Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone
Identifieur interne : 002141 ( Main/Exploration ); précédent : 002140; suivant : 002142Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone
Auteurs : Czar Louie Gaston ; Robert J. Grimer ; Michael Parry ; Silvia Stacchiotti [Italie] ; Angelo Paolo Dei Tos [Italie] ; Hans Gelderblom [Pays-Bas] ; Stefano Ferrari [Italie] ; Giacomo G. Baldi [Italie] ; Robin L. Jones [États-Unis, Royaume-Uni] ; Sant Chawla [États-Unis] ; Paolo Casali [Italie] ; Axel Lecesne [France] ; Jean-Yves Blay [France] ; Sander P. D. Dijkstra [Pays-Bas] ; David M. Thomas [Australie] ; Piotr Rutkowski [Pologne]Source :
- Clinical Sarcoma Research [ 2045-3329 ] ; 2016.
Abstract
Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosumab has also been used pre-operatively to downstage tumours with large soft tissue extension to allow for less morbid surgery. The role of Denosumab for conventional limb GCT of bone is yet to be defined. Further studies are required to determine whether local recurrence rates will be decreased with the adjuvant use of Denosumab along with surgery. The long term use and toxicity of this agent is unknown as is the proportion of patients with primary or secondary resistance. It is advised that complicated cases of GCT requiring Denosumab treatment should be referred and followed up at expert centres. Collaborative studies involving further clinical trials and rigorous data collection are strongly recommended to identify the optimum use of this drug.
Url:
DOI: 10.1186/s13569-016-0056-0
PubMed: 27651889
PubMed Central: 5022265
Affiliations:
- Australie, France, Italie, Pays-Bas, Pologne, Royaume-Uni, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Californie, Grand Londres, Hollande-Méridionale, Lombardie, Nouvelle-Galles du Sud, Rhône-Alpes, Washington (État)
- Leyde, Londres, Lyon, Milan, Sydney
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosumab has also been used pre-operatively to downstage tumours with large soft tissue extension to allow for less morbid surgery. The role of Denosumab for conventional limb GCT of bone is yet to be defined. Further studies are required to determine whether local recurrence rates will be decreased with the adjuvant use of Denosumab along with surgery. The long term use and toxicity of this agent is unknown as is the proportion of patients with primary or secondary resistance. It is advised that complicated cases of GCT requiring Denosumab treatment should be referred and followed up at expert centres. Collaborative studies involving further clinical trials and rigorous data collection are strongly recommended to identify the optimum use of this drug.</p>
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</author>
<author><name sortKey="Dijkstra, Pd" uniqKey="Dijkstra P">PD Dijkstra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rutkowski, P" uniqKey="Rutkowski P">P Rutkowski</name>
</author>
<author><name sortKey="Ferrari, S" uniqKey="Ferrari S">S Ferrari</name>
</author>
<author><name sortKey="Grimer, Rj" uniqKey="Grimer R">RJ Grimer</name>
</author>
<author><name sortKey="Stalley, Pd" uniqKey="Stalley P">PD Stalley</name>
</author>
<author><name sortKey="Dijkstra, Sp" uniqKey="Dijkstra S">SP Dijkstra</name>
</author>
<author><name sortKey="Pienkowski, A" uniqKey="Pienkowski A">A Pienkowski</name>
</author>
<author><name sortKey="Vaz, G" uniqKey="Vaz G">G Vaz</name>
</author>
<author><name sortKey="Wunder, Js" uniqKey="Wunder J">JS Wunder</name>
</author>
<author><name sortKey="Seeger, Ll" uniqKey="Seeger L">LL Seeger</name>
</author>
<author><name sortKey="Feng, A" uniqKey="Feng A">A Feng</name>
</author>
<author><name sortKey="Roberts, Zj" uniqKey="Roberts Z">ZJ Roberts</name>
</author>
<author><name sortKey="Bach, Ba" uniqKey="Bach B">BA Bach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hakozaki, M" uniqKey="Hakozaki M">M Hakozaki</name>
</author>
<author><name sortKey="Tajino, T" uniqKey="Tajino T">T Tajino</name>
</author>
<author><name sortKey="Yamada, H" uniqKey="Yamada H">H Yamada</name>
</author>
<author><name sortKey="Hasegawa, O" uniqKey="Hasegawa O">O Hasegawa</name>
</author>
<author><name sortKey="Tasaki, K" uniqKey="Tasaki K">K Tasaki</name>
</author>
<author><name sortKey="Watanabe, K" uniqKey="Watanabe K">K Watanabe</name>
</author>
<author><name sortKey="Konno, S" uniqKey="Konno S">S Konno</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gaston, Cl" uniqKey="Gaston C">CL Gaston</name>
</author>
<author><name sortKey="Puls, F" uniqKey="Puls F">F Puls</name>
</author>
<author><name sortKey="Grimer, Rj" uniqKey="Grimer R">RJ Grimer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bickels, J" uniqKey="Bickels J">J Bickels</name>
</author>
<author><name sortKey="Meller, I" uniqKey="Meller I">I Meller</name>
</author>
<author><name sortKey="Shmookler, Bm" uniqKey="Shmookler B">BM Shmookler</name>
</author>
<author><name sortKey="Malawer, Mm" uniqKey="Malawer M">MM Malawer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ueda, T" uniqKey="Ueda T">T Ueda</name>
</author>
<author><name sortKey="Morioka, H" uniqKey="Morioka H">H Morioka</name>
</author>
<author><name sortKey="Nishida, Y" uniqKey="Nishida Y">Y Nishida</name>
</author>
<author><name sortKey="Kakunaga, S" uniqKey="Kakunaga S">S Kakunaga</name>
</author>
<author><name sortKey="Tsuchiya, H" uniqKey="Tsuchiya H">H Tsuchiya</name>
</author>
<author><name sortKey="Matsumoto, Y" uniqKey="Matsumoto Y">Y Matsumoto</name>
</author>
<author><name sortKey="Asami, Y" uniqKey="Asami Y">Y Asami</name>
</author>
<author><name sortKey="Inoue, T" uniqKey="Inoue T">T Inoue</name>
</author>
<author><name sortKey="Yoneda, T" uniqKey="Yoneda T">T Yoneda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aponte Tinao, La" uniqKey="Aponte Tinao L">LA Aponte-Tinao</name>
</author>
<author><name sortKey="Piuzzi, Ns" uniqKey="Piuzzi N">NS Piuzzi</name>
</author>
<author><name sortKey="Roitman, P" uniqKey="Roitman P">P Roitman</name>
</author>
<author><name sortKey="Farfalli, Gl" uniqKey="Farfalli G">GL Farfalli</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Californie</li>
<li>Grand Londres</li>
<li>Hollande-Méridionale</li>
<li>Lombardie</li>
<li>Nouvelle-Galles du Sud</li>
<li>Rhône-Alpes</li>
<li>Washington (État)</li>
</region>
<settlement><li>Leyde</li>
<li>Londres</li>
<li>Lyon</li>
<li>Milan</li>
<li>Sydney</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Gaston, Czar Louie" sort="Gaston, Czar Louie" uniqKey="Gaston C" first="Czar Louie" last="Gaston">Czar Louie Gaston</name>
<name sortKey="Grimer, Robert J" sort="Grimer, Robert J" uniqKey="Grimer R" first="Robert J." last="Grimer">Robert J. Grimer</name>
<name sortKey="Parry, Michael" sort="Parry, Michael" uniqKey="Parry M" first="Michael" last="Parry">Michael Parry</name>
</noCountry>
<country name="Italie"><region name="Lombardie"><name sortKey="Stacchiotti, Silvia" sort="Stacchiotti, Silvia" uniqKey="Stacchiotti S" first="Silvia" last="Stacchiotti">Silvia Stacchiotti</name>
</region>
<name sortKey="Baldi, Giacomo G" sort="Baldi, Giacomo G" uniqKey="Baldi G" first="Giacomo G." last="Baldi">Giacomo G. Baldi</name>
<name sortKey="Casali, Paolo" sort="Casali, Paolo" uniqKey="Casali P" first="Paolo" last="Casali">Paolo Casali</name>
<name sortKey="Dei Tos, Angelo Paolo" sort="Dei Tos, Angelo Paolo" uniqKey="Dei Tos A" first="Angelo Paolo" last="Dei Tos">Angelo Paolo Dei Tos</name>
<name sortKey="Ferrari, Stefano" sort="Ferrari, Stefano" uniqKey="Ferrari S" first="Stefano" last="Ferrari">Stefano Ferrari</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Gelderblom, Hans" sort="Gelderblom, Hans" uniqKey="Gelderblom H" first="Hans" last="Gelderblom">Hans Gelderblom</name>
</region>
<name sortKey="Dijkstra, Sander P D" sort="Dijkstra, Sander P D" uniqKey="Dijkstra S" first="Sander P. D." last="Dijkstra">Sander P. D. Dijkstra</name>
</country>
<country name="États-Unis"><region name="Washington (État)"><name sortKey="Jones, Robin L" sort="Jones, Robin L" uniqKey="Jones R" first="Robin L." last="Jones">Robin L. Jones</name>
</region>
<name sortKey="Chawla, Sant" sort="Chawla, Sant" uniqKey="Chawla S" first="Sant" last="Chawla">Sant Chawla</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Jones, Robin L" sort="Jones, Robin L" uniqKey="Jones R" first="Robin L." last="Jones">Robin L. Jones</name>
</region>
</country>
<country name="France"><noRegion><name sortKey="Lecesne, Axel" sort="Lecesne, Axel" uniqKey="Lecesne A" first="Axel" last="Lecesne">Axel Lecesne</name>
</noRegion>
<name sortKey="Blay, Jean Yves" sort="Blay, Jean Yves" uniqKey="Blay J" first="Jean-Yves" last="Blay">Jean-Yves Blay</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Thomas, David M" sort="Thomas, David M" uniqKey="Thomas D" first="David M." last="Thomas">David M. Thomas</name>
</region>
</country>
<country name="Pologne"><noRegion><name sortKey="Rutkowski, Piotr" sort="Rutkowski, Piotr" uniqKey="Rutkowski P" first="Piotr" last="Rutkowski">Piotr Rutkowski</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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