AustralieFrV1, PubMed, Corpus, bibRecord, 003911

Design and rationale of the TOTAL trial: a randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI.

Identifieur interne : 003911 ( PubMed/Corpus ); précédent : 003910; suivant : 003912

Design and rationale of the TOTAL trial: a randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI.

Auteurs : Sanjit S. Jolly ; John Cairns ; Salim Yusuf ; Brandi Meeks ; Olga Shestakovska ; Lehana Thabane ; Kari Niemel ; Philippe Gabriel Steg ; Olivier F. Bertrand ; Sunil V. Rao ; Alvaro Avezum ; Warren J. Cantor ; Samir B. Pancholy ; Raul Moreno ; Anthony Gershlick ; Ravinay Bhindi ; Robert C. Welsh ; Asim N. Cheema ; Shahar Lavi ; Michael Rokoss ; Vladimír Džavík

Source :

American heart journal [ 1097-6744 ] ; 2014.

RBID : pubmed:24576514

English descriptors

KwdEn :
- Combined Modality Therapy, Humans, Microcirculation, Myocardial Infarction (therapy), Percutaneous Coronary Intervention (methods), Prospective Studies, Suction (methods), Thrombectomy (methods), Treatment Outcome.
MESH :
- methods : Percutaneous Coronary Intervention, Suction, Thrombectomy.
- therapy : Myocardial Infarction.
- Combined Modality Therapy, Humans, Microcirculation, Prospective Studies, Treatment Outcome.

Abstract

A major limitation of primary percutaneous coronary intervention (PPCI) for the treatment of ST-elevation myocardial infarction (STEMI) is impaired microvascular perfusion due to embolization and obstruction of microcirculation with thrombus. Manual thrombectomy has the potential to reduce distal embolization and improve microvascular perfusion. Clinical trials have shown mixed results regarding thrombectomy.

DOI: 10.1016/j.ahj.2013.12.002
PubMed: 24576514

Links to Exploration step

pubmed:24576514

Le document en format XML

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<author><name sortKey="Avezum, Alvaro" sort="Avezum, Alvaro" uniqKey="Avezum A" first="Alvaro" last="Avezum">Alvaro Avezum</name>
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<author><name sortKey="Moreno, Raul" sort="Moreno, Raul" uniqKey="Moreno R" first="Raul" last="Moreno">Raul Moreno</name>
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</affiliation>
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<author><name sortKey="Gershlick, Anthony" sort="Gershlick, Anthony" uniqKey="Gershlick A" first="Anthony" last="Gershlick">Anthony Gershlick</name>
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</affiliation>
</author>
<author><name sortKey="Bhindi, Ravinay" sort="Bhindi, Ravinay" uniqKey="Bhindi R" first="Ravinay" last="Bhindi">Ravinay Bhindi</name>
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</affiliation>
</author>
<author><name sortKey="Welsh, Robert C" sort="Welsh, Robert C" uniqKey="Welsh R" first="Robert C" last="Welsh">Robert C. Welsh</name>
<affiliation><nlm:affiliation>University of Alberta, Edmonton, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cheema, Asim N" sort="Cheema, Asim N" uniqKey="Cheema A" first="Asim N" last="Cheema">Asim N. Cheema</name>
<affiliation><nlm:affiliation>St Michael's Hospital, University of Toronto, Toronto, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lavi, Shahar" sort="Lavi, Shahar" uniqKey="Lavi S" first="Shahar" last="Lavi">Shahar Lavi</name>
<affiliation><nlm:affiliation>London Health Sciences Centre, Western University, London, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rokoss, Michael" sort="Rokoss, Michael" uniqKey="Rokoss M" first="Michael" last="Rokoss">Michael Rokoss</name>
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</affiliation>
</author>
<author><name sortKey="Dzavik, Vladimir" sort="Dzavik, Vladimir" uniqKey="Dzavik V" first="Vladimír" last="Džavík">Vladimír Džavík</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Design and rationale of the TOTAL trial: a randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI.</title>
<author><name sortKey="Jolly, Sanjit S" sort="Jolly, Sanjit S" uniqKey="Jolly S" first="Sanjit S" last="Jolly">Sanjit S. Jolly</name>
<affiliation><nlm:affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada. Electronic address: sanjit.jolly@phri.ca.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cairns, John" sort="Cairns, John" uniqKey="Cairns J" first="John" last="Cairns">John Cairns</name>
<affiliation><nlm:affiliation>University of British Columbia, Vancouver, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yusuf, Salim" sort="Yusuf, Salim" uniqKey="Yusuf S" first="Salim" last="Yusuf">Salim Yusuf</name>
<affiliation><nlm:affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Meeks, Brandi" sort="Meeks, Brandi" uniqKey="Meeks B" first="Brandi" last="Meeks">Brandi Meeks</name>
<affiliation><nlm:affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Shestakovska, Olga" sort="Shestakovska, Olga" uniqKey="Shestakovska O" first="Olga" last="Shestakovska">Olga Shestakovska</name>
<affiliation><nlm:affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Thabane, Lehana" sort="Thabane, Lehana" uniqKey="Thabane L" first="Lehana" last="Thabane">Lehana Thabane</name>
<affiliation><nlm:affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Niemel, Kari" sort="Niemel, Kari" uniqKey="Niemel K" first="Kari" last="Niemel">Kari Niemel</name>
<affiliation><nlm:affiliation>Tampere Heart Center and University Hospital, Tampere, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name>
<affiliation><nlm:affiliation>Université Paris-Diderot, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bertrand, Olivier F" sort="Bertrand, Olivier F" uniqKey="Bertrand O" first="Olivier F" last="Bertrand">Olivier F. Bertrand</name>
<affiliation><nlm:affiliation>Quebec Heart-Lung Institute, Laval University, Quebec, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rao, Sunil V" sort="Rao, Sunil V" uniqKey="Rao S" first="Sunil V" last="Rao">Sunil V. Rao</name>
<affiliation><nlm:affiliation>Duke Clinical Research Institute, Duke University, Durham, NC.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Avezum, Alvaro" sort="Avezum, Alvaro" uniqKey="Avezum A" first="Alvaro" last="Avezum">Alvaro Avezum</name>
<affiliation><nlm:affiliation>Dante Pazzanese Institute of Cardiology, São Paulo, Brazil.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cantor, Warren J" sort="Cantor, Warren J" uniqKey="Cantor W" first="Warren J" last="Cantor">Warren J. Cantor</name>
<affiliation><nlm:affiliation>Southlake Regional Health Centre, University of Toronto, Newmarket, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pancholy, Samir B" sort="Pancholy, Samir B" uniqKey="Pancholy S" first="Samir B" last="Pancholy">Samir B. Pancholy</name>
<affiliation><nlm:affiliation>The Commonwealth Medical College, Scranton, PA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Moreno, Raul" sort="Moreno, Raul" uniqKey="Moreno R" first="Raul" last="Moreno">Raul Moreno</name>
<affiliation><nlm:affiliation>Hospital La Paz, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gershlick, Anthony" sort="Gershlick, Anthony" uniqKey="Gershlick A" first="Anthony" last="Gershlick">Anthony Gershlick</name>
<affiliation><nlm:affiliation>National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, University Hospitals of Leicester, Glenfield Hospital, Leicester, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bhindi, Ravinay" sort="Bhindi, Ravinay" uniqKey="Bhindi R" first="Ravinay" last="Bhindi">Ravinay Bhindi</name>
<affiliation><nlm:affiliation>Royal North Shore and North Shore Private Hospitals, Sydney, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Welsh, Robert C" sort="Welsh, Robert C" uniqKey="Welsh R" first="Robert C" last="Welsh">Robert C. Welsh</name>
<affiliation><nlm:affiliation>University of Alberta, Edmonton, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cheema, Asim N" sort="Cheema, Asim N" uniqKey="Cheema A" first="Asim N" last="Cheema">Asim N. Cheema</name>
<affiliation><nlm:affiliation>St Michael's Hospital, University of Toronto, Toronto, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lavi, Shahar" sort="Lavi, Shahar" uniqKey="Lavi S" first="Shahar" last="Lavi">Shahar Lavi</name>
<affiliation><nlm:affiliation>London Health Sciences Centre, Western University, London, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rokoss, Michael" sort="Rokoss, Michael" uniqKey="Rokoss M" first="Michael" last="Rokoss">Michael Rokoss</name>
<affiliation><nlm:affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dzavik, Vladimir" sort="Dzavik, Vladimir" uniqKey="Dzavik V" first="Vladimír" last="Džavík">Vladimír Džavík</name>
<affiliation><nlm:affiliation>Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Canada.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">American heart journal</title>
<idno type="eISSN">1097-6744</idno>
<imprint><date when="2014" type="published">2014</date>
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<term>Humans</term>
<term>Microcirculation</term>
<term>Myocardial Infarction (therapy)</term>
<term>Percutaneous Coronary Intervention (methods)</term>
<term>Prospective Studies</term>
<term>Suction (methods)</term>
<term>Thrombectomy (methods)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Percutaneous Coronary Intervention</term>
<term>Suction</term>
<term>Thrombectomy</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Myocardial Infarction</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Combined Modality Therapy</term>
<term>Humans</term>
<term>Microcirculation</term>
<term>Prospective Studies</term>
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<front><div type="abstract" xml:lang="en">A major limitation of primary percutaneous coronary intervention (PPCI) for the treatment of ST-elevation myocardial infarction (STEMI) is impaired microvascular perfusion due to embolization and obstruction of microcirculation with thrombus. Manual thrombectomy has the potential to reduce distal embolization and improve microvascular perfusion. Clinical trials have shown mixed results regarding thrombectomy.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24576514</PMID>
<DateCreated><Year>2014</Year>
<Month>02</Month>
<Day>28</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>04</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>02</Month>
<Day>28</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-6744</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>167</Volume>
<Issue>3</Issue>
<PubDate><Year>2014</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>American heart journal</Title>
<ISOAbbreviation>Am. Heart J.</ISOAbbreviation>
</Journal>
<ArticleTitle>Design and rationale of the TOTAL trial: a randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI.</ArticleTitle>
<Pagination><MedlinePgn>315-321.e1</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ahj.2013.12.002</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0002-8703(13)00826-0</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A major limitation of primary percutaneous coronary intervention (PPCI) for the treatment of ST-elevation myocardial infarction (STEMI) is impaired microvascular perfusion due to embolization and obstruction of microcirculation with thrombus. Manual thrombectomy has the potential to reduce distal embolization and improve microvascular perfusion. Clinical trials have shown mixed results regarding thrombectomy.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The objective of this study is to evaluate the efficacy of routine upfront manual aspiration thrombectomy during PPCI compared with percutaneous coronary intervention alone in patients with STEMI.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">This is a multicenter, prospective, open, international, randomized trial with blinded assessment of outcomes. Patients with STEMI undergoing PPCI are randomized to upfront routine manual aspiration thrombectomy with the Export catheter (Medtronic CardioVascular, Santa Rosa, CA) or to percutaneous coronary intervention alone. The primary outcome is the composite of cardiovascular death, recurrent myocardial infarction, cardiogenic shock, or new or worsening New York Heart Association class IV heart failure up to 180 days. The trial uses an event-driven design and will recruit 10,700 patients.</AbstractText>
<AbstractText Label="SUMMARY" NlmCategory="CONCLUSIONS">The TOTAL trial will determine the effect of routine manual aspiration thrombectomy during PPCI on clinically important outcomes.</AbstractText>
<CopyrightInformation>Copyright © 2014 The Authors. Published by Mosby, Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jolly</LastName>
<ForeName>Sanjit S</ForeName>
<Initials>SS</Initials>
<AffiliationInfo><Affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada. Electronic address: sanjit.jolly@phri.ca.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cairns</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>University of British Columbia, Vancouver, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yusuf</LastName>
<ForeName>Salim</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meeks</LastName>
<ForeName>Brandi</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shestakovska</LastName>
<ForeName>Olga</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thabane</LastName>
<ForeName>Lehana</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Niemelä</LastName>
<ForeName>Kari</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Tampere Heart Center and University Hospital, Tampere, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Steg</LastName>
<ForeName>Philippe Gabriel</ForeName>
<Initials>PG</Initials>
<AffiliationInfo><Affiliation>Université Paris-Diderot, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bertrand</LastName>
<ForeName>Olivier F</ForeName>
<Initials>OF</Initials>
<AffiliationInfo><Affiliation>Quebec Heart-Lung Institute, Laval University, Quebec, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rao</LastName>
<ForeName>Sunil V</ForeName>
<Initials>SV</Initials>
<AffiliationInfo><Affiliation>Duke Clinical Research Institute, Duke University, Durham, NC.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Avezum</LastName>
<ForeName>Alvaro</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Dante Pazzanese Institute of Cardiology, São Paulo, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cantor</LastName>
<ForeName>Warren J</ForeName>
<Initials>WJ</Initials>
<AffiliationInfo><Affiliation>Southlake Regional Health Centre, University of Toronto, Newmarket, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pancholy</LastName>
<ForeName>Samir B</ForeName>
<Initials>SB</Initials>
<AffiliationInfo><Affiliation>The Commonwealth Medical College, Scranton, PA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moreno</LastName>
<ForeName>Raul</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Hospital La Paz, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gershlick</LastName>
<ForeName>Anthony</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, University Hospitals of Leicester, Glenfield Hospital, Leicester, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bhindi</LastName>
<ForeName>Ravinay</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Royal North Shore and North Shore Private Hospitals, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Welsh</LastName>
<ForeName>Robert C</ForeName>
<Initials>RC</Initials>
<AffiliationInfo><Affiliation>University of Alberta, Edmonton, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cheema</LastName>
<ForeName>Asim N</ForeName>
<Initials>AN</Initials>
<AffiliationInfo><Affiliation>St Michael's Hospital, University of Toronto, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lavi</LastName>
<ForeName>Shahar</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>London Health Sciences Centre, Western University, London, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rokoss</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Džavík</LastName>
<ForeName>Vladimír</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Canada.</Affiliation>
</AffiliationInfo>
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<Language>eng</Language>
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<Day>14</Day>
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<MedlineTA>Am Heart J</MedlineTA>
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<ISSNLinking>0002-8703</ISSNLinking>
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<MeshHeading><DescriptorName UI="D017131" MajorTopicYN="N">Thrombectomy</DescriptorName>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year>
<Month>08</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2013</Year>
<Month>12</Month>
<Day>05</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2014</Year>
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<Day>1</Day>
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<ArticleId IdType="doi">10.1016/j.ahj.2013.12.002</ArticleId>
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   |texte=   Design and rationale of the TOTAL trial: a randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI.
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Design and rationale of the TOTAL trial: a randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI.

Design and rationale of the TOTAL trial: a randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI.

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