Design and rationale of the TOTAL trial: a randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI.
Identifieur interne : 003A51 ( Main/Exploration ); précédent : 003A50; suivant : 003A52Design and rationale of the TOTAL trial: a randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI.
Auteurs : Sanjit S. Jolly [Canada] ; John Cairns [Canada] ; Salim Yusuf [Canada] ; Brandi Meeks [Canada] ; Olga Shestakovska [Canada] ; Lehana Thabane [Canada] ; Kari Niemel [Finlande] ; Philippe Gabriel Steg [France] ; Olivier F. Bertrand [Canada] ; Sunil V. Rao [États-Unis] ; Alvaro Avezum [Brésil] ; Warren J. Cantor [Canada] ; Samir B. Pancholy [États-Unis] ; Raul Moreno [Espagne] ; Anthony Gershlick [Royaume-Uni] ; Ravinay Bhindi [Australie] ; Robert C. Welsh [Canada] ; Asim N. Cheema [Canada] ; Shahar Lavi [Canada] ; Michael Rokoss [Canada] ; Vladimír Džavík [Canada]Source :
- American heart journal [ 1097-6744 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
Abstract
A major limitation of primary percutaneous coronary intervention (PPCI) for the treatment of ST-elevation myocardial infarction (STEMI) is impaired microvascular perfusion due to embolization and obstruction of microcirculation with thrombus. Manual thrombectomy has the potential to reduce distal embolization and improve microvascular perfusion. Clinical trials have shown mixed results regarding thrombectomy.
DOI: 10.1016/j.ahj.2013.12.002
PubMed: 24576514
Affiliations:
- Australie, Brésil, Canada, Espagne, Finlande, France, Royaume-Uni, États-Unis
- Angleterre, Caroline du Nord, Communauté de Madrid, Grand Londres, Nouvelle-Galles du Sud, Ontario, Pennsylvanie, État de São Paulo, Île-de-France
- Londres, Madrid, Paris, Sydney, São Paulo, Toronto
- Université de Toronto
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Jolly</name><affiliation wicri:level="1"><nlm:affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada. Electronic address: sanjit.jolly@phri.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Cairns, John" sort="Cairns, John" uniqKey="Cairns J" first="John" last="Cairns">John Cairns</name><affiliation wicri:level="1"><nlm:affiliation>University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Yusuf, Salim" sort="Yusuf, Salim" uniqKey="Yusuf S" first="Salim" last="Yusuf">Salim Yusuf</name><affiliation wicri:level="1"><nlm:affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Meeks, Brandi" sort="Meeks, Brandi" uniqKey="Meeks B" first="Brandi" last="Meeks">Brandi Meeks</name><affiliation wicri:level="1"><nlm:affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Shestakovska, Olga" sort="Shestakovska, Olga" uniqKey="Shestakovska O" first="Olga" last="Shestakovska">Olga Shestakovska</name><affiliation wicri:level="1"><nlm:affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Thabane, Lehana" sort="Thabane, Lehana" uniqKey="Thabane L" first="Lehana" last="Thabane">Lehana Thabane</name><affiliation wicri:level="1"><nlm:affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Niemel, Kari" sort="Niemel, Kari" uniqKey="Niemel K" first="Kari" last="Niemel">Kari Niemel</name><affiliation wicri:level="1"><nlm:affiliation>Tampere Heart Center and University Hospital, Tampere, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Tampere Heart Center and University Hospital, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name><affiliation wicri:level="3"><nlm:affiliation>Université Paris-Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bertrand, Olivier F" sort="Bertrand, Olivier F" uniqKey="Bertrand O" first="Olivier F" last="Bertrand">Olivier F. Bertrand</name><affiliation wicri:level="1"><nlm:affiliation>Quebec Heart-Lung Institute, Laval University, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Quebec Heart-Lung Institute, Laval University, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Rao, Sunil V" sort="Rao, Sunil V" uniqKey="Rao S" first="Sunil V" last="Rao">Sunil V. Rao</name><affiliation wicri:level="2"><nlm:affiliation>Duke Clinical Research Institute, Duke University, Durham, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Duke Clinical Research Institute, Duke University, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Avezum, Alvaro" sort="Avezum, Alvaro" uniqKey="Avezum A" first="Alvaro" last="Avezum">Alvaro Avezum</name><affiliation wicri:level="3"><nlm:affiliation>Dante Pazzanese Institute of Cardiology, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Dante Pazzanese Institute of Cardiology, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Cantor, Warren J" sort="Cantor, Warren J" uniqKey="Cantor W" first="Warren J" last="Cantor">Warren J. 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Pancholy</name><affiliation wicri:level="2"><nlm:affiliation>The Commonwealth Medical College, Scranton, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>The Commonwealth Medical College, Scranton</wicri:cityArea></affiliation></author><author><name sortKey="Moreno, Raul" sort="Moreno, Raul" uniqKey="Moreno R" first="Raul" last="Moreno">Raul Moreno</name><affiliation wicri:level="3"><nlm:affiliation>Hospital La Paz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital La Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Gershlick, Anthony" sort="Gershlick, Anthony" uniqKey="Gershlick A" first="Anthony" last="Gershlick">Anthony Gershlick</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, University Hospitals of Leicester, Glenfield Hospital, Leicester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, University Hospitals of Leicester, Glenfield Hospital, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Bhindi, Ravinay" sort="Bhindi, Ravinay" uniqKey="Bhindi R" first="Ravinay" last="Bhindi">Ravinay Bhindi</name><affiliation wicri:level="3"><nlm:affiliation>Royal North Shore and North Shore Private Hospitals, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Royal North Shore and North Shore Private Hospitals, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Welsh, Robert C" sort="Welsh, Robert C" uniqKey="Welsh R" first="Robert C" last="Welsh">Robert C. Welsh</name><affiliation wicri:level="1"><nlm:affiliation>University of Alberta, Edmonton, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Alberta, Edmonton</wicri:regionArea><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Cheema, Asim N" sort="Cheema, Asim N" uniqKey="Cheema A" first="Asim N" last="Cheema">Asim N. Cheema</name><affiliation wicri:level="4"><nlm:affiliation>St Michael's Hospital, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>St Michael's Hospital, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lavi, Shahar" sort="Lavi, Shahar" uniqKey="Lavi S" first="Shahar" last="Lavi">Shahar Lavi</name><affiliation wicri:level="3"><nlm:affiliation>London Health Sciences Centre, Western University, London, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>London Health Sciences Centre, Western University, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rokoss, Michael" sort="Rokoss, Michael" uniqKey="Rokoss M" first="Michael" last="Rokoss">Michael Rokoss</name><affiliation wicri:level="1"><nlm:affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Dzavik, Vladimir" sort="Dzavik, Vladimir" uniqKey="Dzavik V" first="Vladimír" last="Džavík">Vladimír Džavík</name><affiliation wicri:level="1"><nlm:affiliation>Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author></analytic><series><title level="j">American heart journal</title><idno type="eISSN">1097-6744</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Combined Modality Therapy</term><term>Humans</term><term>Microcirculation</term><term>Myocardial Infarction (therapy)</term><term>Percutaneous Coronary Intervention (methods)</term><term>Prospective Studies</term><term>Suction (methods)</term><term>Thrombectomy (methods)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aspiration (technique) ()</term><term>Association thérapeutique</term><term>Humains</term><term>Infarctus du myocarde ()</term><term>Intervention coronarienne percutanée ()</term><term>Microcirculation</term><term>Résultat thérapeutique</term><term>Thrombectomie ()</term><term>Études prospectives</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Percutaneous Coronary Intervention</term><term>Suction</term><term>Thrombectomy</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Myocardial Infarction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Combined Modality Therapy</term><term>Humans</term><term>Microcirculation</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Aspiration (technique)</term><term>Association thérapeutique</term><term>Humains</term><term>Infarctus du myocarde</term><term>Intervention coronarienne percutanée</term><term>Microcirculation</term><term>Résultat thérapeutique</term><term>Thrombectomie</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A major limitation of primary percutaneous coronary intervention (PPCI) for the treatment of ST-elevation myocardial infarction (STEMI) is impaired microvascular perfusion due to embolization and obstruction of microcirculation with thrombus. Manual thrombectomy has the potential to reduce distal embolization and improve microvascular perfusion. Clinical trials have shown mixed results regarding thrombectomy.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Brésil</li><li>Canada</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Caroline du Nord</li><li>Communauté de Madrid</li><li>Grand Londres</li><li>Nouvelle-Galles du Sud</li><li>Ontario</li><li>Pennsylvanie</li><li>État de São Paulo</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Madrid</li><li>Paris</li><li>Sydney</li><li>São Paulo</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Jolly, Sanjit S" sort="Jolly, Sanjit S" uniqKey="Jolly S" first="Sanjit S" last="Jolly">Sanjit S. Jolly</name></noRegion><name sortKey="Bertrand, Olivier F" sort="Bertrand, Olivier F" uniqKey="Bertrand O" first="Olivier F" last="Bertrand">Olivier F. Bertrand</name><name sortKey="Cairns, John" sort="Cairns, John" uniqKey="Cairns J" first="John" last="Cairns">John Cairns</name><name sortKey="Cantor, Warren J" sort="Cantor, Warren J" uniqKey="Cantor W" first="Warren J" last="Cantor">Warren J. Cantor</name><name sortKey="Cheema, Asim N" sort="Cheema, Asim N" uniqKey="Cheema A" first="Asim N" last="Cheema">Asim N. Cheema</name><name sortKey="Dzavik, Vladimir" sort="Dzavik, Vladimir" uniqKey="Dzavik V" first="Vladimír" last="Džavík">Vladimír Džavík</name><name sortKey="Lavi, Shahar" sort="Lavi, Shahar" uniqKey="Lavi S" first="Shahar" last="Lavi">Shahar Lavi</name><name sortKey="Meeks, Brandi" sort="Meeks, Brandi" uniqKey="Meeks B" first="Brandi" last="Meeks">Brandi Meeks</name><name sortKey="Rokoss, Michael" sort="Rokoss, Michael" uniqKey="Rokoss M" first="Michael" last="Rokoss">Michael Rokoss</name><name sortKey="Shestakovska, Olga" sort="Shestakovska, Olga" uniqKey="Shestakovska O" first="Olga" last="Shestakovska">Olga Shestakovska</name><name sortKey="Thabane, Lehana" sort="Thabane, Lehana" uniqKey="Thabane L" first="Lehana" last="Thabane">Lehana Thabane</name><name sortKey="Welsh, Robert C" sort="Welsh, Robert C" uniqKey="Welsh R" first="Robert C" last="Welsh">Robert C. Welsh</name><name sortKey="Yusuf, Salim" sort="Yusuf, Salim" uniqKey="Yusuf S" first="Salim" last="Yusuf">Salim Yusuf</name></country><country name="Finlande"><noRegion><name sortKey="Niemel, Kari" sort="Niemel, Kari" uniqKey="Niemel K" first="Kari" last="Niemel">Kari Niemel</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name></region></country><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Rao, Sunil V" sort="Rao, Sunil V" uniqKey="Rao S" first="Sunil V" last="Rao">Sunil V. Rao</name></region><name sortKey="Pancholy, Samir B" sort="Pancholy, Samir B" uniqKey="Pancholy S" first="Samir B" last="Pancholy">Samir B. Pancholy</name></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Avezum, Alvaro" sort="Avezum, Alvaro" uniqKey="Avezum A" first="Alvaro" last="Avezum">Alvaro Avezum</name></region></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Moreno, Raul" sort="Moreno, Raul" uniqKey="Moreno R" first="Raul" last="Moreno">Raul Moreno</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Gershlick, Anthony" sort="Gershlick, Anthony" uniqKey="Gershlick A" first="Anthony" last="Gershlick">Anthony Gershlick</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Bhindi, Ravinay" sort="Bhindi, Ravinay" uniqKey="Bhindi R" first="Ravinay" last="Bhindi">Ravinay Bhindi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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