Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone
Identifieur interne : 000D37 ( Pmc/Curation ); précédent : 000D36; suivant : 000D38Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone
Auteurs : Czar Louie Gaston ; Robert J. Grimer ; Michael Parry ; Silvia Stacchiotti [Italie] ; Angelo Paolo Dei Tos [Italie] ; Hans Gelderblom [Pays-Bas] ; Stefano Ferrari [Italie] ; Giacomo G. Baldi [Italie] ; Robin L. Jones [États-Unis, Royaume-Uni] ; Sant Chawla [États-Unis] ; Paolo Casali [Italie] ; Axel Lecesne [France] ; Jean-Yves Blay [France] ; Sander P. D. Dijkstra [Pays-Bas] ; David M. Thomas [Australie] ; Piotr Rutkowski [Pologne]Source :
- Clinical Sarcoma Research [ 2045-3329 ] ; 2016.
Abstract
Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosumab has also been used pre-operatively to downstage tumours with large soft tissue extension to allow for less morbid surgery. The role of Denosumab for conventional limb GCT of bone is yet to be defined. Further studies are required to determine whether local recurrence rates will be decreased with the adjuvant use of Denosumab along with surgery. The long term use and toxicity of this agent is unknown as is the proportion of patients with primary or secondary resistance. It is advised that complicated cases of GCT requiring Denosumab treatment should be referred and followed up at expert centres. Collaborative studies involving further clinical trials and rigorous data collection are strongly recommended to identify the optimum use of this drug.
Url:
DOI: 10.1186/s13569-016-0056-0
PubMed: 27651889
PubMed Central: 5022265
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Czar Louie Gaston<affiliation><nlm:aff id="Aff1">Oncology Service, Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Birmingham, B31 2AP UK</nlm:aff>
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</affiliation>
<affiliation><nlm:aff id="Aff1">Oncology Service, Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Birmingham, B31 2AP UK</nlm:aff>
<wicri:noCountry code="subfield">B31 2AP UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff1">Oncology Service, Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Birmingham, B31 2AP UK</nlm:aff>
<wicri:noCountry code="subfield">B31 2AP UK</wicri:noCountry>
</affiliation>
Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosumab has also been used pre-operatively to downstage tumours with large soft tissue extension to allow for less morbid surgery. The role of Denosumab for conventional limb GCT of bone is yet to be defined. Further studies are required to determine whether local recurrence rates will be decreased with the adjuvant use of Denosumab along with surgery. The long term use and toxicity of this agent is unknown as is the proportion of patients with primary or secondary resistance. It is advised that complicated cases of GCT requiring Denosumab treatment should be referred and followed up at expert centres. Collaborative studies involving further clinical trials and rigorous data collection are strongly recommended to identify the optimum use of this drug.</p>
</div>
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</author>
<author><name sortKey="Tarpey, Ps" uniqKey="Tarpey P">PS Tarpey</name>
</author>
<author><name sortKey="Presneau, N" uniqKey="Presneau N">N Presneau</name>
</author>
<author><name sortKey="Scheipl, S" uniqKey="Scheipl S">S Scheipl</name>
</author>
<author><name sortKey="Pillay, N" uniqKey="Pillay N">N Pillay</name>
</author>
<author><name sortKey="Van Loo, P" uniqKey="Van Loo P">P Van Loo</name>
</author>
<author><name sortKey="Wedge, Dc" uniqKey="Wedge D">DC Wedge</name>
</author>
<author><name sortKey="Cooke, Sl" uniqKey="Cooke S">SL Cooke</name>
</author>
<author><name sortKey="Gundem, G" uniqKey="Gundem G">G Gundem</name>
</author>
<author><name sortKey="Davies, H" uniqKey="Davies H">H Davies</name>
</author>
<author><name sortKey="Nik Zainal, S" uniqKey="Nik Zainal S">S Nik-Zainal</name>
</author>
<author><name sortKey="Martin, S" uniqKey="Martin S">S Martin</name>
</author>
<author><name sortKey="Mclaren, S" uniqKey="Mclaren S">S McLaren</name>
</author>
<author><name sortKey="Goody, V" uniqKey="Goody V">V Goody</name>
</author>
<author><name sortKey="Robinson, B" uniqKey="Robinson B">B Robinson</name>
</author>
<author><name sortKey="Butler, A" uniqKey="Butler A">A Butler</name>
</author>
<author><name sortKey="Teague, Jw" uniqKey="Teague J">JW Teague</name>
</author>
<author><name sortKey="Halai, D" uniqKey="Halai D">D Halai</name>
</author>
<author><name sortKey="Khatri, B" uniqKey="Khatri B">B Khatri</name>
</author>
<author><name sortKey="Myklebost, O" uniqKey="Myklebost O">O Myklebost</name>
</author>
<author><name sortKey="Baumhoer, D" uniqKey="Baumhoer D">D Baumhoer</name>
</author>
<author><name sortKey="Jundt, G" uniqKey="Jundt G">G Jundt</name>
</author>
<author><name sortKey="Hamoudi, R" uniqKey="Hamoudi R">R Hamoudi</name>
</author>
<author><name sortKey="Tirabosco, R" uniqKey="Tirabosco R">R Tirabosco</name>
</author>
<author><name sortKey="Amary, Mf" uniqKey="Amary M">MF Amary</name>
</author>
<author><name sortKey="Futreal, Pa" uniqKey="Futreal P">PA Futreal</name>
</author>
<author><name sortKey="Stratton, Mr" uniqKey="Stratton M">MR Stratton</name>
</author>
<author><name sortKey="Campbell, Pj" uniqKey="Campbell P">PJ Campbell</name>
</author>
<author><name sortKey="Flanagan, Am" uniqKey="Flanagan A">AM Flanagan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Heijden, L" uniqKey="Van Der Heijden L">L van der Heijden</name>
</author>
<author><name sortKey="Van Der Geest, Ic" uniqKey="Van Der Geest I">IC van der Geest</name>
</author>
<author><name sortKey="Schreuder, Hw" uniqKey="Schreuder H">HW Schreuder</name>
</author>
<author><name sortKey="Van De Sande, Ma" uniqKey="Van De Sande M">MA van de Sande</name>
</author>
<author><name sortKey="Dijkstra, Pd" uniqKey="Dijkstra P">PD Dijkstra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jones, Kb" uniqKey="Jones K">KB Jones</name>
</author>
<author><name sortKey="Deyoung, Br" uniqKey="Deyoung B">BR DeYoung</name>
</author>
<author><name sortKey="Morcuende, Ja" uniqKey="Morcuende J">JA Morcuende</name>
</author>
<author><name sortKey="Buckwalter, Ja" uniqKey="Buckwalter J">JA Buckwalter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gaston, Cl" uniqKey="Gaston C">CL Gaston</name>
</author>
<author><name sortKey="Bhumbra, R" uniqKey="Bhumbra R">R Bhumbra</name>
</author>
<author><name sortKey="Watanuki, M" uniqKey="Watanuki M">M Watanuki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tse, Lf" uniqKey="Tse L">LF Tse</name>
</author>
<author><name sortKey="Wong, Kc" uniqKey="Wong K">KC Wong</name>
</author>
<author><name sortKey="Kumta, Sm" uniqKey="Kumta S">SM Kumta</name>
</author>
<author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name>
</author>
<author><name sortKey="Chow, Tc" uniqKey="Chow T">TC Chow</name>
</author>
<author><name sortKey="Griffith, Jf" uniqKey="Griffith J">JF Griffith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gouin, F" uniqKey="Gouin F">F Gouin</name>
</author>
<author><name sortKey="Rochwerger, Ar" uniqKey="Rochwerger A">AR Rochwerger</name>
</author>
<author><name sortKey="Di Marco, A" uniqKey="Di Marco A">A Di Marco</name>
</author>
<author><name sortKey="Rosset, P" uniqKey="Rosset P">P Rosset</name>
</author>
<author><name sortKey="Bonnevialle, P" uniqKey="Bonnevialle P">P Bonnevialle</name>
</author>
<author><name sortKey="Fiorenza, F" uniqKey="Fiorenza F">F Fiorenza</name>
</author>
<author><name sortKey="Anract, P" uniqKey="Anract P">P Anract</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balke, M" uniqKey="Balke M">M Balke</name>
</author>
<author><name sortKey="Schremper, L" uniqKey="Schremper L">L Schremper</name>
</author>
<author><name sortKey="Gebert, C" uniqKey="Gebert C">C Gebert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kivioja, Ah" uniqKey="Kivioja A">AH Kivioja</name>
</author>
<author><name sortKey="Blomqvist, C" uniqKey="Blomqvist C">C Blomqvist</name>
</author>
<author><name sortKey="Hietaniemi, K" uniqKey="Hietaniemi K">K Hietaniemi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klenke, Fm" uniqKey="Klenke F">FM Klenke</name>
</author>
<author><name sortKey="Wenger, De" uniqKey="Wenger D">DE Wenger</name>
</author>
<author><name sortKey="Inwards, Cy" uniqKey="Inwards C">CY Inwards</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prosser, Gh" uniqKey="Prosser G">GH Prosser</name>
</author>
<author><name sortKey="Baloch, Kg" uniqKey="Baloch K">KG Baloch</name>
</author>
<author><name sortKey="Tillman, Rm" uniqKey="Tillman R">RM Tillman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leggon, Re" uniqKey="Leggon R">RE Leggon</name>
</author>
<author><name sortKey="Zlotecki, R" uniqKey="Zlotecki R">R Zlotecki</name>
</author>
<author><name sortKey="Reith, J" uniqKey="Reith J">J Reith</name>
</author>
<author><name sortKey="Scarborough, Mt" uniqKey="Scarborough M">MT Scarborough</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin, C" uniqKey="Martin C">C Martin</name>
</author>
<author><name sortKey="Mccarthy, Ef" uniqKey="Mccarthy E">EF McCarthy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bhatia, S" uniqKey="Bhatia S">S Bhatia</name>
</author>
<author><name sortKey="Miszczyk, L" uniqKey="Miszczyk L">L Miszczyk</name>
</author>
<author><name sortKey="Roelandts, M" uniqKey="Roelandts M">M Roelandts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balke, M" uniqKey="Balke M">M Balke</name>
</author>
<author><name sortKey="Henrichs, Mp" uniqKey="Henrichs M">MP Henrichs</name>
</author>
<author><name sortKey="Gosheger, G" uniqKey="Gosheger G">G Gosheger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name>
</author>
<author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name>
</author>
<author><name sortKey="Chen, K" uniqKey="Chen K">K Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chakravarti, A" uniqKey="Chakravarti A">A Chakravarti</name>
</author>
<author><name sortKey="Spiro, Ij" uniqKey="Spiro I">IJ Spiro</name>
</author>
<author><name sortKey="Hug, Eb" uniqKey="Hug E">EB Hug</name>
</author>
<author><name sortKey="Mankin, Hj" uniqKey="Mankin H">HJ Mankin</name>
</author>
<author><name sortKey="Efird, Jt" uniqKey="Efird J">JT Efird</name>
</author>
<author><name sortKey="Suit, Hd" uniqKey="Suit H">HD Suit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ruka, W" uniqKey="Ruka W">W Ruka</name>
</author>
<author><name sortKey="Rutkowski, P" uniqKey="Rutkowski P">P Rutkowski</name>
</author>
<author><name sortKey="Morysi Ski, T" uniqKey="Morysi Ski T">T Morysiński</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cornelis, F" uniqKey="Cornelis F">F Cornelis</name>
</author>
<author><name sortKey="Truchetet, Me" uniqKey="Truchetet M">ME Truchetet</name>
</author>
<author><name sortKey="Amoretti, N" uniqKey="Amoretti N">N Amoretti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, W" uniqKey="Xu W">W Xu</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Huang, W" uniqKey="Huang W">W Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Agarwal, A" uniqKey="Agarwal A">A Agarwal</name>
</author>
<author><name sortKey="Larsen, Bt" uniqKey="Larsen B">BT Larsen</name>
</author>
<author><name sortKey="Buadu, Ld" uniqKey="Buadu L">LD Buadu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mattei, Ta" uniqKey="Mattei T">TA Mattei</name>
</author>
<author><name sortKey="Ramos, E" uniqKey="Ramos E">E Ramos</name>
</author>
<author><name sortKey="Rehman, Aa" uniqKey="Rehman A">AA Rehman</name>
</author>
<author><name sortKey="Shaw, A" uniqKey="Shaw A">A Shaw</name>
</author>
<author><name sortKey="Patel, Sr" uniqKey="Patel S">SR Patel</name>
</author>
<author><name sortKey="Mendel, E" uniqKey="Mendel E">E Mendel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stewart, Dj" uniqKey="Stewart D">DJ Stewart</name>
</author>
<author><name sortKey="Belanger, R" uniqKey="Belanger R">R Belanger</name>
</author>
<author><name sortKey="Benjamin, Rs" uniqKey="Benjamin R">RS Benjamin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yamamoto, M" uniqKey="Yamamoto M">M Yamamoto</name>
</author>
<author><name sortKey="Fukushima, T" uniqKey="Fukushima T">T Fukushima</name>
</author>
<author><name sortKey="Sakamoto, S" uniqKey="Sakamoto S">S Sakamoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mella, O" uniqKey="Mella O">O Mella</name>
</author>
<author><name sortKey="Dahl, O" uniqKey="Dahl O">O Dahl</name>
</author>
<author><name sortKey="Bang, G" uniqKey="Bang G">G Bang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thomas, D" uniqKey="Thomas D">D Thomas</name>
</author>
<author><name sortKey="Henshaw, R" uniqKey="Henshaw R">R Henshaw</name>
</author>
<author><name sortKey="Skubitz, K" uniqKey="Skubitz K">K Skubitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chawla, S" uniqKey="Chawla S">S Chawla</name>
</author>
<author><name sortKey="Henshaw, R" uniqKey="Henshaw R">R Henshaw</name>
</author>
<author><name sortKey="Seeger, L" uniqKey="Seeger L">L Seeger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name>
</author>
<author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name>
</author>
<author><name sortKey="Wood, Dj" uniqKey="Wood D">DJ Wood</name>
</author>
<author><name sortKey="Zheng, Mh" uniqKey="Zheng M">MH Zheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Atkins, Gj" uniqKey="Atkins G">GJ Atkins</name>
</author>
<author><name sortKey="Kostakis, P" uniqKey="Kostakis P">P Kostakis</name>
</author>
<author><name sortKey="Vincent, C" uniqKey="Vincent C">C Vincent</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thomas, Dm" uniqKey="Thomas D">DM Thomas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Branstetter, Dg" uniqKey="Branstetter D">DG Branstetter</name>
</author>
<author><name sortKey="Nelson, Sd" uniqKey="Nelson S">SD Nelson</name>
</author>
<author><name sortKey="Manivel, Jc" uniqKey="Manivel J">JC Manivel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goldenberg, Mm" uniqKey="Goldenberg M">MM Goldenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Karras, Na" uniqKey="Karras N">NA Karras</name>
</author>
<author><name sortKey="Polgreen, Le" uniqKey="Polgreen L">LE Polgreen</name>
</author>
<author><name sortKey="Ogilvie, C" uniqKey="Ogilvie C">C Ogilvie</name>
</author>
<author><name sortKey="Manivel, Jc" uniqKey="Manivel J">JC Manivel</name>
</author>
<author><name sortKey="Skubitz, Km" uniqKey="Skubitz K">KM Skubitz</name>
</author>
<author><name sortKey="Lipsitz, E" uniqKey="Lipsitz E">E Lipsitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Demirsoy, U" uniqKey="Demirsoy U">U Demirsoy</name>
</author>
<author><name sortKey="Karadogan, M" uniqKey="Karadogan M">M Karadogan</name>
</author>
<author><name sortKey="Selek, O" uniqKey="Selek O">Ö Selek</name>
</author>
<author><name sortKey="Anik, Y" uniqKey="Anik Y">Y Anik</name>
</author>
<author><name sortKey="Aksu, G" uniqKey="Aksu G">G Aksu</name>
</author>
<author><name sortKey="Muezzinoglu, B" uniqKey="Muezzinoglu B">B Müezzinoglu</name>
</author>
<author><name sortKey="Corapcioglu, F" uniqKey="Corapcioglu F">F Corapcioglu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gossai, N" uniqKey="Gossai N">N Gossai</name>
</author>
<author><name sortKey="Hilgers, Mv" uniqKey="Hilgers M">MV Hilgers</name>
</author>
<author><name sortKey="Polgreen, Le" uniqKey="Polgreen L">LE Polgreen</name>
</author>
<author><name sortKey="Greengard, Eg" uniqKey="Greengard E">EG Greengard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ulas, A" uniqKey="Ulas A">A Ulas</name>
</author>
<author><name sortKey="Bulent Akinci, M" uniqKey="Bulent Akinci M">M Bulent Akinci</name>
</author>
<author><name sortKey="Silay, K" uniqKey="Silay K">K Silay</name>
</author>
<author><name sortKey="Sendur, Ma" uniqKey="Sendur M">MA Sendur</name>
</author>
<author><name sortKey="Sener Dede, D" uniqKey="Sener Dede D">D Sener Dede</name>
</author>
<author><name sortKey="Yalcin, B" uniqKey="Yalcin B">B Yalcin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mak, Iw" uniqKey="Mak I">IW Mak</name>
</author>
<author><name sortKey="Evaniew, N" uniqKey="Evaniew N">N Evaniew</name>
</author>
<author><name sortKey="Popovic, S" uniqKey="Popovic S">S Popovic</name>
</author>
<author><name sortKey="Tozer, R" uniqKey="Tozer R">R Tozer</name>
</author>
<author><name sortKey="Ghert, M" uniqKey="Ghert M">M Ghert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, Cp" uniqKey="Lau C">CP Lau</name>
</author>
<author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name>
</author>
<author><name sortKey="Wong, Kc" uniqKey="Wong K">KC Wong</name>
</author>
<author><name sortKey="Kumta, Sm" uniqKey="Kumta S">SM Kumta</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Bussiere, Jl" uniqKey="Bussiere J">JL Bussiere</name>
</author>
<author><name sortKey="Pyrah, I" uniqKey="Pyrah I">I Pyrah</name>
</author>
<author><name sortKey="Boyce, R" uniqKey="Boyce R">R Boyce</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schilcher, J" uniqKey="Schilcher J">J Schilcher</name>
</author>
<author><name sortKey="Aspenberg, P" uniqKey="Aspenberg P">P Aspenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kajizono, M" uniqKey="Kajizono M">M Kajizono</name>
</author>
<author><name sortKey="Sada, H" uniqKey="Sada H">H Sada</name>
</author>
<author><name sortKey="Sugiura, Y" uniqKey="Sugiura Y">Y Sugiura</name>
</author>
<author><name sortKey="Soga, Y" uniqKey="Soga Y">Y Soga</name>
</author>
<author><name sortKey="Kitamura, Y" uniqKey="Kitamura Y">Y Kitamura</name>
</author>
<author><name sortKey="Matsuoka, J" uniqKey="Matsuoka J">J Matsuoka</name>
</author>
<author><name sortKey="Sendo, T" uniqKey="Sendo T">T Sendo</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Watanabe, N" uniqKey="Watanabe N">N Watanabe</name>
</author>
<author><name sortKey="Matsumoto, S" uniqKey="Matsumoto S">S Matsumoto</name>
</author>
<author><name sortKey="Shimoji, T" uniqKey="Shimoji T">T Shimoji</name>
</author>
<author><name sortKey="Ae, K" uniqKey="Ae K">K Ae</name>
</author>
<author><name sortKey="Tanizawa, T" uniqKey="Tanizawa T">T Tanizawa</name>
</author>
<author><name sortKey="Gokita, T" uniqKey="Gokita T">T Gokita</name>
</author>
<author><name sortKey="Motoi, N" uniqKey="Motoi N">N Motoi</name>
</author>
<author><name sortKey="Ueno, T" uniqKey="Ueno T">T Ueno</name>
</author>
<author><name sortKey="Koizumi, M" uniqKey="Koizumi M">M Koizumi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lipton, A" uniqKey="Lipton A">A Lipton</name>
</author>
<author><name sortKey="Steger, Gg" uniqKey="Steger G">GG Steger</name>
</author>
<author><name sortKey="Figueroa, J" uniqKey="Figueroa J">J Figueroa</name>
</author>
<author><name sortKey="Alvarado, C" uniqKey="Alvarado C">C Alvarado</name>
</author>
<author><name sortKey="Solal Celigny, P" uniqKey="Solal Celigny P">P Solal-Celigny</name>
</author>
<author><name sortKey="Body, Jj" uniqKey="Body J">JJ Body</name>
</author>
<author><name sortKey="De Boer, R" uniqKey="De Boer R">R de Boer</name>
</author>
<author><name sortKey="Berardi, R" uniqKey="Berardi R">R Berardi</name>
</author>
<author><name sortKey="Gascon, P" uniqKey="Gascon P">P Gascon</name>
</author>
<author><name sortKey="Tonkin, Ks" uniqKey="Tonkin K">KS Tonkin</name>
</author>
<author><name sortKey="Coleman, R" uniqKey="Coleman R">R Coleman</name>
</author>
<author><name sortKey="Paterson, Ah" uniqKey="Paterson A">AH Paterson</name>
</author>
<author><name sortKey="Peterson, Mc" uniqKey="Peterson M">MC Peterson</name>
</author>
<author><name sortKey="Fan, M" uniqKey="Fan M">M Fan</name>
</author>
<author><name sortKey="Kinsey, A" uniqKey="Kinsey A">A Kinsey</name>
</author>
<author><name sortKey="Jun, S" uniqKey="Jun S">S Jun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thangaraj, R" uniqKey="Thangaraj R">R Thangaraj</name>
</author>
<author><name sortKey="Grimer, Rj" uniqKey="Grimer R">RJ Grimer</name>
</author>
<author><name sortKey="Carter, Sr" uniqKey="Carter S">SR Carter</name>
</author>
<author><name sortKey="Stirling, Aj" uniqKey="Stirling A">AJ Stirling</name>
</author>
<author><name sortKey="Spilsbury, J" uniqKey="Spilsbury J">J Spilsbury</name>
</author>
<author><name sortKey="Spooner, D" uniqKey="Spooner D">D Spooner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Akaike, K" uniqKey="Akaike K">K Akaike</name>
</author>
<author><name sortKey="Suehara, Y" uniqKey="Suehara Y">Y Suehara</name>
</author>
<author><name sortKey="Takagi, T" uniqKey="Takagi T">T Takagi</name>
</author>
<author><name sortKey="Kaneko, K" uniqKey="Kaneko K">K Kaneko</name>
</author>
<author><name sortKey="Saito, T" uniqKey="Saito T">T Saito</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heijden, Lv" uniqKey="Heijden L">LV Heijden</name>
</author>
<author><name sortKey="Sande, Ma" uniqKey="Sande M">MA Sande</name>
</author>
<author><name sortKey="Hogendoorn, Pc" uniqKey="Hogendoorn P">PC Hogendoorn</name>
</author>
<author><name sortKey="Gelderblom, H" uniqKey="Gelderblom H">H Gelderblom</name>
</author>
<author><name sortKey="Dijkstra, Pd" uniqKey="Dijkstra P">PD Dijkstra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rutkowski, P" uniqKey="Rutkowski P">P Rutkowski</name>
</author>
<author><name sortKey="Ferrari, S" uniqKey="Ferrari S">S Ferrari</name>
</author>
<author><name sortKey="Grimer, Rj" uniqKey="Grimer R">RJ Grimer</name>
</author>
<author><name sortKey="Stalley, Pd" uniqKey="Stalley P">PD Stalley</name>
</author>
<author><name sortKey="Dijkstra, Sp" uniqKey="Dijkstra S">SP Dijkstra</name>
</author>
<author><name sortKey="Pienkowski, A" uniqKey="Pienkowski A">A Pienkowski</name>
</author>
<author><name sortKey="Vaz, G" uniqKey="Vaz G">G Vaz</name>
</author>
<author><name sortKey="Wunder, Js" uniqKey="Wunder J">JS Wunder</name>
</author>
<author><name sortKey="Seeger, Ll" uniqKey="Seeger L">LL Seeger</name>
</author>
<author><name sortKey="Feng, A" uniqKey="Feng A">A Feng</name>
</author>
<author><name sortKey="Roberts, Zj" uniqKey="Roberts Z">ZJ Roberts</name>
</author>
<author><name sortKey="Bach, Ba" uniqKey="Bach B">BA Bach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hakozaki, M" uniqKey="Hakozaki M">M Hakozaki</name>
</author>
<author><name sortKey="Tajino, T" uniqKey="Tajino T">T Tajino</name>
</author>
<author><name sortKey="Yamada, H" uniqKey="Yamada H">H Yamada</name>
</author>
<author><name sortKey="Hasegawa, O" uniqKey="Hasegawa O">O Hasegawa</name>
</author>
<author><name sortKey="Tasaki, K" uniqKey="Tasaki K">K Tasaki</name>
</author>
<author><name sortKey="Watanabe, K" uniqKey="Watanabe K">K Watanabe</name>
</author>
<author><name sortKey="Konno, S" uniqKey="Konno S">S Konno</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gaston, Cl" uniqKey="Gaston C">CL Gaston</name>
</author>
<author><name sortKey="Puls, F" uniqKey="Puls F">F Puls</name>
</author>
<author><name sortKey="Grimer, Rj" uniqKey="Grimer R">RJ Grimer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bickels, J" uniqKey="Bickels J">J Bickels</name>
</author>
<author><name sortKey="Meller, I" uniqKey="Meller I">I Meller</name>
</author>
<author><name sortKey="Shmookler, Bm" uniqKey="Shmookler B">BM Shmookler</name>
</author>
<author><name sortKey="Malawer, Mm" uniqKey="Malawer M">MM Malawer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ueda, T" uniqKey="Ueda T">T Ueda</name>
</author>
<author><name sortKey="Morioka, H" uniqKey="Morioka H">H Morioka</name>
</author>
<author><name sortKey="Nishida, Y" uniqKey="Nishida Y">Y Nishida</name>
</author>
<author><name sortKey="Kakunaga, S" uniqKey="Kakunaga S">S Kakunaga</name>
</author>
<author><name sortKey="Tsuchiya, H" uniqKey="Tsuchiya H">H Tsuchiya</name>
</author>
<author><name sortKey="Matsumoto, Y" uniqKey="Matsumoto Y">Y Matsumoto</name>
</author>
<author><name sortKey="Asami, Y" uniqKey="Asami Y">Y Asami</name>
</author>
<author><name sortKey="Inoue, T" uniqKey="Inoue T">T Inoue</name>
</author>
<author><name sortKey="Yoneda, T" uniqKey="Yoneda T">T Yoneda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aponte Tinao, La" uniqKey="Aponte Tinao L">LA Aponte-Tinao</name>
</author>
<author><name sortKey="Piuzzi, Ns" uniqKey="Piuzzi N">NS Piuzzi</name>
</author>
<author><name sortKey="Roitman, P" uniqKey="Roitman P">P Roitman</name>
</author>
<author><name sortKey="Farfalli, Gl" uniqKey="Farfalli G">GL Farfalli</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Sarcoma Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Clin Sarcoma Res</journal-id>
<journal-title-group><journal-title>Clinical Sarcoma Research</journal-title>
</journal-title-group>
<issn pub-type="epub">2045-3329</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27651889</article-id>
<article-id pub-id-type="pmc">5022265</article-id>
<article-id pub-id-type="publisher-id">56</article-id>
<article-id pub-id-type="doi">10.1186/s13569-016-0056-0</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Gaston</surname>
<given-names>Czar Louie</given-names>
</name>
<address><phone>+44 121 6854037</phone>
<email>louie.gaston@nhs.net</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-1510-4596</contrib-id>
<name><surname>Grimer</surname>
<given-names>Robert J.</given-names>
</name>
<address><email>Robert.grimer@nhs.net</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Parry</surname>
<given-names>Michael</given-names>
</name>
<address><email>michael.parry3@nhs.net</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stacchiotti</surname>
<given-names>Silvia</given-names>
</name>
<address><email>Silvia.Stacchiotti@istitutotumori.mi.it</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dei Tos</surname>
<given-names>Angelo Paolo</given-names>
</name>
<address><email>apdeitos@icloud.com</email>
</address>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gelderblom</surname>
<given-names>Hans</given-names>
</name>
<address><email>A.J.Gelderblom@lumc.nl</email>
</address>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ferrari</surname>
<given-names>Stefano</given-names>
</name>
<address><email>stefano.ferrari@ior.it</email>
</address>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baldi</surname>
<given-names>Giacomo G.</given-names>
</name>
<address><email>ggbaldi@usl4.toscana.it</email>
</address>
<xref ref-type="aff" rid="Aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>Robin L.</given-names>
</name>
<address><email>robin.jones4@nhs.net</email>
</address>
<xref ref-type="aff" rid="Aff7">7</xref>
<xref ref-type="aff" rid="Aff8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chawla</surname>
<given-names>Sant</given-names>
</name>
<address><email>santchawla@sarcomaoncology.com</email>
</address>
<xref ref-type="aff" rid="Aff9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Casali</surname>
<given-names>Paolo</given-names>
</name>
<address><email>paolo.casali@istitutotumori.mi.it</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>LeCesne</surname>
<given-names>Axel</given-names>
</name>
<address><email>Axel.LECESNE@gustaveroussy.fr</email>
</address>
<xref ref-type="aff" rid="Aff10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blay</surname>
<given-names>Jean-Yves</given-names>
</name>
<address><email>jean-yves.blay@lyon.unicancer.fr</email>
</address>
<xref ref-type="aff" rid="Aff11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dijkstra</surname>
<given-names>Sander P. D.</given-names>
</name>
<address><email>P.D.S.Dijkstra@lumc.nl</email>
</address>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thomas</surname>
<given-names>David M.</given-names>
</name>
<address><email>d.thomas@garvan.org.au</email>
</address>
<xref ref-type="aff" rid="Aff12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rutkowski</surname>
<given-names>Piotr</given-names>
</name>
<address><email>piotr.rutkowski@coi.pl</email>
</address>
<xref ref-type="aff" rid="Aff13">13</xref>
</contrib>
<aff id="Aff1"><label>1</label>
Oncology Service, Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Birmingham, B31 2AP UK</aff>
<aff id="Aff2"><label>2</label>
Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy</aff>
<aff id="Aff3"><label>3</label>
Department of Anatomic Pathology, General Hospital of Treviso, Treviso, Italy</aff>
<aff id="Aff4"><label>4</label>
Leiden University Medical Center, Leiden, Netherlands</aff>
<aff id="Aff5"><label>5</label>
Department of Oncology, Rizzoli Institute, Bologna, Italy</aff>
<aff id="Aff6"><label>6</label>
Department of Cancer Medicine, S. Stefano Civil Hospital, Prato, Italy</aff>
<aff id="Aff7"><label>7</label>
University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA USA</aff>
<aff id="Aff8"><label>8</label>
Royal Marsden Hospital, London, UK</aff>
<aff id="Aff9"><label>9</label>
Sarcoma Oncology Center, Santa Monica, CA USA</aff>
<aff id="Aff10"><label>10</label>
Institut Gustave Roussy, Villejuif, France</aff>
<aff id="Aff11"><label>11</label>
Centre Leon Berard, Lyon, France</aff>
<aff id="Aff12"><label>12</label>
Garvan Institute of Medical Research, Sydney, Australia</aff>
<aff id="Aff13"><label>13</label>
Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Center and Institute of Oncology, Warsaw, Poland</aff>
</contrib-group>
<pub-date pub-type="epub"><day>14</day>
<month>9</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>14</day>
<month>9</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><year>2016</year>
</pub-date>
<volume>6</volume>
<issue>1</issue>
<elocation-id>15</elocation-id>
<history><date date-type="received"><day>19</day>
<month>5</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>9</day>
<month>8</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2016</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p>Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosumab has also been used pre-operatively to downstage tumours with large soft tissue extension to allow for less morbid surgery. The role of Denosumab for conventional limb GCT of bone is yet to be defined. Further studies are required to determine whether local recurrence rates will be decreased with the adjuvant use of Denosumab along with surgery. The long term use and toxicity of this agent is unknown as is the proportion of patients with primary or secondary resistance. It is advised that complicated cases of GCT requiring Denosumab treatment should be referred and followed up at expert centres. Collaborative studies involving further clinical trials and rigorous data collection are strongly recommended to identify the optimum use of this drug.</p>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Giant cell tumor of bone</kwd>
<kwd>Denosumab</kwd>
<kwd>Safety</kwd>
<kwd>Neoadjuvant</kwd>
<kwd>Inoperable</kwd>
<kwd>Surgery</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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