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Non-Enzymatic Glycation Impairs the Anti-Inflammatory Properties of Apolipoprotein A-I

Identifieur interne : 006F13 ( Main/Exploration ); précédent : 006F12; suivant : 006F14

Non-Enzymatic Glycation Impairs the Anti-Inflammatory Properties of Apolipoprotein A-I

Auteurs : Estelle Nobécourt ; Fatiha Tabet ; Gilles Lambert [France] ; Rajesh Puranik [Australie] ; Shisan Bao [Australie] ; Ling Yan ; Michael J. Davies [Australie] ; Bronwyn E. Brown ; Alicia J. Jenkins [Australie] ; Gregory J. Dusting [Australie] ; David J. Bonnet ; Linda K. Curtiss ; Philip J. Barter [Australie] ; Kerry-Anne Rye [Australie]

Source :

RBID : PMC:3038672

Abstract

Objective

To investigate the effects of non-enzymatic glycation on the anti-inflammatory properties of apolipoprotein (apo) A-I.

Methods and Results

Rabbits were infused with saline, lipid-free apoA-I from normal subjects (apoA-IN), lipid-free apoA-I non-enzymatically glycated by incubation with methylglyoxal (apoA-IGlyc in vitro), non-enzymatically glycated lipid-free apoA-I from subjects with diabetes (apoA-IGlyc in vivo), discoidal reconstituted HDL containing phosphatidylcholine and apoA-IN, (A-IN)rHDL, or apoA-IGlyc in vitro, (A-IGlyc in vitro)rHDL. At 24 h post-infusion, acute vascular inflammation was induced by inserting a non-occlusive, periarterial carotid collar. The animals were sacrificed 24 h post-collar insertion. The collars caused intima/media neutrophil infiltration and increased endothelial expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). ApoA-IN infusion decreased neutrophil infiltration and VCAM-1 and ICAM-1 expression by 89, 90 and 66%, respectively. The apoA-IGlyc in vitro infusion decreased neutrophil infiltration by 53%, but did not reduce VCAM-1 or ICAM-1 expression. ApoA-IGlyc in vivo did not inhibit neutrophil infiltration or adhesion molecule expression. (A-IGlyc in vitro)rHDL also inhibited vascular inflammation less effectively than (A-IN)rHDL. The reduced anti-inflammatory properties of non-enzymatically glycated apoA-I were attributed to a reduced ability to inhibit nuclear factor-κB activation and reactive oxygen species formation.

Conclusion

Non-enzymatic glycation impairs the anti-inflammatory properties of apoA-I.


Url:
DOI: 10.1161/ATVBAHA.109.201715
PubMed: 20110571
PubMed Central: 3038672


Affiliations:

Links toward previous steps (curation, corpus...)

Le document en format XML

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<name sortKey="Davies, Michael J" sort="Davies, Michael J" uniqKey="Davies M" first="Michael J." last="Davies">Michael J. Davies</name>
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<nlm:aff id="A3">Faculty of Medicine, University of Sydney, NSW, Australia, 2006</nlm:aff>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
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<affiliation>
<nlm:aff id="A5">Free Radical Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff>
<wicri:noCountry code="subfield">2042</wicri:noCountry>
</affiliation>
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<name sortKey="Brown, Bronwyn E" sort="Brown, Bronwyn E" uniqKey="Brown B" first="Bronwyn E." last="Brown">Bronwyn E. Brown</name>
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<nlm:aff id="A5">Free Radical Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff>
<wicri:noCountry code="subfield">2042</wicri:noCountry>
</affiliation>
</author>
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<name sortKey="Jenkins, Alicia J" sort="Jenkins, Alicia J" uniqKey="Jenkins A" first="Alicia J" last="Jenkins">Alicia J. Jenkins</name>
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<nlm:aff id="A6">Department of Medicine, University of Melbourne, Victoria, Australia, 3010</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
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<name sortKey="Dusting, Gregory J" sort="Dusting, Gregory J" uniqKey="Dusting G" first="Gregory J." last="Dusting">Gregory J. Dusting</name>
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<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bonnet, David J" sort="Bonnet, David J" uniqKey="Bonnet D" first="David J." last="Bonnet">David J. Bonnet</name>
<affiliation>
<nlm:aff id="A8">Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA, 92037</nlm:aff>
<wicri:noCountry code="subfield">92037</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Curtiss, Linda K" sort="Curtiss, Linda K" uniqKey="Curtiss L" first="Linda K." last="Curtiss">Linda K. Curtiss</name>
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<wicri:noCountry code="subfield">92037</wicri:noCountry>
</affiliation>
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<author>
<name sortKey="Barter, Philip J" sort="Barter, Philip J" uniqKey="Barter P" first="Philip J." last="Barter">Philip J. Barter</name>
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<wicri:noCountry code="subfield">2042</wicri:noCountry>
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<country>Australie</country>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name>
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<wicri:noCountry code="subfield">2042</wicri:noCountry>
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<country>Australie</country>
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<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
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<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
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<series>
<title level="j">Arteriosclerosis, thrombosis, and vascular biology</title>
<idno type="ISSN">1079-5642</idno>
<idno type="eISSN">1524-4636</idno>
<imprint>
<date when="2010">2010</date>
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<div type="abstract" xml:lang="en">
<sec id="S1">
<title>Objective</title>
<p id="P2">To investigate the effects of non-enzymatic glycation on the anti-inflammatory properties of apolipoprotein (apo) A-I.</p>
</sec>
<sec sec-type="methods" id="S2">
<title>Methods and Results</title>
<p id="P3">Rabbits were infused with saline, lipid-free apoA-I from normal subjects (apoA-I
<sub>
<italic>N</italic>
</sub>
), lipid-free apoA-I non-enzymatically glycated by incubation with methylglyoxal (apoA-I
<italic>
<sub>Glyc in vitro</sub>
</italic>
), non-enzymatically glycated lipid-free apoA-I from subjects with diabetes (apoA-I
<sub>
<italic>Glyc in vivo</italic>
</sub>
), discoidal reconstituted HDL containing phosphatidylcholine and apoA-I
<italic>
<sub>N</sub>
</italic>
, (A-I
<sub>
<italic>N</italic>
</sub>
)rHDL, or apoA-I
<sub>
<italic>Glyc in vitro</italic>
</sub>
, (A-I
<sub>
<italic>Glyc in vitro</italic>
</sub>
)rHDL. At 24 h post-infusion, acute vascular inflammation was induced by inserting a non-occlusive, periarterial carotid collar. The animals were sacrificed 24 h post-collar insertion. The collars caused intima/media neutrophil infiltration and increased endothelial expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). ApoA-I
<sub>
<italic>N</italic>
</sub>
infusion decreased neutrophil infiltration and VCAM-1 and ICAM-1 expression by 89, 90 and 66%, respectively. The apoA-I
<sub>
<italic>Glyc in vitro</italic>
</sub>
infusion decreased neutrophil infiltration by 53%, but did not reduce VCAM-1 or ICAM-1 expression. ApoA-I
<sub>
<italic>Glyc in vivo</italic>
</sub>
did not inhibit neutrophil infiltration or adhesion molecule expression. (A-I
<sub>
<italic>Glyc in vitro</italic>
</sub>
)rHDL also inhibited vascular inflammation less effectively than (A-I
<sub>
<italic>N</italic>
</sub>
)rHDL. The reduced anti-inflammatory properties of non-enzymatically glycated apoA-I were attributed to a reduced ability to inhibit nuclear factor-κB activation and reactive oxygen species formation.</p>
</sec>
<sec id="S3">
<title>Conclusion</title>
<p id="P4">Non-enzymatic glycation impairs the anti-inflammatory properties of apoA-I.</p>
</sec>
</div>
</front>
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<li>Australie</li>
<li>France</li>
</country>
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<li>Nouvelle-Galles du Sud</li>
<li>Pays de la Loire</li>
<li>Victoria (État)</li>
</region>
<settlement>
<li>Melbourne</li>
<li>Nantes</li>
<li>Sydney</li>
</settlement>
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<li>Université de Nantes</li>
<li>Université de Sydney</li>
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<name sortKey="Bonnet, David J" sort="Bonnet, David J" uniqKey="Bonnet D" first="David J." last="Bonnet">David J. Bonnet</name>
<name sortKey="Brown, Bronwyn E" sort="Brown, Bronwyn E" uniqKey="Brown B" first="Bronwyn E." last="Brown">Bronwyn E. Brown</name>
<name sortKey="Curtiss, Linda K" sort="Curtiss, Linda K" uniqKey="Curtiss L" first="Linda K." last="Curtiss">Linda K. Curtiss</name>
<name sortKey="Nobecourt, Estelle" sort="Nobecourt, Estelle" uniqKey="Nobecourt E" first="Estelle" last="Nobécourt">Estelle Nobécourt</name>
<name sortKey="Tabet, Fatiha" sort="Tabet, Fatiha" uniqKey="Tabet F" first="Fatiha" last="Tabet">Fatiha Tabet</name>
<name sortKey="Yan, Ling" sort="Yan, Ling" uniqKey="Yan L" first="Ling" last="Yan">Ling Yan</name>
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<country name="France">
<region name="Pays de la Loire">
<name sortKey="Lambert, Gilles" sort="Lambert, Gilles" uniqKey="Lambert G" first="Gilles" last="Lambert">Gilles Lambert</name>
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<country name="Australie">
<region name="Nouvelle-Galles du Sud">
<name sortKey="Puranik, Rajesh" sort="Puranik, Rajesh" uniqKey="Puranik R" first="Rajesh" last="Puranik">Rajesh Puranik</name>
</region>
<name sortKey="Bao, Shisan" sort="Bao, Shisan" uniqKey="Bao S" first="Shisan" last="Bao">Shisan Bao</name>
<name sortKey="Barter, Philip J" sort="Barter, Philip J" uniqKey="Barter P" first="Philip J." last="Barter">Philip J. Barter</name>
<name sortKey="Davies, Michael J" sort="Davies, Michael J" uniqKey="Davies M" first="Michael J." last="Davies">Michael J. Davies</name>
<name sortKey="Dusting, Gregory J" sort="Dusting, Gregory J" uniqKey="Dusting G" first="Gregory J." last="Dusting">Gregory J. Dusting</name>
<name sortKey="Jenkins, Alicia J" sort="Jenkins, Alicia J" uniqKey="Jenkins A" first="Alicia J" last="Jenkins">Alicia J. Jenkins</name>
<name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name>
<name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name>
</country>
</tree>
</affiliations>
</record>

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