R" first="Rasmus F" last="Br Ndum">Rasmus F. Br Ndum</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele</wicri:regionArea>
<wicri:noRegion>Tjele</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liao, Xiaoping" sort="Liao, Xiaoping" uniqKey="Liao X" first="Xiaoping" last="Liao">Xiaoping Liao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Djari, Anis" sort="Djari, Anis" uniqKey="Djari A" first="Anis" last="Djari">Anis Djari</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet</wicri:regionArea>
<wicri:noRegion>Castanet</wicri:noRegion>
<wicri:noRegion>Castanet</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Sabrina C" sort="Rodriguez, Sabrina C" uniqKey="Rodriguez S" first="Sabrina C" last="Rodriguez">Sabrina C. Rodriguez</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grohs, Cecile" sort="Grohs, Cecile" uniqKey="Grohs C" first="Cécile" last="Grohs">Cécile Grohs</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Esquerre, Diane" sort="Esquerre, Diane" uniqKey="Esquerre D" first="Diane" last="Esquerré">Diane Esquerré</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet</wicri:regionArea>
<wicri:noRegion>Castanet</wicri:noRegion>
<wicri:noRegion>Castanet</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bouchez, Olivier" sort="Bouchez, Olivier" uniqKey="Bouchez O" first="Olivier" last="Bouchez">Olivier Bouchez</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet</wicri:regionArea>
<wicri:noRegion>Castanet</wicri:noRegion>
<wicri:noRegion>Castanet</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rossignol, Marie Noelle" sort="Rossignol, Marie Noelle" uniqKey="Rossignol M" first="Marie-Noëlle" last="Rossignol">Marie-Noëlle Rossignol</name>
<affiliation wicri:level="1"><nlm:affiliation>LABOGENA, Jouy-en-Josas, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>LABOGENA, Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klopp, Christophe" sort="Klopp, Christophe" uniqKey="Klopp C" first="Christophe" last="Klopp">Christophe Klopp</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet</wicri:regionArea>
<wicri:noRegion>Castanet</wicri:noRegion>
<wicri:noRegion>Castanet</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rocha, Dominique" sort="Rocha, Dominique" uniqKey="Rocha D" first="Dominique" last="Rocha">Dominique Rocha</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fritz, Sebastien" sort="Fritz, Sebastien" uniqKey="Fritz S" first="Sébastien" last="Fritz">Sébastien Fritz</name>
<affiliation wicri:level="3"><nlm:affiliation>Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eggen, Andre" sort="Eggen, Andre" uniqKey="Eggen A" first="André" last="Eggen">André Eggen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bowman, Phil J" sort="Bowman, Phil J" uniqKey="Bowman P" first="Phil J" last="Bowman">Phil J. Bowman</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coote, David" sort="Coote, David" uniqKey="Coote D" first="David" last="Coote">David Coote</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chamberlain, Amanda J" sort="Chamberlain, Amanda J" uniqKey="Chamberlain A" first="Amanda J" last="Chamberlain">Amanda J. Chamberlain</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Anderson, Charlotte" sort="Anderson, Charlotte" uniqKey="Anderson C" first="Charlotte" last="Anderson">Charlotte Anderson</name>
<affiliation wicri:level="1"><nlm:affiliation>Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vantassell, Curt P" sort="Vantassell, Curt P" uniqKey="Vantassell C" first="Curt P" last="Vantassell">Curt P. Vantassell</name>
<affiliation wicri:level="2"><nlm:affiliation>US Department of Agriculture, Agricultural Research Service (USDA-ARS), Animal and Natural Resources Institute, Bovine Functional Genomics Laboratory, BARC-East, Beltsville, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>US Department of Agriculture, Agricultural Research Service (USDA-ARS), Animal and Natural Resources Institute, Bovine Functional Genomics Laboratory, BARC-East, Beltsville, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hulsegge, Ina" sort="Hulsegge, Ina" uniqKey="Hulsegge I" first="Ina" last="Hulsegge">Ina Hulsegge</name>
<affiliation wicri:level="1"><nlm:affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen</wicri:regionArea>
<wicri:noRegion>Wageningen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goddard, Mike E" sort="Goddard, Mike E" uniqKey="Goddard M" first="Mike E" last="Goddard">Mike E. Goddard</name>
<affiliation wicri:level="4"><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia. [3] Faculty of Land and Food Resources, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia. [3] Faculty of Land and Food Resources, University of Melbourne, Parkville, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guldbrandtsen, Bernt" sort="Guldbrandtsen, Bernt" uniqKey="Guldbrandtsen B" first="Bernt" last="Guldbrandtsen">Bernt Guldbrandtsen</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele</wicri:regionArea>
<wicri:noRegion>Tjele</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lund, Mogens S" sort="Lund, Mogens S" uniqKey="Lund M" first="Mogens S" last="Lund">Mogens S. Lund</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele</wicri:regionArea>
<wicri:noRegion>Tjele</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Veerkamp, Roel F" sort="Veerkamp, Roel F" uniqKey="Veerkamp R" first="Roel F" last="Veerkamp">Roel F. Veerkamp</name>
<affiliation wicri:level="1"><nlm:affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen</wicri:regionArea>
<wicri:noRegion>Wageningen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boichard, Didier A" sort="Boichard, Didier A" uniqKey="Boichard D" first="Didier A" last="Boichard">Didier A. Boichard</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fries, Ruedi" sort="Fries, Ruedi" uniqKey="Fries R" first="Ruedi" last="Fries">Ruedi Fries</name>
<affiliation wicri:level="1"><nlm:affiliation>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan</wicri:regionArea>
<wicri:noRegion>Freising-Weihenstephan</wicri:noRegion>
<wicri:noRegion>Freising-Weihenstephan</wicri:noRegion>
<wicri:noRegion>Freising-Weihenstephan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hayes, Ben J" sort="Hayes, Ben J" uniqKey="Hayes B" first="Ben J" last="Hayes">Ben J. Hayes</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:25017103</idno>
<idno type="pmid">25017103</idno>
<idno type="doi">10.1038/ng.3034</idno>
<idno type="wicri:Area/PubMed/Corpus">003576</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003576</idno>
<idno type="wicri:Area/PubMed/Curation">003463</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003463</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003463</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003463</idno>
<idno type="wicri:Area/Ncbi/Merge">001C14</idno>
<idno type="wicri:Area/Ncbi/Curation">001C14</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001C14</idno>
<idno type="wicri:Area/Main/Merge">003362</idno>
<idno type="wicri:Area/Main/Curation">003359</idno>
<idno type="wicri:Area/Main/Exploration">003359</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.</title>
<author><name sortKey="Daetwyler, Hans D" sort="Daetwyler, Hans D" uniqKey="Daetwyler H" first="Hans D" last="Daetwyler">Hans D. Daetwyler</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Capitan, Aurelien" sort="Capitan, Aurelien" uniqKey="Capitan A" first="Aurélien" last="Capitan">Aurélien Capitan</name>
<affiliation wicri:level="3"><nlm:affiliation>1] Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France. [2] Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>1] Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France. [2] Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pausch, Hubert" sort="Pausch, Hubert" uniqKey="Pausch H" first="Hubert" last="Pausch">Hubert Pausch</name>
<affiliation wicri:level="1"><nlm:affiliation>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan</wicri:regionArea>
<wicri:noRegion>Freising-Weihenstephan</wicri:noRegion>
<wicri:noRegion>Freising-Weihenstephan</wicri:noRegion>
<wicri:noRegion>Freising-Weihenstephan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stothard, Paul" sort="Stothard, Paul" uniqKey="Stothard P" first="Paul" last="Stothard">Paul Stothard</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Binsbergen, Rianne" sort="Van Binsbergen, Rianne" uniqKey="Van Binsbergen R" first="Rianne" last="Van Binsbergen">Rianne Van Binsbergen</name>
<affiliation wicri:level="1"><nlm:affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen</wicri:regionArea>
<wicri:noRegion>Wageningen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Br Ndum, Rasmus F" sort="Br Ndum, Rasmus F" uniqKey="Br Ndum R" first="Rasmus F" last="Br Ndum">Rasmus F. Br Ndum</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele</wicri:regionArea>
<wicri:noRegion>Tjele</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liao, Xiaoping" sort="Liao, Xiaoping" uniqKey="Liao X" first="Xiaoping" last="Liao">Xiaoping Liao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Djari, Anis" sort="Djari, Anis" uniqKey="Djari A" first="Anis" last="Djari">Anis Djari</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet</wicri:regionArea>
<wicri:noRegion>Castanet</wicri:noRegion>
<wicri:noRegion>Castanet</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Sabrina C" sort="Rodriguez, Sabrina C" uniqKey="Rodriguez S" first="Sabrina C" last="Rodriguez">Sabrina C. Rodriguez</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grohs, Cecile" sort="Grohs, Cecile" uniqKey="Grohs C" first="Cécile" last="Grohs">Cécile Grohs</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Esquerre, Diane" sort="Esquerre, Diane" uniqKey="Esquerre D" first="Diane" last="Esquerré">Diane Esquerré</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet</wicri:regionArea>
<wicri:noRegion>Castanet</wicri:noRegion>
<wicri:noRegion>Castanet</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bouchez, Olivier" sort="Bouchez, Olivier" uniqKey="Bouchez O" first="Olivier" last="Bouchez">Olivier Bouchez</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet</wicri:regionArea>
<wicri:noRegion>Castanet</wicri:noRegion>
<wicri:noRegion>Castanet</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rossignol, Marie Noelle" sort="Rossignol, Marie Noelle" uniqKey="Rossignol M" first="Marie-Noëlle" last="Rossignol">Marie-Noëlle Rossignol</name>
<affiliation wicri:level="1"><nlm:affiliation>LABOGENA, Jouy-en-Josas, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>LABOGENA, Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klopp, Christophe" sort="Klopp, Christophe" uniqKey="Klopp C" first="Christophe" last="Klopp">Christophe Klopp</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet</wicri:regionArea>
<wicri:noRegion>Castanet</wicri:noRegion>
<wicri:noRegion>Castanet</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rocha, Dominique" sort="Rocha, Dominique" uniqKey="Rocha D" first="Dominique" last="Rocha">Dominique Rocha</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fritz, Sebastien" sort="Fritz, Sebastien" uniqKey="Fritz S" first="Sébastien" last="Fritz">Sébastien Fritz</name>
<affiliation wicri:level="3"><nlm:affiliation>Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eggen, Andre" sort="Eggen, Andre" uniqKey="Eggen A" first="André" last="Eggen">André Eggen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bowman, Phil J" sort="Bowman, Phil J" uniqKey="Bowman P" first="Phil J" last="Bowman">Phil J. Bowman</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coote, David" sort="Coote, David" uniqKey="Coote D" first="David" last="Coote">David Coote</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chamberlain, Amanda J" sort="Chamberlain, Amanda J" uniqKey="Chamberlain A" first="Amanda J" last="Chamberlain">Amanda J. Chamberlain</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Anderson, Charlotte" sort="Anderson, Charlotte" uniqKey="Anderson C" first="Charlotte" last="Anderson">Charlotte Anderson</name>
<affiliation wicri:level="1"><nlm:affiliation>Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vantassell, Curt P" sort="Vantassell, Curt P" uniqKey="Vantassell C" first="Curt P" last="Vantassell">Curt P. Vantassell</name>
<affiliation wicri:level="2"><nlm:affiliation>US Department of Agriculture, Agricultural Research Service (USDA-ARS), Animal and Natural Resources Institute, Bovine Functional Genomics Laboratory, BARC-East, Beltsville, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>US Department of Agriculture, Agricultural Research Service (USDA-ARS), Animal and Natural Resources Institute, Bovine Functional Genomics Laboratory, BARC-East, Beltsville, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hulsegge, Ina" sort="Hulsegge, Ina" uniqKey="Hulsegge I" first="Ina" last="Hulsegge">Ina Hulsegge</name>
<affiliation wicri:level="1"><nlm:affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen</wicri:regionArea>
<wicri:noRegion>Wageningen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goddard, Mike E" sort="Goddard, Mike E" uniqKey="Goddard M" first="Mike E" last="Goddard">Mike E. Goddard</name>
<affiliation wicri:level="4"><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia. [3] Faculty of Land and Food Resources, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia. [3] Faculty of Land and Food Resources, University of Melbourne, Parkville, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guldbrandtsen, Bernt" sort="Guldbrandtsen, Bernt" uniqKey="Guldbrandtsen B" first="Bernt" last="Guldbrandtsen">Bernt Guldbrandtsen</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele</wicri:regionArea>
<wicri:noRegion>Tjele</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lund, Mogens S" sort="Lund, Mogens S" uniqKey="Lund M" first="Mogens S" last="Lund">Mogens S. Lund</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele</wicri:regionArea>
<wicri:noRegion>Tjele</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Veerkamp, Roel F" sort="Veerkamp, Roel F" uniqKey="Veerkamp R" first="Roel F" last="Veerkamp">Roel F. Veerkamp</name>
<affiliation wicri:level="1"><nlm:affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen</wicri:regionArea>
<wicri:noRegion>Wageningen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boichard, Didier A" sort="Boichard, Didier A" uniqKey="Boichard D" first="Didier A" last="Boichard">Didier A. Boichard</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas</wicri:regionArea>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
<wicri:noRegion>Jouy-en-Josas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fries, Ruedi" sort="Fries, Ruedi" uniqKey="Fries R" first="Ruedi" last="Fries">Ruedi Fries</name>
<affiliation wicri:level="1"><nlm:affiliation>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan</wicri:regionArea>
<wicri:noRegion>Freising-Weihenstephan</wicri:noRegion>
<wicri:noRegion>Freising-Weihenstephan</wicri:noRegion>
<wicri:noRegion>Freising-Weihenstephan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hayes, Ben J" sort="Hayes, Ben J" uniqKey="Hayes B" first="Ben J" last="Hayes">Ben J. Hayes</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature genetics</title>
<idno type="eISSN">1546-1718</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Cattle (genetics)</term>
<term>Genome</term>
<term>Genome-Wide Association Study (methods)</term>
<term>Genotype</term>
<term>Male</term>
<term>Molecular Sequence Data</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Sequence Homology, Amino Acid</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Bovins (génétique)</term>
<term>Données de séquences moléculaires</term>
<term>Génome</term>
<term>Génotype</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Séquence d'acides aminés</term>
<term>Étude d'association pangénomique ()</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cattle</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Bovins</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genome-Wide Association Study</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Genome</term>
<term>Genotype</term>
<term>Male</term>
<term>Molecular Sequence Data</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Sequence Homology, Amino Acid</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Génome</term>
<term>Génotype</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Séquence d'acides aminés</term>
<term>Étude d'association pangénomique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Danemark</li>
<li>France</li>
<li>Pays-Bas</li>
<li>États-Unis</li>
</country>
<region><li>Maryland</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Melbourne</li>
<li>Paris</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Daetwyler, Hans D" sort="Daetwyler, Hans D" uniqKey="Daetwyler H" first="Hans D" last="Daetwyler">Hans D. Daetwyler</name>
</noRegion>
<name sortKey="Anderson, Charlotte" sort="Anderson, Charlotte" uniqKey="Anderson C" first="Charlotte" last="Anderson">Charlotte Anderson</name>
<name sortKey="Bowman, Phil J" sort="Bowman, Phil J" uniqKey="Bowman P" first="Phil J" last="Bowman">Phil J. Bowman</name>
<name sortKey="Chamberlain, Amanda J" sort="Chamberlain, Amanda J" uniqKey="Chamberlain A" first="Amanda J" last="Chamberlain">Amanda J. Chamberlain</name>
<name sortKey="Coote, David" sort="Coote, David" uniqKey="Coote D" first="David" last="Coote">David Coote</name>
<name sortKey="Goddard, Mike E" sort="Goddard, Mike E" uniqKey="Goddard M" first="Mike E" last="Goddard">Mike E. Goddard</name>
<name sortKey="Hayes, Ben J" sort="Hayes, Ben J" uniqKey="Hayes B" first="Ben J" last="Hayes">Ben J. Hayes</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Capitan, Aurelien" sort="Capitan, Aurelien" uniqKey="Capitan A" first="Aurélien" last="Capitan">Aurélien Capitan</name>
</region>
<name sortKey="Boichard, Didier A" sort="Boichard, Didier A" uniqKey="Boichard D" first="Didier A" last="Boichard">Didier A. Boichard</name>
<name sortKey="Bouchez, Olivier" sort="Bouchez, Olivier" uniqKey="Bouchez O" first="Olivier" last="Bouchez">Olivier Bouchez</name>
<name sortKey="Djari, Anis" sort="Djari, Anis" uniqKey="Djari A" first="Anis" last="Djari">Anis Djari</name>
<name sortKey="Eggen, Andre" sort="Eggen, Andre" uniqKey="Eggen A" first="André" last="Eggen">André Eggen</name>
<name sortKey="Esquerre, Diane" sort="Esquerre, Diane" uniqKey="Esquerre D" first="Diane" last="Esquerré">Diane Esquerré</name>
<name sortKey="Fritz, Sebastien" sort="Fritz, Sebastien" uniqKey="Fritz S" first="Sébastien" last="Fritz">Sébastien Fritz</name>
<name sortKey="Grohs, Cecile" sort="Grohs, Cecile" uniqKey="Grohs C" first="Cécile" last="Grohs">Cécile Grohs</name>
<name sortKey="Klopp, Christophe" sort="Klopp, Christophe" uniqKey="Klopp C" first="Christophe" last="Klopp">Christophe Klopp</name>
<name sortKey="Rocha, Dominique" sort="Rocha, Dominique" uniqKey="Rocha D" first="Dominique" last="Rocha">Dominique Rocha</name>
<name sortKey="Rodriguez, Sabrina C" sort="Rodriguez, Sabrina C" uniqKey="Rodriguez S" first="Sabrina C" last="Rodriguez">Sabrina C. Rodriguez</name>
<name sortKey="Rossignol, Marie Noelle" sort="Rossignol, Marie Noelle" uniqKey="Rossignol M" first="Marie-Noëlle" last="Rossignol">Marie-Noëlle Rossignol</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Pausch, Hubert" sort="Pausch, Hubert" uniqKey="Pausch H" first="Hubert" last="Pausch">Hubert Pausch</name>
</noRegion>
<name sortKey="Fries, Ruedi" sort="Fries, Ruedi" uniqKey="Fries R" first="Ruedi" last="Fries">Ruedi Fries</name>
</country>
<country name="Canada"><noRegion><name sortKey="Stothard, Paul" sort="Stothard, Paul" uniqKey="Stothard P" first="Paul" last="Stothard">Paul Stothard</name>
</noRegion>
<name sortKey="Liao, Xiaoping" sort="Liao, Xiaoping" uniqKey="Liao X" first="Xiaoping" last="Liao">Xiaoping Liao</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Van Binsbergen, Rianne" sort="Van Binsbergen, Rianne" uniqKey="Van Binsbergen R" first="Rianne" last="Van Binsbergen">Rianne Van Binsbergen</name>
</noRegion>
<name sortKey="Hulsegge, Ina" sort="Hulsegge, Ina" uniqKey="Hulsegge I" first="Ina" last="Hulsegge">Ina Hulsegge</name>
<name sortKey="Veerkamp, Roel F" sort="Veerkamp, Roel F" uniqKey="Veerkamp R" first="Roel F" last="Veerkamp">Roel F. Veerkamp</name>
</country>
<country name="Danemark"><noRegion><name sortKey="Br Ndum, Rasmus F" sort="Br Ndum, Rasmus F" uniqKey="Br Ndum R" first="Rasmus F" last="Br Ndum">Rasmus F. Br Ndum</name>
</noRegion>
<name sortKey="Guldbrandtsen, Bernt" sort="Guldbrandtsen, Bernt" uniqKey="Guldbrandtsen B" first="Bernt" last="Guldbrandtsen">Bernt Guldbrandtsen</name>
<name sortKey="Lund, Mogens S" sort="Lund, Mogens S" uniqKey="Lund M" first="Mogens S" last="Lund">Mogens S. Lund</name>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Vantassell, Curt P" sort="Vantassell, Curt P" uniqKey="Vantassell C" first="Curt P" last="Vantassell">Curt P. Vantassell</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003359 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003359 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:25017103
   |texte=   Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25017103" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.

Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.