Perlecan expression influences the keratin 15‐positive cell population fate in the epidermis of aging skin
Identifieur interne : 001971 ( Main/Exploration ); précédent : 001970; suivant : 001972Perlecan expression influences the keratin 15‐positive cell population fate in the epidermis of aging skin
Auteurs : Morgan Dos Santos [France] ; Anna Michopoulou [France] ; Valérie André-Frei [France] ; Sophie Boulesteix [France] ; Christine Guicher [France] ; Guila Dayan [France] ; John Whitelock [Australie] ; Odile Damour [France] ; Patricia Rousselle [France]Source :
- Aging (Albany NY) [ 1945-4589 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Différenciation cellulaire (physiologie), Femelle, Humains, Jeune adulte, Kératine-15 (métabolisme), Kératinocytes (cytologie), Kératinocytes (métabolisme), Matrice extracellulaire (métabolisme), Mâle, Protéoglycanes à sulfate d'héparane (métabolisme), Sujet âgé, Vieillissement de la peau (physiologie), Épiderme (cytologie), Épiderme (métabolisme).
- MESH :
- cytologie : Kératinocytes, Épiderme.
- métabolisme : Kératine-15, Kératinocytes, Matrice extracellulaire, Protéoglycanes à sulfate d'héparane, Épiderme.
- physiologie : Différenciation cellulaire, Vieillissement de la peau.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- Adult, Aged, Cell Differentiation (physiology), Epidermis (cytology), Epidermis (metabolism), Extracellular Matrix (metabolism), Female, Heparan Sulfate Proteoglycans (metabolism), Humans, Keratin-15 (metabolism), Keratinocytes (cytology), Keratinocytes (metabolism), Male, Middle Aged, Skin Aging (physiology), Young Adult.
- MESH :
- chemical , metabolism : Heparan Sulfate Proteoglycans, Keratin-15.
- cytology : Epidermis, Keratinocytes.
- metabolism : Epidermis, Extracellular Matrix, Keratinocytes.
- physiology : Cell Differentiation, Skin Aging.
- Adult, Aged, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
The epidermis is continuously renewed by stem cell proliferation and differentiation. Basal keratinocytes append the dermal‐epidermal junction, a cell surface‐associated, extracellular matrix that provides structural support and influences their behaviour. It consists of laminins, type IV collagen, nidogens, and perlecan, which are necessary for tissue organization and structural integrity. Perlecan is a heparan sulfate proteoglycan known to be involved in keratinocyte survival and differentiation. Aging affects the dermal epidermal junction resulting in decreased contact with keratinocytes, thus impacting epidermal renewal and homeostasis. We found that perlecan expression decreased during chronological skin aging. Our in vitro studies revealed reduced perlecan transcript levels in aged keratinocytes. The production of in vitro skin models revealed that aged keratinocytes formed a thin and poorly organized epidermis. Supplementing these models with purified perlecan reversed the phenomenon allowing restoration of a well‐differentiated multi‐layered epithelium. Perlecan down‐regulation in cultured keratinocytes caused depletion of the cell population that expressed keratin 15. This phenomenon depended on the perlecan heparan sulphate moieties, which suggested the involvement of a growth factor. Finally, we found defects in keratin 15 expression in the epidermis of aging skin. This study highlighted a new role for perlecan in maintaining the self‐renewal capacity of basal keratinocytes.
Url:
DOI: 10.18632/aging.100928
PubMed: 26996820
PubMed Central: 4925826
Affiliations:
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Le document en format XML
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<term>Aged</term>
<term>Cell Differentiation (physiology)</term>
<term>Epidermis (cytology)</term>
<term>Epidermis (metabolism)</term>
<term>Extracellular Matrix (metabolism)</term>
<term>Female</term>
<term>Heparan Sulfate Proteoglycans (metabolism)</term>
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<term>Jeune adulte</term>
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<term>Aged</term>
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<front><div type="abstract" xml:lang="en"><p>The epidermis is continuously renewed by stem cell proliferation and differentiation. Basal keratinocytes append the dermal‐epidermal junction, a cell surface‐associated, extracellular matrix that provides structural support and influences their behaviour. It consists of laminins, type IV collagen, nidogens, and perlecan, which are necessary for tissue organization and structural integrity. Perlecan is a heparan sulfate proteoglycan known to be involved in keratinocyte survival and differentiation. Aging affects the dermal epidermal junction resulting in decreased contact with keratinocytes, thus impacting epidermal renewal and homeostasis. We found that perlecan expression decreased during chronological skin aging. Our in vitro studies revealed reduced perlecan transcript levels in aged keratinocytes. The production of in vitro skin models revealed that aged keratinocytes formed a thin and poorly organized epidermis. Supplementing these models with purified perlecan reversed the phenomenon allowing restoration of a well‐differentiated multi‐layered epithelium. Perlecan down‐regulation in cultured keratinocytes caused depletion of the cell population that expressed keratin 15. This phenomenon depended on the perlecan heparan sulphate moieties, which suggested the involvement of a growth factor. Finally, we found defects in keratin 15 expression in the epidermis of aging skin. This study highlighted a new role for perlecan in maintaining the self‐renewal capacity of basal keratinocytes.</p>
</div>
</front>
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</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
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<settlement><li>Lyon</li>
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<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Dos Santos, Morgan" sort="Dos Santos, Morgan" uniqKey="Dos Santos M" first="Morgan" last="Dos Santos">Morgan Dos Santos</name>
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<name sortKey="Dayan, Guila" sort="Dayan, Guila" uniqKey="Dayan G" first="Guila" last="Dayan">Guila Dayan</name>
<name sortKey="Dos Santos, Morgan" sort="Dos Santos, Morgan" uniqKey="Dos Santos M" first="Morgan" last="Dos Santos">Morgan Dos Santos</name>
<name sortKey="Guicher, Christine" sort="Guicher, Christine" uniqKey="Guicher C" first="Christine" last="Guicher">Christine Guicher</name>
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<country name="Australie"><noRegion><name sortKey="Whitelock, John" sort="Whitelock, John" uniqKey="Whitelock J" first="John" last="Whitelock">John Whitelock</name>
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</record>
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