Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.
Identifieur interne : 003576 ( PubMed/Corpus ); précédent : 003575; suivant : 003577Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.
Auteurs : Hans D. Daetwyler ; Aurélien Capitan ; Hubert Pausch ; Paul Stothard ; Rianne Van Binsbergen ; Rasmus F. Br Ndum ; Xiaoping Liao ; Anis Djari ; Sabrina C. Rodriguez ; Cécile Grohs ; Diane Esquerré ; Olivier Bouchez ; Marie-Noëlle Rossignol ; Christophe Klopp ; Dominique Rocha ; Sébastien Fritz ; André Eggen ; Phil J. Bowman ; David Coote ; Amanda J. Chamberlain ; Charlotte Anderson ; Curt P. Vantassell ; Ina Hulsegge ; Mike E. Goddard ; Bernt Guldbrandtsen ; Mogens S. Lund ; Roel F. Veerkamp ; Didier A. Boichard ; Ruedi Fries ; Ben J. HayesSource :
- Nature genetics [ 1546-1718 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
Abstract
The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle.
DOI: 10.1038/ng.3034
PubMed: 25017103
Links to Exploration step
pubmed:25017103Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.</title><author><name sortKey="Daetwyler, Hans D" sort="Daetwyler, Hans D" uniqKey="Daetwyler H" first="Hans D" last="Daetwyler">Hans D. Daetwyler</name><affiliation><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Capitan, Aurelien" sort="Capitan, Aurelien" uniqKey="Capitan A" first="Aurélien" last="Capitan">Aurélien Capitan</name><affiliation><nlm:affiliation>1] Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France. [2] Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pausch, Hubert" sort="Pausch, Hubert" uniqKey="Pausch H" first="Hubert" last="Pausch">Hubert Pausch</name><affiliation><nlm:affiliation>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Stothard, Paul" sort="Stothard, Paul" uniqKey="Stothard P" first="Paul" last="Stothard">Paul Stothard</name><affiliation><nlm:affiliation>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Van Binsbergen, Rianne" sort="Van Binsbergen, Rianne" uniqKey="Van Binsbergen R" first="Rianne" last="Van Binsbergen">Rianne Van Binsbergen</name><affiliation><nlm:affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Br Ndum, Rasmus F" sort="Br Ndum, Rasmus F" uniqKey="Br Ndum R" first="Rasmus F" last="Br Ndum">Rasmus F. Br Ndum</name><affiliation><nlm:affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Liao, Xiaoping" sort="Liao, Xiaoping" uniqKey="Liao X" first="Xiaoping" last="Liao">Xiaoping Liao</name><affiliation><nlm:affiliation>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Djari, Anis" sort="Djari, Anis" uniqKey="Djari A" first="Anis" last="Djari">Anis Djari</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez, Sabrina C" sort="Rodriguez, Sabrina C" uniqKey="Rodriguez S" first="Sabrina C" last="Rodriguez">Sabrina C. Rodriguez</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation></affiliation></author><author><name sortKey="Grohs, Cecile" sort="Grohs, Cecile" uniqKey="Grohs C" first="Cécile" last="Grohs">Cécile Grohs</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation></affiliation></author><author><name sortKey="Esquerre, Diane" sort="Esquerre, Diane" uniqKey="Esquerre D" first="Diane" last="Esquerré">Diane Esquerré</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bouchez, Olivier" sort="Bouchez, Olivier" uniqKey="Bouchez O" first="Olivier" last="Bouchez">Olivier Bouchez</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rossignol, Marie Noelle" sort="Rossignol, Marie Noelle" uniqKey="Rossignol M" first="Marie-Noëlle" last="Rossignol">Marie-Noëlle Rossignol</name><affiliation><nlm:affiliation>LABOGENA, Jouy-en-Josas, France.</nlm:affiliation></affiliation></author><author><name sortKey="Klopp, Christophe" sort="Klopp, Christophe" uniqKey="Klopp C" first="Christophe" last="Klopp">Christophe Klopp</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rocha, Dominique" sort="Rocha, Dominique" uniqKey="Rocha D" first="Dominique" last="Rocha">Dominique Rocha</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fritz, Sebastien" sort="Fritz, Sebastien" uniqKey="Fritz S" first="Sébastien" last="Fritz">Sébastien Fritz</name><affiliation><nlm:affiliation>Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Eggen, Andre" sort="Eggen, Andre" uniqKey="Eggen A" first="André" last="Eggen">André Eggen</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bowman, Phil J" sort="Bowman, Phil J" uniqKey="Bowman P" first="Phil J" last="Bowman">Phil J. Bowman</name><affiliation><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Coote, David" sort="Coote, David" uniqKey="Coote D" first="David" last="Coote">David Coote</name><affiliation><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chamberlain, Amanda J" sort="Chamberlain, Amanda J" uniqKey="Chamberlain A" first="Amanda J" last="Chamberlain">Amanda J. Chamberlain</name><affiliation><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Anderson, Charlotte" sort="Anderson, Charlotte" uniqKey="Anderson C" first="Charlotte" last="Anderson">Charlotte Anderson</name><affiliation><nlm:affiliation>Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vantassell, Curt P" sort="Vantassell, Curt P" uniqKey="Vantassell C" first="Curt P" last="Vantassell">Curt P. Vantassell</name><affiliation><nlm:affiliation>US Department of Agriculture, Agricultural Research Service (USDA-ARS), Animal and Natural Resources Institute, Bovine Functional Genomics Laboratory, BARC-East, Beltsville, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hulsegge, Ina" sort="Hulsegge, Ina" uniqKey="Hulsegge I" first="Ina" last="Hulsegge">Ina Hulsegge</name><affiliation><nlm:affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Goddard, Mike E" sort="Goddard, Mike E" uniqKey="Goddard M" first="Mike E" last="Goddard">Mike E. Goddard</name><affiliation><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia. [3] Faculty of Land and Food Resources, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Guldbrandtsen, Bernt" sort="Guldbrandtsen, Bernt" uniqKey="Guldbrandtsen B" first="Bernt" last="Guldbrandtsen">Bernt Guldbrandtsen</name><affiliation><nlm:affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Lund, Mogens S" sort="Lund, Mogens S" uniqKey="Lund M" first="Mogens S" last="Lund">Mogens S. Lund</name><affiliation><nlm:affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Veerkamp, Roel F" sort="Veerkamp, Roel F" uniqKey="Veerkamp R" first="Roel F" last="Veerkamp">Roel F. Veerkamp</name><affiliation><nlm:affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Boichard, Didier A" sort="Boichard, Didier A" uniqKey="Boichard D" first="Didier A" last="Boichard">Didier A. Boichard</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fries, Ruedi" sort="Fries, Ruedi" uniqKey="Fries R" first="Ruedi" last="Fries">Ruedi Fries</name><affiliation><nlm:affiliation>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hayes, Ben J" sort="Hayes, Ben J" uniqKey="Hayes B" first="Ben J" last="Hayes">Ben J. Hayes</name><affiliation><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25017103</idno><idno type="pmid">25017103</idno><idno type="doi">10.1038/ng.3034</idno><idno type="wicri:Area/PubMed/Corpus">003576</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003576</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.</title><author><name sortKey="Daetwyler, Hans D" sort="Daetwyler, Hans D" uniqKey="Daetwyler H" first="Hans D" last="Daetwyler">Hans D. Daetwyler</name><affiliation><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Capitan, Aurelien" sort="Capitan, Aurelien" uniqKey="Capitan A" first="Aurélien" last="Capitan">Aurélien Capitan</name><affiliation><nlm:affiliation>1] Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France. [2] Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pausch, Hubert" sort="Pausch, Hubert" uniqKey="Pausch H" first="Hubert" last="Pausch">Hubert Pausch</name><affiliation><nlm:affiliation>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Stothard, Paul" sort="Stothard, Paul" uniqKey="Stothard P" first="Paul" last="Stothard">Paul Stothard</name><affiliation><nlm:affiliation>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Van Binsbergen, Rianne" sort="Van Binsbergen, Rianne" uniqKey="Van Binsbergen R" first="Rianne" last="Van Binsbergen">Rianne Van Binsbergen</name><affiliation><nlm:affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Br Ndum, Rasmus F" sort="Br Ndum, Rasmus F" uniqKey="Br Ndum R" first="Rasmus F" last="Br Ndum">Rasmus F. Br Ndum</name><affiliation><nlm:affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Liao, Xiaoping" sort="Liao, Xiaoping" uniqKey="Liao X" first="Xiaoping" last="Liao">Xiaoping Liao</name><affiliation><nlm:affiliation>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Djari, Anis" sort="Djari, Anis" uniqKey="Djari A" first="Anis" last="Djari">Anis Djari</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez, Sabrina C" sort="Rodriguez, Sabrina C" uniqKey="Rodriguez S" first="Sabrina C" last="Rodriguez">Sabrina C. Rodriguez</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation></affiliation></author><author><name sortKey="Grohs, Cecile" sort="Grohs, Cecile" uniqKey="Grohs C" first="Cécile" last="Grohs">Cécile Grohs</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation></affiliation></author><author><name sortKey="Esquerre, Diane" sort="Esquerre, Diane" uniqKey="Esquerre D" first="Diane" last="Esquerré">Diane Esquerré</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bouchez, Olivier" sort="Bouchez, Olivier" uniqKey="Bouchez O" first="Olivier" last="Bouchez">Olivier Bouchez</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rossignol, Marie Noelle" sort="Rossignol, Marie Noelle" uniqKey="Rossignol M" first="Marie-Noëlle" last="Rossignol">Marie-Noëlle Rossignol</name><affiliation><nlm:affiliation>LABOGENA, Jouy-en-Josas, France.</nlm:affiliation></affiliation></author><author><name sortKey="Klopp, Christophe" sort="Klopp, Christophe" uniqKey="Klopp C" first="Christophe" last="Klopp">Christophe Klopp</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rocha, Dominique" sort="Rocha, Dominique" uniqKey="Rocha D" first="Dominique" last="Rocha">Dominique Rocha</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fritz, Sebastien" sort="Fritz, Sebastien" uniqKey="Fritz S" first="Sébastien" last="Fritz">Sébastien Fritz</name><affiliation><nlm:affiliation>Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Eggen, Andre" sort="Eggen, Andre" uniqKey="Eggen A" first="André" last="Eggen">André Eggen</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bowman, Phil J" sort="Bowman, Phil J" uniqKey="Bowman P" first="Phil J" last="Bowman">Phil J. Bowman</name><affiliation><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Coote, David" sort="Coote, David" uniqKey="Coote D" first="David" last="Coote">David Coote</name><affiliation><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chamberlain, Amanda J" sort="Chamberlain, Amanda J" uniqKey="Chamberlain A" first="Amanda J" last="Chamberlain">Amanda J. Chamberlain</name><affiliation><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Anderson, Charlotte" sort="Anderson, Charlotte" uniqKey="Anderson C" first="Charlotte" last="Anderson">Charlotte Anderson</name><affiliation><nlm:affiliation>Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vantassell, Curt P" sort="Vantassell, Curt P" uniqKey="Vantassell C" first="Curt P" last="Vantassell">Curt P. Vantassell</name><affiliation><nlm:affiliation>US Department of Agriculture, Agricultural Research Service (USDA-ARS), Animal and Natural Resources Institute, Bovine Functional Genomics Laboratory, BARC-East, Beltsville, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hulsegge, Ina" sort="Hulsegge, Ina" uniqKey="Hulsegge I" first="Ina" last="Hulsegge">Ina Hulsegge</name><affiliation><nlm:affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Goddard, Mike E" sort="Goddard, Mike E" uniqKey="Goddard M" first="Mike E" last="Goddard">Mike E. Goddard</name><affiliation><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia. [3] Faculty of Land and Food Resources, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Guldbrandtsen, Bernt" sort="Guldbrandtsen, Bernt" uniqKey="Guldbrandtsen B" first="Bernt" last="Guldbrandtsen">Bernt Guldbrandtsen</name><affiliation><nlm:affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Lund, Mogens S" sort="Lund, Mogens S" uniqKey="Lund M" first="Mogens S" last="Lund">Mogens S. Lund</name><affiliation><nlm:affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Veerkamp, Roel F" sort="Veerkamp, Roel F" uniqKey="Veerkamp R" first="Roel F" last="Veerkamp">Roel F. Veerkamp</name><affiliation><nlm:affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Boichard, Didier A" sort="Boichard, Didier A" uniqKey="Boichard D" first="Didier A" last="Boichard">Didier A. Boichard</name><affiliation><nlm:affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fries, Ruedi" sort="Fries, Ruedi" uniqKey="Fries R" first="Ruedi" last="Fries">Ruedi Fries</name><affiliation><nlm:affiliation>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hayes, Ben J" sort="Hayes, Ben J" uniqKey="Hayes B" first="Ben J" last="Hayes">Ben J. Hayes</name><affiliation><nlm:affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="eISSN">1546-1718</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Cattle (genetics)</term><term>Genome</term><term>Genome-Wide Association Study (methods)</term><term>Genotype</term><term>Male</term><term>Molecular Sequence Data</term><term>Polymorphism, Single Nucleotide</term><term>Sequence Homology, Amino Acid</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cattle</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genome-Wide Association Study</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Genome</term><term>Genotype</term><term>Male</term><term>Molecular Sequence Data</term><term>Polymorphism, Single Nucleotide</term><term>Sequence Homology, Amino Acid</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25017103</PMID><DateCreated><Year>2014</Year><Month>07</Month><Day>29</Day></DateCreated><DateCompleted><Year>2015</Year><Month>01</Month><Day>12</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1546-1718</ISSN><JournalIssue CitedMedium="Internet"><Volume>46</Volume><Issue>8</Issue><PubDate><Year>2014</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Nature genetics</Title><ISOAbbreviation>Nat. Genet.</ISOAbbreviation></Journal><ArticleTitle>Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.</ArticleTitle><Pagination><MedlinePgn>858-65</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ng.3034</ELocationID><Abstract><AbstractText>The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Daetwyler</LastName><ForeName>Hans D</ForeName><Initials>HD</Initials><AffiliationInfo><Affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Capitan</LastName><ForeName>Aurélien</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>1] Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France. [2] Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pausch</LastName><ForeName>Hubert</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stothard</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Binsbergen</LastName><ForeName>Rianne</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brøndum</LastName><ForeName>Rasmus F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liao</LastName><ForeName>Xiaoping</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Djari</LastName><ForeName>Anis</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodriguez</LastName><ForeName>Sabrina C</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grohs</LastName><ForeName>Cécile</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esquerré</LastName><ForeName>Diane</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouchez</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Institut National de la Recherche Agronomique (INRA), Get-Plage, UMR 444 Laboratoire de Génétique Cellulaire, Castanet, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rossignol</LastName><ForeName>Marie-Noëlle</ForeName><Initials>MN</Initials><AffiliationInfo><Affiliation>LABOGENA, Jouy-en-Josas, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klopp</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institut National de la Recherche Agronomique (INRA), Sigenae Bioinformatics Group, UR875, Castanet, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rocha</LastName><ForeName>Dominique</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fritz</LastName><ForeName>Sébastien</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Union Nationale des Coopératives d'Elevage et d'Insémination Animale, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eggen</LastName><ForeName>André</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bowman</LastName><ForeName>Phil J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coote</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chamberlain</LastName><ForeName>Amanda J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>VanTassell</LastName><ForeName>Curt P</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>US Department of Agriculture, Agricultural Research Service (USDA-ARS), Animal and Natural Resources Institute, Bovine Functional Genomics Laboratory, BARC-East, Beltsville, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hulsegge</LastName><ForeName>Ina</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goddard</LastName><ForeName>Mike E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia. [3] Faculty of Land and Food Resources, University of Melbourne, Parkville, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guldbrandtsen</LastName><ForeName>Bernt</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lund</LastName><ForeName>Mogens S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Veerkamp</LastName><ForeName>Roel F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>Animal Breeding and Genomics Centre, Wageningen University and Research Centre, Livestock Research, Wageningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boichard</LastName><ForeName>Didier A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Institut National de la Recherche Agronomique (INRA), UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fries</LastName><ForeName>Ruedi</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Chair of Animal Breeding, Technische Universitaet Muenchen, Freising-Weihenstephan, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hayes</LastName><ForeName>Ben J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>1] Biosciences Research Division, Department of Environment and Primary Industries, Bundoora, Victoria, Australia. [2] School of Applied Systems Biology, La Trobe University, Bundoora, Victoria, Australia. [3] Dairy Futures Cooperative Research Centre, Bundoora, Victoria, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>SRA</DataBankName><AccessionNumberList><AccessionNumber>SRP039339</AccessionNumber><AccessionNumber>SRR1188706</AccessionNumber><AccessionNumber>SRR1205973</AccessionNumber><AccessionNumber>SRR1205992</AccessionNumber><AccessionNumber>SRR1262533</AccessionNumber><AccessionNumber>SRR1262536</AccessionNumber><AccessionNumber>SRR1262538</AccessionNumber><AccessionNumber>SRR1262539</AccessionNumber><AccessionNumber>SRR1262614</AccessionNumber><AccessionNumber>SRR1262615</AccessionNumber><AccessionNumber>SRR1262616</AccessionNumber><AccessionNumber>SRR1262617</AccessionNumber><AccessionNumber>SRR1262618</AccessionNumber><AccessionNumber>SRR1262619</AccessionNumber><AccessionNumber>SRR1262620</AccessionNumber><AccessionNumber>SRR1262621</AccessionNumber><AccessionNumber>SRR1262622</AccessionNumber><AccessionNumber>SRR1262623</AccessionNumber><AccessionNumber>SRR1262624</AccessionNumber><AccessionNumber>SRR1262625</AccessionNumber><AccessionNumber>SRR1262626</AccessionNumber><AccessionNumber>SRR1262627</AccessionNumber><AccessionNumber>SRR1262628</AccessionNumber><AccessionNumber>SRR1262629</AccessionNumber><AccessionNumber>SRR1262630</AccessionNumber><AccessionNumber>SRR1262631</AccessionNumber><AccessionNumber>SRR1262632</AccessionNumber><AccessionNumber>SRR1262633</AccessionNumber><AccessionNumber>SRR1262634</AccessionNumber><AccessionNumber>SRR1262635</AccessionNumber><AccessionNumber>SRR1262636</AccessionNumber><AccessionNumber>SRR1262637</AccessionNumber><AccessionNumber>SRR1262638</AccessionNumber><AccessionNumber>SRR1262639</AccessionNumber><AccessionNumber>SRR1262640</AccessionNumber><AccessionNumber>SRR1262641</AccessionNumber><AccessionNumber>SRR1262642</AccessionNumber><AccessionNumber>SRR1262643</AccessionNumber><AccessionNumber>SRR1262644</AccessionNumber><AccessionNumber>SRR1262645</AccessionNumber><AccessionNumber>SRR1262646</AccessionNumber><AccessionNumber>SRR1262647</AccessionNumber><AccessionNumber>SRR1262648</AccessionNumber><AccessionNumber>SRR1262649</AccessionNumber><AccessionNumber>SRR1262650</AccessionNumber><AccessionNumber>SRR1262651</AccessionNumber><AccessionNumber>SRR1262652</AccessionNumber><AccessionNumber>SRR1262653</AccessionNumber><AccessionNumber>SRR1262654</AccessionNumber><AccessionNumber>SRR1262655</AccessionNumber><AccessionNumber>SRR1262656</AccessionNumber><AccessionNumber>SRR1262657</AccessionNumber><AccessionNumber>SRR1262658</AccessionNumber><AccessionNumber>SRR1262659</AccessionNumber><AccessionNumber>SRR1262660</AccessionNumber><AccessionNumber>SRR1262661</AccessionNumber><AccessionNumber>SRR1262662</AccessionNumber><AccessionNumber>SRR1262663</AccessionNumber><AccessionNumber>SRR1262664</AccessionNumber><AccessionNumber>SRR1262665</AccessionNumber><AccessionNumber>SRR1262666</AccessionNumber><AccessionNumber>SRR1262667</AccessionNumber><AccessionNumber>SRR1262668</AccessionNumber><AccessionNumber>SRR1262669</AccessionNumber><AccessionNumber>SRR1262670</AccessionNumber><AccessionNumber>SRR1262671</AccessionNumber><AccessionNumber>SRR1262672</AccessionNumber><AccessionNumber>SRR1262673</AccessionNumber><AccessionNumber>SRR1262674</AccessionNumber><AccessionNumber>SRR1262675</AccessionNumber><AccessionNumber>SRR1262676</AccessionNumber><AccessionNumber>SRR1262677</AccessionNumber><AccessionNumber>SRR1262678</AccessionNumber><AccessionNumber>SRR1262679</AccessionNumber><AccessionNumber>SRR1262680</AccessionNumber><AccessionNumber>SRR1262681</AccessionNumber><AccessionNumber>SRR1262682</AccessionNumber><AccessionNumber>SRR1262683</AccessionNumber><AccessionNumber>SRR1262684</AccessionNumber><AccessionNumber>SRR1262685</AccessionNumber><AccessionNumber>SRR1262686</AccessionNumber><AccessionNumber>SRR1262687</AccessionNumber><AccessionNumber>SRR1262688</AccessionNumber><AccessionNumber>SRR1262689</AccessionNumber><AccessionNumber>SRR1262690</AccessionNumber><AccessionNumber>SRR1262691</AccessionNumber><AccessionNumber>SRR1262692</AccessionNumber><AccessionNumber>SRR1262693</AccessionNumber><AccessionNumber>SRR1262694</AccessionNumber><AccessionNumber>SRR1262695</AccessionNumber><AccessionNumber>SRR1262696</AccessionNumber><AccessionNumber>SRR1262697</AccessionNumber><AccessionNumber>SRR1262698</AccessionNumber><AccessionNumber>SRR1262699</AccessionNumber><AccessionNumber>SRR1262700</AccessionNumber><AccessionNumber>SRR1262701</AccessionNumber><AccessionNumber>SRR1262702</AccessionNumber><AccessionNumber>SRR1262703</AccessionNumber><AccessionNumber>SRR1262704</AccessionNumber><AccessionNumber>SRR1262705</AccessionNumber><AccessionNumber>SRR1262706</AccessionNumber><AccessionNumber>SRR1262707</AccessionNumber><AccessionNumber>SRR1262708</AccessionNumber><AccessionNumber>SRR1262709</AccessionNumber><AccessionNumber>SRR1262710</AccessionNumber><AccessionNumber>SRR1262711</AccessionNumber><AccessionNumber>SRR1262712</AccessionNumber><AccessionNumber>SRR1262713</AccessionNumber><AccessionNumber>SRR1262714</AccessionNumber><AccessionNumber>SRR1262715</AccessionNumber><AccessionNumber>SRR1262716</AccessionNumber><AccessionNumber>SRR1262717</AccessionNumber><AccessionNumber>SRR1262718</AccessionNumber><AccessionNumber>SRR1262719</AccessionNumber><AccessionNumber>SRR1262720</AccessionNumber><AccessionNumber>SRR1262721</AccessionNumber><AccessionNumber>SRR1262722</AccessionNumber><AccessionNumber>SRR1262723</AccessionNumber><AccessionNumber>SRR1262724</AccessionNumber><AccessionNumber>SRR1262725</AccessionNumber><AccessionNumber>SRR1262726</AccessionNumber><AccessionNumber>SRR1262727</AccessionNumber><AccessionNumber>SRR1262728</AccessionNumber><AccessionNumber>SRR1262729</AccessionNumber><AccessionNumber>SRR1262730</AccessionNumber><AccessionNumber>SRR1262731</AccessionNumber><AccessionNumber>SRR1262732</AccessionNumber><AccessionNumber>SRR1262733</AccessionNumber><AccessionNumber>SRR1262734</AccessionNumber><AccessionNumber>SRR1262735</AccessionNumber><AccessionNumber>SRR1262736</AccessionNumber><AccessionNumber>SRR1262737</AccessionNumber><AccessionNumber>SRR1262738</AccessionNumber><AccessionNumber>SRR1262739</AccessionNumber><AccessionNumber>SRR1262740</AccessionNumber><AccessionNumber>SRR1262741</AccessionNumber><AccessionNumber>SRR1262742</AccessionNumber><AccessionNumber>SRR1262743</AccessionNumber><AccessionNumber>SRR1262744</AccessionNumber><AccessionNumber>SRR1262745</AccessionNumber><AccessionNumber>SRR1262746</AccessionNumber><AccessionNumber>SRR1262747</AccessionNumber><AccessionNumber>SRR1262748</AccessionNumber><AccessionNumber>SRR1262749</AccessionNumber><AccessionNumber>SRR1262750</AccessionNumber><AccessionNumber>SRR1262751</AccessionNumber><AccessionNumber>SRR1262752</AccessionNumber><AccessionNumber>SRR1262753</AccessionNumber><AccessionNumber>SRR1262754</AccessionNumber><AccessionNumber>SRR1262755</AccessionNumber><AccessionNumber>SRR1262756</AccessionNumber><AccessionNumber>SRR1262757</AccessionNumber><AccessionNumber>SRR1262758</AccessionNumber><AccessionNumber>SRR1262759</AccessionNumber><AccessionNumber>SRR1262760</AccessionNumber><AccessionNumber>SRR1262761</AccessionNumber><AccessionNumber>SRR1262762</AccessionNumber><AccessionNumber>SRR1262763</AccessionNumber><AccessionNumber>SRR1262764</AccessionNumber><AccessionNumber>SRR1262765</AccessionNumber><AccessionNumber>SRR1262766</AccessionNumber><AccessionNumber>SRR1262767</AccessionNumber><AccessionNumber>SRR1262768</AccessionNumber><AccessionNumber>SRR1262769</AccessionNumber><AccessionNumber>SRR1262770</AccessionNumber><AccessionNumber>SRR1262771</AccessionNumber><AccessionNumber>SRR1262772</AccessionNumber><AccessionNumber>SRR1262773</AccessionNumber><AccessionNumber>SRR1262774</AccessionNumber><AccessionNumber>SRR1262775</AccessionNumber><AccessionNumber>SRR1262776</AccessionNumber><AccessionNumber>SRR1262777</AccessionNumber><AccessionNumber>SRR1262778</AccessionNumber><AccessionNumber>SRR1262779</AccessionNumber><AccessionNumber>SRR1262780</AccessionNumber><AccessionNumber>SRR1262781</AccessionNumber><AccessionNumber>SRR1262782</AccessionNumber><AccessionNumber>SRR1262783</AccessionNumber><AccessionNumber>SRR1262784</AccessionNumber><AccessionNumber>SRR1262785</AccessionNumber><AccessionNumber>SRR1262786</AccessionNumber><AccessionNumber>SRR1262787</AccessionNumber><AccessionNumber>SRR1262788</AccessionNumber><AccessionNumber>SRR1262789</AccessionNumber><AccessionNumber>SRR1262790</AccessionNumber><AccessionNumber>SRR1262791</AccessionNumber><AccessionNumber>SRR1262792</AccessionNumber><AccessionNumber>SRR1262793</AccessionNumber><AccessionNumber>SRR1262794</AccessionNumber><AccessionNumber>SRR1262795</AccessionNumber><AccessionNumber>SRR1262796</AccessionNumber><AccessionNumber>SRR1262797</AccessionNumber><AccessionNumber>SRR1262798</AccessionNumber><AccessionNumber>SRR1262799</AccessionNumber><AccessionNumber>SRR1262800</AccessionNumber><AccessionNumber>SRR1262801</AccessionNumber><AccessionNumber>SRR1262802</AccessionNumber><AccessionNumber>SRR1262803</AccessionNumber><AccessionNumber>SRR1262804</AccessionNumber><AccessionNumber>SRR1262805</AccessionNumber><AccessionNumber>SRR1262806</AccessionNumber><AccessionNumber>SRR1262807</AccessionNumber><AccessionNumber>SRR1262808</AccessionNumber><AccessionNumber>SRR1262809</AccessionNumber><AccessionNumber>SRR1262810</AccessionNumber><AccessionNumber>SRR1262811</AccessionNumber><AccessionNumber>SRR1262812</AccessionNumber><AccessionNumber>SRR1262813</AccessionNumber><AccessionNumber>SRR1262814</AccessionNumber><AccessionNumber>SRR1262815</AccessionNumber><AccessionNumber>SRR1262816</AccessionNumber><AccessionNumber>SRR1262817</AccessionNumber><AccessionNumber>SRR1262818</AccessionNumber><AccessionNumber>SRR1262819</AccessionNumber><AccessionNumber>SRR1262820</AccessionNumber><AccessionNumber>SRR1262821</AccessionNumber><AccessionNumber>SRR1262822</AccessionNumber><AccessionNumber>SRR1262823</AccessionNumber><AccessionNumber>SRR1262824</AccessionNumber><AccessionNumber>SRR1262825</AccessionNumber><AccessionNumber>SRR1262826</AccessionNumber><AccessionNumber>SRR1262827</AccessionNumber><AccessionNumber>SRR1262828</AccessionNumber><AccessionNumber>SRR1262829</AccessionNumber><AccessionNumber>SRR1262830</AccessionNumber><AccessionNumber>SRR1262831</AccessionNumber><AccessionNumber>SRR1262832</AccessionNumber><AccessionNumber>SRR1262833</AccessionNumber><AccessionNumber>SRR1262834</AccessionNumber><AccessionNumber>SRR1262835</AccessionNumber><AccessionNumber>SRR1262836</AccessionNumber><AccessionNumber>SRR1262837</AccessionNumber><AccessionNumber>SRR1262838</AccessionNumber><AccessionNumber>SRR1262839</AccessionNumber><AccessionNumber>SRR1262840</AccessionNumber><AccessionNumber>SRR1262841</AccessionNumber><AccessionNumber>SRR1262842</AccessionNumber><AccessionNumber>SRR1262843</AccessionNumber><AccessionNumber>SRR1262844</AccessionNumber><AccessionNumber>SRR1262845</AccessionNumber><AccessionNumber>SRR1262846</AccessionNumber><AccessionNumber>SRR1293227</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>07</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Nat Genet</MedlineTA><NlmUniqueID>9216904</NlmUniqueID><ISSNLinking>1061-4036</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Nat Genet. 2014 Aug;46(8):807-9</RefSource><PMID Version="1">25070799</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genetics. 2010 Jun;185(2):623-31</RefSource><PMID Version="1">20308278</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Protoc Bioinformatics. 2002 Aug;Chapter 2:Unit 2.3</RefSource><PMID Version="1">18792934</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 1995 Feb;4(2):285-8</RefSource><PMID Version="1">7757081</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2011 Jan;39(Database issue):D214-9</RefSource><PMID Version="1">21051339</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2012 Feb 08;482(7384):173-8</RefSource><PMID Version="1">22318601</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Dairy Sci. 2008 Nov;91(11):4414-23</RefSource><PMID Version="1">18946147</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2009 Oct 2;326(5949):150-3</RefSource><PMID Version="1">19713490</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genome Res. 2005 Mar;15(3):436-42</RefSource><PMID Version="1">15741513</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Heredity (Edinb). 2014 Jan;112(1):39-47</RefSource><PMID Version="1">23549338</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genomics. 2007 Dec;90(6):703-11</RefSource><PMID Version="1">17920809</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Biol. 2000 May 15;149(4):811-24</RefSource><PMID Version="1">10811823</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Dermatol. 2004 Feb;150(2):195-204</RefSource><PMID Version="1">14996088</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9225-9</RefSource><PMID Version="1">1384046</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genetics. 2011 Jan;187(1):289-97</RefSource><PMID Version="1">21059885</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2010 Nov;42(11):931-6</RefSource><PMID Version="1">20972442</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genome Biol. 2009;10(4):R42</RefSource><PMID Version="1">19393038</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem J. 1995 May 1;307 ( Pt 3):823-30</RefSource><PMID Version="1">7741714</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Sel Evol. 2013 Feb 13;45:3</RefSource><PMID Version="1">23406470</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Res (Camb). 2009 Dec;91(6):413-26</RefSource><PMID Version="1">20122297</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2012 Jul 22;44(8):955-9</RefSource><PMID Version="1">22820512</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Anim Genet. 2007 Oct;38(5):453-9</RefSource><PMID Version="1">17894560</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2398-403</RefSource><PMID Version="1">14983021</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Chromosome Res. 2009;17(2):131-44</RefSource><PMID Version="1">19308696</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2011 Aug 15;27(16):2300-1</RefSource><PMID Version="1">21697123</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2012 Jan;40(Database issue):D84-90</RefSource><PMID Version="1">22086963</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dev Cell. 2003 Aug;5(2):323-36</RefSource><PMID Version="1">12919682</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2013 Jan;41(Database issue):D8-D20</RefSource><PMID Version="1">23193264</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Dairy Sci. 2009 Jun;92(6):2931-46</RefSource><PMID Version="1">19448026</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mamm Genome. 2006 Dec;17(12):1172-82</RefSource><PMID Version="1">17143583</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2005 Oct 14;280(41):34723-34</RefSource><PMID Version="1">16100111</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2009 Jan 22;457(7228):369</RefSource><PMID Version="1">19158758</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2009 Aug 15;25(16):2078-9</RefSource><PMID Version="1">19505943</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(7):e40711</RefSource><PMID Version="1">22792397</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2009 Feb;84(2):210-23</RefSource><PMID Version="1">19200528</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Methods. 2010 Apr;7(4):248-9</RefSource><PMID Version="1">20354512</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Genet. 2013 Apr;29(4):206-14</RefSource><PMID Version="1">23261029</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Med Genet. 2000 May 15;92(2):95-100</RefSource><PMID Version="1">10797431</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Development. 2003 Jul;130(14):3283-95</RefSource><PMID Version="1">12783798</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Vet Diagn Invest. 2004 Jul;16(4):293-8</RefSource><PMID Version="1">15305739</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Cell Biol. 2006 Oct;8(10):1133-42</RefSource><PMID Version="1">16998479</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Dairy Sci. 2011 Dec;94(12):6153-61</RefSource><PMID Version="1">22118103</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Lett. 2007 Aug 22;3(4):449-52</RefSource><PMID Version="1">17535790</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 1988 Dec;43(6):894-903</RefSource><PMID Version="1">3057886</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Methods Mol Biol. 2000;132:365-86</RefSource><PMID Version="1">10547847</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genome Res. 2002 Feb;12(2):222-31</RefSource><PMID Version="1">11827942</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genetics. 2010 Mar;184(3):789-98</RefSource><PMID Version="1">20008575</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Genomics. 2009 Apr 24;10:181</RefSource><PMID Version="1">19393053</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Animal. 2012 Apr;6(4):544-50</RefSource><PMID Version="1">22436268</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2009 Apr 24;324(5926):528-32</RefSource><PMID Version="1">19390050</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Protoc. 2009;4(7):1073-81</RefSource><PMID Version="1">19561590</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Vet Diagn Invest. 2001 Jul;13(4):283-9</RefSource><PMID Version="1">11478598</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Mol Res. 2006 Aug 31;5(3):513-24</RefSource><PMID Version="1">17117367</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2010 Oct 28;467(7319):1061-73</RefSource><PMID Version="1">20981092</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2009 Jul 15;25(14):1754-60</RefSource><PMID Version="1">19451168</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 1989 Nov 5;264(31):18265-7</RefSource><PMID Version="1">2572591</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nutr. 2008 Jun;138(6):1019-24</RefSource><PMID Version="1">18492828</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Sel Evol. 2009 Nov 24;41:51</RefSource><PMID Version="1">19930712</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9300-5</RefSource><PMID Version="1">12077321</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2008 Nov 6;456(7218):53-9</RefSource><PMID Version="1">18987734</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2009 Jun;5(6):e1000529</RefSource><PMID Version="1">19543373</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 1995 Mar 1;9(5):587-99</RefSource><PMID Version="1">7698648</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2010 Apr;42(4):348-54</RefSource><PMID Version="1">20208533</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002417" MajorTopicYN="N">Cattle</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016678" MajorTopicYN="Y">Genome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055106" MajorTopicYN="N">Genome-Wide Association Study</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017386" MajorTopicYN="N">Sequence Homology, Amino Acid</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>08</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>06</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>7</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>7</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>1</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25017103</ArticleId><ArticleId IdType="pii">ng.3034</ArticleId><ArticleId IdType="doi">10.1038/ng.3034</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003576 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 003576 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:25017103
|texte= Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:25017103" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |